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1. 发明申请

WO2008070495A3 SHORT TERM SLOW RELEASE DRUG DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2008070495A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/085732
申请日：2007-11-28
申请人： MISSION PHARMACAL CO. , WALSDORF, Neill, B. , TAYLOR, Jon, C. , ZHANG, Feng , SHERWOOD, Francis, K. , KOLENG, John, J.
发明人： WALSDORF, Neill, B. , TAYLOR, Jon, C. , ZHANG, Feng , SHERWOOD, Francis, K. , KOLENG, John, J.
IPC分类号： A61K9/20
摘要： The present invention is directed to a novel short term slow release drug delivery system, preferably for solid oral dosage forms of water-soluble, alkaline salts of alkali metals and alkaline earth metals comprising polyvinylpyrrolidone and CPAA and preferably a wax component.

2. 发明申请

WO2008070495A2 SHORT TERM SLOW RELEASE DRUG DELIVERY SYSTEM 审中-公开
标题翻译：短期缓释药物递送系统
公开(公告)号：WO2008070495A2
公开(公告)日：2008-06-12
申请号：PCT/US2007085732
申请日：2007-11-28
申请人： MISSION PHARMA CO , WALSDORF NEILL B , TAYLOR JON C , ZHANG FENG , SHERWOOD FRANCIS K , KOLENG JOHN J
发明人： WALSDORF NEILL B , TAYLOR JON C , ZHANG FENG , SHERWOOD FRANCIS K , KOLENG JOHN J
IPC分类号： A61K9/20 , A61K33/00 , A61K33/32
CPC分类号： A61K33/14 , A61K9/2081 , A61K9/5015 , A61K33/00
摘要： The present invention is directed to a novel short term slow release drug delivery system, preferably for solid oral dosage forms of water-soluble, alkaline salts of alkali metals and alkaline earth metals comprising polyvinylpyrrolidone and CPAA and preferably a wax component.
摘要翻译：本发明涉及一种新型的短期缓释药物递送系统，优选用于包含聚乙烯吡咯烷酮和CPAA，优选蜡组分的碱金属和碱土金属的水溶性碱性盐的固体口服剂型。

3. 发明申请

WO2011028799A3 GANGLIOSIDE TRANSMUCOSAL FORMULATIONS 审中-公开
标题翻译：姜黄素透皮制剂
公开(公告)号：WO2011028799A3
公开(公告)日：2011-07-07
申请号：PCT/US2010047527
申请日：2010-09-01
申请人： LAZARUS THERAPEUTICS INC , SCHNEIDER JAY S , KOLENG JOHN J , FLORENTINE ROBERT , ANDERSON DAVID W
发明人： SCHNEIDER JAY S , KOLENG JOHN J , FLORENTINE ROBERT , ANDERSON DAVID W
IPC分类号： A61K31/70 , A61K9/06 , A61K9/08 , A61K31/7028 , A61K31/7032 , A61P25/00 , A61P25/28
CPC分类号： A61K31/7028 , A61K9/0043 , A61K9/006 , A61K9/06 , A61K9/08 , A61K31/70 , A61K31/7032 , A61K45/06 , A61M13/003 , A61M15/009 , A61M31/00
摘要： A transmucosal formulation comprising a ganglioside and a mucosal absorption enhancer, as well as a method of treating or preventing Parkinson's disease in a human patient in need thereof comprising parenterally administering such a transmucosal formulation to said patient.
摘要翻译：包含神经节苷脂和粘膜吸收促进剂的透粘膜制剂，以及治疗或预防有此需要的人类患者的帕金森氏病的方法，包括肠胃外给予所述患者的这种透粘膜制剂。

4. 发明申请

WO2008011595A9 HYDROPHOBIC ABUSE DETERRENT DELIVERY SYSTEM 审中-公开
标题翻译：疏水性废物输送系统
公开(公告)号：WO2008011595A9
公开(公告)日：2008-03-06
申请号：PCT/US2007074023
申请日：2007-07-20
申请人： LAB INTERNAT SRL , VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
发明人： VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
IPC分类号： A61K9/20 , A61K9/48
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2054
摘要： Disclosed herein are oral dosage forms of therapeutic agents that are resistant to abuse and methods of their formulation. In particular, oral dosage forms that are resistant to dissolution in aqueous solutions of ethanol are described.
摘要翻译：本文公开了耐滥用的治疗剂的口服剂型及其制剂的方法。特别地，描述了耐溶于乙醇水溶液的口服剂型。

