专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1994020062A2 BALANOIDS 审中-公开
公开(公告)号：WO1994020062A2
公开(公告)日：1994-09-15
申请号：PCT/US1994002283
申请日：1994-03-02
申请人： NICHOLS, Gina, M. +lf , SPHINX PHARMACEUTICALS CORPORATION , HALL, Steven, Edward , BALLAS, Lawrence, M. , KULANTHAIVEL, Palaniappan , BOROS, Christie , JIANG, Jack, B. , JAGDMANN, Gunnar, Erik, Jr. , LAI, Yen-Shi , BIGGERS, Christopher, K. , HU, Hong , HALLOCK, Yali , HUGHES, Philip, F. , DEFAUW, Jean, Marie , LYNCH, Michael, Patrick , LAMPE, John, William, Crossley , MENALDINO, David, Steven , HEERDING, Julia, Marie , JANZEN, William, P. , HOLLINSHEAD, Sean, Patrick
发明人： NICHOLS, Gina, M. +lf , SPHINX PHARMACEUTICALS CORPORATION , NICHOLS, Jeffrey, Bailey +di
IPC分类号： A61K00/00
CPC分类号： C07D257/04 , C07C235/54 , C07C255/52 , C07C311/09 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/14 , C07D207/48 , C07D211/56 , C07D223/12 , C07D313/04 , C07D337/04 , C07D401/12 , C07D417/12 , C07F9/572
摘要： A novel class of therapeutic compounds, denominated Balanoids, is disclosed. Balanoids have protein kinase C inhibitory activity and selectivity among the isoforms of protein kinase C. Balanoids are useful for treatment of diseases related to protein kinase C in animals, especially humans and is especially indicated for treatment of inflammatory diseases.
摘要翻译：公开了一类新型的治疗化合物，称为平衡物。平衡蛋白在蛋白激酶C的同种型中具有蛋白激酶C抑制活性和选择性。平衡物可用于治疗动物，特别是人类中与蛋白激酶C相关的疾病，并且特别用于治疗炎性疾病。

2. 发明申请

WO1993020695A1 POLYHYDROXYLATED DIBENZ (C,E) AZEPINES AS PROTEIN KINASE C INHIBITORS 审中-公开
标题翻译：作为蛋白激酶C抑制剂的聚甲氧基二苯胺（C，E）
公开(公告)号：WO1993020695A1
公开(公告)日：1993-10-28
申请号：PCT/US1993000193
申请日：1993-01-11
申请人： SPHINX PHARMACEUTICALS CORPORATION , JIANG, Jack, B. , HUGHES, Philip, F.
发明人： SPHINX PHARMACEUTICALS CORPORATION
IPC分类号： A01N43/46
CPC分类号： C07D223/18
摘要： The invention provides compounds having formula (I) wherein: R1, R2, R3, R4, R5 and R6, independently, are H, halo, methoxy or hydroxyl, provided that at least one of R1, R2, R3, R4, R5 and R6 is hydroxyl, R7 and R8 are H or taken together form a carbonyl; R12 and R13 are H or taken together form a carbonyl; A is H or CR9R10R11; R9 and R10 are H or taken together form a carbonyl; R11 is H, C1 - C17 alkyl, C1 - C17 alkenyl, C1 - C17 alkynyl, or aryl; and, R14 and R15, independently are H, halo, methoxy or hydroxyl when at least 5 of R1 - R6 are hydroxyl, and H when less than 5 of R1 - R6 are hydroxyl. The compounds are useful for inhibiting protein kinase C, and treating conditions affected by protein kinase C activity, particularly cancer tumors, inflammatory disease, reperfusion injury and cardiac dysfunctions related to reperfusion injury.
摘要翻译：本发明提供具有式（I）的化合物，其中：R 1，R 2，R 3，R 4，R 5和R 6独立地是H，卤素，甲氧基或羟基，条件是R 1，R 2，R 3，R 4，R 5和 R6是羟基，R7和R8是H或一起形成羰基; R 12和R 13是H或一起形成羰基; A为H或CR9R10R11; R9和R10是H或一起形成羰基; R 11是H，C 1 -C 17烷基，C 1 -C 17烯基，C 1 -C 17炔基或芳基; 当R 1至R 5中的至少5个为羟基时，R 14和R 15独立地为H，卤素，甲氧基或羟基，当小于5的R 1 -R 6为羟基时，R 14和R 15独立地为H。这些化合物可用于抑制蛋白激酶C，以及治疗受蛋白激酶C活性，特别是癌症肿瘤，炎性疾病，再灌注损伤和与再灌注损伤相关的心脏功能障碍的影响。

