专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO02060419A3 A SUBSTANCE FOR USE IN A DIETARY SUPPLEMENT OR FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERTENSION AND/OR THE METABOLIC SYNDROME 审中-公开
标题翻译：用于膳食补充或用于制备治疗非胰岛素依赖性糖尿病的药物的物质，高血压和/或代谢综合征
公开(公告)号：WO02060419A3
公开(公告)日：2003-05-22
申请号：PCT/DK0100523
申请日：2001-07-31
申请人： NUTRI PHARMA AS , HERMANSEN KJELD , GREGERSEN SOEREN , JEPPESEN PER BENDIX , HOEIE LARS H
发明人： HERMANSEN KJELD , GREGERSEN SOEREN , JEPPESEN PER BENDIX , HOEIE LARS H
IPC分类号： A23L33/10 , A23L33/11 , A23L33/185 , A23L33/22 , A61K31/19 , A61K45/06 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61K31/00 , A23L1/30 , A23L1/305 , A61K31/35 , A61K31/70 , A61K31/704 , A61K38/01
CPC分类号： A61K31/704 , A23L33/10 , A23L33/11 , A23L33/185 , A23L33/22 , A61K31/19 , A61K45/06
摘要： A substance including the chemical structures of bicyclo[3.2.1]octan or the chemical structures of kaurene selected from the group consisting of steviol, isosteviol, glucosteviol, gymnemic acid, steviolbioside, stevioside, Rebaudioside A, Rebaudioside B, Rebaudioside C, Rebaudioside D, Rebaudioside E or Dulcoside A, for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. In a combination drug which also comprise a soy protein, and/or fibre and/or at least one phytoestrogen these substances of plant origin act synergistically and such combination drugs are highly useful both prophylacticly or directly in the treatment of e.g. the metabolic syndrome and obesity and has due to the self-regulatory effect a widespread applicability as a dietary supplementation.
摘要翻译：一种物质，包括双环[3.2.1]辛烷的化学结构或选自雪莲醇，异硫氰尿酸，葡萄糖杆菌，肉豆蔻酸，甜菊糖苷，甜菊苷，雷鲍迪甙A，雷鲍迪甙B，雷鲍迪甙C，雷鲍迪苷D ，Rebaudioside E或Dulcoside A，用于膳食补充剂或用作治疗非胰岛素依赖性糖尿病，高血压和/或代谢综合征的药物中的成分。在还包含大豆蛋白和/或纤维和/或至少一种植物雌激素的组合药物中，这些植物来源的这些物质起协同作用，并且这种组合药物既预防性地也可直接用于治疗例如大肠杆菌。代谢综合征和肥胖症，并且由于自我调节作用，作为膳食补充剂广泛适用。

2. 发明申请

WO9616533A3 METHOD FOR TRANSFORMING A SPEECH SIGNAL USING A PIMETHOD FOR TRANSFORMING A SPEECH SIGNAL USING A PITCH MANIPULATOR TCH MANIPULATOR 审中-公开
标题翻译：用于使用PITCH操纵器TCH操纵器来改变语音信号来改变语音信号的方法
公开(公告)号：WO9616533A3
公开(公告)日：1996-08-08
申请号：PCT/DK9500474
申请日：1995-11-27
申请人： FINK FLEMING K , HARTMANN UWE , HERMANSEN KJELD , RUBAK PER
发明人： FINK FLEMING K , HARTMANN UWE , HERMANSEN KJELD , RUBAK PER
IPC分类号： G10L21/003 , G10L21/02 , G10L21/0208 , G10L21/04 , G10L25/12
CPC分类号： G10L21/0208 , G10L21/003 , G10L21/0364 , G10L21/04 , G10L25/12
摘要： Transformation of a speech signal comprises separating the speech signal into two signal parts (a, b), where (a) represents the quasistationary part and (b) the transient part of the signal. The signal (b) is filtered inversely and is supplied in parallel to a transient detector and a pitch manipulator, while the signal (a) is subjected to a spectral analysis. The transformation circuit of the invention permits well-defined manipulation of any speech signal, which is advantageous partly for hearing-impaired persons, partly for persons having normal hearing ability in noisy environments. Finally, the circuit of the invention has been found to be extremely expedient for synthesizing well-defined sounds, which is of great importance in the control of hearing aids (hearing loss simulator).

