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1. 发明申请

WO2010062930A1 COMPOSITIONS AND METHODS FOR HYPERHIDROSIS 审中-公开
标题翻译：高血压病的组合物和方法
公开(公告)号：WO2010062930A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/065854
申请日：2009-11-25
申请人： DRY PHARMA, LLC , KOLENG, John, J. , BOSSART, Josef
发明人： KOLENG, John, J. , BOSSART, Josef
IPC分类号： A61K31/46 , A61P17/00
CPC分类号： A61K31/46
摘要： The present disclosure relates, according to some embodiments, to compositions, systems, and methods for ameliorating, preventing, and/or treating (collectively "treating") hyperhidrosis and/or excessive perspiration (collectively "hyperhidrosis"). For example, a method for treating hyperhidrosis may comprise administering (e.g., topically administering) a composition comprising an anticholinergic compound (e.g., an ipratropium compound) to a mammal. A composition (e.g., a topical composition) for treating hyperhidrosis may comprise an anticholinergic compound (e.g., an ipratropium compound) and a vehicle (e.g., a physiologically acceptable vehicle). In some embodiments, administering a composition comprising an anticholinergic compound may comprise contacting the subject with a medicated article comprising the composition.
摘要翻译：根据一些实施方案，本公开涉及用于改善，预防和/或治疗（统称为“治疗”）多汗症和/或过度出汗（统称为“多汗症”）的组合物，系统和方法。例如，治疗多汗症的方法可以包括向哺乳动物施用（例如，局部施用）包含抗胆碱能化合物（例如异丙托铵化合物）的组合物。用于治疗多汗症的组合物（例如，局部组合物）可以包含抗胆碱能化合物（例如异丙托铵化合物）和载体（例如，生理上可接受的载体）。在一些实施方案中，施用包含抗胆碱能化合物的组合物可包括使受试者与包含该组合物的药物制品接触。

2. 发明申请

WO2008070495A3 SHORT TERM SLOW RELEASE DRUG DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2008070495A3
公开(公告)日：2008-06-12
申请号：PCT/US2007/085732
申请日：2007-11-28
申请人： MISSION PHARMACAL CO. , WALSDORF, Neill, B. , TAYLOR, Jon, C. , ZHANG, Feng , SHERWOOD, Francis, K. , KOLENG, John, J.
发明人： WALSDORF, Neill, B. , TAYLOR, Jon, C. , ZHANG, Feng , SHERWOOD, Francis, K. , KOLENG, John, J.
IPC分类号： A61K9/20
摘要： The present invention is directed to a novel short term slow release drug delivery system, preferably for solid oral dosage forms of water-soluble, alkaline salts of alkali metals and alkaline earth metals comprising polyvinylpyrrolidone and CPAA and preferably a wax component.

3. 发明申请

WO2007016176A3 SCF EXTRACT CONTAINING CARDIAC GLYCOSIDE 审中-公开
公开(公告)号：WO2007016176A3
公开(公告)日：2007-02-08
申请号：PCT/US2006/029061
申请日：2006-07-26
申请人： PHOENIX BIOTECHNOLOGY INC. , ADDINGTON, Crandell , ZHANG, Feng , KOLENG, John, J.
发明人： ADDINGTON, Crandell , ZHANG, Feng , KOLENG, John, J.
IPC分类号： A61K36/18
摘要： A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.

