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1. 发明申请

WO2012158529A3 COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST DRUG RESISTANT ACINETOBACTER BAUMANNII 审中-公开
标题翻译：用于免疫抗药性乙酰胆碱酯酶的组合物和方法
公开(公告)号：WO2012158529A3
公开(公告)日：2014-02-20
申请号：PCT/US2012037550
申请日：2012-05-11
申请人： LOS ANGELES BIOMED RES INST , SPELLBERG BRAD J , LIN LIN , IBRAHIM ASHRAF S , LUO GUANPINGSHENG
发明人： SPELLBERG BRAD J , LIN LIN , IBRAHIM ASHRAF S , LUO GUANPINGSHENG
IPC分类号： A61K39/02
CPC分类号： C07K14/22 , A61K39/02 , A61K39/104 , A61K2039/55505 , C07K14/212 , C07K16/1203 , C07K16/1217 , C07K2317/34
摘要： The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A. baumannii infection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization against A. baumannii infection. The compositions and methods of the invention are useful for preventing or treating A. baumannii infections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR) A. baumannii infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR) A. baumannii infections.
摘要翻译：本发明提供包含OmpA或其抗原性片段的疫苗组合物，以及针对鲍曼不动杆菌感染的主动免疫的相关方法。本发明还提供了特异性结合OmpA的抗体及其抗原结合部分，以及针对鲍氏不动杆菌感染的相关的被动免疫方法。本发明的组合物和方法可用于预防或治疗鲍曼不动杆菌感染，包括由对碳青霉烯类耐受的菌株和除粘菌素或替加环素之外的所有其它抗生素引起的鲍曼不动杆菌感染，也被称为极耐药（XDR）A.鲍曼不动杆菌感染，而那些对每一个FDA批准的抗生素都有抗药性，也被称为泛耐药（PDR）A.鲍曼不动杆菌感染。

2. 发明申请

WO2013040517A3 IMMUNOTHERAPY AND DIAGNOSIS OF MUCORMYCOSIS USING CotH 审中-公开
标题翻译：用CotH免疫治疗和诊断MUCORMYCOSIS
公开(公告)号：WO2013040517A3
公开(公告)日：2013-07-18
申请号：PCT/US2012055659
申请日：2012-09-14
申请人： LOS ANGELES BIOMED RES INST , IBRAHIM ASHRAF S , LIU MINGFU , GHEBREMARIAM TEKLEGIORGIS , FU YUE , EDWARDS JOHN E , FILLER SCOTT
发明人： IBRAHIM ASHRAF S , LIU MINGFU , GHEBREMARIAM TEKLEGIORGIS , FU YUE , EDWARDS JOHN E , FILLER SCOTT
IPC分类号： A61K39/00 , A61K48/00 , C12N15/74
CPC分类号： C07K16/14 , A61K2039/505 , C07K14/37 , C07K2317/24 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/56961 , G01N2333/37 , G01N2469/10
摘要： The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.
摘要翻译：本发明提供了Mucorales CotH多肽和编码核酸分子。 Mucorales CotH多肽和编码核酸可有利地用于诊断，治疗或预防真菌病症，特别是毛霉菌病。

3. 发明申请

WO2013040478A2 HYR1-DERIVED COMPOSITIONS AND METHODS OF TREATMENT USING SAME 审中-公开
标题翻译： HYR1衍生的组合物和使用它们的治疗方法
公开(公告)号：WO2013040478A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/055604
申请日：2012-09-14
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , IBRAHIM, Ashraf, S. , YEAMAN, Michael, R. , EDWARDS, John, E., Jr. , LUO, Guanpingsheng , FU, Yue
发明人： IBRAHIM, Ashraf, S. , YEAMAN, Michael, R. , EDWARDS, John, E., Jr. , LUO, Guanpingsheng , FU, Yue
IPC分类号： A61K39/00
CPC分类号： C07K14/40 , A61K39/00 , A61K39/0002 , A61K47/646 , A61K2039/6081 , C07K16/14
摘要： The invention features isolated polypeptides of Hyrl. The invention further features vaccines and antibodies useful in treating or preventing candidiasis or Acinetobacter infections or both.
摘要翻译：本发明具有Hyr1的分离多肽。本发明还特征在于可用于治疗或预防念珠菌病或不动杆菌感染或两者的疫苗和抗体。

