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    • 4. 发明申请
    • SELECTIVE MODIFICATION OF ORGANIC COMPOUNDS IN THE PRESENCE OF AMINES AND/OR SULFIDES
    • 有机化合物在氨基酸和/或硫化物存在下的选择性修饰
    • WO2014152737A1
    • 2014-09-25
    • PCT/US2014/027678
    • 2014-03-14
    • HEPATOCHEM
    • BUZDYGON, RyanBAZIN, Marc
    • C07D221/20C07D211/60C07D211/94
    • C07D211/60C07D211/94C07D221/20
    • Disclosed herein is a method for selectively modifying a substitutable carbon atom of an organic compound containing an amine, a sulfide, or an amine and a sulfide. The method makes use of the reactivity of amines and sulfides, which can be selectively oxidized to form oxides that are inert under the conditions of many modification reactions and selectively reduced, by protecting the amine, the sulfide, or the amine and the sulfide in the organic compound as an oxide; subjecting the oxide-containing organic compound to reaction conditions suitable to effect a modification reaction; and deprotecting the amine, the sulfide, or the amine and the sulfide in the modified oxide-containing organic compound using a reducing agent, thereby selectively modifiying a substitutable carbon atom of an organic compound containing an amine, a sulfide, or an amine and a sulfide.
    • 本文公开了一种选择性地修饰含有胺,硫化物或胺和硫化物的有机化合物的可取代的碳原子的方法。 该方法利用胺和硫化物的反应性,其可以选择性地氧化形成在许多改性反应条件下是惰性的并选择性还原的氧化物,通过保护胺,硫化物或胺和硫化物在 有机化合物作为氧化物; 使含氧化物的有机化合物进行适于进行改性反应的反应条件; 并使用还原剂使修饰的含氧化物的有机化合物中的胺,硫化物或胺和硫化物脱保护,从而选择性地改性含有胺,硫化物或胺的有机化合物的可取代的碳原子,以及 硫化物。