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1. 发明申请

WO2016210215A1 3-TETRAZOLYL-BENZENE-1,2-DISULFONAMIDE DERIVATIVES AS METALLO-BETA-LACTAMASE INHIBITORS 审中-公开
标题翻译：作为金属 - β-谷氨酰胺酶抑制剂的3-四氢 - 苯甲基-1,2-二磺酰胺衍生物
公开(公告)号：WO2016210215A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039156
申请日：2016-06-24
申请人： MERCK SHARP & DOHME CORP. , BENNETT, Frank , JIANG, Jinlong , PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , SCOTT, Jack, D. , TANG, Haiqun , ZHAO, Zhiqiang , HUANG, Yuhua , YANG, Dexi , YOUNG, Katherine , XIAO, Li , ZHANG, Zhibo , FU, Jianmin
发明人： BENNETT, Frank , JIANG, Jinlong , PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , SCOTT, Jack, D. , TANG, Haiqun , ZHAO, Zhiqiang , HUANG, Yuhua , YANG, Dexi , YOUNG, Katherine , XIAO, Li , ZHANG, Zhibo , FU, Jianmin
IPC分类号： C07D403/12 , C07D413/14 , C07D401/10 , C07D403/10 , C07D403/14 , C07D407/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/04 , A61K31/41 , A61K31/4184 , A61K31/428 , A61K31/4439 , A61P31/04
CPC分类号： C07D403/14 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , A61P31/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/12 , C07D407/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to metallo-beta-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein Z, R A , X 1 , X 2 and R 1 are as defined herein. The present invention also relates to compositions which comprise a metallo-beta-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta-lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
摘要翻译：本发明涉及式I的金属-β-内酰胺酶抑制剂化合物及其药学上可接受的盐，其中Z，RA，X 1，X 2和R 1如本文所定义。本发明还涉及包含本发明的金属-β-内酰胺酶抑制剂化合物或其药学上可接受的盐和可药用载体的组合物，任选地与β-内酰胺抗生素和/或β-内酰胺酶抑制剂组合。本发明还涉及用于治疗细菌感染的方法，其包括向患者施用治疗有效量的本发明化合物与治疗有效量的一种或多种β-内酰胺抗生素并任选与一种或多种组合 β-内酰胺酶抑制剂化合物。本发明的化合物可用于本文所述用于克服抗生素抗性的方法。

2. 发明申请

WO2016206101A1 METALLO-BETA-LACTAMASE INHIBITORS 审中-公开
标题翻译： METALLO-BETA-LACTAMASE抑制剂
公开(公告)号：WO2016206101A1
公开(公告)日：2016-12-29
申请号：PCT/CN2015/082514
申请日：2015-06-26
申请人： MERCK SHARP & DOHME CORP. , BENNETT, Frank , JIANG, Jinlong , PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , SCOTT, Jack D. , TANG, Haiqun , ZHAO, Zhiqiang , HUANG, Yuhua , HUNTER, David , YANG, Dexi , ZHANG, Zhibo , FU, Jianmin , BAI, Yunfeng , ZHENG, Zhixiang , ZHANG, Xu , YOUNG, Katherine , XIAO, Li
发明人： BENNETT, Frank , JIANG, Jinlong , PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , SCOTT, Jack D. , TANG, Haiqun , ZHAO, Zhiqiang , HUANG, Yuhua , HUNTER, David , YANG, Dexi , ZHANG, Zhibo , FU, Jianmin , BAI, Yunfeng , ZHENG, Zhixiang , ZHANG, Xu , YOUNG, Katherine , XIAO, Li
IPC分类号： C07D257/04 , A61K31/41 , A61P31/04
CPC分类号： C07D403/14 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , A61P31/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/12 , C07D407/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
摘要翻译：本发明涉及金属β-内酰胺酶抑制剂的式I化合物，这种化合物的合成，以及这些化合物与β-内酰胺抗生素一起用于克服抗性的用途。