4. 发明申请

WO2007112287A2 HME TRANSDERMAL COMPOSITIONS CONTAINING TESTOSTERONE 审中-公开
标题翻译：含有TESTOSTERONE的HME超耐热组合物
公开(公告)号：WO2007112287A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064716
申请日：2007-03-22
申请人： AUXILIUM PHARMACEUTICALS, INC. , CROWLEY, Michael, M. , KEEN, Justin, M. , KOLENG, John, J. , MACK, Randall , SEBREE, Terri , SMITH, Theodore, M. , ZHANG, Feng
发明人： CROWLEY, Michael, M. , KEEN, Justin, M. , KOLENG, John, J. , MACK, Randall , SEBREE, Terri , SMITH, Theodore, M. , ZHANG, Feng
IPC分类号： A61K9/70
CPC分类号： A61K9/006 , A61K9/7069
摘要： A bioadhesive laminate comprising testosterone and methods for its preparation are provided. The laminate comprises a hot-melt extruded (HME) drug reservoir layer comprising testosterone and an inert backing layer. The drug reservoir layer comprises a thermoplastic bioadhesive composition containing testosterone and the inert backing layer. The laminate is adapted for transdermal administration. When administered buccally to a subject, the laminate provides therapeutically effective plasma levels of testosterone such that the Cmax of testosterone is less than about 1000 ng/dL and the Tmax falls within the period of about two to fifteen hours. In a particular embodiment, the laminate provides therapeutic plasma levels of testosterone in the range of about 300 to 1000 ng/dL throughout a period of about one to twenty four hours after buccal administration to a subject. The laminate provides an in vitro controlled release of testosterone for a period of about four to thirty hours after exposure to an aqueous assay medium.
摘要翻译：提供了包含睾酮的生物粘附层压材料及其制备方法。该层压体包括包含睾酮和惰性背衬层的热熔融挤出（HME）药物储存层。药物储存层包含含有睾酮和惰性背衬层的热塑性生物粘合剂组合物。该层压板适于透皮给药。当口服给予受试者时，该层压板提供治疗有效的睾丸激素水平，使得睾酮的C max小于约1000ng / dL，并且Tmax落入约2至15小时期间。在一个具体的实施方案中，层叠体在颊内施用于受试者后约1至20 4小时期间，提供约300至1000ng / dL范围内的治疗性血浆水平的睾酮。该层压板在暴露于含水测定培养基后约4至30小时内提供睾酮的体外受控释放。

5. 发明申请

WO2007112286A2 STABILIZED COMPOSITIONS CONTAINING ALKALINE LABILE DRUGS 审中-公开
标题翻译：包含碱性可溶性药物的稳定组合物
公开(公告)号：WO2007112286A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/064714
申请日：2007-03-22
申请人： AUXILIUM PHARMACEUTICALS, INC. , CROWLEY, Michael, W. , KEEN, Justin, M. , KOLENG, John, J. , ZHANG, Feng
发明人： CROWLEY, Michael, W. , KEEN, Justin, M. , KOLENG, John, J. , ZHANG, Feng
IPC分类号： A61K9/20
CPC分类号： A61K9/70 , A61K9/0024 , A61K9/006 , A61K9/7023 , A61K9/703 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K31/4468 , A61K31/568 , A61K45/06 , A61K47/10 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/602
摘要： A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion. Various functional excipients can be included in the carrier system to improve process performance and/or improve the chemical or physical properties of the HME composition.
摘要翻译：提供了含有碱性不稳定药物的稳定的生物粘合剂组合物及其制备方法。在一个方面，组合物是热熔挤出（HME）组合物，其包含预先形成的赋形剂混合物，其包含酸性组分和碱性热塑性基质形成材料，例如，聚合物。赋形剂混合物在与碱性不稳定药物混合之前形成。然后将共混物热熔融挤出以形成HME组合物。通过这样做，酸性成分能够中和或赋予赋形剂混合物中度酸性。已经显示了该特定方法，以显着降低热熔融挤出期间碱性不稳定药物的降解。赋形剂混合物在热熔挤出过程中软化或熔化。在挤出过程中可溶解或不溶解含药颗粒。可以在载体体系中包括各种功能赋形剂以改善工艺性能和/或改善HME组合物的化学或物理性能。

