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1. 发明申请

WO2010077234A1 A METHOD OF FORMING AND THE RESULTING MEMBRANE COMPOSITION FOR SURGICAL SITE PRESERVATION 审中-公开
标题翻译：形成和形成外植体保护层的膜结构的方法
公开(公告)号：WO2010077234A1
公开(公告)日：2010-07-08
申请号：PCT/US2008/088444
申请日：2008-12-29
申请人： SYNTHES (U.S.A.) , SYNTHES GMBH , KEANE, Michael , MILLER, William , SMITH, Nigel
发明人： KEANE, Michael , MILLER, William , SMITH, Nigel
IPC分类号： A61L31/14 , A61L31/04 , A61L31/18
CPC分类号： A61L31/14 , A61L31/06 , A61L31/129 , A61L31/145 , A61L31/18 , C08L29/04 , C08L39/06
摘要： A method of forming and the resulting membrane composition for securement to a patient's bone or tissue to reduce the formation of tissue adhesions following a surgical procedure comprises a first component and a second component. The first component comprises a hydrogel including at least one crosslinked polymer. The second component comprises a textile component. The composition has a thickness between about two tenths of a millimeter (0.2 mm) to about six tenths of a millimeter (0.6 mm), a suture retention strength between about one Newton (1 N) to about thirteen Newtons (13 N), a static coefficient of friction between about one hundredth (0.01) and about one-half (0.5), a kinetic coefficient of friction between about one hundredth (0.01) and about one-half (0.5) and a flexibility of less than thirty millimeters (30 mm) bend length. A method of reducing the occurrence of tissue adhesions following surgery comprises applying the membrane composition to a surgical site.
摘要翻译：一种形成方法和所得的膜组合物用于固定到患者的骨骼或组织以减少外科手术后组织粘连的形成包括第一组分和第二组分。第一组分包含包含至少一种交联聚合物的水凝胶。第二部件包括纺织部件。该组合物具有约十分之二十毫米（0.2毫米）至约十六分之一毫米（0.6毫米）之间的厚度，约一牛顿（1N）至约十三牛顿（13N）之间的缝合线保持强度，一静态摩擦系数在约百分之一（0.01）至约一半（0.5）之间，摩擦系数约在百分之一（0.01）至约一半（0.5）之间，弹性小于三十毫米 mm）弯曲长度。减少手术后组织粘连发生的方法包括将膜组合物施用于手术部位。

2. 发明申请

WO2009079507A3 CROSSLINKED HYDROGELS 审中-公开
标题翻译：交联水晶
公开(公告)号：WO2009079507A3
公开(公告)日：2010-04-22
申请号：PCT/US2008086997
申请日：2008-12-16
申请人： SYNTHES USA , SYNTHES GMBH , UNIV DREXEL , KITA KRISTIN , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W , KEANE MICHAEL F
发明人： KITA KRISTIN , SMITH NIGEL G , LOWMAN ANTHONY M , FUSSELL GARLAND W , KEANE MICHAEL F
IPC分类号： A61L27/16
CPC分类号： A61L27/16
摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.
摘要翻译：本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，形成可注射组合物将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。

3. 发明申请

WO2009086523A2 A TACK OR DRIVE SCREW FOR SECURING A PROSTHESIS TO BONE AND ASSOCIATED INSTRUMENTATION AND METHOD 审中-公开
标题翻译：用于保护骨骼和相关仪器和方法的插入或驱动螺丝
公开(公告)号：WO2009086523A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/088462
申请日：2008-12-29
申请人： SYNTHES (U.S.A.) , SYNTHES GMBH , MORGAN, Mickey , PELOZA, John , LEE, Randall , KEANE, Michael , MILLER, William , TALBOT, James , VENNARD, Daniel , GABELBERGER, Josef
发明人： MORGAN, Mickey , PELOZA, John , LEE, Randall , KEANE, Michael , MILLER, William , TALBOT, James , VENNARD, Daniel , GABELBERGER, Josef
IPC分类号： A61B17/86
CPC分类号： A61B17/0401 , A61B17/0642 , A61B17/70 , A61B17/846 , A61B17/863 , A61B17/8685 , A61B17/8695 , A61B17/8872 , A61B17/92 , A61B2017/0414 , A61B2017/044 , A61B2017/0448 , A61B2017/0647 , A61B2017/0648 , A61B2090/08021 , A61B2090/3983
摘要： The present invention relates to a surgical method or procedure for securing a prosthesis to bone. More particularly, the present invention relates to (i) a surgical method or procedure for securing a low load bearing prosthesis such as, for example, an adhesion barrier, to a patient's bone, (ii) a tack or drive screw for securing the low load bearing prosthesis and (iii) associated instrumentation for driving the tack or drive screw into the patient's bone.
摘要翻译：本发明涉及一种将假体固定在骨上的手术方法或程序。更具体地，本发明涉及（i）用于将低负荷假体（例如粘合屏障）固定到患者骨骼的外科方法或程序，（ii）用于固定低位的固定或驱动螺钉承载假体和（iii）用于将钉头或驱动螺钉驱动到患者骨骼中的相关仪器。

