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1. 发明申请

WO2011087266A3 METHOD FOR DISCOVERING AN ORTHOLOGOUS GENE USING GENE NOMENCLATURE 审中-公开
标题翻译：使用基因名称发现人类基因的方法
公开(公告)号：WO2011087266A3
公开(公告)日：2011-12-01
申请号：PCT/KR2011000209
申请日：2011-01-12
申请人： KOREA BASIC SCIENCE INST , KWON KYUNG-HOON , CHOI SUN SHIM , PARK SEUNG GU
发明人： KWON KYUNG-HOON , CHOI SUN SHIM , PARK SEUNG GU
IPC分类号： C12Q1/68 , G01N33/68 , G06F19/00
CPC分类号： G06F19/18 , G06F19/14 , G06F19/22 , G06F19/28 , Y02A90/24 , Y02A90/26
摘要： The present invention relates to a method for discovering an orthologous gene, and more specifically, to an orthologous gene identification method, which comprises: classifying two genes according to molecular biological functions and biological processes by using gene ontology; preparing a gene ontology tree to analyze the gene classification pattern; and identifying an orthologous gene if the number of common interconnects is greater than that between ordinary genes yet the sequence is similar. The method of the present invention can be easily used for the analysis of gene function, and using an orthologous gene, the study of gene function of a species whose gene function is relatively easy to analyze can be applied to the analysis of gene function of a species, such as humans, which is difficult to study. Therefore, the method of the present invention is useful for the prevention or treatment of human diseases or the development of new drugs.
摘要翻译：本发明涉及一种用于发现直系同源基因的方法，更具体地涉及直系同源基因鉴定方法，其包括：通过使用基因本体，根据分子生物学功能和生物学过程对两个基因进行分类; 准备基因本体树分析基因分类模式; 并且如果共同互连的数量大于普通基因之间，而序列相似，则鉴定直系同源基因。本发明的方法可以容易地用于基因功能的分析，并且使用直系同源基因，基因功能相对容易分析的物种的基因功能的研究可以应用于基因功能的分析物种，如人类，难以研究。因此，本发明的方法可用于预防或治疗人类疾病或开发新药。

2. 发明申请

WO2011081329A2 METHOD FOR DISCOVERING PHARMACOLOGICALLY ACTIVE SUBSTANCE OF NATURAL PRODUCTS USING HIGH RESOLUTION MASS SPECTROMETRY AND PHARMACOLOGICAL ACTIVITY TEST 审中-公开
标题翻译：利用高分辨质谱法和药理活性测定法发现天然产物的药理活性物质的方法
公开(公告)号：WO2011081329A2
公开(公告)日：2011-07-07
申请号：PCT/KR2010/008988
申请日：2010-12-15
申请人： KOREA BASIC SCIENCE INSTITUTE , PARK, Kyu Hwan , KIM, Hyun Sik , KWON, Kyung Hoon , YOO, Jong Shin
发明人： PARK, Kyu Hwan , KIM, Hyun Sik , KWON, Kyung Hoon , YOO, Jong Shin
IPC分类号： G01N30/72 , G01N33/15 , B01D15/08
CPC分类号： G01N30/06 , G01N30/8686 , G01N30/96 , G01N33/6848 , G01N2030/8809 , G01N2030/8813 , G01N2500/00 , Y10T436/174614 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要： Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.
摘要翻译：公开了一种从天然产物中高速发现药理活性物质的方法，包括：通过测试多个样品的药理活性来获得活性曲线; 基于通过质谱法分析样品产生的质谱获得质量分布图; 并通过比较和分析活性曲线和质量曲线来确定药理活性物质的分子量。所公开的方法通过对包含在天然产物的提取物样品中的许多组分进行高分辨质谱并且与活性测试数据进行比较而允许药理活性物质的快速发现。有关天然产物药理活性物质活性强度的信息可以有效利用天然产物。