6. 发明申请

WO2005097078A1 COMPRESSED COMPOSITION COMPRISING MAGNESIUM SALT 审中-公开
标题翻译：包含镁盐的压缩组合物
公开(公告)号：WO2005097078A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010979
申请日：2005-03-31
申请人： BLAINE PHARMACEUTICALS , KOLENG, John, J. , CROWLEY, Michael, M.
发明人： KOLENG, John, J. , CROWLEY, Michael, M.
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61K9/2054 , A61K9/2077 , A61K33/06 , A61K33/08 , A61K33/10
摘要： An oral solid compress composition comprising a magnesium salt is provided. The composition provides a rapid dissolution of the magnesium salt, wherein not less than 75% of the magnesium salt dissolves within 45 minutes after placement in hydrochloric acid (0.1 N, 900 mL) as per USP Method . In a particular embodiment, the magnesium salt is an inorganic salt such as MgO, Mg(OH) 2 , MgCl 2 , and others. The composition can be prepared by dry granulation, direct compression or another suitable process. The composition provides a substantially stable dissolution profile for the magnesium salt so that the dissolution profile changes only minimally even after an extended period of storage under pharmaceutically acceptable conditions when packaged in a sealed container-enclosure system. The solid composition may also exclude a cellulose-based composition. The compressed composition can be prepared and stored under anhydrous conditions.
摘要翻译：提供包含镁盐的口服固体压片组合物。该组合物提供镁盐的快速溶解，其中不少于75％的镁盐在按照USP Method <711>放入盐酸（0.1N，900mL）后45分钟内溶解。在一个具体实施方案中，镁盐是无机盐，例如MgO，Mg（OH）2，MgCl 2等。组合物可以通过干法制粒，直接压片或其它合适的方法制备。组合物为镁盐提供了基本上稳定的溶出曲线，使得即使在包装在密封的容器 - 封闭系统中的药学上可接受的条件下长时间的储存后，溶出曲线仅最小化。固体组合物还可以排除基于纤维素的组合物。压缩的组合物可以在无水条件下制备并储存。

7. 发明申请

WO2011085162A3 TOPICAL TRANSDERMAL DEXMEDETOMIDINE COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2011085162A3
公开(公告)日：2011-07-14
申请号：PCT/US2011/020462
申请日：2011-01-07
申请人： RECRO PHARMA, INC. , HENWOOD, Geraldine, A. , MACK, Randall, J. , SHARR, Christopher, T. , KOLENG, John, J.
发明人： HENWOOD, Geraldine, A. , MACK, Randall, J. , SHARR, Christopher, T. , KOLENG, John, J.
IPC分类号： A61K31/415 , A61K9/06 , A61P35/00 , A61P25/06 , A61P25/00
摘要： Analgesic topical formulations of dexmedetomidine and methods of use thereof in the treatment and management of pain and other conditions.

8. 发明申请

WO2011028799A2 GANGLIOSIDE TRANSMUCOSAL FORMULATIONS 审中-公开
标题翻译：姜黄素转运制剂
公开(公告)号：WO2011028799A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047527
申请日：2010-09-01
申请人： LAZARUS THERAPEUTICS, INC. , SCHNEIDER, Jay, S. , KOLENG, John, J. , FLORENTINE, Robert , ANDERSON, David, W.
发明人： SCHNEIDER, Jay, S. , KOLENG, John, J. , FLORENTINE, Robert , ANDERSON, David, W.
IPC分类号： A61K31/70 , A61K31/7032 , A61K31/7028 , A61K9/06 , A61K9/08 , A61P25/28 , A61P25/00
CPC分类号： A61K31/7028 , A61K9/0043 , A61K9/006 , A61K9/06 , A61K9/08 , A61K31/70 , A61K31/7032 , A61K45/06 , A61M13/003 , A61M15/009 , A61M31/00
摘要： A transmucosal formulation comprising a ganglioside and a mucosal absorption enhancer, as well as a method of treating or preventing Parkinson's disease in a human patient in need thereof comprising parenterally administering such a transmucosal formulation to said patient.
摘要翻译：包含神经节苷脂和粘膜吸收增强剂的透粘膜制剂以及在有需要的人类患者中治疗或预防帕金森病的方法包括向所述患者肠胃外施用这种经粘膜制剂。

9. 发明申请

WO2007112285A3 PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE 审中-公开
公开(公告)号：WO2007112285A3
公开(公告)日：2007-10-04
申请号：PCT/US2007/064713
申请日：2007-03-22
申请人： AUXILIUM PHARMACEUTICALS, INC. , CROWLEY, Michael, M. , KEEN, Justin, M. , KOLENG, John, J. , ZHANG, Feng
发明人： CROWLEY, Michael, M. , KEEN, Justin, M. , KOLENG, John, J. , ZHANG, Feng
IPC分类号： B29C47/06 , B29C47/00 , B61F13/00 , A61K9/58 , A61K9/32 , A61K9/14
摘要： A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein.

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