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1. 发明申请

WO2005025588A1 EXTRACT OF OGALPI, ERECTILE DYSFUNCTION FANNING HEALTHY FOOD AND ERECTILE DYSFUNCTION TREATING AGENT CONTAINING THE SAME 审中-公开
标题翻译： OGALPI的提取物，精神分裂症功能性食物健康食品和含有其的精神分裂症治疗剂
公开(公告)号：WO2005025588A1
公开(公告)日：2005-03-24
申请号：PCT/KR2004/002338
申请日：2004-09-14
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Jung Joon , LEE, Jeong-Hyung , HONG, Young Soo , KIM, Young Ho , CHOI, Young Deuk
发明人： LEE, Jung Joon , LEE, Jeong-Hyung , HONG, Young Soo , KIM, Young Ho , CHOI, Young Deuk
IPC分类号： A61K35/78
CPC分类号： A23L33/105 , A21D2/14 , A21D2/36 , A21D13/80 , A23G1/48 , A23G3/48 , A23G4/068 , A23G9/42 , A23L2/52 , A61K36/254
摘要： The present invention relates to an alcohol extract of ogalpi, erectile dysfunction improving health food and a treating agent containing the same, more precisely, an alcohol extract of ogalpi having an effect of improving erectile dysfunction, erectile dysfunction improving health food and an erectile dysfunction treating agent containing the same. The alcohol extract of ogalpi of the present invention has a promoting effect of penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.
摘要翻译：本发明涉及一种卵黄醇提取物，改善健康食品的勃起功能障碍及含有该成分的治疗剂，更准确地说，是具有改善勃起功能障碍，改善勃起功能障碍的健康食品和勃起功能障碍治疗的卵黄醇提取物含有相同的代理本发明的欧氏提取物具有阴茎勃起的促进作用，因此可以有效地用于改善勃起功能障碍。

2. 发明申请

WO2003061553A2 AN EXTRACT OF ACANTHOPANAX KOREANUM FOR THE TREATMENT OR PREVENTION OF HEPATITIS OR THE LIVER PROTECTIVE DRUG 审中-公开
标题翻译： ACANTHOPANAX KOREANUM用于治疗或预防乙型肝炎或肝脏保护性药物的提取物
公开(公告)号：WO2003061553A2
公开(公告)日：2003-07-31
申请号：PCT/KR2003/000155
申请日：2003-01-24
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Jung, Joon , LEE, Jeong-Hyung , HONG, Young, Soo , KIM, Young, Ho , NAM, Jeong, Bum , SOHN, Dong, Hwan , KIM, Hang, Sub
发明人： LEE, Jung, Joon , LEE, Jeong-Hyung , HONG, Young, Soo , KIM, Young, Ho , NAM, Jeong, Bum , SOHN, Dong, Hwan , KIM, Hang, Sub
IPC分类号： A61K
CPC分类号： A61K36/254
摘要： The disclosure concerns an extract of Acanthopanax Koreanum and its use. More particularly, it concerns the extract of Acanthopanax Koreanum comprising: 1) the extract of Acanthopanax Koreanum extracted from water; 2) among the water extract, the extract of Acanthopanax Koreanum only containing ethanol insoluble part obtained by precipitating ethanol; 3) among the ethanol insoluble part, the extract of Acanthopanax Koreanum containing polysaccharide with a molecular weight larger than range of 12,000 ∼ 14,000; or 4) among the ethanol insoluble part, the extract of Acanthopanax Koreanum containing polysaccaride with a molecular weight over 100,000, which is respectively obtained from the root or stem of Acanthopanax Koreanum. The extract of the present invention shows a high inhibition activity against hepatitis and protects the liver, and thus, can be usefully used for the treatment or prevention of hepatitis, or as a liver protective drug.
摘要翻译：本公开涉及刺五加提取物及其用途。更具体地，涉及刺五加提取物，包括：1）从水中提取的刺五加提取物; 2）在水提取物中，刺五加提取物只含乙醇不溶部位，通过沉淀乙醇得到; 3）在乙醇不溶部位中，刺五加含有分子量大于12,000〜14000范围的多糖的提取物; 或4）在乙醇不溶部分中，分子量超过100,000的刺五加含有多糖的提取物分别从刺五加的根或茎获得。本发明的提取物显示出对肝炎的高抑制活性并保护肝脏，因此可用于治疗或预防肝炎或作为肝保护性药物。

