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1. 发明申请

WO2006086720A3 CONTROLLED NEEDLE-FREE TRANSPORT DEVICE 审中-公开
标题翻译：控制无需运输设备
公开(公告)号：WO2006086720A3
公开(公告)日：2007-02-15
申请号：PCT/US2006004899
申请日：2006-02-10
申请人： MASSACHUSETTS INST TECHNOLOGY , HUNTER IAN W , TABERNER ANDREW J , HEMOND BRIAN D , WENDELL DAWN M , BALL NATHAN B , HOGAN NORA CATHERINE
发明人： HUNTER IAN W , TABERNER ANDREW J , HEMOND BRIAN D , WENDELL DAWN M , BALL NATHAN B , HOGAN NORA CATHERINE
IPC分类号： A61M5/30 , A61M5/315 , A61M5/48
CPC分类号： A61M5/3007 , A61M5/30 , A61M5/3291
摘要： A needle-free transdermal transport device (100) for transferring a substance across a surface (155) of a biological body (150) includes a reservoir (113) for storing the substance, a nozzle (114) in fluid communication with the reservoir and a controllable electromagnetic actuator (125) in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly (105) and a moving coil assembly (104) . The coil assembly moves a piston (126) having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo- controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
摘要翻译：用于将物质转移穿过生物体（150）的表面（155）的无针透皮运送装置（100）包括用于储存物质的储存器（113），与储存器流体连通的喷嘴（114）与储存器连通的可控电磁致动器（125）。称为洛伦兹力致动器的致动器包括固定磁体组件（105）和运动线圈组件（104）。线圈组件移动具有位于储存器内的端部的活塞（126）。致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动周期的过程中改变。有利地，致动器可以根据电气输入沿不同方向移动。

2. 发明申请

WO2008027579A8 NEEDLE-FREE INJECTOR DEVICE WITH AUTOLOADING CAPABILITY 审中-公开
标题翻译：具有自动化能力的无针式注射器装置
公开(公告)号：WO2008027579A8
公开(公告)日：2009-04-02
申请号：PCT/US2007019247
申请日：2007-08-31
申请人： MASSACHUSETTS INST TECHNOLOGY , HUNTER IAN W , HEMOND BRIAN D , WENDELL DAWN M , HOGAN NORA CATHERINE , TABERNER ANDREW J , BALL NATHAN B
发明人： HUNTER IAN W , HEMOND BRIAN D , WENDELL DAWN M , HOGAN NORA CATHERINE , TABERNER ANDREW J , BALL NATHAN B
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/204 , A61M5/31525 , A61M5/31546 , A61M5/482 , A61M5/484 , A61M2005/31588 , A61M2205/8287
摘要： A needle-free transdermal transport device includes a chamber (900) for holding the substance to be injected, a nozzle (910) in fluid communication with the chamber, and a drug reservoir (950) for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator (242) in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.
摘要翻译：无针透皮输送装置包括：用于保持待注射物质的腔室（900），与腔室流体连通的喷嘴（910）;以及用于储存要转移到腔室的物质的药物储存器（950）。无针透皮传送装置还包括与腔室连通的可控磁体和线圈电磁致动器（242）。执行器接收电输入并响应于力产生。该力然后使物质从腔室无针转移到生物体。该力是响应于在致动期间接收的输入的变化而变化的。执行器从药物储存器抽取物质，或者，物质可以通过压力源从药物储存器加压到腔室中。

3. 发明申请

WO2006086719A9 SURFACE INJECTION DEVICE 审中-公开
标题翻译：表面注射装置
公开(公告)号：WO2006086719A9
公开(公告)日：2006-12-14
申请号：PCT/US2006004898
申请日：2006-02-10
申请人： MASSACHUSETTS INST TECHNOLOGY , HUNTER IAN W , TABERNER ANDREW J , HEMOND BRIAN D , WENDELL DAWN M , BALL NATHAN B , HOGAN NORA CATHERINE
发明人： HUNTER IAN W , TABERNER ANDREW J , HEMOND BRIAN D , WENDELL DAWN M , BALL NATHAN B , HOGAN NORA CATHERINE
IPC分类号： A61M5/30
CPC分类号： A61M5/3007 , A61M5/30 , A61M5/3291
摘要： A needle-free transdermal transport device (100) for non-axially transferring a substance across a surface of a biological body includes a reservoir (110) for holding a substance being transferred. A piston (105) is positioned within the device in communication with the reservoir (110) . An actuator (105) drives the piston (105) to expel the substance from the reservoir (110) . The reservoir (110) is in fluid communication with a nozzle (115) which includes at least one lateral aperture (145) through which the substance is expelled. Multiple lateral apertures (145) can result in a needle-free transfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle (115) . By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device (100) . The device (108) can also include an optional power source (125) .
摘要翻译：一种用于沿生物体表面非轴向转移物质的无针透皮传送装置（100）包括用于容纳被转移物质的贮存器（110）。活塞（105）定位在与储存器（110）连通的装置内。致动器（105）驱动活塞（105）以将物质从贮存器（110）排出。储存器（110）与喷嘴（115）流体连通，所述喷嘴（115）包括至少一个侧向孔（145），物质通过所述至少一个侧孔（145）排出。多个横向孔（145）可导致穿过可选表面区域的无针转移。注射的深度和方向可以通过喷嘴（115）的参数来控制。通过提供选择性的深度和方向，可以将物质注入目标生物层（如裂解平面）以进一步促进覆盖。控制源可以用于激活设备（100）。设备（108）还可以包括可选的电源（125）。

