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1. 发明申请

WO2023023076A1 SAMPLE ENCAPSULATION SYSTEM 审中-公开
公开(公告)号：WO2023023076A1
公开(公告)日：2023-02-23
申请号：PCT/US2022/040492
申请日：2022-08-16
申请人： JOHNSON, Bruce
发明人： JOHNSON, Bruce
IPC分类号： B32B27/02 , B30B11/02 , G01N35/02 , G01N1/36
摘要： A method for sample encapsulation. A first sampling swab is provided that includes an absorbent portion and a fluid control portion that extends from the absorbent portion. The absorbent portion is proximate a proximal end of the first sampling swab. The fluid control portion is proximate a distal end of the first sampling swab. A sample is collected with the absorbent portion. At least a portion of the sample is liquid. An encapsulation material is provided that includes a first web and a second web. The first sampling swab is positioned between the first web and the second web. The first web is urged into contact with the second web proximate the absorbent portion. The urging of the first web into contact with the second web proximate the absorbent portion causes liquid to move from the absorbent portion towards the fluid control portion. The urging of the first web into contact with the second web proximate the absorbent portion is discontinued which causes the liquid to be drawn into the absorbent portion. The first web is urged into contact with the second web proximate the distal end of the first sampling swab to encapsulate the liquid in the encapsulation material.

2. 发明申请

WO2011079124A1 INTRAVAGINAL INCONTINENCE DEVICE 审中-公开
公开(公告)号：WO2011079124A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061566
申请日：2010-12-21
申请人： MCNEIL-PPC, INC. , HULL, Raymond, J. , JOHNSON, Bruce, C. , MAVINKURVE, Pramod , ROSENFELD, Leonard
发明人： HULL, Raymond, J. , JOHNSON, Bruce, C. , MAVINKURVE, Pramod , ROSENFELD, Leonard
IPC分类号： A61F2/82
CPC分类号： A61F2/005
摘要： An intravaginal urinary incontinence device has an insertion end and an opposed withdrawal end. The device has a resilient frame including a working portion disposed proximate the withdrawal end and an anchoring portion disposed proximate the insertion end. The working portion has a resilient structure having a plurality of connected elongate elements for providing support to an associated urinary system. The anchoring portion has a plurality of connected elongate elements arranged to expand laterally within a user's vagina. The elongate elements are formed of a high modulus polymer having an elastic modulus of at least 2 or 3 GPa. Additionally, the polymer may have an Initial Stress @ 3% Strain of at least about 30 MPa, an elongation at yield of at least 3%, a Stress Ratio of at least about 0.5, and/or an Aged Stress (t=50 hrs @ 40° C) @ 3% Strain is greater than about 35 MPa.
摘要翻译：阴道内尿失禁装置具有插入端和相对的取出端。该装置具有弹性框架，该框架包括靠近抽出端设置的工作部分和靠近插入端设置的锚固部分。工作部分具有弹性结构，其具有多个连接的细长元件，用于向相关的泌尿系统提供支撑。锚定部分具有多个连接的细长元件，其布置成在使用者的阴道内横向膨胀。细长元件由具有至少2或3GPa的弹性模量的高模量聚合物形成。此外，聚合物可具有至少约30MPa的初始应力@ 3％应变，至少3％的屈服伸长率，至少约0.5的应力比和/或老化应力（t = 50小时） @ 40℃）@ 3％应变大于约35MPa。

3. 发明申请

WO2010141704A2 IMAGING OF MYELIN BASIC PROTEIN 审中-公开
标题翻译： MYELIN基础蛋白成像
公开(公告)号：WO2010141704A2
公开(公告)日：2010-12-09
申请号：PCT/US2010037237
申请日：2010-06-03
申请人： GEN ELECTRIC , TAN HEHIR CRISTINA ABUCAY , SICLOVAN TIBERIU MIRCEA , BARNHARDT NICOLE EVELYN , FISH KENNETH MICHAEL , CARTER RANDALL LEE , JOHNSON BRUCE FLETCHER , ZHANG RONG
发明人： TAN HEHIR CRISTINA ABUCAY , SICLOVAN TIBERIU MIRCEA , BARNHARDT NICOLE EVELYN , FISH KENNETH MICHAEL , CARTER RANDALL LEE , JOHNSON BRUCE FLETCHER , ZHANG RONG
IPC分类号： A61K49/10
CPC分类号： A61K49/10
摘要： The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.
摘要翻译：本发明涉及髓鞘碱性蛋白检测的方法，包括鉴定患有髓磷脂相关神经病的风险或被诊断的受试者，通过胃肠外给药该试剂，以及通过检测与髓磷脂碱性蛋白的结合来测定受试者的髓鞘形成。还提供了检测髓磷脂的方法以及使用特异性结合髓磷脂碱性蛋白的药剂对样品中局部浓度的定量测量，其中包含用于检测髓磷脂碱性蛋白质的试剂或其衍生物的试剂盒。