4. 发明申请

WO2006105190A3 METHOD AND APPARATUS FOR IMPLANTING A HYDROGEL PROSTHESIS FOR A NUCLEUS PULPOSUS 审中-公开
标题翻译：用于植入NUCLEUS PULPOSUS的水凝胶预处理方法和装置
公开(公告)号：WO2006105190A3
公开(公告)日：2007-05-24
申请号：PCT/US2006011454
申请日：2006-03-29
申请人： SYNTHES USA , SYNTHES GMBH , VRESILOVIC EDWARD , KEANE MICHAEL F , SCHAER THOMAS P , ARTHUR AMY , SINGHATAT WAMIS
发明人： VRESILOVIC EDWARD , KEANE MICHAEL F , SCHAER THOMAS P , ARTHUR AMY , SINGHATAT WAMIS
IPC分类号： A61F2/46 , A61F2/44
CPC分类号： A61F2/4657 , A61B2090/064 , A61F2/4611 , A61F2002/30075 , A61F2002/3009 , A61F2002/30235 , A61F2002/30581 , A61F2002/30617 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61F2002/4677 , A61F2002/4693 , A61F2002/4694 , A61F2210/0061 , A61F2230/0069 , A61F2250/0091 , A61F2250/0097
摘要： An instrument (100) for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula (200) that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container (300) adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure (400) adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus (700) for determining the volume of prosthesis to be inserted includes a catheter or cannula (702) capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon (704) capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.
摘要翻译：用于将细长水凝胶假体插入椎间盘的器械（100）包括插入穿过椎间盘纤维环的插入套管（200），以提供通向椎间盘的细胞核区域的通路，适于联接到所述插入套管的近端的管状容器（300）以及适于联接到所述管状容器的近端的流体压力源（400）。用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。用于确定待插入的假体的体积的定径装置（700）包括能够穿过插入插管插入椎间盘的核区域中的导管或套管（702），并且在其远端处具有气囊（704）能够在具有可测量体积的流体的椎间盘内充气，以便确定待注射的水凝胶假体的量。

5. 发明申请

WO2008067559A2 METHODS FOR TREATING AND DIAGNOSING FIBROTIC AND FIBROPROLIFERATIVE DISEASES 审中-公开
标题翻译：方法治疗和诊断纤维和纤维增生性疾病
公开(公告)号：WO2008067559A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/086167
申请日：2007-11-30
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MEHRAD, Borna , BURDICK, Marie D. , ZISMAN, David A. , KEANE, Michael P. , BELPERIO, John A. , STRIETER, Robert M.
发明人： MEHRAD, Borna , BURDICK, Marie D. , ZISMAN, David A. , KEANE, Michael P. , BELPERIO, John A. , STRIETER, Robert M.
IPC分类号： G01N33/554
CPC分类号： G01N33/6893 , G01N2333/52 , G01N2800/12 , G01N2800/122
摘要： The present invention provides compositions and methods for diagnosing and treating fibrotic lung disease.
摘要翻译：本发明提供了用于诊断和治疗纤维化肺病的组合物和方法。

6. 发明申请

WO2007025164A3 HYDROGEL BALLOON PROSTHESIS FOR NUCLEUS PULPOSUS 审中-公开
标题翻译：氢化球藻对核仁的影响
公开(公告)号：WO2007025164A3
公开(公告)日：2007-12-06
申请号：PCT/US2006033276
申请日：2006-08-25
申请人： SYNTHES USA , SYNTHES GMBH , MARCOLONGO MICHELE S , LOWMAN ANTHONY M , CLEMOW ALASTAIR J T , KEANE MICHAEL F , VRESILOVIC EDWARD
发明人： MARCOLONGO MICHELE S , LOWMAN ANTHONY M , CLEMOW ALASTAIR J T , KEANE MICHAEL F , VRESILOVIC EDWARD
IPC分类号： A61L27/52 , A61F2/44
CPC分类号： A61L27/52 , A61F2/30767 , A61F2/441 , A61F2002/444
摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.
摘要翻译：用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性水凝胶。优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。

7. 发明申请

WO2007104108A1 NON-CODEINE OPIOID ANALGESIC PROCESS AND FORMULATIONS 审中-公开
标题翻译：非酮类药物治疗方法和制剂
公开(公告)号：WO2007104108A1
公开(公告)日：2007-09-20
申请号：PCT/AU2007/000324
申请日：2007-03-15
申请人： GRAYDON,, Cameron , KEANE, Michael
发明人： KEANE, Michael
IPC分类号： A61K31/485 , A61K31/167 , A61P29/00 , A61K9/20 , A61K31/192
CPC分类号： A61K9/2059 , A61K9/2018 , A61K9/2027 , A61K31/167 , A61K31/192 , A61K31/485 , A61K2300/00
摘要： The invention is directed to the relief of pain using opioid analgesics other than codeine, preferably in combination with a non-steroidal anti-inflammatory agent. Treatment is by self-administration. Compositions for the treatments are provided. Compositions of opioid analgesics other than codeine adapted to avoid the problems of potential abuse are also provided. The compositions have potential use as both prescription and non-prescription medications.
摘要翻译：本发明涉及使用除可待因以外的阿片样镇痛药来缓解疼痛，优选与非甾体抗炎剂组合。治疗是通过自我管理。提供治疗的组合。还提供了适用于避免潜在滥用问题的除可待因以外的阿片样镇痛药的组合物。该组合物作为处方药和非处方药都具有潜在的用途。

