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1. 发明申请

WO2009027063A2 MUTANT DOUBLE CYCLIZED RECEPTOR PEPTIDES INHIBITING ß1-ADRENOCEPTOR ANTIBODIES 审中-公开
标题翻译：突变型双循环受体肽抑制ß1-亚单位抗体
公开(公告)号：WO2009027063A2
公开(公告)日：2009-03-05
申请号：PCT/EP2008006932
申请日：2008-08-22
申请人： UNIV WUERZBURG J MAXIMILIANS , JAHNS ROLAND , JAHNS VALERIE , LOHSE MARTIN , NIKOLAEV VIACHESLAV
发明人： JAHNS ROLAND , JAHNS VALERIE , LOHSE MARTIN , NIKOLAEV VIACHESLAV
IPC分类号： C07K7/64 , A61K38/12 , A61K38/16 , C07K14/705
CPC分类号： C07K7/64 , A61K38/00 , G01N33/6854
摘要： The present invention relates to novel ß-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage, to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding these cyclopeptide-mutants and linear peptides. Moreover, vectors and recombinant host cells comprising said nucleic acid molecule and a method for producing the disclosed cyclopeptide-mutants are provided. Further provided is a composition comprising the peptides, nucleic acid molecules, vectors or host cells of the invention. The present invention also relates to therapeutic and diagnostic means, methods and uses taking advantage of the peptides of the invention and to means, methods and uses for detecting anti-ß-adrenergic receptor antibodies like anti-ßradrenergic receptor antibodies.
摘要翻译：本发明涉及包含仅能形成分子内连锁的两个半胱氨酸残基的新型β-AR同源环肽突变体，可形成这些环肽突变体的线性肽和编码这些环肽突变体和线性肽的核酸分子。此外，提供了包含所述核酸分子的载体和重组宿主细胞以及用于制备所公开的环肽突变体的方法。还提供了包含本发明的肽，核酸分子，载体或宿主细胞的组合物。本发明还涉及利用本发明的肽的治疗和诊断手段，方法和用途以及用于检测抗β肾上腺素能受体抗体（如抗 - 肾上腺素能受体抗体）的手段，方法和用途。

2. 发明申请

WO2012168344A8 BINDING COMPOUNDS TO HUMAN beta1-ADRENORECEPTOR (beta1-AR) AND THEIR USE IN THE MEASUREMENT OF AUTO-ANTI-betaA1-AR ANTIBODIES 审中-公开
标题翻译：人β1受体（β1-AR）的结合化合物及其在自身抗体-βA1-AR抗体测量中的应用
公开(公告)号：WO2012168344A8
公开(公告)日：2013-03-14
申请号：PCT/EP2012060776
申请日：2012-06-06
申请人： CORIMMUN GMBH , HOLTHOFF HANS-PETER , UNGERER MARTIN , ZEIBIG STEFAN , LOHSE MARTIN J , JAHNS ROLAND , JAHNS VALERIE
发明人： HOLTHOFF HANS-PETER , UNGERER MARTIN , ZEIBIG STEFAN , LOHSE MARTIN J , JAHNS ROLAND , JAHNS VALERIE
IPC分类号： C07K16/28 , G01N33/564
CPC分类号： G01N33/74 , C07K16/286 , C07K16/2869 , C07K2317/34 , C07K2317/92 , G01N33/6893 , G01N33/9433 , G01N2800/325
摘要： The present disclosure relates to binding compounds/antibodies that bind to the second extracellular loop of the human beta1-adrenoreceptor (beta1-AR-ECII) that are produced by/obtainable from a host cell/hybridoma with a deposit number selected from the group consisting of DSM ACC3121, DSM ACC3174, DSM ACC3175, DSM ACC3176 and DSM ACC3177. The binding compounds/antibodies are particularly useful in determination of auto-anti-beta1-AR antibodies in an in vitro cell based assay system in order to characterize and to identify auto-antibodies directed against the beta1-AR-ECII in a biological sample. Further aspects of the disclosure are nucleic acid molecules encoding said binding compounds/antibodies, vectors, host cells, methods for producing the binding compounds/antibodies of the disclosure as well as a kit comprising the binding compounds/antibodies of the present disclosure.
摘要翻译：本公开内容涉及结合化合物/抗体，其结合人β1肾上腺素受体（β1-AR-ECII）的第二胞外环，其由具有选自以下的保藏号的宿主细胞/杂交瘤产生/得自 DSM ACC3121，DSM ACC3174，DSM ACC3175，DSM ACC3176和DSM ACC3177。结合化合物/抗体特别可用于在基于体外细胞的测定系统中测定自身抗β1-AR抗体，以便表征和鉴定针对生物样品中的β1-AR-ECII的自身抗体。本公开的另外方面是编码所述结合化合物/抗体，载体，宿主细胞的核酸分子，用于产生本公开的结合化合物/抗体的方法以及包含本公开内容的结合化合物/抗体的试剂盒。

