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    • 1. 发明申请
    • OXAZOLINONE DERIVATIVE HAVING INTRACELLULAR PHOSPHOLIPASE A2 INHIBITOR ACTIVITY
    • 具有细胞内磷脂酶A2抑制剂活性的奥沙罗宁衍生物
    • WO1995010508A1
    • 1995-04-20
    • PCT/JP1994001716
    • 1994-10-13
    • SHIONOGI & CO., LTD.OHTANI, MitsuakiKATO, Toshiyuki
    • SHIONOGI & CO., LTD.
    • C07D263/38
    • C07D231/12C07D233/56C07D249/08C07D263/22C07D263/38C07D413/04C07D413/06C07D413/12C07D413/14
    • A compound represented by general formula (I), and having an intracellular phospholipase A2 inhibitor activity, and a composition containing the same, wherein a and b represent each a carbon atom and the bond -- between the atoms a and b represents either a single or a double bond; X represents hydrogen, optionallysubstituted aryl, heteroaryl or aralkyl; Y represents hydrogen, optionally substituted aryl, aralkyl, carboxyl or a functional group related thereto; and Z represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, aralkyl, arylalkenyl, heteroarylalkyl, heteroarylalkenyl, aryloxyalkyl, aralkyloxyalkyl, arylcarbonylalkyl, arylsulfonylalkyl, heteroarylsulfonylalkyl, aminoalkyl, carboxyalkyl or a functional group related thereto, alkyloxycarbonyl, aralkyloxycarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl or heteroarylsulfonyl; provided the case where X, Y and Z represent simultaneously hydrogen atoms is excluded.
    • 由通式(I)表示的具有细胞内磷脂酶A2抑制剂活性的化合物和含有该化合物的组合物,其中a和b各自表示碳原子和原子之间的键 - a和b表示单键或双键; X表示氢,任选取代的芳基,杂芳基或芳烷基; Y表示氢,任选取代的芳基,芳烷基,羧基或与其相关的官能团; 芳基烷基,芳基磺酰基烷基,杂芳基磺酰基烷基,氨基烷基,羧基烷基或与其有关的官能团,烷氧基羰基,芳烷氧基羰基,芳基羰基,烷基磺酰基,芳基磺酰基 或杂芳基磺酰基; 只要X,Y和Z同时表示氢原子排除的情况。