专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0136433A3 SYNTHETIC LIPID-A ANALOGS AND USES THEREOF 审中-公开
标题翻译：合成脂蛋白A类似物及其用途
公开(公告)号：WO0136433A3
公开(公告)日：2002-05-10
申请号：PCT/US0031281
申请日：2000-11-15
申请人： BIOMIRA INC , JIANG ZI HUA , BACH MIMI , YALAMATI DAMAYANTHI , KOGANTY RAO , LONGENECKER MICHAEL
发明人： JIANG ZI-HUA , BACH MIMI , YALAMATI DAMAYANTHI , KOGANTY RAO , LONGENECKER MICHAEL
IPC分类号： A61K9/127 , A61K39/00 , A61P35/00 , C07C69/734 , C07C237/06 , C07H1/02 , C07H13/06 , C07H15/04 , C07H15/203 , C07K14/47 , A61K39/39
CPC分类号： C07H13/06 , Y10S424/812
摘要： New synthetic Lipid-A analogs based on monosaccharide (1) and disaccharide (2) derivatives were designed and prepared in the present invention. Both structures (1) and (2) incorporate novel lipid structures (3) and (4) that are not found in nature. Also, novel disaccharide Lipid-A structures (2) that incorporate novel contingents of uniform lipids and where R1, R4 and R5 are the same substitution group of structure (III) were synthesized. Liposome formulations containing totally synthetic components such as synthetic Lipid-A and synthetic lipopeptide derived from tumor-associated MUC1 mucin are described along with their therapeutic utility. Comparative test results of immunostimulating properties and toxicity of Lipid-A analogs (1) and (2) are included.
摘要翻译：在本发明中设计并制备了基于单糖（1）和二糖（2）衍生物的新的合成脂质-A类似物。结构（1）和（2）都结合了自然界中没有发现的新型脂质结构（3）和（4）。此外，合成了新型二脂脂质体A结构（2），其结合新颖的均匀脂质偶联物，其中R1，R4和R5是相同的结构（III）取代基。含有完全合成成分的脂质体制剂，如合成脂质A和衍生自肿瘤相关MUC1粘蛋白的合成脂肽，以及其治疗用途。包括Lipid-A类似物（1）和（2）的免疫刺激性质和毒性的比较试验结果。

2. 发明申请

WO2003089574A2 SYNTHETIC GLYCO-LIPO-PEPTIDES AS VACCINES 审中-公开
标题翻译：合成GLYCO-LIPO-PEPTIDES作为疫苗
公开(公告)号：WO2003089574A2
公开(公告)日：2003-10-30
申请号：PCT/US2003/010750
申请日：2003-04-09
申请人： BIOMIRA, INC. , KOGANTY, R., Rao , JIANG, Zi-Hua , YALAMATI, Damayanthi , GANDHI, Sham , BUDZYNSKI, Wladyslaw , KRANTZ, Mark, J. , LONGENECKER, B., Michael
发明人： KOGANTY, R., Rao , JIANG, Zi-Hua , YALAMATI, Damayanthi , GANDHI, Sham , BUDZYNSKI, Wladyslaw , KRANTZ, Mark, J. , LONGENECKER, B., Michael
IPC分类号： C12N
CPC分类号： C07K14/7051 , A61K39/0011 , A61K47/646 , A61K2039/55555 , C07K5/06165 , C07K5/081 , C07K5/1024 , C07K7/06 , C07K7/08 , C07K9/00 , C07K9/001 , C07K14/005 , C07K14/195 , C07K14/4727 , C07K14/4748 , C12N2740/16122
摘要： A glycolipopeptide comprising at least one disease-associated epitope, and characterized by at least one lipidated interior amino acid or by the presence of a MUC1 epitope, may be used in a vaccine, preferably in conjunction with a liposome.
摘要翻译：包含至少一种与疾病相关的表位并且由至少一种脂化的内部氨基酸或通过MUC1表位的存在表征的糖脂肽可以用于疫苗中，优选与脂质体结合使用。