3. 发明申请

WO2008031439A2 TREATMENT OF INSULIN RESISTANCE OR DISEASES ASSOCIATED WITH INSULIN RESISTANCE 审中-公开
标题翻译：治疗与胰岛素抵抗相关的胰岛素抵抗或疾病
公开(公告)号：WO2008031439A2
公开(公告)日：2008-03-20
申请号：PCT/DK2007/050127
申请日：2007-09-14
申请人： Stevia Aps , HERMANSEN, Kjeld , BENDIX JEPPESEN, Per
发明人： HERMANSEN, Kjeld , BENDIX JEPPESEN, Per
CPC分类号： A61K31/19 , A61K31/015 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a substance with the core structure of formula (I), or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the manufacture of a composition for the treatment of insulin resistance or diseases associated with insulin resistance, preferably in human subject in a daily dosage in a range of from about 5 mg to about 1500 mg. The invention furthermore relates to a method of treating insulin resistance or diseases associated with insulin resistance in a mammal, said method comprises administering to said mamma, preferably a human subject, a substance with the core structure of formula (I), preferably in a daily dosage in a range from about 5 mg to about 1500 mg. The substance is preferably isosteviol or steviol, or pharmaceutically acceptable salts, solvates or prodrugs thereof. Examples of diseases associated with insulin resistance are e.g. type 2 diabetes mellitus, insulin resistance syndrome, impaired glucose tolerance, the metabolic syndrome, hyperglycemia, hyperinsulinemia, arteriosclerosis, hypercholesterolemia, hypertriglyceridemia, hyperlipidemia, dyslipidemia, obesity, central obesity, polycystic ovarian syndrome, hypercoagulability, hypertension, microalbuminuria, or any combinations thereof.
摘要翻译：本发明涉及具有式（I）的核心结构的物质或其药学上可接受的盐，溶剂合物或前药用于制备用于治疗胰岛素抵抗或与胰岛素抵抗相关的疾病的组合物的用途，优选地，在约5mg至约1500mg范围内的每日剂量的人受试者。本发明还涉及一种治疗哺乳动物胰岛素抵抗或与胰岛素抵抗相关的疾病的方法，所述方法包括向所述妈妈，优选人受试者施用具有式（I）核心结构的物质，优选在每日剂量范围为约5mg至约1500mg。该物质优选是异硫代醇或甜菊醇，或其药学上可接受的盐，溶剂合物或前药。与胰岛素抵抗相关的疾病的实例是例如。 2型糖尿病，胰岛素抵抗综合征，葡萄糖耐量异常，代谢综合征，高血糖症，高胰岛素血症，动脉硬化，高胆固醇血症，高甘油三酯血症，高脂血症，血脂异常，肥胖，中枢性肥胖，多囊卵巢综合征，高凝状态，高血压，微量白蛋白尿或其任何组合。