4. 发明申请

WO2009079227A3 A CONFIGURABLE WALL MODULE SYSTEM 审中-公开
公开(公告)号：WO2009079227A3
公开(公告)日：2009-06-25
申请号：PCT/US2008/085630
申请日：2008-12-05
申请人： HONEYWELL INTERNATIONAL INC. , BRAY, William J. , JHAWAR, Ankur , KASPER, Gary P. , LABERGE, Jason C. , ANDRZEJEWSKI, Jakub , WACKER, Paul C. , GHULE, Siddharth , GUTHA, Stalin , JOHNSON, Bruce S.
发明人： BRAY, William J. , JHAWAR, Ankur , KASPER, Gary P. , LABERGE, Jason C. , ANDRZEJEWSKI, Jakub , WACKER, Paul C. , GHULE, Siddharth , GUTHA, Stalin , JOHNSON, Bruce S.
IPC分类号： G06F3/048
摘要： A configurable wall module having selectable home screens, custom menu navigation, and incorporating functional design. The display utilizes fixed segments. menu navigation and configuration which may be facilitated with soft keys having indicative labels associated with them. The parameters may be accessed from categories by soft keys via two-level menu navigation. Certain parameter value and setpoint entries may be effected with up/down keys. Module configuration may be performed by a user. To provide such user capability, the module may be programmed and configured by an installer with a software configuration tool used in connection with the building automation system associated with the module.

5. 发明申请

WO2009073677A1 FLUOROALKYL TETRABENAZINE CARBINOL COMPOUNDS AS IMAGING AGENTS AND PROBES 审中-公开
标题翻译：作为成像剂和探针的氟代苄基四氢萘酚化合物
公开(公告)号：WO2009073677A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/085304
申请日：2008-12-03
申请人： GENERAL ELECTRIC COMPANY , AMARASINGHE, Kande Kankananamalage Dayarathna , RISHEL, Michael James , DINN, Sean Richard , JOHNSON, Bruce Fletcher
发明人： AMARASINGHE, Kande Kankananamalage Dayarathna , RISHEL, Michael James , DINN, Sean Richard , JOHNSON, Bruce Fletcher
IPC分类号： C07D471/04 , C07D455/06 , A61K31/4353
CPC分类号： C07D455/06
摘要： The present invention provides novel fluoroalkyl tetrabenazine carbinol compounds. The fluoroalkyl tetrabenazine carbinol compounds are provided in both racemic and enantiomerically enriched forms and may comprise either or both of fluorine-18 and fluorine 19. The fluoroalkyl tetrabenazine carbinol compounds are shown to possess high affinity for VMAT-2, a biomarker implicated in human diabetes. The fluoroalkyl tetrabenazine carbinol compounds comprising a fluorine-18 group are useful as PET imaging agents targeting the VMAT-2 biomarker. The non-radiolabled fluoroalkyl tetrabenazine carbinol compounds are useful as probes for the discovery of PET imaging agents.
摘要翻译：本发明提供新的氟代烷基四苯并嗪甲醇化合物。氟烷基四苯并嗪甲醇化合物以外消旋和对映异构体富集的形式提供，并且可以包含氟-18和氟19中的一种或两种。氟烷基丁苯那嗪甲醇化合物显示对VMAT-2具有高亲和力，VMAT-2是涉及人类糖尿病的生物标记。包含氟-18基团的氟代烷基四苯并嗪甲醇化合物可用作靶向VMAT-2生物标志物的PET显像剂。非放射性氟烷基丁苯那嗪甲醇化合物可用作发现PET成像剂的探针。

