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1. 发明申请

WO2010009246A3 METHODS AND REAGENTS FOR PREPARING MULTIFUNCTIONAL PROBES 审中-公开
标题翻译：制备多功能探针的方法和试剂
公开(公告)号：WO2010009246A3
公开(公告)日：2010-05-06
申请号：PCT/US2009050714
申请日：2009-07-15
申请人： GEN HOSPITAL CORP , JOSEPHSON LEE , GARANGER ELISABETH
发明人： JOSEPHSON LEE , GARANGER ELISABETH
IPC分类号： G01N33/50 , G01N33/53 , G01N33/68
CPC分类号： C07K17/02 , G01N33/531 , G01N33/532
摘要： Multifunctional probes are synthesized in a single step using peptide scaffold-based multifunctional single-attachment-point reagents. To obtain multifunctional probes using the methods of the invention, a substrate (e.g., a nanoparticle, polymer, antibody, protein, low molecular weight compound, drug, etc.) is reacted with a multifunctional single-attachment-point (MSAP) reagent. The MSAP reagents can include three components: (i) a peptide scaffold, (ii) a single chemically reactive group on the peptide scaffold for reaction of the MSAP with a substrate having a complementary reactive group, and (iii) multiple functional groups on the peptide scaffold. The peptide scaffold can include any number of residues; however, for ease of synthesis and reproducibility in clinical trials, it is preferred to limit the residues in the peptide to 20 or less. The reagent can be prepared to yield a predetermined stoichiometric ratio of the functional groups on the scaffold such that the probe has a fixed stoichiometric ratio of the functional groups.
摘要翻译：使用基于肽基脚手架的多功能单附着点试剂，可以一步合成多功能探针。为了使用本发明的方法获得多功能探针，将底物（例如纳米颗粒，聚合物，抗体，蛋白质，低分子量化合物，药物等）与多功能单附着点（MSAP）试剂反应。 MSAP试剂可以包括三种组分：（i）肽支架，（ii）肽支架上的单个化学反应基团，用于MSAP与具有互补反应基团的底物反应，和（iii）多肽上的多个官能团肽支架。肽骨架可以包括任何数量的残基; 然而，为了便于临床试验中的合成和再现性，优选将肽中的残基限制在20或更少。可以制备试剂以产生预定的化学计量比的支架上的官能团，使得探针具有固定的官能团的化学计量比。

2. 发明申请

WO2002098364A3 MAGNETIC-NANOPARTICLE CONJUGATES AND METHODS OF USE 审中-公开
公开(公告)号：WO2002098364A3
公开(公告)日：2002-12-12
申请号：PCT/US2002/017860
申请日：2002-06-06
申请人： THE GENERAL HOSPITAL CORPORATION , PEREZ, J., Manuel , JOSEPHSON, Lee , WEISSLEDER, Ralph
发明人： PEREZ, J., Manuel , JOSEPHSON, Lee , WEISSLEDER, Ralph
IPC分类号： A61B5/055
摘要： The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms.

3. 发明申请

WO2003057175A3 AMINE FUNCTIONALIZED SUPERPARAMAGNETIC NANOPARTICLES FOR THE SYNTHESIS OF BIOCONJUGATES AND USES THEREFOR 审中-公开
公开(公告)号：WO2003057175A3
公开(公告)日：2003-07-17
申请号：PCT/US2003/000051
申请日：2003-01-02
申请人： VISEN MEDICAL, INC. , GAW, Debra, A. , JOSEPHSON, Lee
发明人： GAW, Debra, A. , JOSEPHSON, Lee
IPC分类号： B32B5/16
摘要： Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents.

4. 发明申请

WO2010141833A2 VITAL FLUOROCHROME CONJUGATES AND METHODS OF USE 审中-公开
标题翻译：维生素C和它们的使用方法
公开(公告)号：WO2010141833A2
公开(公告)日：2010-12-09
申请号：PCT/US2010/037425
申请日：2010-06-04
申请人： THE GENERAL HOSPITAL CORPORATION , JOSEPHSON, Lee , GARANGER, Elizabeth , HILDERBRAND, Scott , SOSNOVIK, David , YUAN, Hushan
发明人： JOSEPHSON, Lee , GARANGER, Elizabeth , HILDERBRAND, Scott , SOSNOVIK, David , YUAN, Hushan
IPC分类号： A61K49/10
CPC分类号： A61K49/103 , A61K49/0002 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/1833 , A61K51/0455
摘要： The present invention provides compositions and methods based on vital fluorochrome conjugates that are useful for imaging dying and dead cells.
摘要翻译：本发明提供了基于重要的荧光染料缀合物的组合物和方法，其可用于染色和死细胞成像。