4. 发明申请

WO2006086720A9 CONTROLLED NEEDLE-FREE TRANSPORT DEVICE 审中-公开
标题翻译：受控无针运输装置
公开(公告)号：WO2006086720A9
公开(公告)日：2007-04-05
申请号：PCT/US2006004899
申请日：2006-02-10
申请人： MASSACHUSETTS INST TECHNOLOGY , HUNTER IAN W , TABERNER ANDREW J , HEMOND BRIAN D , WENDELL DAWN M , BALL NATHAN B , HOGAN NORA CATHERINE
发明人： HUNTER IAN W , TABERNER ANDREW J , HEMOND BRIAN D , WENDELL DAWN M , BALL NATHAN B , HOGAN NORA CATHERINE
IPC分类号： A61M5/30 , A61M5/315 , A61M5/48
CPC分类号： A61M5/3007 , A61M5/30 , A61M5/3291
摘要： A needle-free transdermal transport device (100) for transferring a substance across a surface (155) of a biological body (150) includes a reservoir (113) for storing the substance, a nozzle (114) in fluid communication with the reservoir and a controllable electromagnetic actuator (125) in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly (105) and a moving coil assembly (104) . The coil assembly moves a piston (126) having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo- controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
摘要翻译：用于穿过生物体（150）的表面（155）转移物质的无针透皮传送装置（100）包括用于存储物质的贮存器（113），与贮存器流体连通的喷嘴（114）与储液器连通的可控电磁致动器（125）。称为洛伦兹力致动器的致动器包括固定磁体组件（105）和动圈组件（104）。线圈组件移动具有位于储存器内的端部的活塞（126）。致动器接收电输入并且响应于作用在活塞上的相应的力产生并且引起物质在储存器和生物体之间的无针转移。力的大小，方向和持续时间由电输入动态地控制（例如，伺服控制）并且可以在致动周期的过程中改变。有利的是，执行器可以根据电气输入在不同的方向上移动。

5. 发明申请

WO2006086774A2 CONTROLLED NEEDLE-FREE TRANSPORT 审中-公开
标题翻译：受控无针运输
公开(公告)号：WO2006086774A2
公开(公告)日：2006-08-17
申请号：PCT/US2006005043
申请日：2006-02-13
申请人： MASSACHUSETTS INST TECHNOLOGY , HUNTER IAN W , TABERNER ANDREW J , HEMOND BRIAN D , WENDELL DAWN M , BALL NATHAN B , HOGAN NORA CATHERINE
发明人： HUNTER IAN W , TABERNER ANDREW J , HEMOND BRIAN D , WENDELL DAWN M , BALL NATHAN B , HOGAN NORA CATHERINE
IPC分类号： A61M5/30 , A61M5/315 , A61M5/48
CPC分类号： A61M5/30 , A61D7/00 , A61M5/20 , A61M5/204 , A61M5/31525 , A61M5/31546 , A61M5/3291 , A61M5/482 , A61M5/484 , A61M2205/3561
摘要： A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
摘要翻译：用于跨生物体表面转移物质的无针透皮传送装置包括用于存储物质的贮存器，与贮存器流体连通的喷嘴以及与贮存器连通的可控电磁致动器。称为洛伦兹力致动器的致动器包括固定磁体组件和动圈组件。线圈组件移动具有位于储存器内的端部的活塞。致动器接收电输入并且响应于作用在活塞上的相应的力产生并且引起物质在储存器和生物体之间的无针转移。力的大小，方向和持续时间由电输入动态地控制（例如，伺服控制）并且可以在致动循环的过程中改变。有利的是，执行器可以根据电气输入在不同的方向上移动。

