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1. 发明申请

WO2016118915A1 DEVICES AND SYSTEMS FOR MOLECULAR BARCODING OF NUCLEIC ACID TARGETS IN SINGLE CELLS 审中-公开
标题翻译：用于单细胞中核酸靶标分子克隆的设备和系统
公开(公告)号：WO2016118915A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/014612
申请日：2016-01-22
申请人： BECTON, DICKINSON AND COMPANY , LI, Sixing , HUANG, Xiaohua, Chen , METZLER, Kimberly, R. , WALCZAK, Elisabeth, Marie
发明人： LI, Sixing , HUANG, Xiaohua, Chen , METZLER, Kimberly, R. , WALCZAK, Elisabeth, Marie , FAN, Christina , FODOR, Stephen, P., A. , FU, Glenn , FACER, Geoff , STERN, David , LAI, Janice , CHANEY, Ari , SPUHLER, Phillip
IPC分类号： G01N35/10 , G01N35/08 , B01L3/02
CPC分类号： C12N15/1065 , B01L3/502715 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L2200/026 , B01L2200/0647 , B01L2300/06 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , B01L2300/12 , B01L2300/18 , B01L2400/082 , C12Q1/6846 , C12Q1/6874 , G01N35/0098 , C12Q2521/107 , C12Q2525/173 , C12Q2525/185 , C12Q2531/113 , C12Q2535/122 , C12Q2563/143 , C12Q2563/149
摘要： Disclosed herein are devices and systems comprising a) a substrate comprising at least 100 microwells and a plurality of beads, wherein a plurality of the at least 100 microwells each contain a single bead, and wherein the ratio of the average diameter of the microwells to the diameter of the beads ranges from about 1.2 to about 1.8; b) a flow cell in fluid communication with the substrate; and c) at least one inlet port and at least one outlet port, wherein the at least one inlet port and at least one outlet port are capable of directing a flow of a fluid through the flow cell, thereby contacting the microwells with the fluid.
摘要翻译：本文公开的装置和系统包括a）包含至少100个微孔和多个珠的基底，其中多个至少100个微孔各自包含单个珠，并且其中微孔的平均直径与珠的直径范围为约1.2至约1.8; b）与衬底流体连通的流动池; 以及c）至少一个入口端口和至少一个出口端口，其中所述至少一个入口端口和至少一个出口端口能够引导流体流过所述流动池，从而使所述微孔与所述流体接触。

2. 发明申请

WO2010068884A3 METHODS AND SYSTEMS FOR DIRECT SEQUENCING OF SINGLE DNA MOLECULES 审中-公开
标题翻译：用于直接测序单DNA分子的方法和系统
公开(公告)号：WO2010068884A3
公开(公告)日：2010-10-21
申请号：PCT/US2009067697
申请日：2009-12-11
申请人： UNIV CALIFORNIA , HUANG XIAOHUA
发明人： HUANG XIAOHUA
IPC分类号： C12Q1/68 , C12N15/10 , C12Q1/48
CPC分类号： C12Q1/6869 , C12N9/1252 , C12Q2565/101
摘要： The invention provides improved methods for sequencing nucleic acids, e.g., for medical applications and biomedical research. The disclosed methods can be applied to rapid personalized medicine, genetic diagnosis, pathogen identification, and sequencing species genomes.
摘要翻译：本发明提供了用于测序核酸的改进方法，例如用于医学应用和生物医学研究。所公开的方法可以应用于快速个性化医学，遗传诊断，病原体鉴定和测序物种基因组。