3. 发明申请

WO2004028475A3 GLYCOSYLCERAMIDE ANALOGUES 审中-公开
标题翻译：谷氨酰胺类似物
公开(公告)号：WO2004028475A3
公开(公告)日：2006-01-05
申请号：PCT/US0330611
申请日：2003-09-29
申请人： BIOMIRA INC , MCINNIS PATRICIA , JIANG ZI-HUA , GANDHI SHAM , KOGANTY RAO R
发明人： JIANG ZI-HUA , GANDHI SHAM , KOGANTY RAO R
IPC分类号： C07H15/00 , C07J17/00 , A61K31/70
CPC分类号： C07H15/24 , C07H15/00 , C07J17/00
摘要： Glycosylceramide analogues are disclosed in which the ceramide moiety and optionally the carbohydrate moiety are modified or replaced. These analogues are useful as immunomodulators, antitumor agents, and as other pharmaceutical agents.
摘要翻译：公开了糖基神经酰胺类似物，其中神经酰胺部分和任选的碳水化合物部分被修饰或替代。这些类似物可用作免疫调节剂，抗肿瘤剂和其他药剂。

4. 发明申请

WO2003066649A1 IMMUNOSTIMULATORY, COVALENTLY LIPIDATED OLIGONUCLEOTIDES 审中-公开
标题翻译：免疫抑制剂，共同脂肪酸寡核苷酸
公开(公告)号：WO2003066649A1
公开(公告)日：2003-08-14
申请号：PCT/CA2003/000135
申请日：2003-02-04
申请人： BIOMIRA INC. , JIANG, Zi-Hua , KOGANTY, Rao, R. , YALAMATI, Damayanthi , BAEK, Myung-Gi
发明人： JIANG, Zi-Hua , KOGANTY, Rao, R. , YALAMATI, Damayanthi , BAEK, Myung-Gi
IPC分类号： C07H21/00
CPC分类号： C07H21/00 , A61K39/0011 , A61K39/39 , A61K2039/55555 , A61K2039/55561
摘要： Covalently lipidated oligonucleotides comprising the CpG dinucleotide unit, or an analogue thereof, may be used as immunostimulatory agents to protect against a disease caused by a cancer cell or a pathogen, either alone or in conjunction with immunogens and/or non-immunological agents. Lipidated oligonucleotides with special backbones, lipidated oligonucleotides with fewer than eight nucleotides, and lipidated oligonucleotides comprising a plurality of CpG dinucleotide-containing segments connected by a long internucleoside linkage are of particular interest. These compounds are also novel per se .
摘要翻译：包含CpG二核苷酸单元或其类似物的共价脂化寡核苷酸可以单独使用或与免疫原和/或非免疫学试剂一起用作免疫刺激剂以防止由癌细胞或病原体引起的疾病。具有特殊骨架的脂质化寡核苷酸，具有少于8个核苷酸的脂化寡核苷酸和包含通过长核苷间键连接的多个含CpG二核苷酸的片段的脂化寡核苷酸是特别有意义的。这些化合物本身也是新颖的。

5. 发明申请

WO2004028475A2 GLYCOSYLCERAMIDE ANALOGUES 审中-公开
标题翻译：谷氨酰胺类似物
公开(公告)号：WO2004028475A2
公开(公告)日：2004-04-08
申请号：PCT/US2003/030611
申请日：2003-09-29
申请人： BIOMIRA, INC. , MCINNIS, Patricia , JIANG, Zi-Hua , GANDHI, Sham , KOGANTY, Rao, R.
发明人： JIANG, Zi-Hua , GANDHI, Sham , KOGANTY, Rao, R.
IPC分类号： A61K
CPC分类号： C07H15/24 , C07H15/00 , C07J17/00
摘要： Glycosylceramide analogues are disclosed in which the ceramide moiety and optionally the carbohydrate moiety are modified or replaced. These analogues are useful as immunomodulators, antitumor agents, and as other pharmaceutical agents.
摘要翻译：公开了糖基神经酰胺类似物，其中神经酰胺部分和任选的碳水化合物部分被修饰或替代。这些类似物可用作免疫调节剂，抗肿瘤剂和其他药剂。

