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1. 发明申请

WO2012022486A1 IN VIVO IMAGING OF CALCIFIED LESIONS 审中-公开
标题翻译：在计算的LESIONS的VIVO成像
公开(公告)号：WO2012022486A1
公开(公告)日：2012-02-23
申请号：PCT/EP2011/004166
申请日：2011-08-18
申请人： RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE AACHEN , GRÄBER,Steffen , HEISS, Alexander , HERRMANN, Marietta , JAHNEN-DECHENT, Wilhelm , KIESSLING, Fabian , KINKELDEY, Anne , SCHÄFER, Cora
发明人： GRÄBER,Steffen , HEISS, Alexander , HERRMANN, Marietta , JAHNEN-DECHENT, Wilhelm , KIESSLING, Fabian , KINKELDEY, Anne , SCHÄFER, Cora
IPC分类号： G01N33/68 , C07K14/71
CPC分类号： A61K49/0056 , G01N2800/323
摘要： The present invention relates to a fetuin polypeptide for use in a method for diagnosis of calcification.
摘要翻译：本发明涉及用于钙化诊断方法的胎球蛋白多肽。

2. 发明申请

WO2007088129A3 CYANINE DYE COMPOUNDS LINKED TO METAL CHELATOR FOR BI-MODAL DIAGNOSTIC IMAGING 审中-公开
标题翻译：连接到用于双模式诊断成像的金属螯合剂的氰基染料化合物
公开(公告)号：WO2007088129A3
公开(公告)日：2007-11-08
申请号：PCT/EP2007050664
申请日：2007-01-23
申请人： DKFZ KREBSFORSCHUNGSZENTRUM , UNIV RUPRECHT KARLS HEIDELBERG , KIESSLING FABIAN , BEIJER BARBRO , SCHULZ RALF , SEMMLER WOLFHARD , MIER WALTER , WAENGLER BJOERN
发明人： KIESSLING FABIAN , BEIJER BARBRO , SCHULZ RALF , SEMMLER WOLFHARD , MIER WALTER , WAENGLER BJOERN
IPC分类号： A61K49/00 , A61K49/08 , A61K51/04
CPC分类号： A61K49/0032 , A61K49/005 , A61K49/085 , A61K49/10 , A61K51/0478 , A61K51/0482 , C09B23/0066 , C09B23/086
摘要： The present invention relates to compounds of formula (I), Ch-L-D (I), wherein D is a cyanine dye, L is a covalent bond or a linker and Ch is a metal chelating moiety or a pharmaceutically acceptable salt thereof, which can be used for the preparation of a contrast agent for the at least bi-modal diagnostic imaging of a biological system as well as a contrast agent prepared from these compounds, their use in multi-modal diagnostic imaging and imaging methods.
摘要翻译：本发明涉及式（I）化合物，Ch-LD（I），其中D为花青染料，L为共价键或连接基，Ch为金属螯合部分或其药学上可接受的盐，其可以用于制备用于生物系统的至少双模态诊断成像的造影剂以及由这些化合物制备的造影剂，其用于多模式诊断成像和成像方法。

