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1. 发明申请

WO2008011596A3 HYDROPHILIC ABUSE DETERRENT DELIVERY SYSTEM 审中-公开
标题翻译：亲水性垃圾交付系统
公开(公告)号：WO2008011596A3
公开(公告)日：2008-11-13
申请号：PCT/US2007074026
申请日：2007-07-20
申请人： LAB INTERNAT SRL , VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
发明人： VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
IPC分类号： A61K9/20 , A61K9/28 , A61K9/48 , A61P25/36
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2054
摘要： Disclosed herein are oral dosage forms of therapeutic agents that are resistant to abuse and methods of their formulation. In particular, oral dosage forms that are resistant to dissolution in aqueous solutions of ethanol are described.
摘要翻译：本文公开了耐受滥用的治疗剂的口服剂型及其制剂方法。具体而言，描述了耐乙醇水溶液溶解的口服剂型。

2. 发明申请

WO2008028047A2 BIOADHESIVE FILM DRUG DELIVERY SYSTEM 审中-公开
标题翻译： BIOADHESIVE膜药物递送系统
公开(公告)号：WO2008028047A2
公开(公告)日：2008-03-06
申请号：PCT/US2007077251
申请日：2007-08-30
申请人： LAB INTERNAT SRL , VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
发明人： VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
IPC分类号： A61K9/00 , A61K9/70
CPC分类号： A61K9/7007 , A61K9/006
摘要： Disclosed are methods of formulating bioadhesive or mucoadhesive films that include a mixture of polyethylene oxide polymers. The bioadhesive films contain a therapeutic agent and can be used to administer the therapeutic agent to a patient.
摘要翻译：公开了配制生物粘附或粘膜粘附膜的方法，其包括聚环氧乙烷聚合物的混合物。生物粘附膜含有治疗剂，可用于向患者施用治疗剂。

3. 发明申请

WO2008011595A9 HYDROPHOBIC ABUSE DETERRENT DELIVERY SYSTEM 审中-公开
标题翻译：疏水性废物输送系统
公开(公告)号：WO2008011595A9
公开(公告)日：2008-03-06
申请号：PCT/US2007074023
申请日：2007-07-20
申请人： LAB INTERNAT SRL , VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
发明人： VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
IPC分类号： A61K9/20 , A61K9/48
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2054
摘要： Disclosed herein are oral dosage forms of therapeutic agents that are resistant to abuse and methods of their formulation. In particular, oral dosage forms that are resistant to dissolution in aqueous solutions of ethanol are described.
摘要翻译：本文公开了耐滥用的治疗剂的口服剂型及其制剂的方法。特别地，描述了耐溶于乙醇水溶液的口服剂型。

4. 发明申请

WO2008011595A2 HYDROPHOBIC ABUSE DETERRENT DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2008011595A2
公开(公告)日：2008-01-24
申请号：PCT/US2007074023
申请日：2007-07-20
申请人： LAB INTERNAT SRL , VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
发明人： VAUGHN JASON M , CROWLEY MICHAEL M , ZHANG FENG , KOLENG JOHN J , KEEN JUSTIN M , HUGHEY JUSTIN R
IPC分类号： A61K9/20 , A61K9/48
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2054
摘要： Disclosed herein are oral dosage forms of therapeutic agents that are resistant to abuse and methods of their formulation. In particular, oral dosage forms that are resistant to dissolution in aqueous solutions of ethanol are described.

5. 发明申请

WO2008106689A3 BREAKTHROUGH PAIN MANAGEMENT 审中-公开
标题翻译：突破性疼痛管理
公开(公告)号：WO2008106689A3
公开(公告)日：2009-07-23
申请号：PCT/US2008055718
申请日：2008-03-03
申请人： LAB INTERNAT SRL , JOUHIKAINEN TANELI , TAPIO LANKINEN , SANDSTROM KENNETH
发明人： JOUHIKAINEN TANELI , TAPIO LANKINEN , SANDSTROM KENNETH
IPC分类号： A61K31/4468 , A61K9/00 , A61K31/00 , A61K47/26
CPC分类号： A61K31/4468 , A61K9/0075 , A61K9/1694
摘要： The present disclosure is directed to a powdered formulation comprising an analgesic for use in pulmonary inhalation administration for the rapid analgesic titration of pain, in particular breakthrough pain. Upon administration, the powdered formulation is able to provide a narrower titration range in patients suffering from pain, as well as effective analgesic amounts in a shorter time and at lower dose levels when compared to the analgesic administered by an oral transmucosal route.
摘要翻译：本公开涉及一种粉末制剂，其包含用于肺吸入施用的止痛剂，用于快速镇痛滴定疼痛，特别是突破性疼痛。给药时，与通过口服经粘膜途径施用的止痛剂相比，粉末制剂能够在患有疼痛的患者中提供更窄的滴定范围，并且在较短时间和较低剂量水平下提供有效的止痛剂量。

6. 发明申请

WO2009046215A3 SAFETY AND ABUSE DETERRENT IMPROVED DEVICE 审中-公开
标题翻译：安全和防止改进的设备
公开(公告)号：WO2009046215A3
公开(公告)日：2009-07-16
申请号：PCT/US2008078617
申请日：2008-10-02
申请人： LAB INTERNAT SRL , LEHTONEN TIMO , YOUNG MATTHEW , GROSSER JOERG
发明人： LEHTONEN TIMO , YOUNG MATTHEW , GROSSER JOERG
IPC分类号： A61M15/00
CPC分类号： A61M15/00 , A61M15/0081 , A61M15/009 , A61M2205/276
摘要： Modifications of an inhaler and method of use thereof are described. In some embodiments, an inhaler may include one or more systems and/or methods that function to inhibit a child from accessing medicant from an inhaler. A system may function to inhibit a child from accessing an opening of an inhaler from which medicants are dispensed. In some embodiments, a system may inhibit a child from removing a cap for an inhaler. A system may function to inhibit a child from actuating an activation mechanism for an inhaler. A system may function to inhibit a user and/or a child from accidentally actuating an activation mechanism for an inhaler multiple times possibly resulting in an overdose. A system may function to inhibit an activation mechanism for an inhaler from actuating after the activation mechanism has been actuated a predetermined number of times. An inhaler may include a security fitting which functions to permanently plug an inhaler once a prescribed user is finished with the inhaler.
摘要翻译：描述了吸入器的改进及其使用方法。在一些实施例中，吸入器可以包括一种或多种用于抑制儿童从吸入器接近药物的系统和/或方法。系统可以用于抑制儿童进入药物被分配的吸入器的开口。在一些实施例中，系统可以抑制儿童去除用于吸入器的帽。系统可以用于抑制儿童致动吸入器的激活机构。系统可以用于抑制使用者和/或儿童意外地致动吸入器的激活机构多次，可能导致过量。在激活机构已经被致动预定次数之后，系统可以起到抑制吸入器启动机制的作用。吸入器可以包括安全配件，其功能是在规定的使用者完成吸入器之后永久地插入吸入器。

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