3. 发明申请

WO2007018327A1 AN ADDITIVE SCORING METHOD FOR MODIFIED POLYPEPTIDE 审中-公开
标题翻译：改性多糖的添加剂分选方法
公开(公告)号：WO2007018327A1
公开(公告)日：2007-02-15
申请号：PCT/KR2005/003037
申请日：2005-09-14
申请人： KOREA BASIC SCIENCE INSTITUTE , AHN, Yeong Hee , KWON, Kyung-Hoon , YOO, Jong Shin
发明人： AHN, Yeong Hee , KWON, Kyung-Hoon , YOO, Jong Shin
IPC分类号： G01N33/68
CPC分类号： C07K14/4732
摘要： The present invention relates to a method for analyzing modified polypeptide sequence and modified information thereof. More precisely, the invention relates to a method for identifying modified peptide in which fragment ion signals are obtained from target peptide precursor by using tandem mass spectrometry, candidate peptides and every possible peptide fragmentation patterns thereof are designed based on the mass data thereby, match scores corresponding to each fragmentation pattern of candidate peptides are given, and then by combining each matching scores derived from possible fragmentation patterns of a candidate peptide, modified target polypeptide is identified by tandem mass data based on the provided match score. The scoring method for modified polypeptide of the present invention can greatly contribute to increasing searching efficiency of modified peptides and reliability of the searching results by integrating all scored values obtained from different fragmentation patterns of a candidate peptide.
摘要翻译：本发明涉及一种分析修饰多肽序列的方法及其修饰信息。更准确地说，本发明涉及一种用于鉴定通过使用串联质谱法从靶肽前体获得片段离子信号的修饰肽的方法，并且基于质量数据设计候选肽和其每种可能的肽断裂模式，从而匹配得分对应于候选肽的每个断裂模式，然后通过组合从候选肽的可能的断裂模式导出的每个匹配分数，基于所提供的匹配分数，通过串联质量数据鉴定修饰的目标多肽。本发明的修饰多肽的评分方法可以通过整合从候选肽的不同片段化模式获得的所有得分值，大大有助于提高修饰肽的搜索效率和搜索结果的可靠性。

4. 发明申请

WO2011081329A3 METHOD FOR DISCOVERING PHARMACOLOGICALLY ACTIVE SUBSTANCE OF NATURAL PRODUCTS USING HIGH RESOLUTION MASS SPECTROMETRY AND PHARMACOLOGICAL ACTIVITY TEST 审中-公开
标题翻译：使用高分辨质谱法和药理活性测试发现天然产物的药物活性物质的方法
公开(公告)号：WO2011081329A3
公开(公告)日：2011-11-17
申请号：PCT/KR2010008988
申请日：2010-12-15
申请人： KOREA BASIC SCIENCE INST , PARK KYU HWAN , KIM HYUN SIK , KWON KYUNG HOON , YOO JONG SHIN
发明人： PARK KYU HWAN , KIM HYUN SIK , KWON KYUNG HOON , YOO JONG SHIN
IPC分类号： G01N30/72 , B01D15/08 , G01N33/15
CPC分类号： G01N30/06 , G01N30/8686 , G01N30/96 , G01N33/6848 , G01N2030/8809 , G01N2030/8813 , G01N2500/00 , Y10T436/174614 , Y10T436/24 , Y10T436/25 , Y10T436/25375
摘要： Disclosed is a method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining a mass profile based on a mass spectrum resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The disclosed method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.
摘要翻译：公开了一种从天然产物中高速发现药理活性物质的方法，包括：通过测试多个样品的药理活性来获得活性谱; 基于通过质谱分析样品得到的质谱获得质量曲线; 并通过比较和分析活性谱和质量分布来确定药理学活性物质的分子量。所公开的方法允许通过对包括在天然产物的提取物样品中的许多组分执行高分辨率质谱法并与活性测试数据进行比较来快速发现药理学活性物质。关于天然产物的药理活性物质的活性强度的信息允许有效利用天然产物。