3. 发明申请

WO2012038863A1 QUANTIFICATION OF A CHARACTERISTIC OF A LUMEN OF A TUBULAR STRUCTURE 审中-公开
标题翻译：管状结构的特征的定量
公开(公告)号：WO2012038863A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/054034
申请日：2011-09-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , GREMSE, Felix , KIESSLING, Fabian Maximilian Alexander
发明人： GREMSE, Felix , KIESSLING, Fabian Maximilian Alexander
IPC分类号： G06T7/00 , G06T7/60
CPC分类号： G06K9/4671 , G06K9/3233 , G06T7/0012 , G06T7/10 , G06T7/60 , G06T11/003 , G06T2207/10081 , G06T2207/10088 , G06T2207/10132 , G06T2207/20108 , G06T2207/30101 , G06T2211/40
摘要： A method includes generating, based on a distance map, a signal indicative of a quantification of a characteristic of a lumen of a tubular structure of interest over a pre-determined extent of the tubular structure of interest represented in volumetric imaging data. A system includes a quantifying component (216) that generates, based on a distance map, a signal indicative of a quantification of characteristic of a lumen of a tubular structure of interest over a pre-determined extent of the tubular structure of interest represented in volumetric imaging data. A method includes identifying voxels of 3D segmented imaging data that represent tubular structure of interest, determining distances between the identified voxels and nearest voxels corresponding to other structure in a plurality of 2D slices of the segment imaging data, representing the voxels with intensity values that are proportional to the distances, and generating a signal indicative of a 3D distance map based on the intensity values.
摘要翻译：一种方法包括基于距离图产生指示在体积成像数据中表示的感兴趣的管状结构的预定范围内的感兴趣的管状结构的管腔的特征的量化的信号。一种系统包括量化部件（216），该量化部件（216）基于距离图来生成指示所关注的管状结构的管腔的特征的量化的信号，所述管状结构的管腔的体积的预定范围以体积成像数据。一种方法包括识别表示感兴趣的管状结构的3D分割成像数据的体素，确定所识别的体素与分段成像数据的多个2D切片中与其他结构相对应的最近体素之间的距离，其代表具有强度值的体素与距离成比例，并且基于强度值生成指示3D距离图的信号。

4. 发明申请

WO2008084028A2 BESCHICHTETE BARIUMSULFATNANOPARTIKEL ALS KONTRASTMITTEL 审中-公开
标题翻译：涂覆的硫酸钡纳米粒子作为造影剂
公开(公告)号：WO2008084028A2
公开(公告)日：2008-07-17
申请号：PCT/EP2008/050094
申请日：2008-01-07
申请人： NANOGATE AG , DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS , SANDER, Jürgen , DANZEBRINK, Rolf , BARTLING, Sönke , KIESSLING, Fabian , MORGENSTERN, Bernd , SEMMLER, Wolfhardt , HUPPERT, Jochen
发明人： SANDER, Jürgen , DANZEBRINK, Rolf , BARTLING, Sönke , KIESSLING, Fabian , MORGENSTERN, Bernd , SEMMLER, Wolfhardt , HUPPERT, Jochen
IPC分类号： A61K49/04
CPC分类号： A61K49/0404 , A61K49/0428 , B82Y5/00
摘要： Gegenstand der Erfindung ist ein Blood-pool Kontrastmittel und ein Röntgenkontrastmittel für die Röntgendiagnostik auf der Basis von oberflächenbeschichteten Nanopartikeln aus Bariumsulfat.
摘要翻译：本发明提供了一种血池造影剂和X射线造影剂的硫酸钡的表面涂覆的纳米颗粒的基础上，X射线诊断。

5. 发明申请

WO2007088129A2 COMPOUNDS USEFUL FOR THE AT LEAST BI-MODAL DIAGNOSTIC IMAGING 审中-公开
标题翻译：适用于至少双模式诊断成像的化合物
公开(公告)号：WO2007088129A2
公开(公告)日：2007-08-09
申请号：PCT/EP2007/050664
申请日：2007-01-23
申请人： DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM , RUPRECHT-KARLS-UNIVERSITÄT-HEIDELBERG , KIESSLING, Fabian , BEIJER, Barbro , SCHULZ, Ralf , SEMMLER, Wolfhard , MIER, Walter , WÄNGLER, Björn
发明人： KIESSLING, Fabian , BEIJER, Barbro , SCHULZ, Ralf , SEMMLER, Wolfhard , MIER, Walter , WÄNGLER, Björn
IPC分类号： A61K49/00 , A61K49/08 , A61K51/04
CPC分类号： A61K49/0032 , A61K49/005 , A61K49/085 , A61K49/10 , A61K51/0478 , A61K51/0482 , C09B23/0066 , C09B23/086
摘要： The present invention relates to compounds of formula (I), Ch-L-D (I), wherein D is a cyanine dye, L is a covalent bond or a linker and Ch is a metal chelating moiety or a pharmaceutically acceptable salt thereof, which can be used for the preparation of a contrast agent for the at least bi-modal diagnostic imaging of a biological system as well as a contrast agent prepared from these compounds, their use in multi-modal diagnostic imaging and imaging methods.
摘要翻译：本发明涉及式（I）化合物，Ch-LD（I），其中D为花青染料，L为共价键或连接基，Ch为金属螯合部分或其药学上可接受的盐，其可以用于制备用于生物系统的至少双模态诊断成像的造影剂以及由这些化合物制备的造影剂，其用于多模式诊断成像和成像方法。