4. 发明申请

WO1996016533A2 METHOD FOR TRANSFORMING A SPEECH SIGNAL USING A PITCH MANIPULATOR 审中-公开
标题翻译：使用平板手机来转换语音信号的方法
公开(公告)号：WO1996016533A2
公开(公告)日：1996-06-06
申请号：PCT/DK1995000474
申请日：1995-11-27
申请人： FINK, Fleming, K. , HARTMANN, Uwe , HERMANSEN, Kjeld , RUBAK, Per
IPC分类号： G10L21/003 , G10L21/02 , G10L21/0208 , G10L21/04 , G10L25/12
CPC分类号： G10L21/0208 , G10L21/003 , G10L21/0364 , G10L21/04 , G10L25/12
摘要： Transformation of a speech signal comprises separating the speech signal into two signal parts (a, b), where (a) represents the quasistationary part and (b) the transient part of the signal. The signal (b) is filtered inversely and is supplied in parallel to a transient detector and a pitch manipulator, while the signal (a) is subjected to a spectral analysis. The transformation circuit of the invention permits well-defined manipulation of any speech signal, which is advantageous partly for hearing-impaired persons, partly for persons having normal hearing ability in noisy environments. Finally, the circuit of the invention has been found to be extremely expedient for synthesizing well-defined sounds, which is of great importance in the control of hearing aids (hearing loss simulator).
摘要翻译：语音信号的转换包括将语音信号分成两个信号部分（a，b），其中（a）表示准静态部分，（b）信号的瞬态部分。信号（b）被反向滤波，并且在信号（a）进行光谱分析的同时被并行提供给瞬态检测器和俯仰操纵器。本发明的变换电路允许对任何语音信号进行明确的操纵，其部分地对于听力受损的人是有利的，部分是对于在嘈杂环境中具有正常听力的人。最后，已经发现本发明的电路对于合成定义良好的声音非常方便，这对于助听器（听力损失模拟器）的控制是非常重要的。

5. 发明申请

WO2009071099A1 ELEVATION OF THE PLASMA HDL-CHOLESTEROL LEVEL 审中-公开
标题翻译：血浆HDL-胆固醇水平的升高
公开(公告)号：WO2009071099A1
公开(公告)日：2009-06-11
申请号：PCT/DK2008/050297
申请日：2008-12-05
申请人： Aarhus Universitet , HERMANSEN, Kjeld , JEPPESEN, Per Bendix
发明人： HERMANSEN, Kjeld , JEPPESEN, Per Bendix
IPC分类号： A61K31/19 , A61K45/06 , A61P3/04
CPC分类号： A61K31/19 , A61K45/06
摘要： The present invention relates to the use of isosteviol, steviol, and related compounds for elevating the plasma HDL-cholesterol level. The invention furthermore relates to the use of these compounds for reducing the body weight of a subject and/or lowering the plasma triglyceride level of a subject, including a concomitant elevation of the plasma HDL-cholesterol level. Preferably the compounds used are isosteviol and/or steviol, or pharmaceutically acceptable salts, solvates or prodrugs thereof. The compounds may furthermore be administered in combination with one or more further active compounds, such as e.g. LDL-cholesterol lowering agents. The invention furthermore relates to a method for elevating the plasma HDL-cholesterol level in a subject by administering to a subject in need of such treatment a plasma HDL-cholesterol level elevating amount of the compounds, described herein.
摘要翻译：本发明涉及异硫伏醇，甜菊醇和相关化合物用于提高血浆HDL-胆固醇水平的用途。本发明还涉及这些化合物用于减少受试者的体重和/或降低受试者的血浆甘油三酯水平的用途，包括血浆HDL-胆固醇水平的伴随升高。优选地，所用的化合物是异头二糖和/或甜菊醇，或其药学上可接受的盐，溶剂合物或前药。此外，化合物还可以与一种或多种其它活性化合物组合施用，例如，低密度脂蛋白胆固醇降低剂。本发明还涉及通过向需要这种治疗的受试者施用本文所述的化合物的血浆HDL-胆固醇水平升高量来提高受试者中的血浆HDL-胆固醇水平的方法。