3. 发明申请

WO2008004798A8 COMPOUNDS THAT INHIBIT HIF-1 ACTIVITY, THE METHOD FOR PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM AS AN EFFECTIVE COMPONENT 审中-公开
标题翻译：抑制HIF-1活性的化合物，其制备方法和作为有效成分的药物组合物
公开(公告)号：WO2008004798A8
公开(公告)日：2009-08-13
申请号：PCT/KR2007003216
申请日：2007-07-03
申请人： KOREA RES INST OF BIOSCIENCE , LEE JUNG JOON , LEE JEONG-HYUNG , LEE KYEONG , HONG YOUNG-SOO , SHANTHAVEERAPPA B K , JIN YINLAN , KIM JIN HWAN , JIN XUEJUN
发明人： LEE JUNG JOON , LEE JEONG-HYUNG , LEE KYEONG , HONG YOUNG-SOO , SHANTHAVEERAPPA B K , JIN YINLAN , KIM JIN HWAN , JIN XUEJUN
IPC分类号： C07C271/28
CPC分类号： C07C237/42 , C07C235/24 , C07C255/60 , C07C271/42 , C07C307/02 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D213/38 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D235/12 , C07D257/04 , C07D263/56 , C07D307/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer, stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
摘要翻译：本文公开了HIF-1抑制剂，其制备方法和包含其的药物组合物作为活性成分HIF-1抑制剂由于对HIF-1的抑制活性而显示抗癌活性，HIF-1是一种转录因子在癌症的生长和转移中起重要作用，但不是一般的细胞毒性。因此，HIF抑制剂及其药学上可接受的盐可以用作各种癌症如肝癌，胃癌和乳腺癌的治疗剂。此外，对HIF-1具有抑制活性的化合物可用于治疗由HIF-1介导的VEGF表达而恶化的糖尿病性视网膜病变和关节炎。

4. 发明申请

WO2008039008A1 COMPOSITION FOR THE PREVENTION AND TREATMENT OF METABOLIC DISORDER CONTAINING BENZAZOLE DERIVATIVES AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：用于预防和治疗含有苯并唑衍生物的代谢紊乱作为活性成分的组合物
公开(公告)号：WO2008039008A1
公开(公告)日：2008-04-03
申请号：PCT/KR2007/004724
申请日：2007-09-27
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Hyun Sun , LEE, Kyeong , LEE, Jung Joon , KIM, Young Kook , RHO, Mun-Chual , LEE, Jeong Hyung , HONG, Young Soo , PARK, Hye-Ran , LEE, Chul-Ho , CHOI, Yongseok
发明人： LEE, Hyun Sun , LEE, Kyeong , LEE, Jung Joon , KIM, Young Kook , RHO, Mun-Chual , LEE, Jeong Hyung , HONG, Young Soo , PARK, Hye-Ran , LEE, Chul-Ho , CHOI, Yongseok
IPC分类号： A61K31/423
CPC分类号： A61K31/423
摘要： Disclosed is a composition for the prevention and treatment of metabolic diseases, which comprises a benzazole derivative as an active ingredient. The benzazole derivative has inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, thus, the composition is useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.
摘要翻译：公开了用于预防和治疗代谢疾病的组合物，其包含作为有效成分的苯并唑衍生物。苯并唑衍生物对脂质代谢过程中引起代谢性疾病如肥胖和糖尿病的DGAT（二酰基甘油酰基转移酶）具有抑制活性。具有有效控制脂质代谢和能量代谢的能力，因此，该组合物可用于预防和治疗诸如肥胖症和糖尿病的代谢疾病。