6. 发明申请

WO2005094357A3 METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS 审中-公开
标题翻译：确定癌症对肺癌生长因子受体靶向治疗反应的方法
公开(公告)号：WO2005094357A3
公开(公告)日：2008-12-24
申请号：PCT/US2005010645
申请日：2005-03-31
申请人： GEN HOSPITAL CORP , DANA FARBER CANCER INST INC , BELL DAPHNE WINIFRED , HABER DANIEL A , JANNE PASI ANTERO , JOHNSON BRUCE E , LYNCH THOMAS J , MEYERSON MATTHEW , PAEZ JUAN GUILLERMO , SELLERS WILLIAM R , SETTLEMAN JEFFREY E , SORDELLA RAFFAELLA
发明人： BELL DAPHNE WINIFRED , HABER DANIEL A , JANNE PASI ANTERO , JOHNSON BRUCE E , LYNCH THOMAS J , MEYERSON MATTHEW , PAEZ JUAN GUILLERMO , SELLERS WILLIAM R , SETTLEMAN JEFFREY E , SORDELLA RAFFAELLA
IPC分类号： C12Q1/68 , C07H21/04 , C12Q1/48 , G01N33/574 , G01N33/74
CPC分类号： C12Q1/6886 , C12Q1/485 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/574 , G01N33/74 , G01N2333/485 , G01N2800/52
摘要： The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB 1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.
摘要翻译：本发明涉及确定癌症对表皮生长因子受体（EGFR）治疗的反应性的方法。在优选的实施方案中，erbB1基因的激酶结构域中存在至少一个方差赋予对酪氨酸激酶抑制剂吉非替尼的敏感性。因此，这些突变的诊断测定将允许对最可能对药物作出反应的那些患者施用吉非替尼，厄洛替尼和其他酪氨酸激酶抑制剂。

7. 发明申请

WO2008154243A1 METHOD FOR MAKING TETRABENAZINE COMPOUNDS 审中-公开
标题翻译：制备四羧酸化合物的方法
公开(公告)号：WO2008154243A1
公开(公告)日：2008-12-18
申请号：PCT/US2008/065738
申请日：2008-06-04
申请人： GENERAL ELECTRIC COMPANY , RISHEL, Michael James , AMARASINGHE, Kande Kankananamalage Dayarathna , DINN, Sean Richard , JOHNSON, Bruce Fletcher
发明人： RISHEL, Michael James , AMARASINGHE, Kande Kankananamalage Dayarathna , DINN, Sean Richard , JOHNSON, Bruce Fletcher
IPC分类号： C07D217/00 , C07D217/24 , C07D455/00
CPC分类号： C07D455/06 , C07D217/16 , C07D217/18 , Y02P20/55
摘要： A method of preparing a tetrabenazine compound (TBZ compound) having structure I comprising the steps of reacting a nucleophilic alkenyl species with aldehyde compound II and oxidizing the resultant allylic alcohol to provide enone III. The protecting group P 1 on the tetrahydroisoquinoline nitrogen is removed and the resultant deprotected intermediate is induced to undergo an amino cyclization reaction to provide a product TBZ compound having structure I. The method may be used to prepare either enantiomeric form of tetrabenazine; (+)-tetrabenazine or (-)-tetrabenazine. Alternatively the method may be adapted to provide a mixture enriched in one tetrabenazine enantiomer, a racemic mixture, or a diastereomeric mixture of tetrabenazine compounds. In addition, the present invention provides novel synthetic intermediate compositions which may be used to prepare either or both enantiomers of tetrabenazine, derivatives of tetrabenazine, and analogs of tetrabenazine.
摘要翻译：制备具有结构I的丁苯那嗪化合物（TBZ化合物）的方法包括以下步骤：使亲核烯基物质与醛化合物II反应并氧化得到的烯丙基醇以提供烯酮III。除去四氢异喹啉氮上的保护基P1，将所得脱保护的中间体诱导进行氨基环化反应，得到具有结构I的产物TBZ化合物。该方法可用于制备对映体形式的丁苯那嗪; （+） - 丁苯那嗪或（ - ） - 丁苯那嗪。或者，该方法可以适于提供富集一种四苯并嗪对映异构体，外消旋混合物或丁苯那嗪化合物的非对映体混合物的混合物。此外，本发明提供了新的合成中间体组合物，其可用于制备丁苯那嗪，丁苯那敏衍生物和丁苯那嗪类似物的任一种或两种对映异构体。

