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1. 发明申请

WO2009129396A1 PHOTOBIOREACTOR SYSTEMS AND METHODS INCORPORATING CULTIVATION MATRICES 审中-公开
标题翻译：光电子系统和包含生成矩阵的方法
公开(公告)号：WO2009129396A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/040818
申请日：2009-04-16
申请人： GREENFUEL TECHNOLOGIES CORPORATION , AHRENS, Toby , FOWLER, Ben , GAY, Marcus , HEIFETZ, Peter, B. , LEWNARD, John, J. , LOCKWOOD, Kevin , PRAPAS, Jason , PULZ, Otto , WALKER, Miles , WILSON, Christopher
发明人： AHRENS, Toby , FOWLER, Ben , GAY, Marcus , HEIFETZ, Peter, B. , LEWNARD, John, J. , LOCKWOOD, Kevin , PRAPAS, Jason , PULZ, Otto , WALKER, Miles , WILSON, Christopher
IPC分类号： C12M1/00
CPC分类号： C12M43/04 , C12M21/02 , C12M23/56 , C12M25/14 , C12M29/18
摘要： Certain embodiments and aspects of the present invention relate to a photobioreactor including covered photobioreactor units (100) enclosing at least one cultivation matrix (1012) upon which at least one species of phototrophic organism grows.
摘要翻译：本发明的某些实施方案和方面涉及一种光生物反应器，其包括包围有至少一种光营养生物生长的至少一种培养基质（1012）的覆盖的光生物反应器单元（100）。

2. 发明申请

WO2007070389A3 CONTROL OF PARASITIC WEEDS 审中-公开
标题翻译： PARASITIC WEEDS的控制
公开(公告)号：WO2007070389A3
公开(公告)日：2008-06-05
申请号：PCT/US2006046926
申请日：2006-12-11
申请人： SYNGENTA PARTICIPATIONS AG , DEFRAMOND ANIC , HEIFETZ PETER B , MCMILLAN JOHN
发明人： DEFRAMOND ANIC , HEIFETZ PETER B , MCMILLAN JOHN
IPC分类号： C12N15/64 , C12N5/02 , C12N5/10
CPC分类号： C12N15/8279
摘要： The present invention provides methods for making plants resistant to parasitic weeds, the resistant transgenic plants, vectors and methods of integrated parasitic weed management.
摘要翻译：本发明提供了使植物抵抗寄生杂草，抗性转基因植物，载体和综合寄生杂草管理方法的方法。

3. 发明申请

WO2004074491A3 EXPRESSION IN PLANTS OF ANTIBODIES AGAINST ENTEROTOXIGENIC ESCHERICHIA COLI 审中-公开
标题翻译：抗菌药物在植物中的表达
公开(公告)号：WO2004074491A3
公开(公告)日：2004-11-18
申请号：PCT/EP2004001427
申请日：2004-02-16
申请人： SYNGETA PARTICIPATIONS AG , BROWN DEVON , CAMPOS MANUEL , DALMIA BIPIN , DEMAREST STEPHEN , HANSEN GENEVIEVE , HEIFETZ PETER BERNARD
发明人： BROWN DEVON , CAMPOS MANUEL , DALMIA BIPIN , DEMAREST STEPHEN , HANSEN GENEVIEVE , HEIFETZ PETER BERNARD
IPC分类号： C07K16/12 , C12N15/82 , C07K14/415
CPC分类号： C12N15/8257 , C07K16/1232 , C07K2317/13 , C07K2317/20
摘要： The present invention relates to the expression of antibodies and/or fragments thereof in plants, and in particular to the expression of antibodies and/or fragments thereof that have specificity for enterotoxigenic Escherichia coli. Nucleotide and amino acid sequences of such antibodies and/or fragments are disclosed, as are methods of producing such antibodies and /or fragments, transgenic plants expressing such antibodies and/or fragments thereof, and methods of using such transgenic plants or material derived therefrom, in particular in the treatment or prevention of enteric disease. Also described are methods of enhancing the stability antibodies and fragments thereof.
摘要翻译：本发明涉及植物中抗体和/或其片段的表达，特别涉及对产生肠毒素的大肠杆菌具有特异性的抗体和/或其片段的表达。公开了这种抗体和/或片段的核苷酸和氨基酸序列，生产此类抗体和/或片段的方法，表达这种抗体和/或其片段的转基因植物，以及使用这些转基因植物或其衍生物质的方法，特别是治疗或预防肠道疾病。还描述了增强抗体及其片段稳定性的方法。