5. 发明申请

WO2008038877A1 GELDANAMYCIN DERIVATIVES BY MODIFICATION OF BIOSYNTHETIC GENES 审中-公开
标题翻译：通过修饰生物基因的GELDANAMYCIN衍生物
公开(公告)号：WO2008038877A1
公开(公告)日：2008-04-03
申请号：PCT/KR2007/002054
申请日：2007-04-26
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , HONG, Young-Soo , LEE, Jung Joon , LEE, Kyeong , LEE, Dongho , KIM, Woncheol , SHIN, Jin Chul
发明人： HONG, Young-Soo , LEE, Jung Joon , LEE, Kyeong , LEE, Dongho , KIM, Woncheol , SHIN, Jin Chul
IPC分类号： C07D313/00
CPC分类号： C07D498/08 , C07D225/02 , C12P17/10
摘要： The present invention relates to geldanamycin derivatives, benzoquinone ansamycin, biosynthesized by a genetic modification of Streptomyces hygroscopicus subsp. duamyceticus, in particular, to polyketide genetic mutant (AC3 strain), ge17, ge116 or ge17&ge18 double-gene inactive mutant strain and geldanamycin derivatives, 1Ab, 1Ba, 1Bb, 1Bc, 1Ca, 1Cb, 1Cc 1Cd, and 1Cd, obtained from said mutants among a biosynthetic genes modification of Streptomyces hygroscopicus subsp. duamyceticus. The geldanamycin derivatives of the present invention represents an action of suppressing Hsp90 similarly to geldanamycin, thereby being available for being used as antibiotic agent, antifungal agent, anti-viral agent, immune-suppressive agent, therapeutic agent of neurodegenerative disorders, anti-inflammatory agent or anti-cancer agent and the like.
摘要翻译：本发明涉及通过吸水链霉菌亚种的遗传修饰生物合成的格尔德霉素衍生物苯醌安莎霉素。杜马霉素，特别是从所述的抗氧化剂衍生的聚酮化合物遗传突变体（AC3株），ge17，ge116或ge17＆ge18双基因无活性突变菌株和格尔德霉素衍生物，1Ab，1Ba，1Bb，1Bc，1Ca，1Cb，1Cc 1Cd和1Cd 链霉菌吸水链霉菌亚种的生物合成基因修饰中的突变体 duamyceticus。本发明的格尔德霉素衍生物代表与格尔德霉素类似地抑制Hsp90的作用，因此可用作抗生素，抗真菌剂，抗病毒剂，免疫抑制剂，神经变性疾病的治疗剂，抗炎药或抗癌剂等。

6. 发明申请

WO2008004798A1 COMPOUNDS TEAT INHIBIT HBF-I ACTIVITY, THE METHOD FOR PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION CONTAINING THEM AS AN EFFECTIVE COMPONENT 审中-公开
标题翻译：化合物抑制HBF-1活性，其制备方法和含有有效成分的药物组合物
公开(公告)号：WO2008004798A1
公开(公告)日：2008-01-10
申请号：PCT/KR2007/003216
申请日：2007-07-03
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Jung Joon , LEE, Jeong-Hyung , LEE, Kyeong , HONG, Young-Soo , SHANTHAVEERAPPA, B.K. , JIN, Yinlan , KIM, Jin Hwan , JIN, Xuejun
发明人： LEE, Jung Joon , LEE, Jeong-Hyung , LEE, Kyeong , HONG, Young-Soo , SHANTHAVEERAPPA, B.K. , JIN, Yinlan , KIM, Jin Hwan , JIN, Xuejun
IPC分类号： C07C271/28
CPC分类号： C07C237/42 , C07C235/24 , C07C255/60 , C07C271/42 , C07C307/02 , C07C311/46 , C07C317/40 , C07C2603/74 , C07D213/38 , C07D213/75 , C07D213/79 , C07D213/80 , C07D213/81 , C07D235/12 , C07D257/04 , C07D263/56 , C07D307/52 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed herein are an HIF-I inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient The BDDF-I inhibitor shows anticancer activity thanks to the inhibition activity against HIF-I, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer, stomach cancer and breast cancer. Also, the compound having inhibition activity against HDDF-I is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HEF-l-mediated VEGF expression.
摘要翻译：本文公开了HIF-1抑制剂，其制备方法和包含其的药物组合物作为活性成分BDDF-1抑制剂由于对HIF-1的抑制活性显示抗癌活性，HIF-1是一种转录因子在癌症的生长和转移中起重要作用，但不是一般的细胞毒性。因此，HIF抑制剂及其药学上可接受的盐可以用作各种癌症如肝癌，胃癌和乳腺癌的治疗剂。此外，具有对HDDF-1的抑制活性的化合物可用于治疗由HEF-1介导的VEGF表达加重的糖尿病性视网膜病变和关节炎。