6. 发明申请

WO2010025946A1 SYSTEM AND METHOD FOR AUTOMATED, INTRINSIC GATED IMAGING 审中-公开
标题翻译：自动化系统和方法，内置栅格成像
公开(公告)号：WO2010025946A1
公开(公告)日：2010-03-11
申请号：PCT/EP2009/006468
申请日：2009-09-07
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS , BARTLING, Sönke , KIESSLING, Fabian , SEMMLER, Wolfhard , KUNTZ, Jan , DINKEL, Julien
发明人： BARTLING, Sönke , KIESSLING, Fabian , SEMMLER, Wolfhard , KUNTZ, Jan , DINKEL, Julien
IPC分类号： A61B6/00 , G06T7/00 , G06T7/20 , G06T11/00
CPC分类号： A61B6/5288 , A61B6/469 , A61B6/503 , A61B6/508 , A61B6/5217 , A61B6/541
摘要： Systems, methods and devices for imaging data are presented. In particular, embodiments of the present application are useful in CT imaging of moving subjects, such as animals, plants or machines, and in particular, small animal subjects. The embodiments present techniques to identify a region of interest for which gating signals can be derived to separate image data into groups representing particular stages of a motion of interest, such as a heartbeat.
摘要翻译：介绍了成像数据的系统，方法和设备。特别地，本申请的实施例可用于运动的受试者，例如动物，植物或机器，特别是小型动物受试者的CT成像。实施例提出了用于识别可以导出门控信号以将图像数据分离成表示感兴趣的运动的特定阶段（例如心跳）的组的感兴趣区域的技术。

7. 发明申请

WO2004097739A1 3-DIMENSIONAL VISUALIZATION AND QUANTIFICATION OF HISTOLOGICAL SECTIONS 审中-公开
标题翻译：三维可视化和定量分析
公开(公告)号：WO2004097739A1
公开(公告)日：2004-11-11
申请号：PCT/EP2004/004536
申请日：2004-04-29
申请人： DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS , LE-HUU, Martin , KIESSLING, Fabian , KUNERT, Tobias , THORN, Matthias , VOSSELER, Silvia , VAN KAICK, Gerhard , MEINZER, Hans-Peter , FUSENIG, Norbert
发明人： LE-HUU, Martin , KIESSLING, Fabian , KUNERT, Tobias , THORN, Matthias , VOSSELER, Silvia , VAN KAICK, Gerhard , MEINZER, Hans-Peter , FUSENIG, Norbert
IPC分类号： G06T7/00
CPC分类号： G06T15/08 , G06T7/33 , G06T2207/10116 , G06T2207/30024
摘要： The present invention relates to a method for the 3D reconstruction and visualization of histological data, particularly for comparison with radiological data. According to the method, a radiological image of a biological or non-biological specimen is created, said specimen is cut into histological sections, photographic images are taken of all or a subset of said histological sections, the resulting images are registered in the horizontal plane (XY-plane), a virtual stack of the images is created along in the vertical direction (along the Z-axis), a virtual section of the same thickness, level and direction as represented by the radiological image is created, a 2-dimensional image of said virtual section is created, and said 2-dimensional image is compared with the radiological image. In preferred embodiments, the invention provides additional methods particularly suited for the processing of large specimen.
摘要翻译：本发明涉及用于3D重建和组织学数据可视化的方法，特别是用于与放射学数据进行比较。根据该方法，产生生物或非生物样本的放射图像，将所述样本切成组织切片，拍摄所述组织学部分的全部或子集的摄影图像，将所得图像记录在水平面（XY平面），沿着垂直方向（沿Z轴）创建图像的虚拟堆叠，产生与放射图像所表示的相同厚度，水平和方向的虚拟部分，创建所述虚拟部分的三维图像，并将所述二维图像与放射图像进行比较。在优选的实施方案中，本发明提供了特别适用于处理大样品的附加方法。