6. 发明申请

WO2003094850A3 LIPID A AND OTHER CARBOHYDRATE LIGAND ANALOGS 审中-公开
公开(公告)号：WO2003094850A3
公开(公告)日：2003-11-20
申请号：PCT/US2003/014633
申请日：2003-05-09
申请人： BIOMIRA, INC. , MCINNIS, Patricia , JIANG, Zi-Hua , KOGANTY, R., Rao , BUDZYNSKI, Wladyslaw
发明人： JIANG, Zi-Hua , KOGANTY, R., Rao , BUDZYNSKI, Wladyslaw
IPC分类号： A61K31/70
摘要： The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and location of negatively charged groups, and the number, nature and location of the lipid chains. The lipid A analogs may be lipid A agonists useful as immunostimulatory agents, or lipid A antagonists useful in the treatment of septic shock. In a like manner, a residue of pentaerythritylamine may be used as a replacement for an amino sugar residue in a carbohydrate ligand having a biological activity of interest, generating a series of ligand analogs. These are useful, e.g., as haptens, inhibitors of bacterial-host cell adhesion, etc.

7. 发明申请

WO2003094850A2 LIPID A AND OTHER CARBOHYDRATE LIGAND ANALOGS 审中-公开
标题翻译：脂肪酸和其他碳水化合物配体模拟物
公开(公告)号：WO2003094850A2
公开(公告)日：2003-11-20
申请号：PCT/US2003/014633
申请日：2003-05-09
申请人： BIOMIRA, INC. , MCINNIS, Patricia , JIANG, Zi-Hua , KOGANTY, R., Rao , BUDZYNSKI, Wladyslaw
发明人： JIANG, Zi-Hua , KOGANTY, R., Rao , BUDZYNSKI, Wladyslaw
IPC分类号： A61K
CPC分类号： C07F9/091 , C07H13/06 , C07H15/04
摘要： The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and location of negatively charged groups, and the number, nature and location of the lipid chains. The lipid A analogs may be lipid A agonists useful as immunostimulatory agents, or lipid A antagonists useful in the treatment of septic shock. In a like manner, a residue of pentaerythritylamine may be used as a replacement for an amino sugar residue in a carbohydrate ligand having a biological activity of interest, generating a series of ligand analogs. These are useful, e.g., as haptens, inhibitors of bacterial-host cell adhesion, etc.
摘要翻译：季戊四醇的核心结构已被用作脂质A中的一种或两种糖的替代物，导致产生一系列脂质A类似物。这些脂质A类似物可以进一步不同于脂质A，例如，带负电基团的数目，性质和位置以及脂链的数量，性质和位置。脂质A类似物可以是可用作免疫刺激剂的脂质A激动剂或可用于治疗败血性休克的脂质A拮抗剂。以类似的方式，可以使用季戊四胺的残基作为具有目标生物活性的碳水化合物配体中的氨基糖残基的替代物，产生一系列配体类似物。这些是有用的，例如作为半抗原，细菌宿主细胞粘附抑制剂等

8. 发明申请

WO2003089574A3 SYNTHETIC GLYCO-LIPO-PEPTIDES AS VACCINES 审中-公开
公开(公告)号：WO2003089574A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/010750
申请日：2003-04-09
申请人： BIOMIRA, INC. , KOGANTY, R., Rao , JIANG, Zi-Hua , YALAMATI, Damayanthi , GANDHI, Sham , BUDZYNSKI, Wladyslaw , KRANTZ, Mark, J. , LONGENECKER, B., Michael
发明人： KOGANTY, R., Rao , JIANG, Zi-Hua , YALAMATI, Damayanthi , GANDHI, Sham , BUDZYNSKI, Wladyslaw , KRANTZ, Mark, J. , LONGENECKER, B., Michael
IPC分类号： A61K38/04
摘要： A glycolipopeptide comprising at least one disease-associated epitope, and characterized by at least one lipidated interior amino acid or by the presence of a MUC1 epitope, may be used in a vaccine, preferably in conjunction with a liposome.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式