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1. 发明申请

WO2007100954A3 IMAGE RECONSTRUCTION USING DATA ORDERING 审中-公开
公开(公告)号：WO2007100954A3
公开(公告)日：2007-09-07
申请号：PCT/US2007/061595
申请日：2007-02-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HU, Zhiqiang , WANG, Wenli , GAGNON, Daniel
发明人： HU, Zhiqiang , WANG, Wenli , GAGNON, Daniel
IPC分类号： G06T11/00
摘要： Methods, systems and apparatuses for processing data associated with nuclear medical imaging techniques are provided. Data is ordered in LUT's and memory structures. Articles of manufacture are provided for causing computers to carry out aspects of the invention. Data elements are ordered into a plurality of ordered data groups according to a spatial index order, and fetched and processed in the spatial index order. The data elements include sensitivity matrix elements, PET annihilation event data, and system and image matrix elements, the data grouped in orders corresponding to their processing. In one aspect geometric symmetry of a PET scanner FOV is used in ordering the data and processing. In one aspect a system matrix LUT comprises total number of system matrix elements equal to a total number of image matrix elements divided by a total number of possible third index values.

2. 发明申请

WO2007054843A1 PET IMAGING USING ANATOMIC LIST MODE MASK 审中-公开
标题翻译： PET成像使用解剖列表模式掩模
公开(公告)号：WO2007054843A1
公开(公告)日：2007-05-18
申请号：PCT/IB2006/053824
申请日：2006-10-17
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , WANG, Wenli , HU, Zhiqiang
发明人： GAGNON, Daniel , WANG, Wenli , HU, Zhiqiang
IPC分类号： G01T1/29 , G06T11/00
CPC分类号： G01T1/2985 , A61B6/037 , G01T1/1611 , G06T11/006 , G06T2211/424
摘要： A method and apparatus are provided for reconstructing list mode data acquired during a positron emission tomography scan of an object, the data including information indicative of a plurality of detected positron annihilation events. Detected events occurring in a region of interest are identified; the identified events are reconstructed using an iterative reconstruction technique which includes a ray tracing operation to generate volumetric data indicative of the region of interest, wherein the ray tracing operation traces only image matrix elements located in the region of interest; and a human readable image indicative of the volumetric data is generated. In another aspect an image mask and a projection mask are defined correlating to the region of interest; image matrix elements located in the region of interest are determined by applying the image mask; and detected events occurring in a region of interest are identified by applying the projection mask.
摘要翻译：提供了一种方法和装置，用于重构在对象的正电子发射断层摄影扫描期间获取的列表模式数据，该数据包括指示多个检测到的正电子湮灭事件的信息。确定在感兴趣区域发生的检测事件; 使用迭代重建技术来重建所识别的事件，所述迭代重建技术包括用于产生指示感兴趣区域的体积数据的光线跟踪操作，其中光线跟踪操作仅跟踪位于感兴趣区域中的图像矩阵元素; 并产生指示体积数据的人类可读取的图像。在另一方面，图像掩模和投影掩模被定义为与感兴趣区域相关; 通过应用图像掩模来确定位于感兴趣区域中的图像矩阵元素; 并且通过应用投影掩模来识别在感兴趣区域中发生的检测到的事件。

3. 发明申请

WO2007039841A3 METHOD AND SYSTEM FOR PET IMAGE RECONSTRUCTION USING A SURROGATE IMAGE 审中-公开
公开(公告)号：WO2007039841A3
公开(公告)日：2007-04-12
申请号：PCT/IB2006/053287
申请日：2006-09-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GAGNON, Daniel , WANG, Wenli , HU, Zhiqiang
发明人： GAGNON, Daniel , WANG, Wenli , HU, Zhiqiang
IPC分类号： G06T11/00 , G01T1/00
摘要： A method and system for use in positron emission tomography, wherein a first processor element (234) is configured to reconstruct a plurality of positron annihilation events detected during a positron emission tomography scan using a list-based reconstruction technique to generate first volumetric data. A second reconstructor (226) is configured to reconstruct the plurality of events using a second reconstruction technique to generate second volumetric data for determining an error correction (228), the error correction applied to the first volumetric data to generate corrected volumetric data for generating a human-readable image (234). In one embodiment a multiplicative error correction is performed on the plurality of events, the first processor element (234) reconstructing the corrected plurality of events; and the second volumetric data error correction comprises an additive error correction.