5. 发明申请

WO2009026251A1 DETECTING IONS AND MEASURING ION CONCENTRATIONS 审中-公开
标题翻译：检测离子和测量离子浓度
公开(公告)号：WO2009026251A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073515
申请日：2008-08-18
申请人： THE GENERAL HOSPITAL CORPORATION , JOSEPHSON, Lee , TAKTAK, Sonia
发明人： JOSEPHSON, Lee , TAKTAK, Sonia
IPC分类号： A61K9/16
CPC分类号： A61K49/1863 , A61K49/085 , A61K49/1833 , G01N33/84
摘要： The present inventions include methods and compositions for detecting the presence of ions and measuring the level or concentration of ions in a sample by nuclear magnetic resonance (NMR) using magnetic particles. In particular, the inventions include the preparation and use of magnetic particles having synthetic ion chelators covalently bound to their surfaces. In the presence of target ions, the surface-modified magnetic particles form clusters, which can be monitored by NMR relaxation measurements. The relaxation times can then be used to detect specific ions and determine their concentration. The described methods, compositions, and devices are useful for a variety of applications including biomedical applications in diagnostics and imaging.
摘要翻译：本发明包括用于通过使用磁性颗粒的核磁共振（NMR）检测离子的存在和测量样品中离子的水平或浓度的方法和组合物。特别地，本发明包括制备和使用具有共价结合到其表面上的合成离子螯合剂的磁性颗粒。在存在目标离子的情况下，表面改性的磁性颗粒形成簇，这可以通过NMR弛豫测量来监测。然后松弛时间可用于检测特定离子并确定其浓度。所描述的方法，组合物和装置对于包括诊断和成像中的生物医学应用的各种应用是有用的。

6. 发明申请

WO2007086943A3 WORTMANNIN CONJUGATES AND USES THEREOF 审中-公开
标题翻译： WORTMANNIN结合物及其用途
公开(公告)号：WO2007086943A3
公开(公告)日：2008-10-09
申请号：PCT/US2006034046
申请日：2006-08-31
申请人： BETH ISRAEL HOSPITAL , GEN HOSPITAL CORP , YUAN HUSHAN , LUO JI , WEISSLEDER RALPH , CANTLEY LEWIS , JOSEPHSON LEE
发明人： YUAN HUSHAN , LUO JI , WEISSLEDER RALPH , CANTLEY LEWIS , JOSEPHSON LEE
IPC分类号： A61K31/35 , C07D313/06
CPC分类号： C07D493/06 , C07D311/94 , C07D405/12 , C07J73/003
摘要： The invention features conjugates of wortmannin, and wortmannin derivatives, and their use as inhibitors of PI3 -kinase activity in treating cancer, inflammatory diseases, and C. albicans infections.
摘要翻译：本发明具有渥曼青霉素和渥曼青霉素衍生物的缀合物及其作为PI3激酶抑制剂用于治疗癌症，炎性疾病和白色念珠菌感染的用途。

7. 发明申请

WO2007086943A2 WORTMANNIN CONJUGATES AND USES THEREOF 审中-公开
标题翻译： WORTMANNIN结合物及其用途
公开(公告)号：WO2007086943A2
公开(公告)日：2007-08-02
申请号：PCT/US2006/034046
申请日：2006-08-31
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER , THE GENERAL HOSPITAL CORPORATION , YUAN, Hushan , LUO, Ji , WEISSLEDER, Ralph , CANTLEY, Lewis , JOSEPHSON, Lee
发明人： YUAN, Hushan , LUO, Ji , WEISSLEDER, Ralph , CANTLEY, Lewis , JOSEPHSON, Lee
IPC分类号： A61K31/366
CPC分类号： C07D493/06 , C07D311/94 , C07D405/12 , C07J73/003
摘要： The invention features conjugates of wortmannin, and wortmannin derivatives, and their use as inhibitors of PI3 -kinase activity in treating cancer, inflammatory diseases, and C. albicans infections.
摘要翻译：本发明具有渥曼青霉素和渥曼青霉素衍生物的缀合物及其作为PI3激酶抑制剂用于治疗癌症，炎性疾病和白色念珠菌感染的用途。