6. 发明申请

WO2008031439A3 TREATMENT OF INSULIN RESISTANCE OR DISEASES ASSOCIATED WITH INSULIN RESISTANCE WITH BICYCLO [ 3.2. I ]OCTANS SUCH AS STEVIOL AND ISOSTEVIOL 审中-公开
标题翻译：治疗与胰岛素抵抗相关的胰岛素抵抗或疾病[3.2。 I] OCTANS如STEVIOL和ISOSTEVIOL
公开(公告)号：WO2008031439A3
公开(公告)日：2008-06-19
申请号：PCT/DK2007050127
申请日：2007-09-14
申请人： STEVIA APS , HERMANSEN KJELD , BENDIX JEPPESEN PER
发明人： HERMANSEN KJELD , BENDIX JEPPESEN PER
IPC分类号： A61K31/015 , A61K31/19 , A61P3/06 , A61P3/08 , A61P3/10
CPC分类号： A61K31/19 , A61K31/015 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a substance with the core structure of formula (I), or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the manufacture of a composition for the treatment of insulin resistance or diseases associated with insulin resistance, preferably in human subject in a daily dosage in a range of from about 5 mg to about 1500 mg. The invention furthermore relates to a method of treating insulin resistance or diseases associated with insulin resistance in a mammal, said method comprises administering to said mamma, preferably a human subject, a substance with the core structure of formula (I), preferably in a daily dosage in a range from about 5 mg to about 1500 mg. The substance is preferably isosteviol or steviol, or pharmaceutically acceptable salts, solvates or prodrugs thereof. Examples of diseases associated with insulin resistance are e.g. type 2 diabetes mellitus, insulin resistance syndrome, impaired glucose tolerance, the metabolic syndrome, hyperglycemia, hyperinsulinemia, arteriosclerosis, hypercholesterolemia, hypertriglyceridemia, hyperlipidemia, dyslipidemia, obesity, central obesity, polycystic ovarian syndrome, hypercoagulability, hypertension, microalbuminuria, or any combinations thereof.
摘要翻译：本发明涉及具有式（I）的核心结构的物质或其药学上可接受的盐，溶剂合物或前药用于制备用于治疗胰岛素抵抗或与胰岛素抵抗相关的疾病的组合物的用途，优选地，在约5mg至约1500mg范围内的每日剂量的人受试者。本发明还涉及一种治疗哺乳动物胰岛素抵抗或与胰岛素抵抗相关的疾病的方法，所述方法包括向所述妈妈，优选人受试者施用具有式（I）核心结构的物质，优选在每日剂量范围为约5mg至约1500mg。该物质优选是异硫代醇或甜菊醇，或其药学上可接受的盐，溶剂合物或前药。与胰岛素抵抗相关的疾病的实例是例如。 2型糖尿病，胰岛素抵抗综合征，糖耐量异常，代谢综合征，高血糖症，高胰岛素血症，动脉硬化，高胆固醇血症，高甘油三酯血症，高脂血症，血脂异常，肥胖，中枢性肥胖，多囊卵巢综合征，高凝状态，高血压，微量白蛋白尿或其任何组合。

7. 发明申请

WO0072305A3 A METHOD AND APPARATUS FOR NOISE REDUCTION IN SPEECH SIGNALS 审中-公开
标题翻译：用于语音信号中减少噪声的方法和装置
公开(公告)号：WO0072305A3
公开(公告)日：2008-01-10
申请号：PCT/DK0000263
申请日：2000-05-16
申请人： NOISECOM APS , HERMANSEN KJELD
发明人： HERMANSEN KJELD
IPC分类号： G10L21/0208
CPC分类号： G10L21/0208
摘要： A method and apparatus for reducing noise in speech signals employing a priori knowledge regarding human speech production and knowledge of the speech dynamics, such as knowledge regarding the production of sounds in the mouth and throat region. Further employing a new model based spectral subtraction algorithm. Employs replacing part of the original signal containing voiced sounds by synthetically produced pulses. Improves the noise reduction without affecting the wanted (speech) components of the signal. The method may be used for low SNR (SNR
摘要翻译：一种使用关于人类语音产生的先验知识和语音动力学知识的语音信号中的噪声的方法和装置，例如关于口腔和喉部区域中的声音的产生的知识。进一步采用基于模型的谱减法算法。通过合成产生的脉冲来代替含有有声声音的原始信号的一部分。改善噪音，而不会影响信号的想要（语音）分量。该方法可用于低SNR（SNR <10dB）。当与使用蜂窝电话的通信结合使用时有利。