4. 发明申请

WO1998011235A2 TRANSGENIC PLANTS EXPRESSING CELLULOLYTIC ENZYMES 审中-公开
标题翻译：表达微生物酶的转基因植物
公开(公告)号：WO1998011235A2
公开(公告)日：1998-03-19
申请号：PCT/US1997016187
申请日：1997-09-12
申请人： NOVARTIS AG , LEBEL, Edouard , HEIFETZ, Peter , WARD, Eric , UKNES, Scott
发明人： NOVARTIS AG
IPC分类号： C12N15/56
CPC分类号： C12N15/8216 , C12N9/2437 , C12N15/8214 , C12N15/8217 , C12N15/8237 , C12N15/8238 , C12N15/8242 , C12N15/8246 , C12Y302/01004 , Y02E50/16 , Y02E50/17
摘要： The invention provides novel methods of controlling gene expression in plastids, using an inducible, transactivator-mediated system, and plants comprising the novel expression systems. The present invention further describes the production of cellulose-degrading enzymes in plants via the application of genetic engineering techniques. Cellulase coding sequences are fused to promoters active in plants and transformed into the nuclear genome and the chloroplast genome. As cellulases may be toxic to plants, preferred promoters are those that are chemically-inducible. In this manner, expression of the cellulase genes transformed into plants may be chemically induced at an appropriate time. In addition, the expressed cellulases may be targeted to vacuoles or other organelles to alleviate toxicity problems. The present invention finds utility in any industrial process requiring a plentiful supply of cellulases, but particularly finds utility in the conversion of cellulosic biomass to ethanol.
摘要翻译：本发明提供了使用诱导型反式激活因子介导的系统以及包含新型表达系统的植物来控制质体中基因表达的新方法。本发明进一步描述了通过应用基因工程技术在植物中生产纤维素降解酶。纤维素酶编码序列与在植物中有活性的启动子融合，并转化到核基因组和叶绿体基因组中。由于纤维素酶对植物有毒性，优选的启动子是化学诱导型的启动子。以这种方式，可以在适当的时间化学诱导转化到植物中的纤维素酶基因的表达。此外，表达的纤维素酶可以靶向液泡或其他细胞器以减轻毒性问题。本发明可用于需要大量供应纤维素酶的任何工业过程中，特别是在纤维素生物质转化为乙醇方面具有实用价值。

5. 发明申请

WO2019222665A1 THIOL-BASED MULTIVALENT DRUG DELIVERY COMPOSITIONS 审中-公开
公开(公告)号：WO2019222665A1
公开(公告)日：2019-11-21
申请号：PCT/US2019/032932
申请日：2019-05-17
申请人： ORPRO THERAPEUTICS, INC. , HEIFETZ, Peter B.
发明人： HEIFETZ, Peter B. , MOSKOWITZ, Haim
IPC分类号： A61K38/44 , C12N9/02 , C12P21/02
摘要： The present invention is related to a drug delivery composition that includes a thioredoxin homologue protein having an N-terminal monocysteinic active site, with the cysteine residue of the active site in a reduced state and an active agent conjugated to the thioredoxin homologue protein and methods of making and using the composition.

