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1. 发明申请

WO2011084387A3 METHODS AND KITS FOR DETECTING RISK FACTORS FOR DEVELOPMENT OF JAW OSTEONECROSIS AND METHODS OF TREATMENT THEREOF 审中-公开
标题翻译：用于检测颌骨骨软骨发育风险因子的方法和试剂盒及其治疗方法
公开(公告)号：WO2011084387A3
公开(公告)日：2011-10-27
申请号：PCT/US2010060139
申请日：2010-12-13
申请人： UNIV FLORIDA , KATZ JOSEPH , LANGAEE TAIMOUR Y
发明人： KATZ JOSEPH , LANGAEE TAIMOUR Y
IPC分类号： C12Q1/68 , C12N15/12
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Methods of and kits for determining the pharmacogenetic, pharmacokinetic and cellular basis of bisphosphonate-induced osteonecrosis of the jaw (BONJ) involve associating particular proteins and particular single nucleotide polymorphisms with a risk for developing BONJ after receiving bisphosphonate treatment. Methods and kits for identifying the genetic basis for a patient's predisposition to BONJ, and methods of identifying patients who are prone to develop BONJ following bisphosphonate administration provide for the development of a tool for physicians to prescribe treatment protocols for BONJ patients based on the patients' genomes ("personal/tailored medicine"). A haplotype tagging SNP approach was used to analyze candidate genes involved in bone absorption and destruction and to examine the influence of genetic variants on the susceptibility of BONJ. Bone biomarkers of BONJ were examined using molecular cell techniques. The methods described herein can be used to identify differences in how patients are genetically predisposed to BONJ as well as genetic differences amongst patients that account for differences in how these patients clear bisphosphonate s from their systems. Determining such genetic differences provides for improved monitoring of the drugs used to treat BONJ, improved prevention of BONJ, and optimized treatment for patients having BONJ or predisposed to BONJ.
摘要翻译：用于确定双膦酸盐诱导的颌骨骨坏死（BONJ）的药物遗传学，药代动力学和细胞基础的方法和试剂盒涉及使特定蛋白质和特定的单核苷酸多态性与接受双磷酸盐治疗后发生BONJ的风险相关联。用于鉴定患者对BONJ易感性的遗传基础的方法和试剂盒以及鉴定在施用双膦酸盐后容易发生BONJ的患者的方法提供了开发一种工具，用于医师根据患者的情况为BONJ患者规定治疗方案，基因组（“个人/定制医学”）。使用单体型标记SNP方法分析参与骨吸收和破坏的候选基因，并检查遗传变体对BONJ易感性的影响。使用分子细胞技术检查BONJ的骨生物标志物。本文所述的方法可用于鉴定患者如何遗传易感BONJ的差异以及患者之间的遗传差异，这些差异解释了这些患者如何从其系统中清除二膦酸盐。确定此类遗传差异可改善对用于治疗BONJ的药物的监测，改善对BONJ的预防，以及对患有BONJ或易患BONJ的患者的优化治疗。

2. 发明申请

WO2010005939A1 METHODS AND KITS FOR DETECTING RISK FACTORS FOR DEVELOPMENT OF JAW OSTEONECROSIS AND METHODS OF TREATMENT THEREOF 审中-公开
标题翻译：检测风险因素的方法和检测手段，用于发展AW AW AW AW R IS IS IS IS OF OF OF OF OF OF OF OF OF OF
公开(公告)号：WO2010005939A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/049767
申请日：2009-07-07
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , KATZ, Joseph , LANGAEE, Taimour
发明人： KATZ, Joseph , LANGAEE, Taimour
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Determining the pharmacogenetic, pharmacokinetic and cellular basis of bisphosphonate-induced osteonecrosis of the jaw (BONJ) via associating particular proteins and particular single nucleotide polymorphisms with a risk for developing BONJ after receiving bisphosphonate treatment. Methods and kits for identifying the genetic basis for a patient's predisposition to BONJ. A haplotype tagging SNP approach was used to analyze candidate genes involved in bone absorption and destruction and to examine the influence of genetic variants on the susceptibility of BONJ. Bone biomarkers of BONJ are disclosed. Said biomarkers provide for improved monitoring of the drugs used to treat BONJ, improved prevention of BONJ, and optimized treatment of patients having BONJ or predisposed to BONJ.
摘要翻译：通过将特定蛋白质和特定单核苷酸多态性与接受双膦酸盐治疗后发生BONJ风险相关联，确定双膦酸盐诱导的颌骨骨坏死（BONJ）的药代动力学，药代动力学和细胞学基础。用于识别患者对BONJ倾向的遗传基础的方法和试剂盒。使用单倍型标记SNP方法分析参与骨吸收和破坏的候选基因，并检查遗传变异对BONJ敏感性的影响。 BONJ的骨生物标志物被公开。所述生物标志物提供对用于治疗BONJ的药物的改进监测，改善BONJ的预防，以及对具有BONJ或易患BONJ的患者的优化治疗。

