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1. 发明申请

WO1998017804A2 A HELICOBACTER ANTIGEN ('gamma'-GLUTAMYLTRANSFERASE) AND SEQUENCES ENCODING THE SAME 审中-公开
标题翻译： HELICOBACTER ANTIGEN（γ-GLUTAMYLTRANSFERASE）及其编码序列
公开(公告)号：WO1998017804A2
公开(公告)日：1998-04-30
申请号：PCT/EP1997005727
申请日：1997-10-17
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CHEVALIER, Catherine , THIBERGE, Jean-Michel , LABIGNE, Agnès
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
IPC分类号： C12N15/31
CPC分类号： C12N9/1044 , A61K38/00 , Y02A50/473
摘要： The present invention relates to a purified polynucleotide of Helicobacter characterized in that it comprises in its structure a coding sequence for a protein carrying transfer catalytic activity, for example, gamma -glutamyl residues transfer activity or its fragment or that it is capable of being hybridized with the nucleotide sequence of approximately 2kb which is inserted in the plasmid pILL308.
摘要翻译：本发明涉及纯化的幽门螺杆菌多核苷酸，其特征在于其结构中包含携带转移催化活性的蛋白质的编码序列，例如γ-谷氨酰残基转移活性或其片段，或其能够与大约2kb的插入质粒pILL308的核苷酸序列。

2. 发明申请

WO1993007273A1 HELICOBACTER PYLORI GENES NECESSARY FOR THE REGULATION AND MATURATION OF UREASE, AND USE THEREOF 审中-公开
标题翻译： HELICOBACTER PYLORI基因对UREASE的调控和成熟的必要条件及其使用
公开(公告)号：WO1993007273A1
公开(公告)日：1993-04-15
申请号：PCT/FR1992000921
申请日：1992-10-02
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , LABIGNE, Agnès , CUSSAC, Valérie , FERRERO, Richard
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ...
IPC分类号： C12N15/31
CPC分类号： C07K16/40 , A61K38/00 , C07K14/205 , C12N9/80 , C12Q1/689
摘要： Nucleotide sequence, characterized in that it consists of or comprises at least one nucleic sequence corresponding to the genes known as ureE, ureF, ureH, ureI or any part of at least one of these nucleic sequences. The application of these sequences in methods and hits for the detection of H. pylori is also disclosed.

3. 发明申请

WO2002066501A2 PROTEIN-PROTEIN INTERACTIONS IN HELICOBACTER PYLORI 审中-公开
标题翻译： HELICOBACTER PYLORI中的蛋白质 - 蛋白质相互作用
公开(公告)号：WO2002066501A2
公开(公告)日：2002-08-29
申请号：PCT/EP2001/015428
申请日：2001-12-28
申请人： HYBRIGENICS , INSTITUT PASTEUR , LEGRAIN, Pierre , RAIN, Jean-Christophe , COLLAND, Frédéric , DE REUSE, Hilde , LABIGNE, Agnès
发明人： LEGRAIN, Pierre , RAIN, Jean-Christophe , COLLAND, Frédéric , DE REUSE, Hilde , LABIGNE, Agnès
IPC分类号： C07K14/205
CPC分类号： C07K14/205 , A61K39/00 , A61K2039/5156
摘要： The present invention relates to protein-protein interactions of Helicobacter pylori . More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.
摘要翻译：本发明涉及幽门螺杆菌的蛋白质 - 蛋白质相互作用。更具体地，本发明涉及编码多肽的多肽或多核苷酸的复合物，多肽的片段，复合物的抗体，由于蛋白质 - 蛋白质相互作用而鉴定的选择性相互作用域（SID3），用于筛选药剂的方法其调节能够调节蛋白质 - 蛋白质相互作用的蛋白质和药物组合物的相互作用。

