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1. 发明申请

WO2010144845A3 MINIMAL SURFACE AREA CONTACT DEVICE FOR HOLDING PLAQUE TO BLOOD VESSEL WALL 审中-公开
标题翻译：最小面积联系设备，用于保存淋巴细胞壁
公开(公告)号：WO2010144845A3
公开(公告)日：2011-04-28
申请号：PCT/US2010038379
申请日：2010-06-11
申请人： INNOVASC LLC
发明人： SCHNEIDER PETER , GIASOLLI ROBERT
IPC分类号： A61F2/82 , A61F2/86 , A61F2/92 , A61L27/54 , A61M29/04
CPC分类号： A61F2/848 , A61F2/844 , A61F2/86 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2/95 , A61F2/958 , A61F2002/823 , A61F2002/825 , A61F2002/826 , A61F2002/8483 , A61F2002/8486 , A61F2002/91508 , A61F2002/91575 , A61F2002/91583 , A61F2002/9665 , A61F2220/0016 , A61F2220/0066 , A61L31/16
摘要： A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of focal elevating elements on its outer annular periphery for holding loose plaque under a spring or other expansion force against a blood vessel wall. The focal elevating elements are designed to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the intraluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.
摘要翻译：形成用于在治疗动脉粥样硬化闭塞性疾病中保持斑块抵抗血管壁的粘合装置，作为耐用的柔性材料的薄的环形带，在其外环形周边上具有多个焦点升高元件，用于在弹簧或其他膨胀下保持松弛的斑块对血管壁的力量。焦点提升元件被设计成在斑块位置上施加保持力，同时使与斑块或血管壁接触的材料表面积的量最小化并降低与腔内表面摩擦的可能性。这种方法为临床医生提供了进行微创后血管成形术治疗的能力，并且在不使用支架的情况下产生支架样结果。

2. 发明申请

WO2012006602A3 DEPLOYMENT DEVICE FOR PLACEMENT OF MULTIPLE INTRALUMINAL SURGICAL STAPLES 审中-公开
标题翻译：用于放置多个内窥镜外科手术器械的部署装置
公开(公告)号：WO2012006602A3
公开(公告)日：2012-04-05
申请号：PCT/US2011043471
申请日：2011-07-08
申请人： INNOVASC LLC , GIASOLLI ROBERT , SCHNEIDER PETER
发明人： GIASOLLI ROBERT , SCHNEIDER PETER
IPC分类号： A61B17/068 , A61B17/34 , A61F2/82 , A61F2/848 , A61F2/95 , A61F2/966 , A61M29/02
CPC分类号： A61B17/068 , A61B17/064 , A61B2017/0641 , A61B2017/0645 , A61F2/966 , A61F2002/826 , A61F2002/8483 , A61F2002/9505 , A61F2002/9665
摘要： A system for delivering a surgical staple can include various components. The system may include an elongate body with a proximal end, a distal end, and a plurality of delivery platforms disposed adjacent the distal end. A sheath can move relative to the elongate body from a first position in which the distal end of the sheath is disposed distally of a distal-most distal delivery platform to a second position in which the distal end of the sheath is disposed proximally of at least one delivery platform. A plurality of intravascular tacks can be within the system with each disposed about a corresponding delivery platform.
摘要翻译：用于输送外科缝合钉的系统可以包括各种部件。该系统可以包括具有近端，远端和与远端相邻设置的多个传送平台的细长主体。护套可以相对于细长体从第一位置移动到第二位置，在第一位置中，护套的远端设置在最远端的远侧递送平台的远侧，在第二位置，护套的远侧端部设置在至少近侧一个交付平台。多个血管内钉可位于系统内，每个都布置在相应的输送平台周围。