5. 发明申请

WO2003104775A1 METHOD FOR PROTEIN CHIP ANALYSIS BY USING SURFACE PLASMON RESONANCE SPECTROSCOPIC IMAGING TECHNOLOGY 审中-公开
标题翻译：使用表面等离子共振光谱成像技术的蛋白质芯片分析方法
公开(公告)号：WO2003104775A1
公开(公告)日：2003-12-18
申请号：PCT/KR2002/001659
申请日：2002-09-02
申请人： KOREA BASIC SCIENCE INSTITUTE , HA, Kwon, Soo , YUK, Jong, Seol , YI, Sun, Ju , LEE, Hyeon, Gon , KWON, Kyung, Hoon
发明人： HA, Kwon, Soo , YUK, Jong, Seol , YI, Sun, Ju , LEE, Hyeon, Gon , KWON, Kyung, Hoon
IPC分类号： G01N21/25
CPC分类号： G01N21/553
摘要： The present invention provides a method for protein chip analysis by using surface plasmon resonance spectroscopic image technology. A protein chip with a plurality of spots, arranged at a specific interval in vertical and horizontal directions, is mounted on a x-y stage, and p-polarized beams that passed through a prism are sequentially irradiated on each spot of the protein chip. The light signal reflected from each spot of the protein chip is collected into a spectrometer and its surface plasmon resonance wavelength is determined. This surface plasmon resonance wavelength value is represented by a color at the position of each protein spot to obtain a two dimensional image. Otherwise, the surface plasmon resonance wavelength value is allocated to a z-coordinate value to obtain a three-dimensional image.
摘要翻译：本发明提供了使用表面等离子体共振光谱图像技术进行蛋白质芯片分析的方法。将具有多个点的蛋白质芯片以垂直和水平方向的特定间隔安装在x-y平台上，并且通过棱镜的p偏振光束依次照射在蛋白质芯片的每个点上。从蛋白质芯片的每个点反射的光信号被收集到光谱仪中，并且确定其表面等离子体共振波长。该表面等离子体共振波长值由每个蛋白点的位置处的颜色表示，以获得二维图像。否则，将表面等离子体共振波长值分配给z坐标值以获得三维图像。

6. 发明申请

WO2010018882A1 APPARATUS FOR VISUALIZING AND ANALYZING GENE EXPRESSION PATTERNS USING GENE ONTOLOGY TREE AND METHOD THEREOF 审中-公开
标题翻译：用于使用基因本体树观察和分析基因表达模式的装置及其方法
公开(公告)号：WO2010018882A1
公开(公告)日：2010-02-18
申请号：PCT/KR2008/004735
申请日：2008-08-14
申请人： KOREA BASIC SCIENCE INSTITUTE , KWON, Kyung-Hoon , PARK, Gun Wook , LEE, Jeong Hwa , YOO, Jong Shin
发明人： KWON, Kyung-Hoon , PARK, Gun Wook , LEE, Jeong Hwa , YOO, Jong Shin
IPC分类号： G06F17/30 , C12Q1/68
CPC分类号： G06F19/28 , G06F19/20 , G06F19/26
摘要： The present invention relates to an apparatus for visualizing or analyzing gene expression patterns of a biological sample using gene ontology tree and a method of the same, more precisely, an apparatus for visualizing or analyzing gene expression patterns which are regarded as biologically important using gene ontology tree by calculating complexity and a method of the same. This apparatus of the present invention is useful for comparing gene expression patterns in different biological samples using data produced by the said apparatus and the method of the present invention. According to the present invention, gene expression patterns in relation to molecular functions, biological processes or cellular components can be analyzed by investigating protein or RNA expression in biological samples. So, the apparatus and the method of the present invention can be effectively used for analysis of biologically important aspects such as functional changes, evolutionary stages or developmental stages of each biological sample.
摘要翻译：本发明涉及使用基因本体树来观察或分析生物样品的基因表达模式的装置及其方法，更确切地说，涉及用于使用基因本体论被视为生物学重要性的基因表达模式进行可视化或分析的装置树的计算复杂度和方法相同。本发明的该装置可用于使用由所述装置产生的数据和本发明的方法来比较不同生物样品中的基因表达模式。根据本发明，可以通过研究生物样品中的蛋白质或RNA表达来分析与分子功能，生物过程或细胞成分有关的基因表达模式。因此，本发明的装置和方法可以有效地用于生物学重要方面的分析，例如每个生物样品的功能变化，进化阶段或发育阶段。