3. 发明申请

WO2006103101A2 MEANS FOR THE INHIBITION OF ANTI-ß1-ADRENERGIC RECEPTOR ANTIBODIES 审中-公开
标题翻译：抑制抗Aβ抗体受体抗体的方法
公开(公告)号：WO2006103101A2
公开(公告)日：2006-10-05
申请号：PCT/EP2006002977
申请日：2006-03-31
申请人： UNIV WUERZBURG J MAXIMILIANS , JAHNS ROLAND , JAHNS VALERIE , LOHSE MARTIN J , PALM DIETER
发明人： JAHNS ROLAND , JAHNS VALERIE , LOHSE MARTIN J , PALM DIETER
CPC分类号： C07K14/70571 , C07K7/64
摘要： The present invention is related to a peptide selected from the group comprising a) a cyclic peptide of formula (I): Cyclo(AIa-x-x-x-x-x-x-x-x-x-Cys-x-x-x-Pro-x-Cys-Cys-xk-GIn), (I) whereby k is any integer from 0 to 6, preferably any integer from 1 to 6, more preferably k = 6; b) a cyclic peptide of formula (II): Cyclo(Ala-x-x-Trp-x-x-Gly-x-Phe-x-Cys-xh-Gln), (II) whereby h is any integer from 0 to 2, preferably 1 or 2; c) a cyclic peptide of formula (III): Cyclo(AIa-x-x-x-x-x-x-x-x-x-Cys-xj-Cys-x-x-x-Pro-x-Cys-Cys-xi-Gln); (HI) whereby j is any integer from 0 to 4, preferably j = 4; whereby i is any integer from 0 to 6, preferably any integer from 1 to 6, more preferably i - 6; and d) a peptide of formula (IV) : Ala-xl-Cys-xm-Cys-x-x-x-Pro-x-Cys-Cys-xn-Gln, (IV) whereby 1 is any integer from 0 to 9, preferably any integer from 1 to 9, more preferably n = 9; whereby m is any integer from 0 to 4, preferably any integer from 1 to 4, more preferably m = 4; whereby n is any integer from O to 6, preferably any integer from 1 to 6, more preferably n = 6; whereby x is any amino acid, preferably any naturally occurring amino acid, more preferably any naturally occurring L-amino acid.
摘要翻译：本发明涉及一种选自以下的肽：a）式（I）的环状肽：Cyclo（Ala-xxxxxxxxx-Cys-xxx-Pro-x-Cys-Cys-xk-Gln），（I）其中k是0至6的任何整数，优选1至6的任何整数，更优选k = 6; b）式（II）的环状肽：环（Ala-xx-Trp-xx-Gly-x-Phe-x-Cys-xh-Gln），（II），其中h是0至2的任何整数， 1或2; c）式（III）的环肽：环（Ala-x-x-x-x-x-x-x-x-x-x-Pro-x-Cys-Cys-xi-Gln）（HI），其中j是0至4的任何整数，优选j = 4; 其中i是0至6的整数，优选1至6的任何整数，更优选i-6; 和d）式（IV）的肽：Ala-xl-Cys-xm-Cys-xxx-Pro-x-Cys-Cys-xn-Gln，（IV）其中1是0至9的任何整数， 1〜9的整数，更优选n = 9; 其中m是0至4的整数，优选1至4的任何整数，更优选m = 4; 其中n是0至6的整数，优选1至6的任何整数，更优选n = 6; 其中x是任何氨基酸，优选任何天然存在的氨基酸，更优选任何天然存在的L-氨基酸。

4. 发明申请

WO2012168344A1 BINDING COMPOUNDS TO HUMAN β1-ADRENORECEPTOR (β1-AR) AND THEIR USE IN THE MEASUREMENT OF AUTO-ANTI-βA1-AR ANTIBODIES 审中-公开
标题翻译：人ß1-ADRENORECEPTOR（ß1-AR）的结合化合物及其在自身抗体抗原抗体测量中的应用
公开(公告)号：WO2012168344A1
公开(公告)日：2012-12-13
申请号：PCT/EP2012/060776
申请日：2012-06-06
申请人： CORIMMUN GMBH , HOLTHOFF, Hans-Peter , UNGERER, Martin , ZEIBIG, Stefan , LOHSE, Martin J. , JAHNS, Roland , JAHNS, Valerie
发明人： HOLTHOFF, Hans-Peter , UNGERER, Martin , ZEIBIG, Stefan , LOHSE, Martin J. , JAHNS, Roland , JAHNS, Valerie
IPC分类号： C07K16/28 , G01N33/564
CPC分类号： G01N33/74 , C07K16/286 , C07K16/2869 , C07K2317/34 , C07K2317/92 , G01N33/6893 , G01N33/9433 , G01N2800/325
摘要： The present disclosure relates to binding compounds/antibodies that bind to the second extracellular loop of the human β1-adrenoreceptor (β1-AR-ECII) that are produced by/obtainable from a host cell/hybridoma with a deposit number selected from the group consisting of DSM ACC3121, DSM ACC3174, DSM ACC3175, DSM ACC3176 and DSM ACC3177. The binding compounds/antibodies are particularly useful in determination of auto-anti-β1-AR antibodies in an in vitro cell based assay system in order to characterize and to identify auto-antibodies directed against the β1-AR-ECII in a biological sample. Further aspects of the disclosure are nucleic acid molecules encoding said binding compounds/antibodies, vectors, host cells, methods for producing the binding compounds/antibodies of the disclosure as well as a kit comprising the binding compounds/antibodies of the present disclosure.
摘要翻译：本公开涉及结合化合物/抗体，所述化合物/抗体结合人β1肾上腺素受体（β1-AR-ECII）的第二胞外环，其由具有选自以下的保藏号的宿主细胞/杂交瘤产生/得自 DSM ACC3121，DSM ACC3174，DSM ACC3175，DSM ACC3176和DSM ACC3177。结合化合物/抗体特别可用于在基于体外细胞的测定系统中测定自身抗-β1-AR抗体，以便表征和鉴定针对生物样品中的β1-AR-ECII的自身抗体。本公开的另外方面是编码所述结合化合物/抗体，载体，宿主细胞的核酸分子，用于产生本公开的结合化合物/抗体的方法以及包含本公开内容的结合化合物/抗体的试剂盒。

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