3. 发明申请

WO2012006602A9 DEPLOYMENT DEVICE FOR PLACEMENT OF MULTIPLE INTRALUMINAL SURGICAL STAPLES 审中-公开
公开(公告)号：WO2012006602A9
公开(公告)日：2012-01-12
申请号：PCT/US2011/043471
申请日：2011-07-08
申请人： INNOVASC LLC , GIASOLLI, Robert , SCHNEIDER, Peter
发明人： GIASOLLI, Robert , SCHNEIDER, Peter
IPC分类号： A61F2/84 , A61F2/82 , A61B17/34 , A61M29/02 , A61B17/068
摘要： A system for delivering a surgical staple can include various components. The system may include an elongate body with a proximal end, a distal end, and a plurality of delivery platforms disposed adjacent the distal end. A sheath can move relative to the elongate body from a first position in which the distal end of the sheath is disposed distally of a distal-most distal delivery platform to a second position in which the distal end of the sheath is disposed proximally of at least one delivery platform. A plurality of intravascular tacks can be within the system with each disposed about a corresponding delivery platform.

4. 发明申请

WO2011153110A2 STENT DEVICE HAVING FOCAL ELEVATING ELEMENTS FOR MINIMAL SURFACE AREA CONTACT WITH LUMEN WALLS 审中-公开
标题翻译：具有最小表面积的焦点元素的连接装置与LUMEN WALLS接触
公开(公告)号：WO2011153110A2
公开(公告)日：2011-12-08
申请号：PCT/US2011/038468
申请日：2011-05-28
申请人： INNOVASC LLC
发明人： SCHNEIDER, Peter , GIASOLLI, Robert
IPC分类号： A61F2/82 , A61F2/04 , B23K26/00
CPC分类号： A61F2/91 , A61F2/848 , A61F2220/0016 , A61F2230/0017 , A61F2230/0054
摘要： An improved stent device has a body structure in tubular form sized to an organ lumen in which it is to be used and made of a wire mesh or cage structure of interwoven or interdigitated strut sections, and a plurality of focal elevating elements of relatively small point-like size or vector-like edge in an array over outer surfaces of the wire mesh or strut sections of the stent body structure. The focal elevating elements elevate the wire mesh or strut sections away from and minimize surface area contact with the organ lumen walls. They also reduce contact pressure in regions neighboring the focal elevating elements in order to minimize trauma due to contact or movement against the organ lumen walls. A preferred use for the stent device is in a blood vessel lumen, particularly to retain plaque dissection after balloon angioplasty.
摘要翻译：改进的支架装置具有管状形状的体结构，其尺寸适于器官腔，其中其将被使用并由具有交织或交叉指状支柱部分的丝网或笼结构构成，并且具有相对小点的多个焦点升高元件在支架主体结构的丝网或支柱部分的外表面上的阵列中的类似尺寸或矢状样边缘。焦点升高元件将丝网或支柱部分提升远离并使与器官管腔壁的表面区域接触最小化。它们还降低与焦点升高元件相邻的区域中的接触压力，以便最小化由于与器官腔壁的接触或运动引起的创伤。用于支架装置的优选用途是在血管内腔中，特别是在球囊血管成形术后保留斑块解剖。

5. 发明申请

WO2011035132A3 PRE-ANGIOPLASTY SERRATION OF ATHEROSCLEROTIC PLAQUE ENABLING LOW-PRESSURE BALLOON ANGIOPLASTY & AVOIDANCE OF STENTING 审中-公开
公开(公告)号：WO2011035132A3
公开(公告)日：2011-03-24
申请号：PCT/US2010/049297
申请日：2010-09-17
申请人： INNOVASC LLC
发明人： SCHNEIDER, Peter , GIASOLLI, Robert
IPC分类号： A61M29/02 , A61M25/06 , A61M37/00
摘要： A device and method for intravascular treatment of atherosclerotic plaque prior to balloon angioplasty which microperforates the plaque with small sharp spikes acting as serrations for forming cleavage lines or planes in the plaque. The spikes may also be used to transport medication into the plaque. The plaque preparation treatment enables subsequent angioplasty to be performed at low balloon pressures of about 4 atmospheres or less, reduces dissections, and avoids injury to the arterial wall. The subsequent angioplasty may be performed with a drug-eluting balloon (DEB) or drug-coated balloon (DCB). The pre-angioplasty perforation procedure enables more drug to be absorbed during DEB or DCB angioplasty, and makes the need for a stent less likely. Alternatively, any local incidence of plaque dissection after balloon angioplasty may be treated by applying a thin, ring-shaped tack at the dissection site only, rather than applying a stent over the plaque site.