3. 发明申请

WO2008095110A3 COMPOSITIONS AND METHODS FOR DETECTING CANCERS IN A SUBJECT 审中-公开
标题翻译：检测受试者中癌症的组合物和方法
公开(公告)号：WO2008095110A3
公开(公告)日：2008-11-20
申请号：PCT/US2008052673
申请日：2008-01-31
申请人： UNIV FLORIDA , KATZ JOSEPH , CHAN EDWARD
发明人： KATZ JOSEPH , CHAN EDWARD
IPC分类号： C07K16/00 , C07K14/00 , G01N33/53
CPC分类号： G01N33/57407 , G01N33/57419 , G01N33/57446 , G01N33/57484 , G01N2333/47
摘要： Disclosed are compositions and methods for detecting oral and gastrointestinal cancers in a subject. Autoantigen p90 was shown to be overexpressed in oral cancer cells, and this protein, as well as its companion autoantigen p62 and antibodies directed to both proteins, can be used as markers for detecting oral digestive and other cancers in a subject at an early stage.
摘要翻译：公开了用于检测受试者中的口腔和胃肠癌的组合物和方法。自身抗原p90显示在口腔癌细胞中过表达，并且该蛋白以及其伴侣自身抗原p62和针对两种蛋白的抗体可以用作早期阶段在受试者中检测口腔消化和其他癌症的标记。

4. 发明申请

WO2013032925A1 NETWORK PREDICTIVE CUSTOMER SERVICE QUEUE MANAGEMENT 审中-公开
标题翻译：网络预测客户服务队伍管理
公开(公告)号：WO2013032925A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052330
申请日：2012-08-24
申请人： FACE IT CORP. , FRIED, Lance , KATZ, Joseph , KORFIN, Rick
发明人： FRIED, Lance , KATZ, Joseph , KORFIN, Rick
IPC分类号： G06Q10/00
CPC分类号： H04M3/5231 , H04M3/42059 , H04M3/42221 , H04M3/42306 , H04M3/4283 , H04M3/5238 , H04M7/125 , H04M2207/12
摘要： A communications portal for interfacing with a carrier network, a contact center, and a user is disclosed. Telecommunications links are connected to the communications portal to receive inbound calls and place outbound calls. A gateway signaling proxy containing an application server and a reverse automation subsystem is connected to the telecommunications links to recognize and store user selections, detect answer supervision, and execute scripts as configured in the user interface.
摘要翻译：公开了一种用于与运营商网络，联络中心和用户进行接口的通信门户。电信链路连接到通信门户，以接收来电和拨出呼叫。包含应用服务器和反向自动化子系统的网关信令代理连接到电信链路，以识别和存储用户选择，检测应答监视和执行在用户界面中配置的脚本。

5. 发明申请

WO2011084387A2 METHODS AND KITS FOR DETECTING RISK FACTORS FOR DEVELOPMENT OF JAW OSTEONECROSIS AND METHODS OF TREATMENT THEREOF 审中-公开
标题翻译：检测风险因素的方法和检测手段，用于发展AW AW AW AW R IS IS IS IS OF OF OF OF OF OF OF OF OF OF
公开(公告)号：WO2011084387A2
公开(公告)日：2011-07-14
申请号：PCT/US2010/060139
申请日：2010-12-13
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , KATZ, Joseph , LANGAEE, Taimour, Y.
发明人： KATZ, Joseph , LANGAEE, Taimour, Y.
IPC分类号： C12Q1/68 , C12N15/12
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： Methods of and kits for determining the pharmacogenetic, pharmacokinetic and cellular basis of bisphosphonate-induced osteonecrosis of the jaw (BONJ) involve associating particular proteins and particular single nucleotide polymorphisms with a risk for developing BONJ after receiving bisphosphonate treatment. Methods and kits for identifying the genetic basis for a patient's predisposition to BONJ, and methods of identifying patients who are prone to develop BONJ following bisphosphonate administration provide for the development of a tool for physicians to prescribe treatment protocols for BONJ patients based on the patients' genomes ("personal/tailored medicine"). A haplotype tagging SNP approach was used to analyze candidate genes involved in bone absorption and destruction and to examine the influence of genetic variants on the susceptibility of BONJ. Bone biomarkers of BONJ were examined using molecular cell techniques. The methods described herein can be used to identify differences in how patients are genetically predisposed to BONJ as well as genetic differences amongst patients that account for differences in how these patients clear bisphosphonate s from their systems. Determining such genetic differences provides for improved monitoring of the drugs used to treat BONJ, improved prevention of BONJ, and optimized treatment for patients having BONJ or predisposed to BONJ.
摘要翻译：用于测定双膦酸盐诱导的颌骨骨坏死（BONJ）的药物遗传学，药代动力学和细胞学基础的方法和试剂盒涉及将具体的蛋白质和具体的单核苷酸多态性与接受双膦酸盐治疗后发生BONJ的风险相关联。用于鉴定患者对BONJ倾向的遗传基础的方法和试剂盒，以及鉴定双膦酸盐给药后容易发展BONJ的患者的方法，为医师开发出一种工具，用于根据患者的BONJ开发BONJ患者的治疗方案，基因组（“个人/定制药”）。使用单倍型标记SNP方法分析参与骨吸收和破坏的候选基因，并检查遗传变异对BONJ敏感性的影响。使用分子细胞技术检查BONJ的骨生物标志物。本文描述的方法可以用于鉴定患者如何遗传易感BONJ的差异以及患者之间的遗传差异，这些差异表明这些患者如何从其系统中清除双膦酸盐。确定这样的遗传差异提供改进的用于治疗BONJ的药物的监测，改善BONJ的预防，以及对具有BONJ或倾向于BONJ的患者的优化治疗。