8. 发明申请

WO2004059614A3 A METHOD AND APPARATUS FOR ENHANCING THE PERCEPTUAL QUALITY OF SYNTHESIZED SPEECH SIGNALS 审中-公开
标题翻译：提高合成语音信号的知觉质量的方法和设备
公开(公告)号：WO2004059614A3
公开(公告)日：2004-09-23
申请号：PCT/DK0300917
申请日：2003-12-19
申请人： MICROSOUND AS , HERMANSEN KJELD
发明人： HERMANSEN KJELD
IPC分类号： G10L13/04 , G10L21/0208 , G10L25/15
CPC分类号： G10L13/04 , G10L21/0208 , G10L25/15
摘要： A method and an apparatus for enhancing the perceptual quality of synthesized speech signals is disclosed. According to the present invention, the time-varying synthesis filter comprises one or several filter section(s) of fractional order, i.e. filter sections having a non-integer order. Traditionally, synthesis filters employed for synthesis of parametric speech data have been of integer order, and often been constituted by a composition of paralleled or cascaded second order filter sections. The speech synthesis filter may in the latter situation be composed of a set of cascaded or parallel second order filters or filer sections as disclosed in WO 00/72305.
摘要翻译：公开了一种用于增强合成语音信号的感知质量的方法和设备。根据本发明，时变合成滤波器包括一个或多个分数阶的滤波器部分，即具有非整数阶的滤波器部分。传统上，用于合成参数语音数据的合成滤波器具有整数阶，并且通常由并行或级联二阶滤波器部分的组合构成。语音合成滤波器在后一种情况下可以由一组级联或并行的二阶滤波器或滤波器部分组成，如WO 00/72305中所公开的。

9. 发明申请

WO2002060419A2 A SUBSTANCE FOR THE USE IN A DIETARY SUPPLEMENTATION OR FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERTENSION AND/OR THE METABOLIC SYNDROME 审中-公开
标题翻译：用于膳食补充或用于制备治疗非胰岛素依赖性糖尿病的药物的物质，高血压和/或代谢综合征
公开(公告)号：WO2002060419A2
公开(公告)日：2002-08-08
申请号：PCT/DK2001/000523
申请日：2001-07-31
申请人： NUTRI PHARMA ASA , HERMANSEN, Kjeld , GREGERSEN, Søren , JEPPESEN, Per, Bendix , HØIE, Lars, H.
发明人： HERMANSEN, Kjeld , GREGERSEN, Søren , JEPPESEN, Per, Bendix , HØIE, Lars, H.
IPC分类号： A61K31/00
CPC分类号： A61K31/704 , A23L33/10 , A23L33/11 , A23L33/185 , A23L33/22 , A61K31/19 , A61K45/06
摘要： A substance including the chemical structures of bicyclo[3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The unique chemical structures of bicyclo[3.2.1]octan alone or in a kaurene structure provides the substances, such as e.g. steviol, isosteviol and stevioside with the capability of enhancing or potentiating the secretion of insulin in a plasma glucose dependent manner. The substances including these unique chemical structures also have the capability of reducing the glucagon concentration in the blood and/or lowering the blood pressure thereby providing a self-regulatory treatment system for non-insulin dependent diabetes mellitus and/or hyperten-sion. In a combination drug which also comprise a soy protein, and/or fibre and/or at least one phytoestrogen these substances act synergistically and such combination drugs are highly useful both prophylacticly or directly in the treatment of e.g. the metabolic syndrome and obesity and has due to the self-regulatory effect a widespread applicability as a dietary supplementation.
摘要翻译：一种物质，包括双环[3.2.1]辛烷的化学结构或用于膳食补充剂中的kaurene的化学结构或作为用于治疗非胰岛素依赖性糖尿病，高血压和/或代谢综合征。双环[3.2.1]辛烷独特的化学结构单独或在凯恩结构中提供了物质，甜菊醇，异硫脲和甜菊苷，具有以血浆葡萄糖依赖性方式增强或增强胰岛素分泌的能力。包括这些独特的化学结构的物质还具有降低血液中胰高血糖素浓度和/或降低血压的能力，从而为非胰岛素依赖性糖尿病和/或高血压提供自我调节治疗系统。在还包含大豆蛋白质和/或纤维和/或至少一种植物雌激素的组合药物中，这些物质协同作用，并且这种组合药物既预防性也可直接用于治疗例如血液。代谢综合征和肥胖症，并且由于自我调节作用，作为膳食补充剂广泛适用。

