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1. 发明申请

WO2021167453A1 WEARABLE AND PORTABLE DEVICE FOR RECIRCULATING FLOW DIALYSIS 审中-公开
公开(公告)号：WO2021167453A1
公开(公告)日：2021-08-26
申请号：PCT/NL2021/050105
申请日：2021-02-18
申请人： ICINNOVATION BV
发明人： SIMONIS, Frank
IPC分类号： A61M1/16 , A61M1/28
摘要： Wearable and portable device for recirculating flow dialysis The invention relates to a dialysis device that provides recirculating flow dialysis in a wearable and portable format. It uses an exchangeable purification unit holding a volume of dialysate and / or a sorbent system for the in-situ regeneration of dialysate. The invented dialysis device comprises a carrier that is mounted on a replaceable cartridge. The carrier holds the electronics, user-interface, actuators and sensors. It actuates, controls and monitors the dialysis operation. The cartridge is a replaceable part that is connected to the patient via a flexible tubing. It consists of a reusable housing with a memory chip and holds a disposable inlay containing the purification unit with fluid lines, connectors, dialysate and/or sorbents in combination with a nanofilter. The cartridge is intended for use during the day, as a wearable system. The cartridge can be enlarged with an extension set to offer more capacity. The extended cartridge is intended to be used during the night as a bedside device.

2. 发明申请

WO2015060716A1 REDOX CONTROLLED ELECTROSORPTION AND DECOMPOSITION DEVICE FOR THE PURIFICATION OF BLOOD AND OTHER FLUIDS 审中-公开
标题翻译：用于净化血液和其他液体的REDOX控制电解和分解装置
公开(公告)号：WO2015060716A1
公开(公告)日：2015-04-30
申请号：PCT/NL2014/050729
申请日：2014-10-17
申请人： ICINNOVATION BV
发明人： SIMONIS, Frank
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36 , B01D61/24 , C02F1/00
CPC分类号： A61M1/1621 , A61M1/1656 , A61M1/1658 , A61M1/1672 , A61M1/1676 , A61M1/1696 , A61M1/28 , A61M1/284 , A61M1/3472 , A61M1/3496 , A61M1/3679 , A61M1/3687 , A61M2205/7554 , B01D15/203 , B01D15/361 , B01D15/3885 , B01D19/0084 , B01D61/243 , B01D61/32 , B01D2311/246 , B01D2311/2623 , B01D2311/2626 , B01D2311/2634 , B01D2311/2684 , B01D2311/2696 , B01D2313/345 , B01D2313/40 , B01D2313/90 , C02F1/281 , C02F1/283 , C02F1/285 , C02F1/42 , C02F1/4672 , C02F1/469 , C02F1/66 , C02F1/70 , C02F2001/46142 , C02F2101/16 , C02F2101/38 , C02F2103/026 , C02F2103/20 , C02F2201/006 , C02F2201/4613 , C02F2201/46135 , C02F2209/02 , C02F2209/04 , C02F2209/05 , C02F2209/06 , C02F2303/16 , C02F2305/08
摘要： The present invention relates to a device for the removal of substances from blood and other fluids, said device comprising i) an electrocatalytic decomposition filter for removing substances such as toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from blood, blood plasma, ultrafiltrate or dialysate fluid, said electrocatalytic decomposition filter comprising a DC power source, a set of electrodes with a catalytic surface or in direct contact with sorbents offering catalytic activity, ii) an electrosorption filter for removing substances such as toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from blood, blood plasma, ultrafiltrate or dialysate fluid, said electrosorption filter comprising a DC power source, a set of electrodes, nanostructured sorption material and/or a porous polymer matrix, iii) an inlet for entry of blood or blood plasma or dialysate fluid into said device, iv) an outlet for the removal of purified blood, blood plasma, ultrafiltrate or dialysate fluid from said device, and v) a conduit connecting said inlet with said outlet and holding said electrosorption filter such that said blood, blood plasma, ultrafiltrate or dialysate fluid is forced through said electrosorption and electrocatalytic decomposition filter, and vi) a sensor and control system to safeguard the device from producing oxidative stress. The device of the present invention is also applicable for the purification of other fluids such as water, waste water, chemicals and other biofluids.
摘要翻译：本发明涉及一种用于从血液和其它流体中去除物质的装置，所述装置包括：i）电催化分解过滤器，用于从血液中除去毒素，毒性溶质，有毒小中小分子和蛋白质结合毒素等物质，血浆，超滤液或透析液，所述电催化分解过滤器包括直流电源，一组具有催化表面的电极或与提供催化活性的吸附剂直接接触，ii）用于去除毒素等有毒物质的电吸收过滤器溶质，有毒的中小分子和来自血液，血浆，超滤液或透析液的蛋白质结合的毒素，所述电吸收过滤器包括直流电源，一组电极，纳米结构吸附材料和/或多孔聚合物基质，iii ）用于将血液或血浆或透析液进入所述装置的入口，iv）用于去除的出口纯血液，血浆，超滤液或透析液，以及v）连接所述入口与所述出口并保持所述电吸收过滤器的导管，使得所述血液，血浆，超滤液或透析液被强制通过所述电吸收和电催化分解过滤器和vi）传感器和控制系统，以保护设备不产生氧化应激。本发明的装置也适用于净化其它流体如水，废水，化学品和其它生物流体。