7. 发明申请

WO2008102922A1 A SYSTEM OF ANALYZING PROTEIN MODIFICATION WITH ITS BAND POSITION OF ONE-DIMENSIONAL GEL BY THE MASS SPECTRAL DATA ANALYSIS AND THE METHOD OF ANALYZING PROTEIN MODIFICATIO USING THEREOF 审中-公开
标题翻译：通过大量光谱数据分析分析其一维凝胶带位置的蛋白质修饰系统及其分析蛋白质修饰方法
公开(公告)号：WO2008102922A1
公开(公告)日：2008-08-28
申请号：PCT/KR2007/000946
申请日：2007-02-23
申请人： KOREA BASIC SCIENCE INSTITUTE , PARK, Gun Wook , KWON, Kyung-Hoon , KIM, Jin Young , YOO, Jong Shin , PARK, Young Mok , KIM, Seung Il
发明人： PARK, Gun Wook , KWON, Kyung-Hoon , KIM, Jin Young , YOO, Jong Shin , PARK, Young Mok , KIM, Seung Il
IPC分类号： G06F19/00
CPC分类号： G01N33/6848 , H01J49/004
摘要： The present invention relates to a method of analyzing protein modification. The method of invention for analyzing protein distribution and characteristics on one-dimensional gel provides the way to analyze proteins of samples on one-dimensional gel quantitatively and provides information on interactions among proteins and further can be effectively used for the development of a novel diagnostic and therapeutic method for a disease by screening a disease marker protein.
摘要翻译：本发明涉及分析蛋白质修饰的方法。本发明用于分析一维凝胶上的蛋白质分布和特征的方法提供了定量分析一维凝胶上样品蛋白质的方法，提供蛋白质间相互作用信息，进一步有效地用于开发新型诊断和通过筛选疾病标记蛋白来治疗疾病的治疗方法。

8. 发明申请

WO2008007821A1 A METHOD FOR RECONSTRUCTING PROTEIN DATABASE AND A METHOD FOR IDENTIFYING PROTEINS BY USING THE SAME METHOD 审中-公开
标题翻译：重组蛋白数据库的方法和使用相同方法识别蛋白质的方法
公开(公告)号：WO2008007821A1
公开(公告)日：2008-01-17
申请号：PCT/KR2006/003261
申请日：2006-08-18
申请人： KOREA BASIC SCIENCE INSTITUTE , KWON, Kyung-Hoon , YOO, Jong Shin
发明人： KWON, Kyung-Hoon , YOO, Jong Shin
IPC分类号： G06F17/30
CPC分类号： G06F19/28 , G06F19/18 , G06F19/22
摘要： The present invention relates to a method for reconstructing protein database for identifying a protein and a method for screening a protein using the same, more precisely a method for reconstructing protein database comprising the steps of i) Grouping proteins having a required homology by using the clustering software from the primary database which minimizes the overlapping of proteins and then recording sequence information of each protein group on a recording system of a computer; and ii) Designating a representative protein in each protein group and then constructing the representative protein database composed of the representative proteins, followed by recording the results containing sequence information on a recording system of a computer, and a method for identifying a protein using the same. The method for reconstructing protein database and the method for identifying the protein of the invention are very useful for the investigation of endogenous proteins and their functions and interactions, and are further effectively used for the development of diagnostic and therapeutic agents for various diseases.
摘要翻译：本发明涉及一种用于重建用于鉴定蛋白质的蛋白质数据库的方法和使用该蛋白质筛选蛋白质的方法，更准确地说，一种重建蛋白质数据库的方法，包括以下步骤：i）通过使用聚类分组具有所需同源性的蛋白质来自主数据库的软件，其最小化蛋白质的重叠，然后在计算机的记录系统上记录每个蛋白质组的序列信息; 和ii）指定每个蛋白质组中的代表性蛋白质，然后构建由代表性蛋白质组成的代表性蛋白质数据库，然后将含有序列信息的结果记录在计算机的记录系统上，以及用于鉴定使用其的蛋白质的方法。重组蛋白质数据库的方法和鉴定本发明蛋白质的方法对于内源蛋白质及其功能和相互作用的研究非常有用，并且进一步有效地用于各种疾病的诊断和治疗剂的开发。

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