3. 发明申请

WO2004026267A2 TRI(ALKYLCARBOXYLATO) GALLIUM (III) PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：三唑（ALKYLCARBOXYLATO）GALLIUM（III）产品和含有它们的药物组合物
公开(公告)号：WO2004026267A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/030792
申请日：2003-09-22
申请人： GENTA INC. , JIANG, Jack, B. , WARRELL, Raymond, P., Jr. , RAMASWAMY, Kollengoode, K. , KLEM, Robert, E.
发明人： JIANG, Jack, B. , WARRELL, Raymond, P., Jr. , RAMASWAMY, Kollengoode, K. , KLEM, Robert, E.
IPC分类号： A61K
CPC分类号： C07C51/412 , C07C53/126 , C07F5/003
摘要： Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
摘要翻译：提供了新颖的三（烷基羧基）镓（III）化合物，其例子是三异氰酸镓（III），其制备方法，含有它们的药物组合物和使用该药物组合物的方法。

4. 发明申请

WO0219967A3 SUBSTITUTED HYDRAZINE DERIVATIVES 审中-公开
标题翻译：取代的氢化衍生物
公开(公告)号：WO0219967A3
公开(公告)日：2002-06-13
申请号：PCT/US0128095
申请日：2001-09-07
申请人： GLIATECH INC , ALI SYED M , BRUNDEN KURT R , DOLLER DARIO , HERBERT BRIAN , JIANG JACK B , JORDAN AMY
发明人： ALI SYED M , BRUNDEN KURT R , DOLLER DARIO , HERBERT BRIAN , JIANG JACK B , JORDAN AMY
IPC分类号： A61K31/145 , A61K31/15 , A61K31/16 , A61K31/216 , A61K31/277 , A61K31/4152 , A61K31/4439 , A61P21/02 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07C243/22 , C07C243/28 , C07C243/34 , C07C243/38 , C07C255/24 , C07C255/66 , C07C259/06 , C07C327/42 , C07C327/44 , C07D231/08 , C07D401/04 , A61K31/135 , C07C251/00
CPC分类号： C07C243/38 , C07C243/22 , C07C243/28 , C07C243/34 , C07C255/24 , C07C255/66 , C07C259/06 , C07C327/44 , C07D231/08
摘要： A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.
摘要翻译：抑制高亲和力甘氨酸转运蛋白的方法，抑制这些转运蛋白的化合物; 包含这些化合物的药物活性组合物; 并且公开了如上所述的这样的化合物或用于控制或预防其中涉及甘氨酸的疾病状态的制剂中的用途。