8. 发明申请

WO2006122083A2 WATER RELAXATION-BASED SENSORS 审中-公开
标题翻译：基于水松弛的传感器
公开(公告)号：WO2006122083A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017842
申请日：2006-05-09
申请人： THE GENERAL HOSPITAL CORPORATION , JOSEPHSON, Lee , SUN, Yi , WEISSLEDER, Ralph
发明人： JOSEPHSON, Lee , SUN, Yi , WEISSLEDER, Ralph
CPC分类号： G01N27/745 , A61B5/14503 , G01N33/54326 , G01N33/54366 , G01R33/465 , G01R33/50
摘要： This invention relates to magnetic resonance-based sensors and related methods.
摘要翻译：本发明涉及基于磁共振的传感器及相关方法。

9. 发明申请

WO2010009246A2 METHODS AND REAGENTS FOR PREPARING MULTIFUNCTIONAL PROBES 审中-公开
标题翻译：制备多功能探针的方法和试剂
公开(公告)号：WO2010009246A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/050714
申请日：2009-07-15
申请人： THE GENERAL HOSPITAL CORPORATION , JOSEPHSON, Lee , GARANGER, Elisabeth
发明人： JOSEPHSON, Lee , GARANGER, Elisabeth
IPC分类号： G01N33/50 , G01N33/53 , G01N33/68
CPC分类号： C07K17/02 , G01N33/531 , G01N33/532
摘要： Multifunctional probes are synthesized in a single step using peptide scaffold-based multifunctional single-attachment-point reagents. To obtain multifunctional probes using the methods of the invention, a substrate (e.g., a nanoparticle, polymer, antibody, protein, low molecular weight compound, drug, etc.) is reacted with a multifunctional single-attachment-point (MSAP) reagent. The MSAP reagents can include three components: (i) a peptide scaffold, (ii) a single chemically reactive group on the peptide scaffold for reaction of the MSAP with a substrate having a complementary reactive group, and (iii) multiple functional groups on the peptide scaffold. The peptide scaffold can include any number of residues; however, for ease of synthesis and reproducibility in clinical trials, it is preferred to limit the residues in the peptide to 20 or less. The reagent can be prepared to yield a predetermined stoichiometric ratio of the functional groups on the scaffold such that the probe has a fixed stoichiometric ratio of the functional groups.
摘要翻译：多功能探针使用基于肽支架的多功能单连接点试剂在一个步骤中合成。为了使用本发明的方法获得多功能探针，将底物（例如纳米颗粒，聚合物，抗体，蛋白质，低分子化合物，药物等）与多功能单连接点（MSAP）试剂反应。 MSAP试剂可以包括三个组分：（i）肽支架，（ii）肽支架上的单个化学反应性基团，用于使MSAP与具有互补反应性基团的底物反应，和（iii）多个官能团肽支架。肽支架可以包括任何数量的残基; 然而，为了便于在临床试验中的合成和再现性，优选将肽中的残基限制在20以下。可以制备试剂以产生支架上官能团的预定化学计量比，使得探针具有官能团的固定化学计量比。

10. 发明申请

WO2005061724A1 SELF-ASSEMBLING NANOPARTICLE CONJUGATES 审中-公开
标题翻译：自组装纳米粒子结合体
公开(公告)号：WO2005061724A1
公开(公告)日：2005-07-07
申请号：PCT/US2004/041300
申请日：2004-12-09
申请人： THE GENERAL HOSPITAL CORPORATION , JOSEPHSON, Lee , WEISSLEDER, Ralph , PEREZ, Jesus, Manuel
发明人： JOSEPHSON, Lee , WEISSLEDER, Ralph , PEREZ, Jesus, Manuel
IPC分类号： C12Q1/26
CPC分类号： B82Y5/00 , A61K47/555 , A61K49/10 , A61K49/1833 , C12Q1/00 , C12Q1/28 , C12Q1/37
摘要： This invention relates to magnetic nanoparticle conjugates and related compositions and methods of use.
摘要翻译：本发明涉及磁性纳米颗粒共轭物及其相关组合物和使用方法。

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