3. 发明申请

WO2013071686A3 QUICK BRAKING ASSEMBLY 审中-公开
标题翻译：快速制动总成
公开(公告)号：WO2013071686A3
公开(公告)日：2013-07-04
申请号：PCT/CN2012001011
申请日：2012-07-27
申请人： LI ZHONGHUA , HUANG YUHUA
发明人： LI ZHONGHUA , HUANG YUHUA
IPC分类号： B60T13/02 , B60T1/08 , B61H7/00 , B64C25/32
CPC分类号： B61H11/14 , B60T1/14 , B60T1/16 , B61H7/06 , B62L1/00 , E01H8/10
摘要： The present invention relates to the technical field of vehicle braking of high speed trains, high speed automobiles, high speed aircraft, high speed motorcycles and the like. Disclosed is a quick braking assembly. In order to overcome the defect of deficient braking capability of vehicles such as high speed trains, high speed automobiles, high speed aircraft, high speed motorcycles and the like, a braking track device is designed to be installed at proper positions at the bottom of a high speed train and a high speed automobile. Adopted are a specialized braking material and a serrated occlusal surface, and a windscreen braking device designed to be installed at the tail and two wings of a high speed train and a high speed automobile. A pressure spray gun with braking material is installed underneath a vehicle. Also adopted are a specialized braking material and a serrated occlusal surface, and a braking track device designed to be installed underneath the body of a high speed aircraft. A windscreen brake device is designed to be installed at the tail of a motorcycle.
摘要翻译：本发明涉及高速列车，高速汽车，高速飞机，高速摩托车等的车辆制动技术领域。公开了一种快速制动组件。为了克服高速列车，高速汽车，高速飞机，高速摩托车等车辆制动能力不足的缺陷，制动轨道装置被设计成安装在底部的适当位置高速列车和高速汽车。采用专门的制动材料和锯齿状咬合面，以及设计用于安装在高速列车和高速汽车的尾翼和两翼的挡风玻璃制动装置。具有制动材料的压力喷枪安装在车辆下方。还采用专门的制动材料和锯齿状咬合面，以及设计成安装在高速飞机身体下方的制动轨道装置。挡风玻璃制动装置被设计成安装在摩托车尾部。

4. 发明申请

WO2009032116A1 2, 3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS 审中-公开
标题翻译： 2，3替代的用于治疗病毒感染的吲哚酚衍生物
公开(公告)号：WO2009032116A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010130
申请日：2008-08-27
申请人： SCHERING CORPORATION , ANILKUMAR, Gopinadhan, N. , BENNETT, Frank , CHAN, Tin-Yau , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , ZENG, Qingbei , DUCA, Jose, S. , LESBURG, Charles, A. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , GAVALAS, Stephen, J. , JIANG, Yueheng , PINTO, Patrick, A. , PU, Haiyan , SELYUTIN, Oleg, B. , VIBULBHAN, Bancha , WANG, Li , WU, Wanli , YANG, Weiying , HUANG, Yuhua , HUANG, Hsueh-Cheng , PALERMO, Robert , FELD, Boris
发明人： ANILKUMAR, Gopinadhan, N. , BENNETT, Frank , CHAN, Tin-Yau , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , ZENG, Qingbei , DUCA, Jose, S. , LESBURG, Charles, A. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , GAVALAS, Stephen, J. , JIANG, Yueheng , PINTO, Patrick, A. , PU, Haiyan , SELYUTIN, Oleg, B. , VIBULBHAN, Bancha , WANG, Li , WU, Wanli , YANG, Weiying , HUANG, Yuhua , HUANG, Hsueh-Cheng , PALERMO, Robert , FELD, Boris
IPC分类号： C07D209/42 , C07D401/04 , C07D401/14 , A61K31/404 , A61P31/12
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译：本发明涉及2,3-取代的吲哚衍生物，包含至少一种2,3-取代的吲哚衍生物的组合物和使用2,3-取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关的方法病人无序。