6. 发明申请

WO2009064777A2 PRODUCTION OF FC-FUSION POLYPEPTIDES IN EUKARYOTIC ALGAE 审中-公开
标题翻译：在欧洲阿尔卑斯山脉生产FC-融合多糖
公开(公告)号：WO2009064777A2
公开(公告)日：2009-05-22
申请号：PCT/US2008/083225
申请日：2008-11-12
申请人： SAPPHIRE ENERGY, INC. , HEIFETZ, Peter, B. , FRANKLIN, Scott, E.
发明人： HEIFETZ, Peter, B. , FRANKLIN, Scott, E.
IPC分类号： C07K19/00 , C07K16/00 , C12N15/62 , C12N1/12 , C12N1/00
CPC分类号： C12N15/8257 , C12N15/8258
摘要： Methods and compositions are disclosed to engineer plastids comprising heterologous genes encoding immuno-activating domains fused to an extracellular domain (ECD) of a receptor or surface glycoprotein, a growth factor or an enzyme and produced within a subcellular organelle, such as a chloroplast. The immuno-activating domains may include those regions of a protein capable of modulating the interaction between immune effector cells via proteins containing stereoselective binding domains and specific ligands, such as the Fc regions of antibodies. The present disclosure also demonstrates the utility of plants, including green algae, for the production of complex multi-domain fusion proteins as soluble bioactive therapeutic agents.
摘要翻译：公开了方法和组合物来工程化，其包括编码与受体或表面糖蛋白，生长因子或酶的细胞外结构域（ECD）融合并且在亚细胞器如叶绿体内产生的免疫活性结构域的异源基因的质体。免疫活化结构域可以包括能够通过含有立体选择性结合结构域和特异性配体（例如抗体的Fc区）的蛋白质调节免疫效应细胞之间相互作用的蛋白质的那些区域。本公开还显示了包括绿藻在内的植物用于生产复合多结构域融合蛋白作为可溶性生物活性治疗剂的效用。

7. 发明申请

WO2004074491A2 EXPRESSION IN PLANTS OF ANTIBODIES AGAINST ENTEROTOXIGENIC ESCHERICHIA COLI 审中-公开
标题翻译：抗生素对大肠埃希菌大肠杆菌的表达
公开(公告)号：WO2004074491A2
公开(公告)日：2004-09-02
申请号：PCT/EP2004/001427
申请日：2004-02-16
申请人： SYNGETA PARTICIPATIONS AG , BROWN, Devon , CAMPOS, Manuel , DALMIA, Bipin , DEMAREST, Stephen , HANSEN, Genevieve , HEIFETZ, Peter, Bernard
发明人： BROWN, Devon , CAMPOS, Manuel , DALMIA, Bipin , DEMAREST, Stephen , HANSEN, Genevieve , HEIFETZ, Peter, Bernard
IPC分类号： C12N15/82
CPC分类号： C12N15/8257 , C07K16/1232 , C07K2317/13 , C07K2317/20
摘要： The present invention relates to the expression of antibodies and/or fragments thereof in plants, and in particular to the expression of antibodies and/or fragments thereof that have specificity for enterotoxigenic Escherichia coli . Nucleotide and amino acid sequences of such antibodies and/or fragments are disclosed, as are methods of producing such antibodies and /or fragments, transgenic plants expressing such antibodies and/or fragments thereof, and methods of using such transgenic plants or material derived therefrom, in particular in the treatment or prevention of enteric disease. Also described are methods of enhancing the stability antibodies and fragments thereof.
摘要翻译：本发明涉及抗体和/或其片段在植物中的表达，并且具体涉及对产肠毒素大肠杆菌（Escherichia coli）具有特异性的抗体和/或其片段的表达， I>。公开了这些抗体和/或片段的核苷酸和氨基酸序列，以及生产这些抗体和/或片段的方法，表达这种抗体和/或其片段的转基因植物，以及使用这些转基因植物或由其衍生的材料的方法，特别是在治疗或预防肠疾病中。还描述了增强抗体及其片段的稳定性的方法。