4. 发明申请

WO2006054193A1 OPTIMAL CONVERSION OF 3D IMAGE SETS BETWEEN DIFFERENT SPACES 审中-公开
标题翻译：三维图像集在不同空间之间的最优转换
公开(公告)号：WO2006054193A1
公开(公告)日：2006-05-26
申请号：PCT/IB2005/053630
申请日：2005-11-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GAGNON, Daniel , WANG, Wenli
发明人： GAGNON, Daniel , WANG, Wenli
IPC分类号： G06T3/00
CPC分类号： G06T3/4061 , A61B6/583
摘要： A multi-modality system (10) includes a nuclear imaging system (12) and a computed tomography (CT) scanner (14). The nuclear system (12) includes a PET scanner (28) which acquires electronic data that is reconstructed into a PET blob image by a PET reconstruction processor (50). The CT scanner (14) acquires the scanned data which is reconstructed into a 3D CT voxel image by a CT reconstruction processor (56). An interpolation processor (62) interpolates the PET blob image directly into the CT voxel space. Once the PET and CT images are in the same space, they are combined by a combining means (110). A video processor (66) processes the received composite PET-CT data for a display on a monitor (68).
摘要翻译：多模态系统（10）包括核成像系统（12）和计算机断层摄影（CT）扫描器（14）。核系统（12）包括PET扫描器（28），其通过PET重建处理器（50）获取被重建为PET斑点图像的电子数据。 CT扫描器（14）通过CT重建处理器（56）获取重建成3D CT体素图像的扫描数据。插值处理器（62）将PET斑点图像直接内插到CT体素空间中。一旦PET和CT图像在相同的空间中，它们通过组合装置（110）组合。视频处理器（66）处理所接收的复合PET-CT数据以用于监视器（68）上的显示。

5. 发明申请

WO2009138898A1 USING NON-ATTENUATION CORRECTED PET EMISSION IMAGES TO COMPENSATE FOR INCOMPLETE ANATOMIC IMAGES 审中-公开
标题翻译：使用非衰减校正的PET排放图像补偿不完整的解剖图像
公开(公告)号：WO2009138898A1
公开(公告)日：2009-11-19
申请号：PCT/IB2009/051825
申请日：2009-05-04
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , HU, Zhiqiang , GAGNON, Daniel , TUNG, Chia-Hua
发明人： HU, Zhiqiang , GAGNON, Daniel , TUNG, Chia-Hua
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , G06T2211/424 , G06T2211/432
摘要： When compensating for truncated patient scan data acquired by a multi¬ modal PET/CT or PET/MR imaging system (14, 16), such as occurs when a patient is larger than a field of view for an anatomical imaging device, a segmented contour of a non- attenuation-corrected (NAC) PET image is used to identify a contour of the truncated region. An appropriate tissue type is used to fill in truncated regions of a truncated CT or MR image for the attenuation map. The corrected attenuation map is then used to generate an attenuation-corrected PET image of the patient or a region of interest. Alternatively, the system can be employed in PET/CT or PET/MR imaging scenarios where two modalities are performed sequentially (e.g., not simultaneously), and thus the contour derived from the PET scan can be compared to the CT or MR image to infer potential subject motion between the PET and CT or MR scans. Additionally, the system can be employed in PET imaging scenarios where the contour derived from the NAC PET image is used as emission boundary for scatter correction using single-scatter simulation, in which a tail-fitting procedure utilizes an emission boundary to define pure-scatter tails (e.g., in the absence of true coincidence events).
摘要翻译：当补偿由多模PET / CT或PET / MR成像系统（14,16）获取的截断的患者扫描数据时，例如当患者大于解剖成像装置的视野时发生，分段轮廓使用非衰减校正（NAC）PET图像来识别截断区域的轮廓。使用适当的组织类型来填充用于衰减图的截断的CT或MR图像的截断区域。然后校正的衰减图用于产生患者或感兴趣区域的衰减校正的PET图像。或者，该系统可以用于PET / CT或PET / MR成像场合，其中顺序执行两种模式（例如，不同时执行），因此可以将从PET扫描导出的轮廓与CT或MR图像进行比较以推断 PET和CT或MR扫描之间的潜在主体运动。此外，该系统可以用于PET成像场景，其中从NAC PET图像导出的轮廓用作使用单分散模拟的散射校正的发射边界，其中尾部拟合过程利用发射边界来定义纯散射尾巴（例如，没有真正的巧合事件）。