7. 发明申请

WO2002074110A1 HEALTH UNDERPANTS 审中-公开
标题翻译：健康服务
公开(公告)号：WO2002074110A1
公开(公告)日：2002-09-26
申请号：PCT/KR2001/000336
申请日：2001-03-05
申请人： HONG, Young-Soo
发明人： HONG, Young-Soo
IPC分类号： A41B9/02
CPC分类号： A41B9/02
摘要： Disclosed is a health underwear allowing a mass production by simplifying the construction thereof. The underwear comprises a body (100) having a waist band (110), a fabric panel (120), and a leg gripping band (130), and a healthy mechanism detachable to the waist band and having a penis wire (210), scrotum wires (220a and 220b), penis training wires (230a and 230b), penis supporting wires (250a and 250b), actuating force transmitting members (240a and 240b), and reverse guide wires (260a and 260b). With the construction, the health underwear has a simple construction, and is a help to men suffering from sexual problems.
摘要翻译：公开了通过简化其构造允许批量生产的健康内衣。所述内衣包括具有腰带（110），织物面板（120）和腿部抓持带（130）的主体（100），以及可拆卸到所述腰带并具有阴茎线（210）的健康机构，阴茎线（220a和220b），阴茎训练线（230a和230b），阴茎支撑线（250a和250b），致动力传递部件（240a和240b）以及反向导丝（260a和260b）。随着施工，保健内衣的施工简单，是对性问题的男人的帮助。

8. 发明申请

WO2008093912A1 NOVEL ANSAMYCIN DERIVATIVES AND THE METHOD FOR MUTATIONAL BIOSYNTHESIS THEREOF 审中-公开
标题翻译：新的阿萨米辛衍生物及其生物合成的方法
公开(公告)号：WO2008093912A1
公开(公告)日：2008-08-07
申请号：PCT/KR2007/002378
申请日：2007-05-15
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , HONG, Young-Soo , LEE, Jung Joon , LEE, Kyeong , KIM, Woncheol , CAI, Xingfu , LEE, Dongho
发明人： HONG, Young-Soo , LEE, Jung Joon , LEE, Kyeong , KIM, Woncheol , CAI, Xingfu , LEE, Dongho
IPC分类号： C07D225/06
CPC分类号： C07D225/06 , C07C271/12 , C07D313/00 , C12P13/02 , C12P17/08 , C12P17/10
摘要： The present invention relates to a method for producing ansamycin derivatives by using a mutant strain with the mutation of 3-amino-5-hydroxylbenzoic acid (AHBA) biosynthesis gene, more precisely a method for producing novel ansamycin derivatives by adding various types of AHBA analogs to the growth medium of the transformant with the mutation of an AHBA biosynthesis gene. Ansamycin derivatives produced by the method of the present invention have ansamycin-like Hsp90 inhibitory effect, so that it can be effectively used as antibiotics, antifungal agents, antiviral agents, immunosuppressants, anti-inflammatory agents or anticancer agents.
摘要翻译：本发明涉及通过使用具有3-氨基-5-羟基苯甲酸（AHBA）生物合成基因突变的突变菌株来制备安莎霉素衍生物的方法，更准确地说，涉及通过添加各种类型的AHBA类似物来生产新型安莎霉素衍生物的方法转化为具有AHBA生物合成基因突变的转化体的生长培养基。通过本发明方法生产的安沙霉素衍生物具有类霉素样Hsp90抑制作用，因此可有效地用作抗生素，抗真菌剂，抗病毒剂，免疫抑制剂，抗炎剂或抗癌剂。