3. 发明申请

WO2012060700A1 ELECTROSORPTION AND DECOMPOSITION DEVICE FOR THE PURIFICATION OF BLOOD AND OTHER FLUIDS 审中-公开
标题翻译：用于净化血液和其他液体的电解和分解装置
公开(公告)号：WO2012060700A1
公开(公告)日：2012-05-10
申请号：PCT/NL2011/050746
申请日：2011-11-02
申请人： ICinnovation BV , SIMONIS, Frank
发明人： SIMONIS, Frank
IPC分类号： A61M1/16 , A61M1/36 , A61M1/34 , B01D15/00 , B01J20/34 , B01J20/28
CPC分类号： A61M1/14 , A61M1/1696 , A61M1/28 , A61M1/3472 , A61M1/3482 , A61M1/3486 , A61M1/3679 , A61M2209/088 , B01D61/145 , B01D61/243 , B01D61/28 , B01D2311/2623 , B01D2311/2626 , B01D2311/2634 , B01D2311/2649 , B01D2311/2684 , B01D2311/2696 , B01J20/06 , B01J20/12 , B01J20/18 , B01J20/205 , B01J20/226 , B01J20/24 , B01J20/26 , B01J20/267 , B01J20/28007 , B01J20/28033 , B01J20/3208 , B01J20/3234 , B82Y30/00
摘要： The present invention relates to a device for the removal of substances from blood and other fluids, said device comprising i) an electrocatalytic decomposition filter for removing substances such as toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from blood, blood plasma, ultrafiltrate or dialysate fluid, said electrocatalytic decomposition filter comprising a DC power source, a set of electrodes with a catalytic surface or in direct contact with sorbents offering catalytic activity, ii) an electrosorption filter for removing substances such as toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from blood, blood plasma, ultrafiltrate or dialysate fluid, said electrosorption filter comprising a DC power source, a set of electrodes, nano structured sorption material and/or a porous polymer matrix, iii) an inlet for entry of blood or blood plasma or dialysate fluid into said device, iv) an outlet for the removal of purified blood, blood plasma, ultrafiltrate or dialysate fluid from said device, and v) a conduit connecting said inlet with said outlet and holding said electrosorption filter such that said blood, blood plasma, ultrafiltrate or dialysate fluid is forced through said electrosorption and electrocatalytic decomposition filter. The device of the present invention is also applicable for the purification of other fluids such as water, chemicals and other biofluids.
摘要翻译：本发明涉及一种用于从血液和其它流体中去除物质的装置，所述装置包括：i）电催化分解过滤器，用于从血液中除去毒素，毒性溶质，有毒小中小分子和蛋白质结合毒素等物质，血浆，超滤液或透析液，所述电催化分解过滤器包括直流电源，一组具有催化表面的电极或与提供催化活性的吸附剂直接接触，ii）用于去除毒素等有毒物质的电吸收过滤器溶质，有毒的中小分子和来自血液，血浆，超滤液或透析液的蛋白质结合的毒素，所述电吸收过滤器包括直流电源，一组电极，纳米结构吸附材料和/或多孔聚合物基质， iii）用于将血液或血浆或透析液进入所述装置的入口，iv）用于去除的出口o 从所述装置获取纯化血液，血浆，超滤液或透析液，以及v）连接所述入口与所述出口并保持所述电吸收过滤器的导管，使得所述血液，血浆，超滤液或透析液被强制通过所述电吸收和电催化分解过滤器。本发明的装置也适用于净化其它流体如水，化学品和其它生物流体。

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