6. 发明申请

WO2007052211A1 METHOD AND SYSTEM FOR PET IMAGE RECONSTRUCTION USING PORTION OF EVENT DATA 审中-公开
标题翻译：使用事件数据部分进行PET图像重构的方法和系统
公开(公告)号：WO2007052211A1
公开(公告)日：2007-05-10
申请号：PCT/IB2006/054013
申请日：2006-10-30
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GAGNON, Daniel , KOLTHAMMER, Jeffrey, A.
发明人： GAGNON, Daniel , KOLTHAMMER, Jeffrey, A.
IPC分类号： G06T11/00
CPC分类号： A61B6/037 , G06T11/006
摘要： A method and system for use in positron emission tomography, wherein a list-based reconstructor means (129) is configured to generate first portion volumetric data responsive to a first portion of a plurality of positron annihilation events detected during a positron emission tomography scan; generate a human-readable image indicative of the first portion volumetric data; use a list-based reconstruction technique to generate composite volumetric data responsive to the first portion volumetric data and a second portion of the plurality of positron annihilation events; and generate a composite human-readable image indicative of the composite volumetric data. In another aspect the reconstructor (129) is configured to selecting first or second portion event quantities responsive to one or more parameters including image definition requirements and processing time requirements.
摘要翻译：一种用于正电子发射断层摄影的方法和系统，其中基于列表的重建器装置（129）被配置为响应于在正电子发射断层摄影扫描期间检测到的多个正电子湮灭事件的第一部分而产生第一部分体积数据; 生成指示第一部分体积数据的人类可读图像; 使用基于列表的重建技术来响应于第一部分体积数据和多个正电子湮灭事件的第二部分来生成复合体积数据; 并生成指示复合体积数据的复合人类可读图像。在另一方面，重建器（129）被配置为响应于包括图像定义要求和处理时间要求的一个或多个参数来选择第一或第二部分事件量。

7. 发明申请

WO2006114717A1 ECG-GATED TEMPORAL SAMPLING IN CARDIAC KINETIC MODELING 审中-公开
标题翻译：心电图动态建模中的心电门静脉采样
公开(公告)号：WO2006114717A1
公开(公告)日：2006-11-02
申请号：PCT/IB2006/051092
申请日：2006-04-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , BRAESS, Henning
发明人： GAGNON, Daniel , BRAESS, Henning
IPC分类号： A61B5/04
CPC分类号： A61B6/541 , A61B5/02755 , A61B5/7289 , A61B6/037 , A61B6/5288 , A61B8/5276 , A61B8/543
摘要： In a diagnostic imaging system (10), a monitor (50) monitors periodic biological cycles of the subject (14). A trigger point detector (60) detects a time (tl, t2, ..., tn) of a common, reoccurring reference point (Rl, R2, ..., Rn) in each periodic cycle of the subject (14). A sequence selector (62) selects a sequence (64) of nominal sampling segments (Si, S2, ..., Sn). An adjustor (70) adjusts duration of each nominal sampling segment (Si, S2, ..., Sn) to coincide with the times of detected reference points (Rl, R2, ..., Rn). A scaling processor (72) scales each adjusted segment based on a difference in duration between the corresponding nominal (Si, S2, ..., Sn) and adjusted sampling segments (S'i, S'2, ..., S'n).
摘要翻译：在诊断成像系统（10）中，监视器（50）监视对象（14）的周期性生物学周期。触发点检测器（60）检测对象（14）的每个周期循环中的共同的重现的参考点（R1，R2，...，Rn）的时间（t1，t2，...，tn）。序列选择器（62）选择标称采样段（Si，S2，...，Sn）的序列（64）。调节器（70）调整每个标称采样段（Si，S2，...，Sn）的持续时间以与检测到的参考点（R1，R2，...，Rn）的时间一致。缩放处理器（72）基于相应的标称（Si，S2，...，Sn）和调整的采样段（S'i，S'2，...，S'）之间的持续时间差来缩放每个经调整的段， N）。

8. 发明申请

WO2010032167A2 MR SEGMENTATION USING TRANSMISSION DATA IN HYBRID NUCLEAR/MR IMAGING 审中-公开
标题翻译：在混合核/ MR成像中使用传输数据的MR分段
公开(公告)号：WO2010032167A2
公开(公告)日：2010-03-25
申请号：PCT/IB2009/053944
申请日：2009-09-09
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , HU, Zhiquiang
发明人： GAGNON, Daniel , HU, Zhiquiang
CPC分类号： G01R33/481 , G01R33/5608 , G06T7/11 , G06T2207/10088 , G06T2207/10104 , G06T2207/30004
摘要： When correcting attenuation in a nuclear image (e.g., PET or SPECT), an MR-based attenuation correction (AC) map (16) is generated using MR image data (14) of a subject (60). The subject (60) is then placed in a nuclear imaging device with a radioactive point or line source (18, 18') from which transmission data is measured as the patient is imaged. In order to resolve ambiguity between air voxels and bone voxels in the MR-based AC map (16), estimated transmission data (24) is generated from the AC map and compared to the measured transmission data (22) from the point or line source. An error is iteratively calculated for the estimated and measured transmission data, and attenuation values of the AC map (16) are refined to minimize the error. The refined AC map (32) is used to correct attenuation in collected nuclear data (41) which is reconstructed into an attenuation corrected image (99) of the patient.
摘要翻译：当校正核图像（例如PET或SPECT）中的衰减时，使用对象（60）的MR图像数据（14）来生成基于MR的衰减校正（AC）图（16）。然后将受试者（60）放置在具有放射性点或线源（18,18'）的核成像装置中，当患者被成像时，将从该成像装置测量透射数据。为了解决基于MR的AC映射（16）中的空气体素和骨骼体素之间的模糊性，从AC映射产生估计的传输数据（24），并与来自点或线源的测量的传输数据（22）进行比较。对估计和测量的传输数据迭代地计算误差，并且AC图（16）的衰减值被改进以使误差最小化。精细AC图（32）用于校正收集的核数据（41）中的衰减，其被重建为患者的衰减校正图像（99）。