8. 发明申请

WO2008084028A3 COATED BARIUM SULPHATE NANOPARTICLES AS CONTRAST AGENT 审中-公开
标题翻译：涂覆的硫酸钡纳米粒子作为造影剂
公开(公告)号：WO2008084028A3
公开(公告)日：2009-03-05
申请号：PCT/EP2008050094
申请日：2008-01-07
申请人： NANOGATE AG , DEUTSCHES KREBSFORSCH , SANDER JUERGEN , DANZEBRINK ROLF , BARTLING SOENKE , KIESSLING FABIAN , MORGENSTERN BERND , SEMMLER WOLFHARDT , HUPPERT JOCHEN
发明人： SANDER JUERGEN , DANZEBRINK ROLF , BARTLING SOENKE , KIESSLING FABIAN , MORGENSTERN BERND , SEMMLER WOLFHARDT , HUPPERT JOCHEN
IPC分类号： A61K49/04
CPC分类号： A61K49/0404 , A61K49/0428 , B82Y5/00
摘要： The invention relates to a blood pool contrast agent and an X-ray contrast agent for X-ray diagnosis made from surface coated nanoparticles of barium sulphate.
摘要翻译：本发明提供了一种血池造影剂和X射线造影剂的硫酸钡的表面涂覆的纳米颗粒的基础上，X射线诊断。