4. 发明申请

WO2010107500A1 VACCINE COMPOSITIONS AND METHODS FOR TREATMENT OF MUCORMYCOSIS AND OTHER FUNGAL DISEASES 审中-公开
标题翻译：疫苗组合物和治疗纤维瘤和其他真菌病的方法
公开(公告)号：WO2010107500A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/000820
申请日：2010-03-19
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , IBRAHIM, Ashraf, S. , SPELLBERG, Brad, J. , FU, Yue , EDWARDS, John, E.
发明人： IBRAHIM, Ashraf, S. , SPELLBERG, Brad, J. , FU, Yue , EDWARDS, John, E.
IPC分类号： C07K14/00 , C07K16/00
CPC分类号： C07K16/14 , A61K2039/505 , C12N9/00 , C12N15/1138 , C12N2310/14
摘要： The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The therapeutic methods and compositions of the invention include vaccine compositions having an FTR polypeptide or an antigenic fragment of the polypeptide; a vector including a nucleotide sequence that is substantially complimentary to at least 18 contiguous nucleotides of FTR sequence; an antisense; a small interfering RNA or an antibody inhibitor of FTR . The vaccine compositions of the invention can further include an adjuvant.
摘要翻译：本发明提供治疗和预防真菌病或包括毛霉菌病的病症的治疗组合物和方法。本发明的治疗方法和组合物包括具有多肽的FTR多肽或抗原性片段的疫苗组合物; 包含与FTR序列的至少18个连续核苷酸基本互补的核苷酸序列的载体; 反义词小干扰RNA或FTR的抗体抑制剂。本发明的疫苗组合物还可包含佐剂。

5. 发明申请

WO2008008537A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUCORMYCOSIS AND OTHER FUNGAL DISEASES 审中-公开
标题翻译：用于治疗结肠炎和其他真菌病的组合物和方法
公开(公告)号：WO2008008537A2
公开(公告)日：2008-01-17
申请号：PCT/US2007016065
申请日：2007-07-13
申请人： LOS ANGELES BIOMED RES INST , IBRAHIM ASHRAF S , SPELLBERG BRAD J , EDWARDS JOHN E
发明人： IBRAHIM ASHRAF S , SPELLBERG BRAD J , EDWARDS JOHN E
IPC分类号： A61K31/4196 , A61K31/4412 , A61K31/7048 , A61P31/10
CPC分类号： A61K31/4196 , A61K31/4412 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： The invention provides a composition including at least one iron chelating compound and at least one antifungal agent. The composition can include the iron chelating compounds deferiprone or deferasirox. An antifungal agent included in the composition can include a polyene antifungal agent, an azole antifungal agent or an echinocandin antifungal agent. The invention also provides a method of treating or preventing a fungal condition. The method includes administering to an individual having, or susceptible to having, a fungal condition a therapeutically effective amount of at least one iron chelating compound for a sufficient time to reduce the severity of a fungal condition, wherein the iron chelating compound comprises a non-siderophore or non-xenosiderophore relative to the fungal condition. A method of treating or preventing a fungal condition provided by the invention also can include administering to an individual having, or susceptible of having, a fungal condition a therapeutically effective amount of at least one iron chelating compound and at least one antifungal agent. Provided further by the invention is a method including prophylactic administration of the at least one iron chelating compound or at least one iron chelating compound and at least one antifungal agent prior to onset of the fungal condition.
摘要翻译：本发明提供包含至少一种铁螯合化合物和至少一种抗真菌剂的组合物。组合物可以包括铁螯合化合物去铁酮或去铁素。包含在组合物中的抗真菌剂可以包括多烯抗真菌剂，唑类抗真菌剂或棘皮动物抗真菌剂。本发明还提供了治疗或预防真菌病症的方法。该方法包括向具有或易于具有治疗有效量的至少一种铁螯合化合物的个体具有或易于具有足够时间以降低真菌病症的严重性的个体，其中所述铁螯合化合物包含非 - 铁载体或非脱铁载体相对于真菌条件。治疗或预防本发明提供的真菌病症的方法还可以包括向具有或易于具有治疗有效量的至少一种铁螯合化合物和至少一种抗真菌剂的真菌病症的个体施用。通过本发明进一步提供的方法包括在真菌病症发作之前预防性施用至少一种铁螯合化合物或至少一种铁螯合化合物和至少一种抗真菌剂。