8. 发明申请

WO2008097908A2 METHODS OF DIAGNOSING AND PROGNOSING LUNG CANCER 审中-公开
标题翻译：诊断和预防肺癌的方法
公开(公告)号：WO2008097908A2
公开(公告)日：2008-08-14
申请号：PCT/US2008052920
申请日：2008-02-04
申请人： DANA FARBER CANCER INST INC , GEN HOSPITAL CORP , UNIV NORTH CAROLINA , WONG KWOK-KIN , JOHNSON BRUCE , JANNE PASI , JI HONGBIN , BARDEESY NABEEL , SHARPLESS NORMAN E
发明人： WONG KWOK-KIN , JOHNSON BRUCE , JANNE PASI , JI HONGBIN , BARDEESY NABEEL , SHARPLESS NORMAN E
IPC分类号： G01N33/50
CPC分类号： G01N33/57423 , G01N2333/9121
摘要： The present invention provides methods of detecting cancer using biomarkers.
摘要翻译：本发明提供使用生物标志物检测癌症的方法。

9. 发明申请

WO2006055759A3 LAMINAR FLOW WATER JET WITH ENERGETIC PULSE WAVE SEGMENTATION AND CONTROLLER 审中-公开
标题翻译：层流水喷射器与能量脉冲波分段和控制器
公开(公告)号：WO2006055759A3
公开(公告)日：2007-02-01
申请号：PCT/US2005041778
申请日：2005-11-17
申请人： JOHNSON BRUCE
发明人： JOHNSON BRUCE
IPC分类号： B05B17/08 , A01G27/00 , B05B1/14 , B05B17/04 , F21S8/00
CPC分类号： B05B12/06 , B05B1/34 , B05B17/08 , F21S8/00 , F21W2121/02 , F21Y2103/00 , F21Y2115/10
摘要： An apparatus for producing and controlling an energetic pulse wave in a laminar flow having an at least one water input and a housing with a water channel flowing therethrough. At least one jetting element for jetting a laminar flow tube from a laminar flow passing through the water channel. With at least one energetic pulse wave generating element generating an energetic pulse in a controlled fashion that travels into the laminar flow and selectively interrupts the laminarity therein.
摘要翻译：一种用于生产和控制具有至少一个水输入的层流中的能量脉冲波的装置和具有流过其中的水通道的壳体。至少一个喷射元件，用于从穿过水通道的层流喷射层流管。具有至少一个能量脉冲波产生元件，其以受控的方式产生能量脉冲，其以行进到层流中并选择性地中断其中的层流。

10. 发明申请

WO2006113834A2 NETWORK COMMERCIAL TRANSACTIONS 审中-公开
标题翻译：网络商业交易
公开(公告)号：WO2006113834A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014801
申请日：2006-04-19
申请人： MICROSOFT CORPORATION , JOHNSON, Bruce, E. , WEBSTER-LAM, Chung
发明人： JOHNSON, Bruce, E. , WEBSTER-LAM, Chung
IPC分类号： G06Q30/00
CPC分类号： G06F21/10 , G06F21/34 , G06F2221/2135 , G06F2221/2137 , G06Q20/02 , G06Q20/12 , G06Q20/32 , G06Q20/3223 , G06Q20/4014 , G06Q20/407 , G06Q30/00 , H04L63/08 , H04W12/06
摘要： Current embodiments provide for authorization and payment of an online commercial transaction between a purchaser and a merchant including verification of an identity of the purchaser and verification of an ability of the purchaser to pay for the transaction, where the identity provider and the payment provider are often different network entities. Other embodiments also provide for protocols, computing systems, and other mechanisms that allow for identity and payment authentication using a mobile module, which establishes single or multilevel security over an untrusted network (e.g., the Internet). Still other embodiments also provide for a three-way secure communication between a merchant, consumer, and payment provider such that sensitive account information is opaque to the merchant, yet the merchant is sufficiently confident of the consumer's ability to pay for requested purchases. In yet another embodiment, electronic billing information is used for authorization, auditing, payment federation, and other purposes.
摘要翻译：当前的实施例规定了购买者和商家之间的在线商业交易的授权和支付，包括验证购买者的身份以及验证购买者支付交易的能力，其中身份提供者和支付提供者经常是不同的网络实体。其他实施例还提供协议，计算系统和允许使用移动模块进行身份和支付认证的其他机制，该移动模块通过不可信网络（例如因特网）建立单一或多级安全性。其他实施例还提供商家，消费者和支付提供商之间的三向安全通信，使得敏感的帐户信息对于商家是不透明的，但是商家对消费者支付所请求的购买的能力充满信心。在另一个实施例中，电子账单信息用于授权，审计，支付联合等目的。

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