6. 发明申请

WO2010144845A2 MINIMAL SURFACE AREA CONTACT DEVICE FOR HOLDING PLAQUE TO BLOOD VESSEL WALL 审中-公开
标题翻译：最小面积接触装置，用于保存血液池
公开(公告)号：WO2010144845A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/038379
申请日：2010-06-11
申请人： INNOVASC LLC
发明人： SCHNEIDER, Peter , GIASOLLI, Robert
IPC分类号： A61F2/04 , A61L27/54 , A61M29/04 , A61F2/06
CPC分类号： A61F2/848 , A61F2/844 , A61F2/86 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2/95 , A61F2/958 , A61F2002/823 , A61F2002/825 , A61F2002/826 , A61F2002/8483 , A61F2002/8486 , A61F2002/91508 , A61F2002/91575 , A61F2002/91583 , A61F2002/9665 , A61F2220/0016 , A61F2220/0066 , A61F2230/0054 , A61F2250/0067 , A61L31/16
摘要： A tack device for holding plaque against blood vessel walls in treating atherosclerotic occlusive disease is formed as a thin, annular band of durable, flexible material having a plurality of focal elevating elements on its outer annular periphery for holding loose plaque under a spring or other expansion force against a blood vessel wall. The focal elevating elements are designed to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the intraluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.
摘要翻译：形成用于在治疗动脉粥样硬化闭塞性疾病中保持斑块抵抗血管壁的粘合装置，作为耐用的柔性材料的薄的环形带，在其外环形周边上具有多个焦点升高元件，用于在弹簧或其它膨胀下保持松弛的斑块对血管壁的力量。焦点提升元件被设计成在斑块位置上施加保持力，同时使与斑块或血管壁接触的材料表面积的量最小化并降低与腔内表面摩擦的可能性。这种方法为临床医生提供了进行微创后血管成形术治疗的能力，并且在不使用支架的情况下产生支架样结果。

7. 发明申请

WO2009076517A2 DEVICE AND METHOD FOR TACKING PLAQUE TO BLOOD VESSEL WALL 审中-公开
标题翻译：装置和方法用于将斑块装入血管壁
公开(公告)号：WO2009076517A2
公开(公告)日：2009-06-18
申请号：PCT/US2008086396
申请日：2008-12-11
申请人： INNOVASC LLC , SCHNEIDER PETER A , GIASOLLI ROBERT
发明人： SCHNEIDER PETER A , GIASOLLI ROBERT
IPC分类号： A61B17/22 , A61F2/82 , A61F2/86 , A61F2/92
CPC分类号： A61F2/848 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/91 , A61F2/92 , A61F2/95 , A61F2002/823 , A61F2002/825 , A61F2002/8483 , A61F2220/0016 , A61F2230/0069 , A61F2230/0091
摘要： A plaque tack device for treating atherosclerotic occlusive disease is formed as a thin, annular band (30, 80, 90, 100, 110) of durable, flexible material having a plurality of barbs or anchoring points (33, 34) on its outer periphery for preventing it from being dislodged. The plaque tack may be used with a balloon angioplasty procedure or as a de novo treatment for blood vessel blockage to reopen the vessel lumen for desired blood flow. It has a width that is small relative to its diameter, to minimize the amount of foreign structure placed in the blood vessel. One or more tacks may be applied in positions along a plaque accumulation site as needed to stabilize the site and/or hold pieces of plaque out of the way of blood flow. The barbs of the tack may be pressed into the plaque and/or blood vessel walls by balloon expansion. Related methods of deployment and delivery devices are provided for insertion of the plaque tack in a compressed state into the blood vessel and expanding it back to its annular shape for holding plaque against the blood vessel walls.
摘要翻译：用于治疗动脉粥样硬化闭塞疾病的斑块钉装置形成为在其外周边上具有多个倒钩或锚定点（33,34）的耐用柔性材料的薄环形带（30,80,90,100,110）防止它被驱逐。斑块钉可以与球囊血管成形术程序一起使用或者作为血管阻塞的重新治疗以重新打开血管腔以获得期望的血流。它的宽度相对于其直径较小，以尽量减少放置在血管中的异物结构的数量。根据需要，沿着斑块积聚部位的位置可以施加一个或多个钉以稳定部位和/或将斑块保持在血流的方式之外。钉的倒钩可通过球囊扩张被压入斑块和/或血管壁。提供展开和递送装置的相关方法，用于将斑块钉以压缩状态插入血管并将其扩张回其环形形状，以将斑块保持在血管壁上。