5. 发明申请

WO2005087731A1 SULFUR COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE 审中-公开
标题翻译：作为乙型肝炎病毒NS3丝氨酸蛋白酶抑制剂的硫化合物
公开(公告)号：WO2005087731A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/005795
申请日：2005-02-24
申请人： SCHERING CORPORATION , BENNETT, Frank , LOVEY, Raymond, G. , HUANG, Yuhua , HENDRATA, Siska , SAKSENA, Anil, K. , BOGEN, Stephane, L. , LIU, Yi-Tsung , NJOROGE, F., George , VENKATRAMAN, Srikanth , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , ARASAPPAN, Ashok , GIRIJAVALLABHAN, Viyyoor, M. , VELAZQUEZ, Francisco
发明人： BENNETT, Frank , LOVEY, Raymond, G. , HUANG, Yuhua , HENDRATA, Siska , SAKSENA, Anil, K. , BOGEN, Stephane, L. , LIU, Yi-Tsung , NJOROGE, F., George , VENKATRAMAN, Srikanth , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , ARASAPPAN, Ashok , GIRIJAVALLABHAN, Viyyoor, M. , VELAZQUEZ, Francisco
IPC分类号： C07D209/52
CPC分类号： C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

6. 发明申请

WO2016210234A1 METALLO-BETA-LACTAMASE INHIBITORS 审中-公开
标题翻译： METALLO-BETA-LACTAMASE抑制剂
公开(公告)号：WO2016210234A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039185
申请日：2016-06-24
申请人： MERCK SHARP & DOHME CORP. , BENNETT, Frank , JIANG, Jinlong , PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , SCOTT, Jack, D. , TANG, Haiqun , ZHAO, Zhiqiang , HUANG, Yuhua , HUNTER, David , YANG, Dexi , YOUNG, Katherine , XIAO, Li , ZHANG, Zhibo , FU, Jianmin , BAI, Yunfeng , ZHENG, Zhixiang , ZHANG, Xu
发明人： BENNETT, Frank , JIANG, Jinlong , PASTERNAK, Alexander , DONG, Shuzhi , GU, Xin , SCOTT, Jack, D. , TANG, Haiqun , ZHAO, Zhiqiang , HUANG, Yuhua , HUNTER, David , YANG, Dexi , YOUNG, Katherine , XIAO, Li , ZHANG, Zhibo , FU, Jianmin , BAI, Yunfeng , ZHENG, Zhixiang , ZHANG, Xu
IPC分类号： C07D257/02 , C07D257/04 , A61K31/41 , A61K31/395
CPC分类号： C07D403/14 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , A61P31/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/12 , C07D407/14 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to metallo-β-lactamase inhibitor compounds of Formula I: (I) and pharmaceutically acceptable salts thereof, wherein Z, R A , X 1 , X 2 and R B are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt therof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.
摘要翻译：本发明涉及式I的金属-β-内酰胺酶抑制剂化合物：（I）及其药学上可接受的盐，其中Z，RA，X1，X2和RB如本文所定义。本发明还涉及包含本发明的金属-β-内酰胺酶抑制剂化合物或其药学上可接受的盐的组合物，以及任选与β内酰胺抗生素和/或β-内酰胺酶抑制剂组合的药学上可接受的载体。本发明还涉及用于治疗细菌感染的方法，其包括向患者施用治疗有效量的本发明化合物与治疗有效量的一种或多种β-内酰胺抗生素并任选与一种或多种组合 β-内酰胺酶抑制剂化合物。本发明的化合物可用于本文所述用于克服抗生素抗性的方法。