5. 发明申请

WO2008011595A3 HYDROPHOBIC ABUSE DETERRENT DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2008011595A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/074023
申请日：2007-07-20
申请人： LAB INTERNATIONAL SRL , VAUGHN, Jason M. , CROWLEY, Michael M. , ZHANG, Feng , KOLENG, John J. , KEEN, Justin M. , HUGHEY, Justin R.
发明人： VAUGHN, Jason M. , CROWLEY, Michael M. , ZHANG, Feng , KOLENG, John J. , KEEN, Justin M. , HUGHEY, Justin R.
IPC分类号： A61K9/20 , A61K9/48 , A61P25/36
摘要： Disclosed herein are oral dosage forms of therapeutic agents that are resistant to abuse and methods of their formulation. In particular, oral dosage forms that are resistant to dissolution in aqueous solutions of ethanol are described.

6. 发明申请

WO2008011595A2 HYDROPHOBIC ABUSE DETERRENT DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2008011595A2
公开(公告)日：2008-01-24
申请号：PCT/US2007074023
申请日：2007-07-20
申请人： LAB INTERNAT SRL , VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
发明人： VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
IPC分类号： A61K9/20 , A61K9/48
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2054
摘要： Disclosed herein are oral dosage forms of therapeutic agents that are resistant to abuse and methods of their formulation. In particular, oral dosage forms that are resistant to dissolution in aqueous solutions of ethanol are described.

7. 发明申请

WO2011085162A3 TOPICAL TRANSDERMAL DEXMEDETOMIDINE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2011085162A3
公开(公告)日：2011-07-14
申请号：PCT/US2011/020462
申请日：2011-01-07
申请人： RECRO PHARMA, INC. , HENWOOD, Geraldine, A. , MACK, Randall, J. , SHARR, Christopher, T. , KOLENG, John, J.
发明人： HENWOOD, Geraldine, A. , MACK, Randall, J. , SHARR, Christopher, T. , KOLENG, John, J.
IPC分类号： A61K31/415 , A61K9/06 , A61P35/00 , A61P25/06 , A61P25/00
摘要： Analgesic topical formulations of dexmedetomidine and methods of use thereof in the treatment and management of pain and other conditions.

8. 发明申请

WO2011028799A2 GANGLIOSIDE TRANSMUCOSAL FORMULATIONS 审中-公开
标题翻译：姜黄素转运制剂
公开(公告)号：WO2011028799A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047527
申请日：2010-09-01
申请人： LAZARUS THERAPEUTICS, INC. , SCHNEIDER, Jay, S. , KOLENG, John, J. , FLORENTINE, Robert , ANDERSON, David, W.
发明人： SCHNEIDER, Jay, S. , KOLENG, John, J. , FLORENTINE, Robert , ANDERSON, David, W.
IPC分类号： A61K31/70 , A61K31/7032 , A61K31/7028 , A61K9/06 , A61K9/08 , A61P25/28 , A61P25/00
CPC分类号： A61K31/7028 , A61K9/0043 , A61K9/006 , A61K9/06 , A61K9/08 , A61K31/70 , A61K31/7032 , A61K45/06 , A61M13/003 , A61M15/009 , A61M31/00
摘要： A transmucosal formulation comprising a ganglioside and a mucosal absorption enhancer, as well as a method of treating or preventing Parkinson's disease in a human patient in need thereof comprising parenterally administering such a transmucosal formulation to said patient.
摘要翻译：包含神经节苷脂和粘膜吸收增强剂的透粘膜制剂以及在有需要的人类患者中治疗或预防帕金森病的方法包括向所述患者肠胃外施用这种经粘膜制剂。