5. 发明申请

WO1992007557A1 BIS-(HYDROXYALKYLAMINO)-ANTHRAQUINONE INHIBITORS OF PROTEIN KINASE C 审中-公开
标题翻译：蛋白激酶C（BIS-（羟基喹啉）） - 氨基丁酸酯抑制剂
公开(公告)号：WO1992007557A1
公开(公告)日：1992-05-14
申请号：PCT/US1991008026
申请日：1991-10-30
申请人： SPINX PHARMACEUTICALS CORPORATION , JIANG, Jack, B. , JOHNSON, Mary, George
发明人： SPINX PHARMACEUTICALS CORPORATION
IPC分类号： A61K31/045
CPC分类号： C07D303/36 , C07C225/34 , C07C225/36 , C07C229/74 , C07C271/12 , C07C335/32 , C07C2603/24
摘要： The present invention provides novel substituted anthraquinones having formula ( alpha ), wherein R1 and R2 are independently H, C1-C10 alkyl, aryl, arylalkyl, alkylaryl, or R1 and R2 taken together with the adjacent nitrogen atom N form a substituted or unsubstituted cyclic ring which may contain additional heteroatoms; n and m are independently 1, 2, or 3; A is halogen, OH, alkoxy, OCO(NR3R4), S-C(NH2)=NR5, or when m = 1, comprises an oxirane ring with the adjacent oxygen atom; R3, R4, and R5 are independently H, alkyl, or aryl; X is H, OH, NR6R7, Cl, Br, I, F, alkyl, aryl, alkoxy, aryloxy, COOR8, or CONR9R10; and R6, R7, R8, R9, and R10 are independently H, lower alkyl, or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.
摘要翻译：本发明提供具有式（α）的新的取代的蒽醌，其中R 1和R 2独立地为H，C 1 -C 10烷基，芳基，芳基烷基，烷基芳基或R 1和R 2与相邻的氮原子N一起形成取代或未取代的环状可能含有其他杂原子的环; n和m独立地为1,2或3; A是卤素，OH，烷氧基，OCO（NR 3 R 4），S-C（NH 2）= NR 5，或当m = 1时，包含具有相邻氧原子的环氧乙烷环; R3，R4和R5独立地是H，烷基或芳基; X是H，OH，NR 6 R 7，Cl，Br，I，F，烷基，芳基，烷氧基，芳氧基，COOR 8或CONR 9 R 10; R 6，R 7，R 8，R 9和R 10独立地为可用于抑制蛋白激酶C的H，低级烷基或芳基，并且与抑制蛋白激酶C，特别是癌症肿瘤，炎性疾病，再灌注损伤有关或受其影响，以及与再灌注损伤相关的心脏功能障碍。

6. 发明申请

WO2004026267A3 TRI(ALKYLCARBOXYLATO) GALLIUM (III) PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译： TRI（烷基乙氧基）镓（III）产品和含有它们的药物组合物
公开(公告)号：WO2004026267A3
公开(公告)日：2004-06-10
申请号：PCT/US0330792
申请日：2003-09-22
申请人： GENTA INC , JIANG JACK B , WARRELL RAYMOND P JR , RAMASWAMY KOLLENGOODE K , KLEM ROBERT E
发明人： JIANG JACK B , WARRELL RAYMOND P JR , RAMASWAMY KOLLENGOODE K , KLEM ROBERT E
IPC分类号： A61K31/28 , C07C51/41 , C07C53/126 , C07F5/00 , C30B7/10
CPC分类号： C07C51/412 , C07C53/126 , C07F5/003
摘要： Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
摘要翻译：提供了新的三（烷基羧基）镓（III）化合物，例如三棕榈酸镓（III），其制备方法，含有它们的药物组合物，以及使用该药物组合物的方法。

7. 发明申请

WO1997026873A1 ANTIMICROBIAL AURONE DERIVATIVES 审中-公开
标题翻译：抗微生物AURONE DERIVATIVES
公开(公告)号：WO1997026873A1
公开(公告)日：1997-07-31
申请号：PCT/US1997001195
申请日：1997-01-27
申请人： PHYTERA, INC. , MCALPINE, James, B. , CHU, Wai-Lam, Alex , RATNAYAKE, Sunil , JIANG, Jack, B. , STAFFORD, Angela, M. , JACKSON, Catherine
发明人： PHYTERA, INC.
IPC分类号： A61K31/34
CPC分类号： C07D307/83 , A61K31/343
摘要： Aurone derivatives which are useful as antimicrobial agents.
摘要翻译：可用作抗微生物剂的Aurone衍生物。