6. 发明申请

WO2005067310A1 A LASER PROJECTION DISPLAY 审中-公开
标题翻译：激光投影显示
公开(公告)号：WO2005067310A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/042836
申请日：2004-12-21
申请人： SYMBOL TECHNOLOGIES, INC. , STERN, Miklos , DVORKIS, Paul , NAMBUDIRI, Narayan , WITTENBERG, Carl , TAN, Chinh , GOLDMAN, Ron , YAVID, Dmitriy , WOOD, Frederick, F. , KATZ, Joseph
发明人： STERN, Miklos , DVORKIS, Paul , NAMBUDIRI, Narayan , WITTENBERG, Carl , TAN, Chinh , GOLDMAN, Ron , YAVID, Dmitriy , WOOD, Frederick, F. , KATZ, Joseph
IPC分类号： H04N9/31
CPC分类号： H04N9/3129
摘要： A method and apparatus are provided for controlling the operation of a Laser Projection Display (LPD). Generally, the LPD is comprised of a laser, an optical system and a controller. The laser is adapted to emit a beam of laser light. The optical system is adapted to scan the beam of laser light on a display surface in a two-dimensional raster pattern. The controller is adapted to control the rate at which the laser beam is scanned to produce regions of varying resolution on the display surface. The controller is also adapted to present laser light onto the display surface within only selected portions of the two-dimensional raster scan pattern so that spaced apart image regions may be created.
摘要翻译：提供了一种用于控制激光投射显示器（LPD）的操作的方法和装置。通常，LPD由激光器，光学系统和控制器组成。激光器适于发射激光束。光学系统适于以二维光栅图案扫描显示表面上的激光束。控制器适于控制激光束被扫描的速率，以在显示表面上产生不同分辨率的区域。该控制器还适于在二维光栅扫描图案的所选部分内的显示表面上呈现激光，从而可以产生间隔开的图像区域。

7. 发明申请

WO02060377A3 THE SEPARATION, IDENTIFICATION AND QUANTITATION OF PROTEIN MIXTURES 审中-公开
标题翻译：蛋白质混合物的分离，鉴定和定量
公开(公告)号：WO02060377A3
公开(公告)日：2003-01-03
申请号：PCT/US0147754
申请日：2001-12-14
申请人： UNIV JOHNS HOPKINS , KATZ JOSEPH L , WIRTZ DENIS
发明人： KATZ JOSEPH L , WIRTZ DENIS
IPC分类号： B01J19/00 , G01N33/543 , G01N33/553 , G01N33/53 , G01N33/537
CPC分类号： B01J19/0093 , B01J2219/00864 , B01J2219/00952 , G01N33/54326
摘要： A Repeated Classification Procedure (RCP) for the rapid separation, identification, classification, and quantitation of proteins in a mixture of proteins utilizes general-motif antibodies which typically bind to a plurality of proteins in a mixture which have a common motif or are homologs in some respect. By repeatedly using general-motif antibodies or using general-motif antibodies in conjunction with specific antibodies, a pattern of binding can be produced which uniquely identifies proteins of interest. By using immobilized general-motif antibodies to effect separation, the identification, classification, and quantitation of proteins in a sample can be use to characterize the protein synthesis pattern of disease states. Quantitation of protein in a sample can be determined based on the movement of very small beads with bound protein in a magnetic field, wherein larger quantities of bound protein causes the beads to travel relatively smaller distances or at relatively slower rates.
摘要翻译：用于蛋白质混合物中蛋白质的快速分离，鉴定，分类和定量的重复分类程序（RCP）利用通常基序抗体，其通常结合具有共同基序或同系物的混合物中的多种蛋白质一些尊重通过重复使用一般基序抗体或使用一般基序抗体与特异性抗体结合，可以产生唯一识别感兴趣蛋白质的结合模式。通过使用固定的一般基序抗体来实现分离，样品中蛋白质的鉴定，分类和定量可用于表征疾病状态的蛋白质合成模式。可以基于磁场中具有结合蛋白质的非常小的珠粒的移动来确定样品中的蛋白质的定量，其中较大量的结合蛋白质导致珠粒行进相对较小的距离或以相对较慢的速率行进。