3. 发明申请

WO2008109207A9 METHODS AND DEVICES FOR BIOMOLECULAR ARRAYS 审中-公开
标题翻译：生物分子阵列的方法和装置
公开(公告)号：WO2008109207A9
公开(公告)日：2008-10-23
申请号：PCT/US2008052484
申请日：2008-01-30
申请人： UNIV CALIFORNIA , HUANG XIAOHUA , BARBEE KRISTOPHER D
发明人： HUANG XIAOHUA , BARBEE KRISTOPHER D
IPC分类号： B44C1/22 , C03C15/00 , C23F1/00
CPC分类号： G01N33/54346 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00576 , B01J2219/00648 , B01J2219/00655 , G01N33/54326 , G01N33/54353 , G03F7/00 , G03F7/16
摘要： The disclosure provides methods and devices for rapidly assembling high density biomolecular arrays.
摘要翻译：本公开提供了用于快速组装高密度生物分子阵列的方法和装置。

4. 发明申请

WO0129260A3 ALLELE DETECTION USING PRIMER EXTENSION WITH SEQUENCE-CODED IDENTITY TAGS 审中-公开
标题翻译：使用基于序列标识的标准扩展的ALLELE检测
公开(公告)号：WO0129260A3
公开(公告)日：2002-01-17
申请号：PCT/US0028284
申请日：2000-10-13
申请人： AFFYMETRIX INC , HUANG XIAOHUA , RYDER TOM , KAPLAN PAUL
发明人： HUANG XIAOHUA , RYDER TOM , KAPLAN PAUL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6858 , C12Q2525/161 , C12Q2535/125 , C12Q2565/501
摘要： A method for determining the genotype of one or more individuals at a polymorphic locus employs amplification of a region of DNA, labeling of allele-specific extension primers containing tags, and hybridization of the products to an array of probes. The genotype is identified from the pattern of hybridization. The method can also be used to determine the frequency of different alleles in a population.
摘要翻译：用于确定多态性位点处的一个或多个个体的基因型的方法使用扩增DNA区域，标记含有标签的等位基因特异性扩增引物，以及产物与探针阵列的杂交。从杂交模式中鉴定出基因型。该方法也可用于确定群体中不同等位基因的频率。

5. 发明申请

WO9830883A2 ANALYSIS OF GENETIC POLYMORPHISMS AND GENE COPY NUMBER 审中-公开
标题翻译：遗传多态性分析及遗传复制数
公开(公告)号：WO9830883A2
公开(公告)日：1998-07-16
申请号：PCT/US9806414
申请日：1998-01-02
申请人： AFFYMETRIX INC , CRONIN MAUREEN T , MIYADA CHARLES G , HUBBELL EARL A , CHEE MARK , FODOR STEPHEN P A , HUANG XIAOHUA C , LIPSHUTZ ROBERT J , LOBBAN PETER E , MORRIS MACDONALD S , SHELDON EDWARD L
发明人： CRONIN MAUREEN T , MIYADA CHARLES G , HUBBELL EARL A , CHEE MARK , FODOR STEPHEN P A , HUANG XIAOHUA C , LIPSHUTZ ROBERT J , LOBBAN PETER E , MORRIS MACDONALD S , SHELDON EDWARD L
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N
CPC分类号： B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6827 , C12Q1/6837 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B60/14 , C12Q2565/513
摘要： The invention provides methods for detecting variations in polymorphic sites and/or variations in gene copy number. The methods are particularly useful for analysis of biotransformation genes, such as cytochromes P450.
摘要翻译：本发明提供了用于检测多态位点变异和/或基因拷贝数变异的方法。该方法对生物转化基因如细胞色素P450的分析特别有用。

6. 发明申请

WO2012087772A1 INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS 审中-公开
标题翻译：用作ERK抑制剂的INDAZOLE衍生物
公开(公告)号：WO2012087772A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065318
申请日：2011-12-16
申请人： SCHERING CORPORATION , SHIPPS, Gerald, W., JR. , HUANG, Xiaohua , DENG, Yongqi , ZHU, Liang , COOPER, Alan, B. , SUN, Binyuan , ACHAB, Abdelghani Abe , LO, Sie-Mun
发明人： SHIPPS, Gerald, W., JR. , HUANG, Xiaohua , DENG, Yongqi , ZHU, Liang , COOPER, Alan, B. , SUN, Binyuan , ACHAB, Abdelghani Abe , LO, Sie-Mun
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： A61K31/4439 , A61K31/416 , A61K31/437 , A61K45/06 , C07D231/56 , C07D401/04 , C07D401/14 , C07D403/14 , C07D417/04 , C07D471/04 , A61K2300/00
摘要： The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R 1 , R 2 , R 3 , m and are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions that comprise the above compounds, and methods of treating cancer using the same.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，溶剂化物或酯，其中R，R 1，R 2，R 3，m如本文所定义。这些化合物是ERK抑制剂。还公开了包含上述化合物的药物组合物和使用其的癌症治疗方法。