4. 发明申请

WO2002060934A2 IDENTIFICATION OF THE ANTI-σ28 FACTOR IN HELICOBACTER PYLORI, IN CAMPYLOBACTER JEJUNI AND IN PSEUDOMONAS AERUGINOSA AND APPLICATION THEREOF 审中-公开
标题翻译：鉴定抗生素黄酮，琼脂糖凝胶中和抗氧化酶AERUGINOSA中的抗性28因子及其应用
公开(公告)号：WO2002060934A2
公开(公告)日：2002-08-08
申请号：PCT/EP2002/001625
申请日：2002-01-28
申请人： HYBRIGENICS , INSTITUT PASTEUR , LEGRAIN, Pierre , COLLAND, Frédéric , RAIN, Jean-Christophe , LABIGNE, Agnès , DE REUSE, Hilde
发明人： LEGRAIN, Pierre , COLLAND, Frédéric , RAIN, Jean-Christophe , LABIGNE, Agnès , DE REUSE, Hilde
IPC分类号： C07K14/205
CPC分类号： C07K14/21 , C07K14/205
摘要： The present invention relates to the function of a polypeptides named HP1122, Cj1464 and PA3351 which are the anti-σ 28 factor of Helicobacter pylori , Campylobacter jejuni and Pseudomonas aeruginosa , respectively. The present invention also relates to a polypeptide named SID1122 which is the domain of Helicobacter pylori's HP1122 polypeptide involved in a specific interaction with Helicobacter pylori σ 28 (HP1032) and which has an anti-σ 28 factor activity. More specifically, the present invention relates to SID1122 polypeptide that interact with HP1032, identification of the HP1032 interacting domain (SID1032) that is specifically involved in the interaction with HP1122, complexes of two polypeptides such as HP1122 HP1032, or SID1122 SID1032, fragments and variants of the SID1122 and SID1032 polypeptides, antibodies to the SID1122 and SID1032 polypeptides, methods for screening drugs or agents which modulate the interaction of Helicobacter pylori's polypeptides encoded by HP1122 and HP1032 and pharmaceutical compositions for treating or preventing Gram negative flagellated bacteria infection in a human or mammal, more specifically Helicobacter sp. or Campylobacter jejuni or Pseudomonas aeruginosa infection, in particular Helicobacter pylori infection in a human or a mammal.
摘要翻译：本发明涉及分别作为幽门螺杆菌抗幽门螺杆菌，空肠弯曲杆菌和铜绿假单胞菌的抗HP1122，Cj1464和PA3351的多肽的功能。本发明还涉及一种称为SID1122的多肽，其是幽门螺杆菌HP1122多肽的参与与幽门螺杆菌σ28（HP1032）的特异性相互作用并且具有抗西格玛28因子活性的结构域。更具体地，本发明涉及与HP1032相互作用的SID1122多肽，特异性参与与HP1122的相互作用的HP1032相互作用结构域（SID1032）的鉴定，两种多肽如HP1122 HP1032或SID1122 SID1032的复合物，片段和变体 SID1122和SID1032多肽的抗体，SID1122和SID1032多肽的抗体，用于筛选调节由HP1122和HP1032编码的幽门螺杆菌多肽的相互作用的药物或试剂的方法和用于治疗或预防人类革兰氏阴性鞭毛细菌感染的药物组合物，哺乳动物，更具体地说是幽门螺杆菌或空肠弯曲杆菌或铜绿假单胞菌感染，特别是人或哺乳动物的幽门螺杆菌感染。

5. 发明申请

WO1996034624A1 IMMUNOGENIC COMPOSITIONS AGAINST HELICOBACTER INFECTION, POLYPEPTIDES FOR USE IN THE COMPOSITIONS, AND NUCLEIC ACID SEQUENCES ENCODING SAID POLYPEPTIDES 审中-公开
标题翻译：抗真菌感染的免疫组合物，组合物中使用的多肽和编码同源多肽的核酸序列
公开(公告)号：WO1996034624A1
公开(公告)日：1996-11-07
申请号：PCT/EP1996001834
申请日：1996-05-02
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , LABIGNE, Agnès , SUERBAUM, Sébastian , FERRERO, Richard, L. , THIBERGE, Jean-Michel
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
IPC分类号： A61K39/106
CPC分类号： A61K39/105 , A61K39/00 , C07K14/205 , C07K16/121 , C07K2319/00
摘要： There is provided an immunogenic composition capabale of inducing protective antibodies against Helicobacter infection characterized in that it comprises: i) at least one sub-unit of a urease structural polypeptide from Helicobacter pylori, or a fragment thereof, said fragment being recognized by antibodies reacting with Helicobacter felis urease, and/or at least one sub-unit of a urease structural polypeptide from Helicobacter felis, or a fragment thereof, said fragment being recognized by antibodies reacting with Helicobacter pylori urease; ii) and/or, a heat shock protein (Hsp), or chaperonin, from Helicobacter, or a fragment of said protein. The preparation, by recombinant means, of such immunogenic composition is also provided.
摘要翻译：提供了诱导针对幽门螺杆菌感染的保护性抗体的免疫原性组合物载体，其特征在于其包含：i）幽门螺杆菌的脲酶结构多肽的至少一个亚单位或其片段，所述片段被抗体与幽门螺杆菌脲酶，和/或来自幽门螺杆菌的脲酶结构多肽的至少一个亚单位或其片段，所述片段被与幽门螺杆菌脲酶反应的抗体识别; ii）和/或来自幽门螺杆菌的热休克蛋白（Hsp）或伴侣蛋白，或所述蛋白质的片段。还提供了通过重组方法制备这种免疫原性组合物的制备。

6. 发明申请

WO2002066501A3 PROTEIN-PROTEIN INTERACTIONS IN HELICOBACTER PYLORI 审中-公开
公开(公告)号：WO2002066501A3
公开(公告)日：2002-08-29
申请号：PCT/EP2001/015428
申请日：2001-12-28
申请人： HYBRIGENICS , INSTITUT PASTEUR , LEGRAIN, Pierre , RAIN, Jean-Christophe , COLLAND, Frédéric , DE REUSE, Hilde , LABIGNE, Agnès
发明人： LEGRAIN, Pierre , RAIN, Jean-Christophe , COLLAND, Frédéric , DE REUSE, Hilde , LABIGNE, Agnès
IPC分类号： C07K14/205
摘要： The present invention relates to protein-protein interactions of Helicobacter pylori . More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for agents which modulate the interaction of proteins and pharmaceutical compositions that are capable of modulating the protein-protein interactions.