8. 发明申请

WO2002060377A2 THE SEPARATION, IDENTIFICATION AND QUANTITATION OF PROTEIN MIXTURES 审中-公开
标题翻译：蛋白质混合物的分离，鉴定和定量
公开(公告)号：WO2002060377A2
公开(公告)日：2002-08-08
申请号：PCT/US2001/047754
申请日：2001-12-14
申请人： THE JOHNS HOPKINS UNIVERSITY , KATZ, Joseph, L. , WIRTZ, Denis
发明人： KATZ, Joseph, L. , WIRTZ, Denis
IPC分类号： A61K
CPC分类号： B01J19/0093 , B01J2219/00864 , B01J2219/00952 , G01N33/54326
摘要： A Repeated Classification Procedure (RCP) for the rapid separation, identification, classification, and quantitation of proteins in a mixture of proteins utilizes general-motif antibodies which typically bind to a plurality of proteins in a mixture which have a common motif or are homologs in some respect. By repeatedly using general-motif antibodies or using general-motif antibodies in conjunction with specific antibodies, a pattern of binding can be produced which uniquely identifies proteins of interest. By using immobilized general-motif antibodies to effect separation, the identification, classification, and quantitation of proteins in a sample can be use to characterize the protein synthesis pattern of disease states. Quantitation of protein in a sample can be determined based on the movement of very small beads with bound protein in a magnetic field, wherein larger quantities of bound protein causes the beads to travel relatively smaller distances or at relatively slower rates.
摘要翻译：用于蛋白质混合物中蛋白质的快速分离，鉴定，分类和定量的重复分类程序（RCP）利用通常基序抗体，其通常结合具有共同基序或同系物的混合物中的多种蛋白质一些尊重通过重复使用一般基序抗体或使用一般基序抗体与特异性抗体结合，可以产生唯一识别感兴趣蛋白质的结合模式。通过使用固定的一般基序抗体来实现分离，样品中蛋白质的鉴定，分类和定量可用于表征疾病状态的蛋白质合成模式。可以基于磁场中具有结合蛋白质的非常小的珠粒的移动来确定样品中的蛋白质的定量，其中较大量的结合蛋白质导致珠粒行进相对较小的距离或以相对较慢的速率行进。

9. 发明申请

WO1996005715A1 CELLULAR TELEPHONE USER'S PROTECTIVE DEVICE 审中-公开
标题翻译：蜂窝电话用户的保护设备
公开(公告)号：WO1996005715A1
公开(公告)日：1996-02-22
申请号：PCT/US1994008963
申请日：1994-08-09
申请人： KATZ, Joseph, M.
IPC分类号： H05K09/00
CPC分类号： H05K9/0052 , H01Q1/245
摘要： A low cost non-electric device to afford some protection to the operators of Lap-Top and Notebook computers (1) from the electro-magnetic fields radiation emitted therefrom and to afford a comfortable cushion to rest the computer (1) upon.
摘要翻译：一种低成本的非电气设备，能够对由Lap-Top和Notebook计算机（1）的操作者提供对从其发射的电磁场辐射的一些保护，并提供舒适的缓冲垫以使计算机（1）保持在其上。

10. 发明申请

WO2010129576A1 TRUST-BASED PERSONALIZED OFFER PORTAL 审中-公开
标题翻译：基于信任的个性化门市
公开(公告)号：WO2010129576A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033583
申请日：2010-05-04
申请人： FACE IT CORP. , FRIED, Lance , KATZ, Joseph
发明人： FRIED, Lance , KATZ, Joseph
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0251 , G06Q30/02
摘要： A portal system for secure, aggregated and centralized management of delivering various offers in accordance with specified customer preferences is contemplated. An offer configuration server permits the vendor to specify offers based on various factors such as volume, start time, expiration, and to specify the particular customer device to which the offers are delivered. Customers have associated receive settings that define the preferred frequency, nature of the offers, vendors, and demographic exposure. The offers are delivered to the customer in accordance with these settings.
摘要翻译：考虑到根据指定的客户偏好来安全，集中和集中管理提供各种报价的门户系统。提供配置服务器允许供应商基于诸如卷，开始时间，到期之类的各种因素来指定报价，并且指定要提供报价的特定客户设备。客户具有相关的接收设置，定义首选频率，优惠性质，供应商和人口统计信息。根据这些设置，这些优惠将交付给客户。

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