9. 发明申请

WO2008038964A1 GELDANAMYCIN DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREOF AND AGENT FOR THE PREVENTION AND TREATMENT OF TUMOR CONTAINING THE SAME AS AN ACTIVE INGREDIENT 审中-公开
标题翻译：药物衍生物，其药物可接受的盐，其制备方法和用于预防和治疗含有其作为活性成分的肿瘤的药剂
公开(公告)号：WO2008038964A1
公开(公告)日：2008-04-03
申请号：PCT/KR2007/004645
申请日：2007-09-21
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , HONG, Young-Soo , LEE, Kyeong , LEE, Jung Joon , JIN, Yinlan , KIM, Woncheol
发明人： HONG, Young-Soo , LEE, Kyeong , LEE, Jung Joon , JIN, Yinlan , KIM, Woncheol
IPC分类号： C07D245/06
CPC分类号： C07D225/02
摘要： Disclosed are geldanamycin derivatives of Chemical Formula 1, pharmaceutically acceptable salts thereof, a preparation method thereof, and agents for the preparation and treatment of cancerous diseases, comprising the same as an active ingredient. Having inhibitory activity against the chaperone protein Hsp90, which plays an important role in the growth and metastasis of cancer cells, the geldanamycin derivatives can be used as antibiotics, antifungal agents, anti-viral agents, immuno- suppressors, therapeutics for degenerative nerve diseases, or anti-inflammatory agents, in addition to being applied to the treatment of cancerous diseases. (Chemical Formula 1) (wherein, X, Y, and Z are as defined in the specification)
摘要翻译：公开了化学式1的格尔德霉素衍生物，其药学上可接受的盐，其制备方法和用于制备和治疗癌性疾病的试剂，其包含其作为活性成分。对于在癌细胞的生长和转移中起重要作用的伴侣蛋白Hsp90具有抑制活性，格尔德霉素衍生物可用作抗生素，抗真菌剂，抗病毒剂，免疫抑制剂，退行性神经疾病的治疗剂，或抗炎药，还可用于治疗癌性疾病。（化学式1）（其中，X，Y和Z如说明书中所定义）

10. 发明申请

WO2006016773A1 GELDANAMYCIN DERIVATIVES AND THE METHOD FOR BIOSYNTHESIS THEREOF 审中-公开
标题翻译： GELDAAMYCIN衍生物及其生产方法
公开(公告)号：WO2006016773A1
公开(公告)日：2006-02-16
申请号：PCT/KR2005/002601
申请日：2005-08-11
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , LEE, Jung Joon , HONG, Young Soo , LEE, Dongho , LEE, Jeong-Hyung , SUNG, Kwang Soo
发明人： LEE, Jung Joon , HONG, Young Soo , LEE, Dongho , LEE, Jeong-Hyung , SUNG, Kwang Soo
IPC分类号： C07D225/06
CPC分类号： C07D225/06
摘要： The present invention relates to geldanamycin derivatives, benzoquinone ansamycin biosynthesized by gene manipulation of Streptomyces hygroscopicus subsp. duamyceticus and the method producing them, more particularly to a geldanamycin O-carbamoyl transferase gene ( gel8 )-inactive mutant, the method producing it and geldanamycin derivatives, 4, 5-dihydro-7-0-descarbamoyl-7-hydroxy geldanamycin and 4, 5-dihydro-7-0-descarbamoyl-7-hydroxy- 17-O-demethyl geldanamycin. Since geldanamycin derivatives of the present invention suppress Hsp90 like geldanamycin, they can effectively be used for antibiotic, antifungal, antiviral, antiinflammatory and antitumor agents and an immune su ressant.
摘要翻译：本发明涉及通过吸湿链霉菌subsp。的基因操作生物合成的格尔德霉素衍生物，苯醌安莎霉素。杜氏霉素及其制备方法，更具体地涉及格尔德霉素O-氨基甲酰转移酶基因（gel8） - 活性突变体，其制备方法和格尔德霉素衍生物，4,5-二氢-7-0-氨基甲酰基-7-羟基格尔德霉素和4 ，5-二氢-7-0-氨基甲酰基-7-羟基-17-O-脱甲基格尔德霉素。由于本发明的格尔德霉素衍生物抑制类似格尔德霉素的Hsp90，因此它们可以有效地用于抗生素，抗真菌剂，抗病毒剂，抗炎剂和抗肿瘤剂和免疫抑制剂。

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