8. 发明申请

WO2012006602A2 DEPLOYMENT DEVICE FOR PLACEMENT OF MULTIPLE INTRALUMINAL SURGICAL STAPLES 审中-公开
标题翻译：用于放置多发性内膜外手术带的部署装置
公开(公告)号：WO2012006602A2
公开(公告)日：2012-01-12
申请号：PCT/US2011043471
申请日：2011-07-08
申请人： INNOVASC LLC , GIASOLLI ROBERT , SCHNEIDER PETER
发明人： GIASOLLI ROBERT , SCHNEIDER PETER
IPC分类号： A61B17/068 , A61B17/34 , A61F2/82 , A61F2/848 , A61F2/95 , A61F2/966 , A61M29/02
CPC分类号： A61B17/068 , A61B17/064 , A61B2017/0641 , A61B2017/0645 , A61F2/966 , A61F2002/826 , A61F2002/8483 , A61F2002/9505 , A61F2002/9665
摘要： A system for delivering a surgical staple can include various components. The system may include an elongate body with a proximal end, a distal end, and a plurality of delivery platforms disposed adjacent the distal end. A sheath can move relative to the elongate body from a first position in which the distal end of the sheath is disposed distally of a distal-most distal delivery platform to a second position in which the distal end of the sheath is disposed proximally of at least one delivery platform. A plurality of intravascular tacks can be within the system with each disposed about a corresponding delivery platform.
摘要翻译：用于递送外科缝合钉的系统可以包括各种部件。该系统可以包括具有近端，远端以及邻近远端设置的多个输送平台的细长主体。护套可以从第一位置相对于细长主体移动，在第一位置，护套的远端设置在远端远端传送平台的远侧，至第二位置，其中护套的远端至少设置在近侧一个交付平台。多个血管内钉可以在系统内，每个血管内钉均设置在相应的输送平台周围。