8. 发明申请

WO2009146331A1 PHASE TRANSITIONING HYDROGELS 审中-公开
标题翻译：相转移水凝胶
公开(公告)号：WO2009146331A1
公开(公告)日：2009-12-03
申请号：PCT/US2009/045328
申请日：2009-05-27
申请人： SYNTHES USA, LLC , SYNTHES GMBH , DREXEL UNIVERSITY , KITA, Kristin, B. , SMITH, Nigel, G. , LOWMAN, Anthony, M. , FUSSELL, Garland, W. , KEANE, Michael
发明人： KITA, Kristin, B. , SMITH, Nigel, G. , LOWMAN, Anthony, M. , FUSSELL, Garland, W. , KEANE, Michael
IPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , C08L39/06 , C08L71/02 , C08K3/30
CPC分类号： C08L29/04 , A61L27/26 , A61L27/52 , A61L2400/06 , C08K3/30 , C08L39/06 , C08L71/02 , C08L2666/14 , C08L2666/02
摘要： A method of forming and the resulting hydrogel composition comprising poly( vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentration of about 2% (w/w) to about 20% (w/w), wherein the hydrogel composition has a total polymer content, above about 30% (w/w), higher than the total polymer content of a precursor polymer solution formulated prior to the formulation of the hydrogel composition. The hydrogel composition may further comprise poly( vinyl pyrrolidone) at a final concentration of about 0.10% (w/w) to about 0.75% (w/w).
摘要翻译：一种形成方法，所得到的水凝胶组合物包含最终浓度为约20％（w / w）至约65％（w / w）的聚乙烯醇和最终浓度为约2％的聚乙二醇（w / w）至约20％（w / w），其中所述水凝胶组合物的总聚合物含量高于约30％（w / w），高于在配制之前配制的前体聚合物溶液的总聚合物含量水凝胶组合物。水凝胶组合物还可以包含最终浓度为约0.10％（w / w）至约0.75％（w / w）的聚（乙烯基吡咯烷酮）。

9. 发明申请

WO2009079507A2 CROSSLINKED HYDROGELS 审中-公开
标题翻译：交联水晶
公开(公告)号：WO2009079507A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/086997
申请日：2008-12-16
申请人： SYNTHES (U.S.A) , SYNTHES, Gmbh , DREXEL UNIVERSITY , KITA, Kristin , SMITH, Nigel, G. , LOWMAN, Anthony, M. , FUSSELL, Garland, W. , KEANE, Michael, F.
发明人： KITA, Kristin , SMITH, Nigel, G. , LOWMAN, Anthony, M. , FUSSELL, Garland, W. , KEANE, Michael, F.
IPC分类号： A61L27/16
CPC分类号： A61L27/16
摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.
摘要翻译：本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，形成可注射组合物将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。

10. 发明申请

WO2006105190A2 METHOD AND APPARATUS FOR IMPLANTING A HYDROGEL PROSTHESIS FOR A NUCLEUS PULPOSUS 审中-公开
标题翻译：用于植入NUCLEUS PULPOSUS的水凝胶预处理方法和装置
公开(公告)号：WO2006105190A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011454
申请日：2006-03-29
申请人： SYNTHES INC. , VRESILOVIC, Edward , KEANE, Michael, F. , SCHAER, Thomas, P. , ARTHUR, Amy , SINGHATAT, Wamis
发明人： VRESILOVIC, Edward , KEANE, Michael, F. , SCHAER, Thomas, P. , ARTHUR, Amy , SINGHATAT, Wamis
IPC分类号： A61F2/46 , A61F2/44
CPC分类号： A61F2/4657 , A61B2090/064 , A61F2/4611 , A61F2002/30075 , A61F2002/3009 , A61F2002/30235 , A61F2002/30581 , A61F2002/30617 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61F2002/4677 , A61F2002/4693 , A61F2002/4694 , A61F2210/0061 , A61F2230/0069 , A61F2250/0091 , A61F2250/0097
摘要： An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus for determining the volume of prosthesis to be inserted includes a catheter or cannula capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.
摘要翻译：用于将细长水凝胶假体插入椎间盘的器械包括插入插入穿过椎间盘纤维环的插入套管，以提供进入椎间盘的细胞核区域的细长水凝胶假体，耦合到插入套管的近端，以及适于联接到管状容器的近端的流体源的源。用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。用于确定要插入的假体的体积的定径装置包括导管或套管，其能够穿过插入插管插入到椎间盘的细胞核区域中，并且在其远端具有能够在椎间盘内膨胀的气囊，可测量体积的流体，以确定待注射的水凝胶假体的量。

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