7. 发明申请

WO2011103441A1 SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 审中-公开
标题翻译：取代的吡啶和吡嗪衍生物及其在治疗病毒感染中的应用
公开(公告)号：WO2011103441A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025453
申请日：2011-02-18
申请人： SCHERING CORPORATION , SOUTHERN RESEARCH INSTITUTE , ARASAPPAN, Ashok , NJOROGE, George, F. , KWONG, Cecil, D. , ANANTHAN, Subramaniam , BENNETT, Frank , CLARK, Jeremy , GENG, Feng , GIRIJAVALLABHAN, Vinay, M. , HUANG, Yuhua , KEZAR, Hollis, S., III , MADDRY, Joseph, A. , REYNOLDS, Robert, C. , ROYCHOWDHURY, Abhijit , FOWLER, Anita, T. , SECRIST, John, A., III , KOZLOWSKI, Joseph, A. , SHANKAR, Bandarpalle, B. , TONG, Ling , KIM, Seong Heon , MACCOSS, Malcolm
发明人： ARASAPPAN, Ashok , NJOROGE, George, F. , KWONG, Cecil, D. , ANANTHAN, Subramaniam , BENNETT, Frank , CLARK, Jeremy , GENG, Feng , GIRIJAVALLABHAN, Vinay, M. , HUANG, Yuhua , KEZAR, Hollis, S., III , MADDRY, Joseph, A. , REYNOLDS, Robert, C. , ROYCHOWDHURY, Abhijit , FOWLER, Anita, T. , SECRIST, John, A., III , KOZLOWSKI, Joseph, A. , SHANKAR, Bandarpalle, B. , TONG, Ling , KIM, Seong Heon , MACCOSS, Malcolm
IPC分类号： A61K31/535
CPC分类号： A61K31/506 , A61K45/06 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/048 , C07D513/04
摘要： The present invention provides compounds of Formula(I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R 1 , X, Y, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 18 , R 19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing dieases or disorders such as viral infections and virus-related disorders.
摘要翻译：本发明提供式（I）的化合物：所述化合物的互变异构体，异构体和酯，以及所述化合物的药学上可接受的盐，溶剂合物和前药，其中R，R 1，X，Y，Z，R 2 ，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 18，R 19和n独立地如本文所定义。还提供了包含这些化合物的组合物。本发明的化合物作为HCV的抑制剂是有效的，并且可单独使用和与其它治疗剂一起用于治疗或预防死亡或病症如病毒感染和病毒相关疾病。

8. 发明申请

WO2010022121A1 SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 审中-公开
标题翻译：取代的吡啶和吡嗪衍生物及其在治疗病毒感染中的应用
公开(公告)号：WO2010022121A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/054264
申请日：2009-08-19
申请人： SCHERING CORPORATION , SOUTHERN RESEARCH INSTITUTE , ARASAPPAN, Ashok , NJOROGE, F., George , BENNETT, Frank , GIRIJAVALLABHAN, Vinay, M. , HUANG, Yuhua , HUELGAS, Regina , PIWINSKI, John, J. , SHIH, Neng-Yang , VERMA, Vishal , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , KWONG, Cecil, D. , ANANTHAN, Subramaniam , CLARK, Jeremy , GENG, Feng , KEZAR, Hollis, S., III. , MADDRY, Joseph, A. , REYNOLDS, Robert, C. , ROYCHOWDHURY, Abhijit , SECRIST, John, A., III. , FOWLER, Anita, T.
发明人： ARASAPPAN, Ashok , NJOROGE, F., George , BENNETT, Frank , GIRIJAVALLABHAN, Vinay, M. , HUANG, Yuhua , HUELGAS, Regina , PIWINSKI, John, J. , SHIH, Neng-Yang , VERMA, Vishal , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , KWONG, Cecil, D. , ANANTHAN, Subramaniam , CLARK, Jeremy , GENG, Feng , KEZAR, Hollis, S., III. , MADDRY, Joseph, A. , REYNOLDS, Robert, C. , ROYCHOWDHURY, Abhijit , SECRIST, John, A., III. , FOWLER, Anita, T.
IPC分类号： C07D239/48 , C07D491/04 , C07D409/04 , C07D417/04 , C07D413/04 , C07D405/04 , C07D417/14 , C07D401/04 , C07D403/04 , C07D401/14 , C07D413/14 , A61K31/506 , A61P31/12
CPC分类号： C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/04
摘要： The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein wherein each of R, R 1 , X, Y, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 18 , R 19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译：本发明提供式（I）的化合物：所述化合物的互变异构体，异构体和酯，以及所述化合物的药学上可接受的盐，溶剂合物和前药，其中R，R 1，X，Y，Z，R 2 ，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 18，R 19和n独立地如本文所定义。还提供了包含这些化合物的组合物。本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。