7. 发明申请

WO2010117804A3 MOSTLY NATURAL DNA SEQUENCING BY SYNTHESIS 审中-公开
标题翻译：通过合成测序的大多数天然DNA
公开(公告)号：WO2010117804A3
公开(公告)日：2011-06-09
申请号：PCT/US2010029238
申请日：2010-03-30
申请人： UNIV CALIFORNIA , HUANG XIAOHUA , ROLLER ERIC
发明人： HUANG XIAOHUA , ROLLER ERIC
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/52
CPC分类号： C12Q1/6869 , C12Q2535/119 , C12Q2525/301 , C12Q2527/137 , C12Q2535/113
摘要： The invention provides a new method for DNA sequencing called "natural sequencing by synthesis" (nSBS). According to the method, DNA that includes a desired sequence is synthesized using a dNTP mix with a small percentage of fluorescently-labeled nucleotides. The fluorescent label is cleavable. In contrast to previous methods that utilize 100% labeled nucleic acids, use of a small percentage of labeled nucleic acids minimizes the distortion of the natural structure of the extending DNA strand and the DNA polymerase. Using the disclosed methods with less than 10,000 copies of template DNA and 10% of the nucleotides labeled, long homopolymer stretches up to 20 bases can be sequenced with high accuracy and Q20 (with 99% accuracy) read lengths of up to 1,000 bases can be achieved. A Q20 read length of greater than 100 bases can potentially be achieved, even if the sequencing is performed with 1,000 copies of a template and 10% of the nucleotides labeled.
摘要翻译：本发明提供了一种称为“合成天然测序”（nSBS）的DNA测序的新方法。根据该方法，使用具有小百分比的荧光标记核苷酸的dNTP混合物合成包含所需序列的DNA。荧光标记是可切割的。与使用100％标记的核酸的先前方法相比，使用小百分比的标记的核酸使延伸的DNA链和DNA聚合酶的天然结构的变形最小化。使用所公开的方法，使用少于10,000拷贝的模板DNA和10％标记的核苷酸，长均聚物延伸多达20个碱基可以高精度测序，Q20（具有99％的准确度）读取长度可达1,000个碱基可以实现。即使用1000份拷贝的模板和10％的标记的核苷酸进行测序，潜在地可以实现大于100个碱基的Q20读取长度。