7. 发明申请

WO1994026901A1 IMMUNOGENIC COMPOSITIONS AGAINST HELICOBACTER INFECTION, POLYPEPTIDES FOR USE IN THE COMPOSITIONS AND NUCLEIC ACID SEQUENCES ENCODING SAID POLYPEPTIDES 审中-公开
标题翻译：抗真菌感染的免疫组织化合物，用于组合物和核酸序列的多核苷酸编码同源多肽
公开(公告)号：WO1994026901A1
公开(公告)日：1994-11-24
申请号：PCT/EP1994001625
申请日：1994-05-19
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , LABIGNE, Agnès , SUERBAUM, Sébastien , FERRERO, Richard , THIBERGE, Jean-Michel
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
IPC分类号： C12N15/31
CPC分类号： C12Q1/689 , A61K39/00 , C07K14/205 , C07K2319/00 , C07K2319/24 , C07K2319/40 , C12N9/80
摘要： The invention relates to an immunogenic composition, capable of inducing protective antibodies against Helicobacter infection, characterised in that it comprises: i) at least one sub-unit of a urease structural polypeptide from Helicobacter pylori, or a fragment thereof, said fragment being recognised by antibodies reacting with Helicobacter felis urease, and/or at least one sub-unit of a urease structural polypeptide from Helicobacter felis, or a fragment thereof, said fragment being recognised by antibodies reacting with Helicobacter pylori urease; ii) and/or, a Heat Shock protein (HSP), or chaperonin, from Helicobacter, or a fragment of said protein. The invention also relates to the preparation, by recombinant means, of such immunogenic compositions.
摘要翻译：本发明涉及能够诱导针对幽门螺杆菌感染的保护性抗体的免疫原性组合物，其特征在于其包括：i）幽门螺杆菌的脲酶结构多肽的至少一个亚单位或其片段，所述片段被与幽门螺杆菌脲酶反应的抗体，和/或来自幽门螺杆菌的脲酶结构多肽的至少一个亚单位或其片段，所述片段由与幽门螺杆菌脲酶反应的抗体识别; ii）和/或来自幽门螺杆菌的热休克蛋白（HSP）或伴侣蛋白，或所述蛋白质的片段。本发明还涉及通过重组手段制备这种免疫原性组合物。

8. 发明申请

WO2004069997A2 PROCEDE POUR LA PREPARATION D'UNE COMPOSITION DE SEQUENCES D'ADN OU DE LEURS PRODUITS D'EXPRESSION PERMETTANT L'IDENTIFICATION DES SOUCHES D'HELICOBACTER PYLORI ET SON UTILISATION DANS UN PROCEDE DE PRONOSTIC OU DE DIAGNOSTIC 审中-公开
标题翻译：过程对于DNA或其产品表达的组成序列用于识别干幽门螺杆菌并使用了一种预后或诊断的制备
公开(公告)号：WO2004069997A2
公开(公告)日：2004-08-19
申请号：PCT/FR2004/000217
申请日：2004-01-30
申请人： INSTITUT PASTEUR , THIBERGE, Jean-Michel , LABIGNE, Agnès , COPPEE, Jean-Yves , LACROIX, Céline
发明人： THIBERGE, Jean-Michel , LABIGNE, Agnès , COPPEE, Jean-Yves , LACROIX, Céline
IPC分类号： C12N
CPC分类号： C12Q1/689 , C07K14/205 , C12Q2600/158
摘要： La présente invention concerne une composition de séquences d’ADN, ou de leurs produits d’expression, permettant l’identification des souches d’Helicobacter pylori, un procédé pour la préparation de cette composition et son utilisation dans un procédé de pronostic ou de diagnostic.
摘要翻译：
公关＆eacute;感觉的组合物S＆eacute;使幽门螺杆菌菌株的鉴定DNA，或其表达产物的序列，一个方法EDé 用于制备这种组合物及其在制备过程中的用途预后或诊断。

9. 发明申请

WO1990004030A1 SEQUENCES OF NUCLEOTIDES CODING FOR A PROTEIN HAVING AN UREASIC ACTIVITY 审中-公开
标题翻译：具有尿素活性的蛋白质核苷酸编码序列
公开(公告)号：WO1990004030A1
公开(公告)日：1990-04-19
申请号：PCT/FR1989000518
申请日：1989-10-06
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ... , LABIGNE, Agnès
发明人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE ...
IPC分类号： C12N15/55
CPC分类号： C07K16/40 , A61K38/00 , C12N9/80 , C12Q1/689 , Y02A50/47 , Y10S435/975
摘要： The invention relates to a sequence of nucleotides, characterized in that it is comprised of at least one portion of a sequence coding for a protein having a urease activity as expressed by C. pylori. The invention also relates to the applications of this sequence, particularly for the in vitro diagnosis of pathologies associated with the presence of Campylobacter pylori in the organism of an individual.

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