9. 发明申请

WO2010062930A1 COMPOSITIONS AND METHODS FOR HYPERHIDROSIS 审中-公开
标题翻译：高血压病的组合物和方法
公开(公告)号：WO2010062930A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/065854
申请日：2009-11-25
申请人： DRY PHARMA, LLC , KOLENG, John, J. , BOSSART, Josef
发明人： KOLENG, John, J. , BOSSART, Josef
IPC分类号： A61K31/46 , A61P17/00
CPC分类号： A61K31/46
摘要： The present disclosure relates, according to some embodiments, to compositions, systems, and methods for ameliorating, preventing, and/or treating (collectively "treating") hyperhidrosis and/or excessive perspiration (collectively "hyperhidrosis"). For example, a method for treating hyperhidrosis may comprise administering (e.g., topically administering) a composition comprising an anticholinergic compound (e.g., an ipratropium compound) to a mammal. A composition (e.g., a topical composition) for treating hyperhidrosis may comprise an anticholinergic compound (e.g., an ipratropium compound) and a vehicle (e.g., a physiologically acceptable vehicle). In some embodiments, administering a composition comprising an anticholinergic compound may comprise contacting the subject with a medicated article comprising the composition.
摘要翻译：根据一些实施方案，本公开涉及用于改善，预防和/或治疗（统称为“治疗”）多汗症和/或过度出汗（统称为“多汗症”）的组合物，系统和方法。例如，治疗多汗症的方法可以包括向哺乳动物施用（例如，局部施用）包含抗胆碱能化合物（例如异丙托铵化合物）的组合物。用于治疗多汗症的组合物（例如，局部组合物）可以包含抗胆碱能化合物（例如异丙托铵化合物）和载体（例如，生理上可接受的载体）。在一些实施方案中，施用包含抗胆碱能化合物的组合物可包括使受试者与包含该组合物的药物制品接触。

10. 发明申请

WO2007112287A3 HME TRANSDERMAL COMPOSITIONS CONTAINING TESTOSTERONE 审中-公开
标题翻译：含有TESTOSTERONE的HME超耐热组合物
公开(公告)号：WO2007112287A3
公开(公告)日：2009-03-26
申请号：PCT/US2007064716
申请日：2007-03-22
申请人： AUXILIUM PHARMACEUTICALS INC , CROWLEY MICHAEL M , KEEN JUSTIN M , KOLENG JOHN J , MACK RANDALL , SEBREE TERRI , SMITH THEODORE M , ZHANG FENG
发明人： CROWLEY MICHAEL M , KEEN JUSTIN M , KOLENG JOHN J , MACK RANDALL , SEBREE TERRI , SMITH THEODORE M , ZHANG FENG
IPC分类号： A61K9/70 , A61F13/00 , A61K31/56
CPC分类号： A61K9/006 , A61K9/7069
摘要： A bioadhesive laminate comprising testosterone and methods for its preparation are provided. The laminate comprises a hot-melt extruded (HME) drug reservoir layer comprising testosterone and an inert backing layer. The drug reservoir layer comprises a thermoplastic bioadhesive composition containing testosterone and the inert backing layer. The laminate is adapted for transdermal administration. When administered buccally to a subject, the laminate provides therapeutically effective plasma levels of testosterone such that the Cmax of testosterone is less than about 1000 ng/dL and the Tmax falls within the period of about two to fifteen hours. In a particular embodiment, the laminate provides therapeutic plasma levels of testosterone in the range of about 300 to 1000 ng/dL throughout a period of about one to twenty four hours after buccal administration to a subject. The laminate provides an in vitro controlled release of testosterone for a period of about four to thirty hours after exposure to an aqueous assay medium.
摘要翻译：提供了包含睾酮的生物粘附层压材料及其制备方法。该层压体包括包含睾酮和惰性背衬层的热熔融挤出（HME）药物储存层。药物储存层包含含有睾酮和惰性背衬层的热塑性生物粘合剂组合物。该层压板适于透皮给药。当口服给予受试者时，该层压板提供治疗有效的睾丸激素水平，使得睾酮的C max小于约1000ng / dL，并且Tmax落入约2至15小时期间。在一个具体的实施方案中，层叠体在颊内施用于受试者后约1至20 4小时的时间内提供在约300至1000ng / dL范围内的治疗性血浆水平的睾酮。该层压板在暴露于含水测定培养基后约4至30小时内提供睾酮的体外受控释放。

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