8. 发明申请

WO2010117804A2 MOSTLY NATURAL DNA SEQUENCING BY SYNTHESIS 审中-公开
标题翻译：通过合成测序的大多数天然DNA
公开(公告)号：WO2010117804A2
公开(公告)日：2010-10-14
申请号：PCT/US2010/029238
申请日：2010-03-30
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HUANG, Xiaohua , ROLLER, Eric
发明人： HUANG, Xiaohua , ROLLER, Eric
IPC分类号： C12Q1/68 , C12N15/11 , G01N33/52
CPC分类号： C12Q1/6869 , C12Q2535/119 , C12Q2525/301 , C12Q2527/137 , C12Q2535/113
摘要： The invention provides a new method for DNA sequencing called "natural sequencing by synthesis" (nSBS). According to the method, DNA that includes a desired sequence is synthesized using a dNTP mix with a small percentage of fluorescently-labeled nucleotides. The fluorescent label is cleavable. In contrast to previous methods that utilize 100% labeled nucleic acids, use of a small percentage of labeled nucleic acids minimizes the distortion of the natural structure of the extending DNA strand and the DNA polymerase. Using the disclosed methods with less than 10,000 copies of template DNA and 10% of the nucleotides labeled, long homopolymer stretches up to 20 bases can be sequenced with high accuracy and Q20 (with 99% accuracy) read lengths of up to 1,000 bases can be achieved. A Q20 read length of greater than 100 bases can potentially be achieved, even if the sequencing is performed with 1,000 copies of a template and 10% of the nucleotides labeled.
摘要翻译：本发明提供了一种称为“合成天然测序”（nSBS）的DNA测序的新方法。根据该方法，使用具有小百分比的荧光标记核苷酸的dNTP混合物合成包含所需序列的DNA。荧光标记是可切割的。与使用100％标记的核酸的先前方法相比，使用小百分比的标记的核酸使延伸的DNA链和DNA聚合酶的天然结构的变形最小化。使用所公开的方法，使用少于10,000拷贝的模板DNA和10％标记的核苷酸，长均聚物延伸多达20个碱基可以高精度测序，Q20（具有99％的准确度）读取长度可达1,000个碱基可以实现。即使用1000份拷贝的模板和10％的标记的核苷酸进行测序，潜在地可以实现大于100个碱基的Q20读取长度。

9. 发明申请

WO2010056631A1 INHIBITORS OF FATTY ACID BINDING PROTEIN (FABP) 审中-公开
标题翻译：脂肪酸结合蛋白抑制剂（FABP）
公开(公告)号：WO2010056631A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/063787
申请日：2009-11-10
申请人： SCHERING CORPORATION , SHIPPS, JR., Gerald, W. , CHENG, Cliff, C. , HUANG, Xiaohua , ACHAB, Abdelghani, Abe , ORTH, Peter , VOIGT, Johannes, H. , SOUCY, Kyle, Ann
发明人： SHIPPS, JR., Gerald, W. , CHENG, Cliff, C. , HUANG, Xiaohua , ACHAB, Abdelghani, Abe , ORTH, Peter , VOIGT, Johannes, H. , SOUCY, Kyle, Ann
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates to novel heterocyclic compounds as Fatty Acid Binding Protein ("FABP") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the present invention is shown below: (I)
摘要翻译：本发明涉及作为脂肪酸结合蛋白（“FABP”）抑制剂的新型杂环化合物，包含杂环化合物的药物组合物和用于治疗或预防心血管疾病，代谢障碍，肥胖或肥胖相关的化合物的用途糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。本发明的说明性化合物如下所示：（I）

10. 发明申请

WO2009058729A3 THIAZOLE CARBOXAMIDE DERIVATIVES AND THEIR TO TREAT CANCER 审中-公开
标题翻译：噻唑羧酰胺衍生物及其治疗癌症
公开(公告)号：WO2009058729A3
公开(公告)日：2009-06-25
申请号：PCT/US2008081317
申请日：2008-10-27
申请人： SCHERING CORP , SHIPPS GERALD W JR , RICHARDS MATTHEW , CHENG CLIFF C , HUANG XIAOHUA
发明人： SHIPPS GERALD W JR , RICHARDS MATTHEW , CHENG CLIFF C , HUANG XIAOHUA
IPC分类号： C07D417/14 , A61K31/427 , A61P35/00
CPC分类号： C07D417/14
摘要： The present invention relates to novel Heterocyclic Ether or Thioether Derivatives, compositions comprising the Heterocyclic Ether or Thioether Derivatives, and methods for using the Heterocyclic Ether or Thioether Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.
摘要翻译：本发明涉及新颖的杂环醚或硫醚衍生物，包含杂环醚或硫代醚衍生物的组合物，以及使用杂环醚或硫代醚衍生物治疗或预防增殖性病症，抗增殖性疾病，炎症，关节炎，中枢神经系统疾病，心血管疾病，脱发，神经元疾病，缺血性损伤，病毒感染，真菌感染或与蛋白激酶的活性相关的病症。

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