6. 发明申请

WO2013040478A3 HYR1-DERIVED COMPOSITIONS AND METHODS OF TREATMENT USING SAME 审中-公开
标题翻译： HYR1衍生的组合物和使用它们的治疗方法
公开(公告)号：WO2013040478A3
公开(公告)日：2013-06-27
申请号：PCT/US2012055604
申请日：2012-09-14
申请人： LOS ANGELES BIOMED RES INST , IBRAHIM ASHRAF S , YEAMAN MICHAEL R , EDWARDS JOHN E JR , LUO GUANPINGSHENG , FU YUE
发明人： IBRAHIM ASHRAF S , YEAMAN MICHAEL R , EDWARDS JOHN E JR , LUO GUANPINGSHENG , FU YUE
IPC分类号： A61K36/06 , A61K38/00 , C07K14/00 , C12Q1/68
CPC分类号： C07K14/40 , A61K39/00 , A61K39/0002 , A61K47/646 , A61K2039/6081 , C07K16/14
摘要： The disclosure features isolated polypeptides of Hyr1. The disclosure further features vaccines and antibodies useful in treating or preventing candidiasis or Acinetobacter infections or both. Further disclosed are isolated polypeptides consisting of between 14 and 20 amino acids for vaccine preparation. The specific amino acid sequences of isolated polypeptides of Hyr1 are also disclosed.
摘要翻译：该公开的特征是Hyr1的分离的多肽。本公开进一步具有用于治疗或预防念珠菌病或不动杆菌感染或两者的疫苗和抗体。进一步公开的是用于疫苗制备的由14个和20个氨基酸组成的分离的多肽。还公开了Hyr1的分离的多肽的特定氨基酸序列。

7. 发明申请

WO2013040517A2 IMMUNOTHERAPY AND DIAGNOSIS OF MUCORMYCOSIS USING CotH 审中-公开
标题翻译：使用CotH的肌肉瘤的免疫和诊断
公开(公告)号：WO2013040517A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/055659
申请日：2012-09-14
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , IBRAHIM, Ashraf, S. , LIU, Mingfu , GHEBREMARIAM, Teklegiorgis , FU, Yue , EDWARDS, John, E. , FILLER, Scott
发明人： IBRAHIM, Ashraf, S. , LIU, Mingfu , GHEBREMARIAM, Teklegiorgis , FU, Yue , EDWARDS, John, E. , FILLER, Scott
IPC分类号： C07K14/37 , C07K16/14
CPC分类号： C07K16/14 , A61K2039/505 , C07K14/37 , C07K2317/24 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/56961 , G01N2333/37 , G01N2469/10
摘要： The invention provided Mucorales CotH polypeptides and encoding nucleic acid molecules. The Mucorales CotH polypeptides and encoding nucleic acids can be advantageously used to diagnose, treat or prevent fungal conditions, in particular mucormycosis.
摘要翻译：本发明提供了Mucorales CotH多肽并编码核酸分子。 Mucorales CotH多肽和编码核酸可有利地用于诊断，治疗或预防真菌病症，特别是毛霉菌病。

8. 发明申请

WO2012158529A2 COMPOSITIONS AND METHODS FOR IMMUNIZATION AGAINST DRUG RESISTANT ACINETOBACTER BAUMANNII 审中-公开
标题翻译：用于免疫抗药性乙酰胆碱酯酶的组合物和方法
公开(公告)号：WO2012158529A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/037550
申请日：2012-05-11
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , SPELLBERG, Brad, J. , LIN, Lin , IBRAHIM, Ashraf, S. , LUO, Guanpingsheng
发明人： SPELLBERG, Brad, J. , LIN, Lin , IBRAHIM, Ashraf, S. , LUO, Guanpingsheng
IPC分类号： A61K39/02 , C07K14/21 , C07K7/08 , C07K7/06 , C07K5/08 , C12N15/31 , C12N15/63 , C07K16/12 , A61K39/395 , A61P31/04 , A61P37/04
CPC分类号： C07K14/22 , A61K39/02 , A61K39/104 , A61K2039/55505 , C07K14/212 , C07K16/1203 , C07K16/1217 , C07K2317/34
摘要： The present invention provides vaccine compositions comprising OmpA, or antigenic fragments thereof, and related methods of active immunization against A. baumannii infection. The invention also provides antibodies and antigen-binding parts thereof that specifically bind to OmpA, and related methods of passive immunization against A. baumannii infection. The compositions and methods of the invention are useful for preventing or treating A. baumannii infections, including those caused by strains resistant to carbapenems and all other antibiotics except colistin or tigecycline, also referred to as extreme drug resistant (XDR) A. baumannii infections, and those resistant to every FDA approved antibiotic, also referred to as pan-drug resistant (PDR) A. baumannii infections.
摘要翻译：本发明提供包含OmpA或其抗原性片段的疫苗组合物，以及针对鲍曼不动杆菌感染的主动免疫的相关方法。本发明还提供了特异性结合OmpA的抗体及其抗原结合部分，以及针对鲍氏不动杆菌感染的相关的被动免疫方法。本发明的组合物和方法可用于预防或治疗鲍曼不动杆菌感染，包括由对碳青霉烯类耐受的菌株和除粘菌素或替加环素之外的所有其它抗生素引起的鲍曼不动杆菌感染，也被称为极耐药（XDR）A.鲍曼不动杆菌感染，而那些对每一个FDA批准的抗生素都有抗药性，也被称为泛耐药（PDR）A.鲍曼不动杆菌感染。