9. 发明申请

WO2007020543A1 POSITRON EMISSION TOMOGRAPHY TIME-OF-FLIGHT LIST MODE RECONSTRUCTION WITH DETECTOR RESPONSE FUNCTION 审中-公开
标题翻译： POSITRON排放TOMOGRAPHY具有检测器响应功能的飞行时间列表模式重建
公开(公告)号：WO2007020543A1
公开(公告)日：2007-02-22
申请号：PCT/IB2006/052583
申请日：2006-07-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , KARP, Joel , POPESCU, Lucretiu, M.
发明人： GAGNON, Daniel , KARP, Joel , POPESCU, Lucretiu, M.
IPC分类号： G01T1/29 , G06T11/00
CPC分类号： G01T1/2985 , G06T11/006
摘要： A PET system includes an improved image reconstruction algorithm based on an improved modeling of the point-spread function. PET time of flight data is used to obtain a mean emitting point and a time of flight probability function. This information is then used to model the point-spread function. The time of flight probability function and the detector response function are used to define a probability volume for a given line of response, which is then used in the reconstruction of the image.
摘要翻译： PET系统包括基于点扩散函数的改进建模的改进的图像重建算法。 PET飞行时间数据用于获得平均发射点和飞行时间概率函数。然后将该信息用于对点扩散函数建模。飞行时间概率函数和检测器响应函数用于定义给定响应线的概率体积，然后将其用于图像的重建。

10. 发明申请

WO2009144607A2 GEOMETRICAL TRANSFORMATIONS PRESERVING LIST-MODE FORMAT 审中-公开
标题翻译：几何变换保存列表模式格式
公开(公告)号：WO2009144607A2
公开(公告)日：2009-12-03
申请号：PCT/IB2009/051987
申请日：2009-05-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , GAGNON, Daniel , OLIVIER, Patrick , KHURD, Parmeshwar, Kishore
发明人： GAGNON, Daniel , OLIVIER, Patrick , KHURD, Parmeshwar, Kishore
CPC分类号： G01T1/1648 , A61B6/037 , G06T11/005
摘要： A diagnostic imaging device includes detector elements (16) for detecting γ- rays indicative of nuclear decay events. The detected γ-rays are used to produce lines of response (LORs) (46), which are time stamped (20) and stored in list mode. The LORs are reconstructed (34) into an image. An image analysis processor (38) analyzes the image for motion artifacts and iteratively adjusts an event transform processor (30) to transform selected LORs to minimize the motion artifacts. If the transformed LOR (50) does not correspond with a pair of detector elements (16), closest detector elements (52, 54) are determined. Candidate LORs (62) are created between the closest and neighboring detector elements. An event location (40) on an LOR (46) is determined from the time-of- flight (TOF) information and then transformed (47) to generate a transformed event location (48). The candidate LOR (62) which most nearly intersects the transformed event location (40) and the appropriately updated TOF information is selected for use in image reconstruction.
摘要翻译：诊断成像装置包括用于检测指示核衰变事件的γ射线的检测器元件（16）。检测到的γ射线用于产生响应列（LOR）（46），它们是时间戳的（20）并以列表模式存储。 LOR被重构（34）成为图像。图像分析处理器（38）分析运动伪影的图像并迭代地调整事件变换处理器（30）以变换所选择的LOR以最小化运动伪影。如果变换的LOR（50）不对应于一对检测器元件（16），则确定最近的检测器元件（52,54）。在最近和相邻的检测器元件之间创建候选LOR（62）。从飞行时间（TOF）信息确定LOR（46）上的事件位置（40），然后变换（47）以生成转换的事件位置（48）。选择与变换的事件位置（40）最接近相交的候选LOR（62）和适当更新的TOF信息用于图像重建。

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