6. 发明申请

WO2006086719A1 SURFACE INJECTION DEVICE 审中-公开
标题翻译：表面注射装置
公开(公告)号：WO2006086719A1
公开(公告)日：2006-08-17
申请号：PCT/US2006/004898
申请日：2006-02-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian, W. , TABERNER, Andrew, J. , HEMOND, Brian, D. , WENDELL, Dawn, M. , BALL, Nathan, B. , HOGAN, Nora, Catherine
发明人： HUNTER, Ian, W. , TABERNER, Andrew, J. , HEMOND, Brian, D. , WENDELL, Dawn, M. , BALL, Nathan, B. , HOGAN, Nora, Catherine
IPC分类号： A61M5/30
CPC分类号： A61M5/3007 , A61M5/30 , A61M5/3291
摘要： A needle-free transdermal transport device (100) for non-axially transferring a substance across a surface of a biological body includes a reservoir (110) for holding a substance being transferred. A piston (105) is positioned within the device in communication with the reservoir (110) . An actuator (105) drives the piston (105) to expel the substance from the reservoir (110) . The reservoir (110) is in fluid communication with a nozzle (115) which includes at least one lateral aperture (145) through which the substance is expelled. Multiple lateral apertures (145) can result in a needle-free transfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle (115) . By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device (100) . The device (108) can also include an optional power source (125) .
摘要翻译：用于在物体表面不轴向转移物质的无针透皮输送装置（100）包括用于保持被转移物质的储存器（110）。活塞（105）位于与储存器（110）连通的装置内。致动器（105）驱动活塞（105）以将物质从储存器（110）排出。储存器（110）与喷嘴（115）流体连通，该喷嘴包括至少一个侧向孔（145），物质被排出。多个侧向孔（145）可导致穿过可选表面区域的无针转移。注射的深度和方向可以通过喷嘴（115）的参数来控制。通过提供选择性的深度和方向，可以将物质注入目标生物层，例如劈裂平面，以进一步促进覆盖。可以使用控制源来激活设备（100）。设备（108）还可以包括可选的电源（125）。

7. 发明申请

WO2006086774A3 NEEDLE-FREE TRANSDERMAL TRANSPORT DEVICE 审中-公开
公开(公告)号：WO2006086774A3
公开(公告)日：2006-08-17
申请号：PCT/US2006/005043
申请日：2006-02-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian, W. , TABERNER, Andrew, J. , HEMOND, Brian, D. , WENDELL, Dawn, M. , BALL, Nathan, B. , HOGAN, Nora, Catherine
发明人： HUNTER, Ian, W. , TABERNER, Andrew, J. , HEMOND, Brian, D. , WENDELL, Dawn, M. , BALL, Nathan, B. , HOGAN, Nora, Catherine
IPC分类号： A61M5/30 , A61M5/315 , A61M5/48
摘要： A needle-free transdermal transport device (100) for transferring a substance across a surface (155) of a biological body (150) includes a reservoir (113) for storing the substance, a nozzle (114) in fluid communication with the reservoir and a controllable electromagnetic actuator (125) in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly (105) and a moving coil assembly (104) . The coil assembly moves a piston (126) having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.

8. 发明申请

WO2008027579A1 NEEDLE-FREE INJECTOR DEVICE WITH AUTOLOADING CAPABILITY 审中-公开
标题翻译：具有自动化能力的无针式注射器装置
公开(公告)号：WO2008027579A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/019247
申请日：2007-08-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian, W. , HEMOND, Brian, D. , WENDELL, Dawn, M. , HOGAN, Nora, Catherine , TABERBER, Andrew, J. , BALL, Nathan, B.
发明人： HUNTER, Ian, W. , HEMOND, Brian, D. , WENDELL, Dawn, M. , HOGAN, Nora, Catherine , TABERBER, Andrew, J. , BALL, Nathan, B.
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/204 , A61M5/31525 , A61M5/31546 , A61M5/482 , A61M5/484 , A61M2005/31588 , A61M2205/8287
摘要： A needle-free transdermal transport device includes a chamber (900) for holding the substance to be injected, a nozzle (910) in fluid communication with the chamber, and a drug reservoir (950) for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator (242) in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.
摘要翻译：无针透皮输送装置包括：用于保持待注射物质的腔室（900），与腔室流体连通的喷嘴（910）;以及用于储存要转移到腔室的物质的药物储存器（950）。无针透皮传送装置还包括与腔室连通的可控磁体和线圈电磁致动器（242）。执行器接收电输入并且产生响应的力。该力然后使物质从腔室无针转移到生物体。该力是响应于在致动期间接收到的输入的变化而变化的。执行器从药物储存器抽取物质，或者，物质可以通过压力源从药物贮存器加压到腔室中。

9. 发明申请

WO2006086720A2 CONTROLLED NEEDLE-FREE TRANSPORT 审中-公开
标题翻译：控制无需运输
公开(公告)号：WO2006086720A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/004899
申请日：2006-02-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , HUNTER, Ian, W. , TABERNER, Andrew, J. , HEMOND, Brian, D. , WENDELL, Dawn, M. , BALL, Nathan, B. , HOGAN, Nora, Catherine
发明人： HUNTER, Ian, W. , TABERNER, Andrew, J. , HEMOND, Brian, D. , WENDELL, Dawn, M. , BALL, Nathan, B. , HOGAN, Nora, Catherine
IPC分类号： A61M5/30 , A61M5/315 , A61M5/48
CPC分类号： A61M5/3007 , A61M5/30 , A61M5/3291
摘要： A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
摘要翻译：用于将物质转移到生物体的表面上的无针透皮传送装置包括用于储存物质的储存器，与储存器流体连通的喷嘴和与储存器连通的可控电磁致动器。称为洛伦兹力致动器的致动器包括固定磁体组件和移动线圈组件。线圈组件移动具有位于储存器内的端部的活塞。致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动循环的过程中改变。有利地，致动器可以根据电气输入沿不同方向移动。

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