9. 发明申请

WO2008008537A3 COMBI) COMPOSITIONS FOR THE TREATMENT OF MUCORMYCOSIS. COMPRISING IRON CHELATOR AND ANTIFUNGAL AGENT 审中-公开
公开(公告)号：WO2008008537A3
公开(公告)日：2008-01-17
申请号：PCT/US2007/016065
申请日：2007-07-13
申请人： LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , IBRAHIM, Ashraf, S. , SPELLBERG, Brad, J. , EDWARDS, John, E.
发明人： IBRAHIM, Ashraf, S. , SPELLBERG, Brad, J. , EDWARDS, John, E.
IPC分类号： A61K31/4196 , A61K31/4412 , A61K31/7048 , A61P31/10
摘要： The invention provides a composition including at least one iron chelating compound and at least one antifungal agent. The composition can include the iron chelating compounds deferiprone or deferasirox. An antifungal agent included in the composition can include a polyene antifungal agent, an azole antifungal agent or an echinocandin antifungal agent. The invention also provides a method of treating or preventing a fungal condition. The method includes administering to an individual having, or susceptible to having, a fungal condition a therapeutically effective amount of at least one iron chelating compound for a sufficient time to reduce the severity of a fungal condition, wherein the iron chelating compound comprises a non-siderophore or non-xenosiderophore relative to the fungal condition. A method of treating or preventing a fungal condition provided by the invention also can include administering to an individual having, or susceptible of having, a fungal condition a therapeutically effective amount of at least one iron chelating compound and at least one antifungal agent. Provided further by the invention is a method including prophylactic administration of the at least one iron chelating compound or at least one iron chelating compound and at least one antifungal agent prior to onset of the fungal condition.

10. 发明申请

WO2013015831A1 METHODS AND COMPOSITIONS FOR VACCINATING AGAINST STAPHYLOCOCCUS AUREUS 审中-公开
标题翻译：用于吸入抗生素的方法和组合物
公开(公告)号：WO2013015831A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/000328
申请日：2012-07-20
申请人： NOVADIGM THERAPEUTICS, INC. , LA BIOMED LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER , YEAMAN, Michael, R. , EDWARDS, John, E., Jr. , FILLER, Scott, G. , IBRAHIM, Ashraf, S , FU, Yue , HENNESSEY, John, P., Jr.
发明人： YEAMAN, Michael, R. , EDWARDS, John, E., Jr. , FILLER, Scott, G. , IBRAHIM, Ashraf, S , FU, Yue , HENNESSEY, John, P., Jr.
IPC分类号： A61K39/00
CPC分类号： A61K39/0002 , A61K45/06 , A61K2039/55505 , A61K2039/58
摘要： The invention features a method of vaccinating a mammal against Staphylococcus aureus which includes the steps of: a) identifying a mammal at risk for the development of a Staphylococcus aureus skin or soft tissue infection; and b) administering to said mammal an immunogenic amount of a vaccine that includes a polypeptide including an isolated agglutinin-like sequence (Als) 3 protein (Als3p), or an immunogenic fragment thereof, in a pharmaceutically acceptable medium.
摘要翻译：本发明的特征在于一种针对金黄色葡萄球菌接种哺乳动物的方法，其包括以下步骤：a）鉴定处于发生金黄色葡萄球菌皮肤或软组织感染风险的哺乳动物; 和b）向所述哺乳动物施用免疫原性量的疫苗，其包含在药学上可接受的培养基中包含分离的凝集素样序列（Als）3蛋白（Als3p）或其免疫原性片段的多肽。

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