专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008031439A3 TREATMENT OF INSULIN RESISTANCE OR DISEASES ASSOCIATED WITH INSULIN RESISTANCE WITH BICYCLO [ 3.2. I ]OCTANS SUCH AS STEVIOL AND ISOSTEVIOL 审中-公开
标题翻译：治疗与胰岛素抵抗相关的胰岛素抵抗或疾病[3.2。 I] OCTANS如STEVIOL和ISOSTEVIOL
公开(公告)号：WO2008031439A3
公开(公告)日：2008-06-19
申请号：PCT/DK2007050127
申请日：2007-09-14
申请人： STEVIA APS , HERMANSEN KJELD , BENDIX JEPPESEN PER
发明人： HERMANSEN KJELD , BENDIX JEPPESEN PER
IPC分类号： A61K31/015 , A61K31/19 , A61P3/06 , A61P3/08 , A61P3/10
CPC分类号： A61K31/19 , A61K31/015 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a substance with the core structure of formula (I), or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the manufacture of a composition for the treatment of insulin resistance or diseases associated with insulin resistance, preferably in human subject in a daily dosage in a range of from about 5 mg to about 1500 mg. The invention furthermore relates to a method of treating insulin resistance or diseases associated with insulin resistance in a mammal, said method comprises administering to said mamma, preferably a human subject, a substance with the core structure of formula (I), preferably in a daily dosage in a range from about 5 mg to about 1500 mg. The substance is preferably isosteviol or steviol, or pharmaceutically acceptable salts, solvates or prodrugs thereof. Examples of diseases associated with insulin resistance are e.g. type 2 diabetes mellitus, insulin resistance syndrome, impaired glucose tolerance, the metabolic syndrome, hyperglycemia, hyperinsulinemia, arteriosclerosis, hypercholesterolemia, hypertriglyceridemia, hyperlipidemia, dyslipidemia, obesity, central obesity, polycystic ovarian syndrome, hypercoagulability, hypertension, microalbuminuria, or any combinations thereof.
摘要翻译：本发明涉及具有式（I）的核心结构的物质或其药学上可接受的盐，溶剂合物或前药用于制备用于治疗胰岛素抵抗或与胰岛素抵抗相关的疾病的组合物的用途，优选地，在约5mg至约1500mg范围内的每日剂量的人受试者。本发明还涉及一种治疗哺乳动物胰岛素抵抗或与胰岛素抵抗相关的疾病的方法，所述方法包括向所述妈妈，优选人受试者施用具有式（I）核心结构的物质，优选在每日剂量范围为约5mg至约1500mg。该物质优选是异硫代醇或甜菊醇，或其药学上可接受的盐，溶剂合物或前药。与胰岛素抵抗相关的疾病的实例是例如。 2型糖尿病，胰岛素抵抗综合征，糖耐量异常，代谢综合征，高血糖症，高胰岛素血症，动脉硬化，高胆固醇血症，高甘油三酯血症，高脂血症，血脂异常，肥胖，中枢性肥胖，多囊卵巢综合征，高凝状态，高血压，微量白蛋白尿或其任何组合。

2. 发明申请

WO2008031439A2 TREATMENT OF INSULIN RESISTANCE OR DISEASES ASSOCIATED WITH INSULIN RESISTANCE 审中-公开
标题翻译：治疗与胰岛素抵抗相关的胰岛素抵抗或疾病
公开(公告)号：WO2008031439A2
公开(公告)日：2008-03-20
申请号：PCT/DK2007/050127
申请日：2007-09-14
申请人： Stevia Aps , HERMANSEN, Kjeld , BENDIX JEPPESEN, Per
发明人： HERMANSEN, Kjeld , BENDIX JEPPESEN, Per
CPC分类号： A61K31/19 , A61K31/015 , A61K45/06 , A61K2300/00
摘要： The present invention relates to the use of a substance with the core structure of formula (I), or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the manufacture of a composition for the treatment of insulin resistance or diseases associated with insulin resistance, preferably in human subject in a daily dosage in a range of from about 5 mg to about 1500 mg. The invention furthermore relates to a method of treating insulin resistance or diseases associated with insulin resistance in a mammal, said method comprises administering to said mamma, preferably a human subject, a substance with the core structure of formula (I), preferably in a daily dosage in a range from about 5 mg to about 1500 mg. The substance is preferably isosteviol or steviol, or pharmaceutically acceptable salts, solvates or prodrugs thereof. Examples of diseases associated with insulin resistance are e.g. type 2 diabetes mellitus, insulin resistance syndrome, impaired glucose tolerance, the metabolic syndrome, hyperglycemia, hyperinsulinemia, arteriosclerosis, hypercholesterolemia, hypertriglyceridemia, hyperlipidemia, dyslipidemia, obesity, central obesity, polycystic ovarian syndrome, hypercoagulability, hypertension, microalbuminuria, or any combinations thereof.
摘要翻译：本发明涉及具有式（I）的核心结构的物质或其药学上可接受的盐，溶剂合物或前药用于制备用于治疗胰岛素抵抗或与胰岛素抵抗相关的疾病的组合物的用途，优选地，在约5mg至约1500mg范围内的每日剂量的人受试者。本发明还涉及一种治疗哺乳动物胰岛素抵抗或与胰岛素抵抗相关的疾病的方法，所述方法包括向所述妈妈，优选人受试者施用具有式（I）核心结构的物质，优选在每日剂量范围为约5mg至约1500mg。该物质优选是异硫代醇或甜菊醇，或其药学上可接受的盐，溶剂合物或前药。与胰岛素抵抗相关的疾病的实例是例如。 2型糖尿病，胰岛素抵抗综合征，葡萄糖耐量异常，代谢综合征，高血糖症，高胰岛素血症，动脉硬化，高胆固醇血症，高甘油三酯血症，高脂血症，血脂异常，肥胖，中枢性肥胖，多囊卵巢综合征，高凝状态，高血压，微量白蛋白尿或其任何组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式