9. 发明申请

WO2008037666A1 UPAR SELECTIVE CONTRAST AGENT FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：用于磁共振成像的最新选择性对比剂
公开(公告)号：WO2008037666A1
公开(公告)日：2008-04-03
申请号：PCT/EP2007/060051
申请日：2007-09-21
申请人： DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM, STIFTUNG DES ÖFFENTLICHEN RECHTS , JUGOLD, Manfred , KIESSLING, Fabian , ZHANG, Chunfu , WÄNGLER, Björn , PIPKORN, Rüdiger , SEMMLER, Wolfhard
发明人： JUGOLD, Manfred , KIESSLING, Fabian , ZHANG, Chunfu , WÄNGLER, Björn , PIPKORN, Rüdiger , SEMMLER, Wolfhard
IPC分类号： A61K47/48 , A61K38/04
CPC分类号： A61K38/04 , A61K49/14 , A61K49/186 , A61K49/1863 , A61K49/1866 , B82Y5/00
摘要： The present invention relates to a contrast agent for magnetic resonance imaging comprising a compound of the formula Pep-L-Im, wherein Pep is a polypeptide molecule selected from the group consisting of (i) polypept ide having an amino acid sequence of NO:1; SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO: 7; SEQ ID NO: 8; SEQ ID NO: 9; or SEQ ID NO: 13; (ii) polypept ide having an amino acid sequence which is at least 80 % identical with one of the amino acid sequences of NO:1; SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO: 7; SEQ ID NO: 8; SEQ ID NO: 9; or SEQ ID NO: 13; and (iii) polypept ide derivative obtained through substitution, addition, inversion and/or deletion of one or two amino acids of the amino acid sequences of NO:1; SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO: 7; SEQ ID NO: 8; SEQ ID NO: 9; or SEQ ID NO: 13, which binds to uPAR; L is a covalent single bond or a spacer; and Im is at least one superparamagnetic iron oxide particle having a coating of an anorganic or organic or anorganic and organic polymer, wherein the coating is covalently attached to L or to Pep, when L is a bond. Another aspect of the present invention is an in-vivo diagnostic method based on magnetic resonance imaging using said contrast agent.
摘要翻译：本发明涉及一种用于磁共振成像的造影剂，其包含式Pep-L-Im的化合物，其中Pep是选自（i）具有NO：1氨基酸序列的多肽的多肽分子 ; SEQ ID NO：2; SEQ ID NO：3; SEQ ID NO：7; SEQ ID NO：8; SEQ ID NO：9; 或SEQ ID NO：13; （ii）具有与NO：1的氨基酸序列之一至少80％相同的氨基酸序列的多肽; SEQ ID NO：2; SEQ ID NO：3; SEQ ID NO：7; SEQ ID NO：8; SEQ ID NO：9; 或SEQ ID NO：13; 和（iii）通过取代，添加，倒位和/或缺失NO：1的氨基酸序列的一个或两个氨基酸获得的多肽衍生物; SEQ ID NO：2; SEQ ID NO：3; SEQ ID NO：7; SEQ ID NO：8; SEQ ID NO：9; 或SEQ ID NO：13，其结合uPAR; L是共价单键或间隔基; 并且Im是至少一种具有无机或有机或有机和有机聚合物涂层的超顺磁性氧化铁颗粒，其中当L是键时，涂层共价连接到L或Pep。本发明的另一方面是使用所述造影剂的基于磁共振成像的体内诊断方法。

10. 发明申请

WO2006074996A1 IMPLANTABLE CHAMBER, IMAGING METHOD AND MAGNETIC RESONANCE IMAGING SYSTEM 审中-公开
标题翻译：可塑室，成像方法和磁共振成像系统
公开(公告)号：WO2006074996A1
公开(公告)日：2006-07-20
申请号：PCT/EP2006/050120
申请日：2006-01-10
申请人： DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS , BOCK, Michael , UMATHUM, Reiner , KIESSLING, Fabian , FUSENIG, Norbert , MÜLLER, Margaretha
发明人： BOCK, Michael , UMATHUM, Reiner , KIESSLING, Fabian , FUSENIG, Norbert , MÜLLER, Margaretha
IPC分类号： A61B5/055
CPC分类号： G01R33/34053 , A61B5/055 , G01R33/34084 , G01R33/5608
摘要： The present invention relates to an implantable chamber (1) with a connecting element (2), comprising a connecting sleeve (6) and a surrounding contact surface (7), an insert element (3), comprising an insert sleeve (8) and a surrounding abutment surface (9). The insert sleeve (8) is inserted into the connecting sleeve (6) of the connecting element (2). The implantable chamber (1) further comprises a cap (4) with a surrounding edge (11), the cap (4) partly covering the connecting element (2) and the insert element (3), leaving an opening (13) on one side. The implantable chamber (1) contains a passive resonance circuit (14) with an inductance and a capacitance, the passive resonance circuit (14) surrounding at least part of a cavity (15) inside the insert element (3).
摘要翻译：本发明涉及具有连接元件（2）的可植入室（1），其包括连接套筒（6）和环绕接触表面（7），插入元件（3），其包括插入套筒（8）和周围的邻接表面（9）。插入套筒（8）插入到连接元件（2）的连接套筒（6）中。植入式腔室（1）还包括具有周围边缘（11）的帽（4），帽部分（4）部分地覆盖连接元件（2）和插入元件（3），在其上留下一个开口（13）侧。可植入室（1）包含具有电感和电容的无源谐振电路（14），无源谐振电路（14）围绕插入元件（3）内的空腔（15）的至少一部分。

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