8. 发明申请

WO9420062A3 BALANOIDS 审中-公开
公开(公告)号：WO9420062A3
公开(公告)日：1996-08-15
申请号：PCT/US9402283
申请日：1994-03-02
申请人： NICHOLS GINA M & LF , SPHINX PHARMA CORP , HALL STEVEN EDWARD , BALLAS LAWRENCE M , KULANTHAIVEL PALANIAPPAN , BOROS CHRISTIE , JIANG JACK B , JAGDMANN GUNNAR ERIK JR , LAI YEN SHI , BIGGERS CHRISTOPHER K , HU HONG , HALLOCK YALI , HUGHES PHILIP F , DEFAUW JEAN MARIE , LYNCH MICHAEL PATRICK , LAMPE JOHN WILLIAM CROSSLEY , MENALDINO DAVID STEVEN , HEERDING JULIA MARIE , JANZEN WILLIAM P , HOLLINSHEAD SEAN PATRICK
发明人： HALL STEVEN EDWARD , BALLAS LAWRENCE M , KULANTHAIVEL PALANIAPPAN , BOROS CHRISTIE , JIANG JACK B , JAGDMANN GUNNAR ERIK JR , LAI YEN-SHI , BIGGERS CHRISTOPHER K , HU HONG , HALLOCK YALI , HUGHES PHILIP F , DEFAUW JEAN MARIE , LYNCH MICHAEL PATRICK , LAMPE JOHN WILLIAM CROSSLEY , MENALDINO DAVID STEVEN , HEERDING JULIA MARIE , JANZEN WILLIAM P , HOLLINSHEAD SEAN PATRICK , NICHOLS JEFFREY BAILEY
IPC分类号： C07D333/36 , A61K31/165 , A61K31/24 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K31/50 , A61K31/55 , A61P9/00 , A61P25/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07C69/734 , C07C233/23 , C07C233/41 , C07C235/48 , C07C235/54 , C07C235/84 , C07C255/52 , C07C311/09 , C07C325/00 , C07D207/14 , C07D207/48 , C07D211/56 , C07D223/12 , C07D257/04 , C07D307/22 , C07D313/04 , C07D337/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07F9/572 , A61K
CPC分类号： C07D257/04 , C07C235/54 , C07C255/52 , C07C311/09 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D207/14 , C07D207/48 , C07D211/56 , C07D223/12 , C07D313/04 , C07D337/04 , C07D401/12 , C07D417/12 , C07F9/5721
摘要： A novel class of therapeutic compounds, denominated Balanoids, is disclosed. Balanoids have protein kinase C inhibitory activity and selectivity among the isoforms of protein kinase C. Balanoids are useful for treatment of diseases related to protein kinase C in animals, especially humans and is especially indicated for treatment of inflammatory diseases.
摘要翻译：公开了一类新型的治疗化合物，称为平衡物。平衡蛋白在蛋白激酶C的同种型中具有蛋白激酶C抑制活性和选择性。平衡物可用于治疗动物，特别是人类中与蛋白激酶C相关的疾病，并且特别用于治疗炎性疾病。

9. 发明申请

WO1992007558A1 1,4-BIS-(AMINO-HYDROXYALKYLAMINO)-ANTHRAQUINONES FOR INHIBITING PROTEIN KINASE C 审中-公开
标题翻译：用于抑制蛋白激酶C的1,4-BIS-（氨基 - 羟基甲酰氨基） - 亚硝基
公开(公告)号：WO1992007558A1
公开(公告)日：1992-05-14
申请号：PCT/US1991008030
申请日：1991-10-30
申请人： SPINX PHARMACEUTICALS CORPORATION , JIANG, Jack, B. , JOHNSON, Mary, George
发明人： SPINX PHARMACEUTICALS CORPORATION
IPC分类号： A61K31/045
CPC分类号： C07C225/36 , C07C225/34
摘要： The present invention provides novel substituted anthraquinones having formula (I), wherein R1 and R2 are independently H, alkyl, aryl, or arylalkyl; m and n are independently 1, 2, or 3; X is H, OH, NR3R4, Cl, Br, I, F, alkyl, aryl alkoxy, aroxy, COOR5, or CONR6R7; R3, R4, R5, R6, and R7 are independently H, lower alkyl or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式