9. 发明申请

WO2011035132A2 PRE-ANGIOPLASTY SERRATION OF ATHEROSCLEROTIC PLAQUE ENABLING LOW-PRESSURE BALLOON ANGIOPLASTY & AVOIDANCE OF STENTING 审中-公开
标题翻译：动脉粥样硬化早期血管成形术治疗低位球囊血管成形术并发症的临床观察
公开(公告)号：WO2011035132A2
公开(公告)日：2011-03-24
申请号：PCT/US2010049297
申请日：2010-09-17
申请人： INNOVASC LLC
发明人： SCHNEIDER PETER , GIASOLLI ROBERT
IPC分类号： A61M29/02 , A61M25/06 , A61M37/00
CPC分类号： A61M25/104 , A61B17/205 , A61B17/320725 , A61B2017/00004 , A61B2017/22061 , A61M25/1011 , A61M25/1027 , A61M2025/0096 , A61M2025/1013 , A61M2025/1031 , A61M2025/105 , A61M2025/1059 , A61M2025/1084 , A61M2025/1086 , A61M2025/109 , A61M2037/0023 , A61M2037/003 , A61M2037/0046
摘要： A device and method for intravascular treatment of atherosclerotic plaque prior to balloon angioplasty which microperforates the plaque with small sharp spikes acting as serrations for forming cleavage lines or planes in the plaque. The spikes may also be used to transport medication into the plaque. The plaque preparation treatment enables subsequent angioplasty to be performed at low balloon pressures of about 4 atmospheres or less, reduces dissections, and avoids injury to the arterial wall. The subsequent angioplasty may be performed with a drug-eluting balloon (DEB) or drug-coated balloon (DCB). The pre-angioplasty perforation procedure enables more drug to be absorbed during DEB or DCB angioplasty, and makes the need for a stent less likely. Alternatively, any local incidence of plaque dissection after balloon angioplasty may be treated by applying a thin, ring-shaped tack at the dissection site only, rather than applying a stent over the plaque site.
摘要翻译：一种用于在球囊血管成形术之前用于血管内治疗动脉粥样硬化斑块的装置和方法，所述装置和方法利用作为锯齿的小锐利尖刺使斑块微穿孔以在斑块中形成切割线或平面。钉也可以用来运送药物进入斑块。斑块制备治疗使得随后的血管成形术能够在约4个大气压或更低的低气囊压力下进行，减少了解剖并且避免了对动脉壁的损伤。随后的血管成形术可以用药物洗脱球囊（DEB）或药物涂层球囊（DCB）进行。预血管成形术穿孔程序能够在DEB或DCB血管成形术过程中吸收更多的药物，并且不太可能需要支架。或者，球囊血管成形术后任何局部斑块解剖发生率可以通过仅在解剖部位应用薄环形钉来治疗，而不是在斑块部位上施加支架。

10. 发明申请

WO2009117158A3 DEVICE AND METHOD FOR OPENING BLOOD VESSELS BY PRE-ANGIOPLASTY SERRATION AND DILATATION OF AETHEROSCLEROTIC PLAQUE 审中-公开
标题翻译：通过预血管成形术血管扩张并扩张无环斑块开放血管的装置和方法
公开(公告)号：WO2009117158A3
公开(公告)日：2009-11-12
申请号：PCT/US2009001786
申请日：2009-03-20
申请人： INNOVASC LLC
发明人： SCHNEIDER PETER , GIASOLLI ROBERT
IPC分类号： A61M25/00 , A61B17/34 , A61M29/02
CPC分类号： A61B17/320725 , A61B17/205 , A61B17/22 , A61B2017/22061 , A61M25/0082 , A61M25/104 , A61M2025/0096 , A61M2025/1086 , A61M2025/109
摘要： A device and method for intravascular treatment of atherosclerotic plaque perforates the plaque with microperforations by small sharp spikes to act as serrations for forming cleavage lines or planes in the plaque. In preferred embodiments, expansion may be obtained by mechanical apparatus, expansion balloon, or balloon-assisted deployment. The plaque treatment enables a subsequent balloon angioplasty to be performed without creating substantial dissections and at low balloon pressure so as to avoid injury to the arterial wall. The plaque treatment may include dilatation of the plaque at low pressure, sufficiently that no subsequent balloon angioplasty is needed. The plaque preparation may be followed by applying one or a few ring tacks to secure the compressed plaque with minimal emplacement of foreign material.
摘要翻译：一种用于血管内治疗动脉粥样硬化斑块的装置和方法通过小锐利尖刺穿过具有微穿孔的斑块，以充当在牙斑中形成分裂线或平面的锯齿。在优选实施例中，可以通过机械装置，扩张球囊或球囊辅助部署来获得扩张。斑块治疗能够进行随后的球囊血管成形术而不产生大量的夹层并且在低气囊压力下进行，以避免损伤动脉壁。斑块治疗可包括在低压下扩张斑块，足以使得不需要随后的球囊血管成形术。在斑块制备之后可以施加一个或几个环形钉来固定压缩的斑块，同时最小程度地放置异物。

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