9. 发明申请

WO2005087731A8 SULFUR COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE 审中-公开
标题翻译：作为乙型肝炎病毒NS3丝氨酸蛋白酶抑制剂的硫化合物
公开(公告)号：WO2005087731A8
公开(公告)日：2006-06-22
申请号：PCT/US2005005795
申请日：2005-02-24
申请人： SCHERING CORP , BENNETT FRANK , LOVEY RAYMOND G , HUANG YUHUA , HENDRATA SISKA , SAKSENA ANIL K , BOGEN STEPHANE L , LIU YI-TSUNG , NJOROGE F GEORGE , VENKATRAMAN SRIKANTH , CHEN KEVIN X , SANNIGRAHI MOUSUMI , ARASAPPAN ASHOK , GIRIJAVALLABHAN VIYYOOR M , VELAZQUEZ FRANCISCO , NAIR LATHA
发明人： BENNETT FRANK , LOVEY RAYMOND G , HUANG YUHUA , HENDRATA SISKA , SAKSENA ANIL K , BOGEN STEPHANE L , LIU YI-TSUNG , NJOROGE F GEORGE , VENKATRAMAN SRIKANTH , CHEN KEVIN X , SANNIGRAHI MOUSUMI , ARASAPPAN ASHOK , GIRIJAVALLABHAN VIYYOOR M , VELAZQUEZ FRANCISCO , NAIR LATHA
IPC分类号： C07D209/52 , C07D209/56 , C07D491/04 , C07K5/08 , C07K7/02
CPC分类号： C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

10. 发明申请

WO2015171474A1 BETA-TETRAZOLYL-PROPIONIC ACIDS AS METALLO-BETA-LACTAMASE INHIBITORS 审中-公开
标题翻译：作为METALLO-BETA-LACTAMASE抑制剂的BETA-TETRAZOLYL-PROPIONIC
公开(公告)号：WO2015171474A1
公开(公告)日：2015-11-12
申请号：PCT/US2015/028989
申请日：2015-05-04
申请人： MERCK SHARP & DOHME CORP. , TANG, Haifeng , YANG, Shu-Wei , MANDAL, Mihir , SU, Jing , LI, Guoqing , PAN, Weidong , TANG, Haiqun , DEJESUS, Reynalda , PAN, Jianping , HAGMANN, William , DING, Fa-Xiang , XIAO, Li , PASTERNAK, Alexander , HUANG, Yuhua , DONG, Shuzhi , YANG, Dexi
发明人： TANG, Haifeng , YANG, Shu-Wei , MANDAL, Mihir , SU, Jing , LI, Guoqing , PAN, Weidong , TANG, Haiqun , DEJESUS, Reynalda , PAN, Jianping , HAGMANN, William , DING, Fa-Xiang , XIAO, Li , PASTERNAK, Alexander , HUANG, Yuhua , DONG, Shuzhi , YANG, Dexi
IPC分类号： A61K31/41 , A61K31/192
CPC分类号： A61K31/546 , A61K31/407 , A61K31/41 , A61K31/427 , A61K31/43 , A61K31/44 , A61K31/496 , A61K45/06 , A61K2121/00 , C07D257/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/10 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/06 , C07D471/04 , C07D471/10 , C07D487/04 , A61K2300/00
摘要： The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
摘要翻译：本发明涉及金属β-内酰胺酶抑制剂的式I化合物，这种化合物的合成，以及这些化合物与β-内酰胺抗生素一起用于克服抗性的用途。

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