10. 发明申请

WO0156959B1 A SUBSTANCE FOR THE USE IN A DIETARY SUPPLEMENTATION OR FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERTENSION AND/OR THE METABOLIC SYNDROME 审中-公开
标题翻译：用于膳食补充或用于制备治疗非胰岛素依赖性糖尿病的药物的物质，高血压和/或代谢综合征
公开(公告)号：WO0156959B1
公开(公告)日：2002-02-07
申请号：PCT/DK0100075
申请日：2001-02-01
申请人： HERMANSEN KJELD , GREGERSEN SOEREN , JEPPESEN PER BENDIX
发明人： HERMANSEN KJELD , GREGERSEN SOEREN , JEPPESEN PER BENDIX
IPC分类号： A61K38/00 , A61K31/015 , A61K31/045 , A61K31/19 , A61K31/352 , A61K31/7034 , A61K31/704 , A61K36/00 , A61K36/28 , A61K36/48 , A61K45/06 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , C07C13/64 , C07C13/68 , C07C61/35 , C07H15/24 , C07H15/256 , C07C61/29 , C07C62/32
CPC分类号： A61K31/19 , A61K31/015 , A61K31/192 , A61K31/352 , A61K31/70 , A61K31/704 , A61K36/00 , A61K36/48 , A61K38/16 , A61K38/168 , A61K45/06 , C07C13/68 , C07C61/35 , C07C2603/86 , C07H15/256 , A61K2300/00
摘要： A substance including the chemical structures of bicyclo[3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The unique chemical structures of bicyclo[3.2.1]octan alone or in a kaurene structure provides the substances, such as e.g. steviol, isosteviol and stevioside with the capability of enhancing or potentiating the secretion of insulin in a plasma glucose dependent manner. The substances including these unique chemical structures also have the capability of reducing the glucagon concentration in the blood and/or lowering the blood pressure thereby providing a self-regulatory treatment system for non-insulin dependent diabetes mellitus and/or hypertension. In a combination drug which also comprise a soy protein, and/or soy fiber and/or at least one isoflavone these substances act synergistically and such combination drugs are highly useful both prophylacticly or directly in the treatment of e.g. the metabolic syndrome and obesity and has due to the self-regulatory effect a widespread applicability as a dietary supplementation.
摘要翻译：一种物质，包括双环[3.2.1]辛烷的化学结构或用于膳食补充剂中的kaurene的化学结构或作为治疗非胰岛素依赖性糖尿病，高血压和/或代谢综合征。双环[3.2.1]辛烷独特的化学结构单独或在凯恩结构中提供了物质，甜菊醇，异硫脲和甜菊苷，具有以血浆葡萄糖依赖性方式增强或增强胰岛素分泌的能力。包括这些独特化学结构的物质还具有降低血液中胰高血糖素浓度和/或降低血压的能力，从而为非胰岛素依赖性糖尿病和/或高血压提供自我调节治疗系统。在还包含大豆蛋白和/或大豆纤维和/或至少一种异黄酮的组合药物中，这些物质协同作用，并且这样的组合药物既预防性地也可直接用于例如治疗。代谢综合征和肥胖症，并且由于自我调节作用，作为膳食补充剂广泛适用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式