8. 发明申请

WO0250289A9 METHODS FOR THE PRODUCTION OF MULTIMERIC PROTEINS, AND RELATED COMPOSITIONS 审中-公开
标题翻译：生产多种蛋白质的方法及相关组合物
公开(公告)号：WO0250289A9
公开(公告)日：2003-04-17
申请号：PCT/US0150240
申请日：2001-12-19
申请人： SEMBIOSYS GENETICS INC , SYNGENTA PARTICIPATIONS AG , VAN ROOIJEN GIJS , DECKERS HARM , HEIFETZ PETER BERNARD , BRIGGS STEVEN P , DALMIA BIPIN KUMAR , DEL VAL GREGG , ZAPLACHINSKI STEVE , MOLONEY MAURICE
发明人： VAN ROOIJEN GIJS , DECKERS HARM , HEIFETZ PETER BERNARD , BRIGGS STEVEN P , DALMIA BIPIN KUMAR , DEL VAL GREGG , ZAPLACHINSKI STEVE , MOLONEY MAURICE
IPC分类号： A01H5/00 , A23L1/30 , A23L1/305 , A61K38/00 , A61K38/43 , A61P1/04 , A61P3/10 , A61P9/00 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00 , C07K14/315 , C07K14/415 , C07K16/00 , C07K19/00 , C11B1/04 , C11D7/44 , C12N5/00 , C12N5/10 , C12N9/02 , C12N15/09 , C12N15/82 , C12P7/64 , C12P21/02 , C12N15/79
CPC分类号： C12N15/8258 , C12N15/8257
摘要： Improved methods for the production of multimeric-protein-complexes, such as redox proteins and immunoglobins, in association with oil bodies are described. The redox protein is enzymatically active when prepared in association with the oil bodies. Also provided are related nucleic acids, proteins, cells, plants, and compositions.
摘要翻译：描述了与油体相关的用于生产多聚体 - 蛋白质复合物（例如氧化还原蛋白和免疫球蛋白）的改进方法。当与油体结合制备时，氧化还原蛋白具有酶促活性。还提供了相关的核酸，蛋白质，细胞，植物和组合物。

9. 发明申请

WO0107590A3 CHIMERIC GENES FOR PLASTID EXPRESSION 审中-公开
标题翻译： PLASTID表达的CHIMERIC基因
公开(公告)号：WO0107590A3
公开(公告)日：2001-07-26
申请号：PCT/EP0007118
申请日：2000-07-25
申请人： SYNGENTA PARTICIPATIONS AG , HEIFETZ PETER BERNARD , COX KEVIN
发明人： HEIFETZ PETER BERNARD , COX KEVIN
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8274 , C12N15/8214 , C12N15/8223
摘要： Novel chimeric genes and methods for the control of expression of nucleic acid sequences in plant plastids are described in the instant invention. Multiple genes or polycistronic units are expressed using upstream elements of plastid genes naturally found in divergent orientation. These upstream elements may be derived from sequences found in the native plastid genome of the same plant, or preferably from the plastid genome of a different plant species having sequence identity of less than 90 %.
摘要翻译：用于控制植物质体中核酸序列表达的新型嵌合基因和方法在本发明中描述。使用天然存在于发散方向的质体基因的上游元件表达多个基因或多顺反子单位。这些上游元件可以衍生自在相同植物的天然质体基因组中发现的序列，或优选来自具有小于90％的序列同一性的不同植物物种的质体基因组。

10. 发明申请

WO2007070389A2 CONTROL OF PARASITIC WEEDS 审中-公开
标题翻译： PARASITIC WEEDS的控制
公开(公告)号：WO2007070389A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/046926
申请日：2006-12-11
申请人： SYNGENTA PARTICIPATIONS AG , DEFRAMOND, Anic , HEIFETZ, Peter, B. , MCMILLAN, John
发明人： DEFRAMOND, Anic , HEIFETZ, Peter, B. , MCMILLAN, John
IPC分类号： A01H5/00
CPC分类号： C12N15/8279
摘要： The present invention provides methods for making plants resistant to parasitic weeds, the resistant transgenic plants, vectors and methods of integrated parasitic weed management.
摘要翻译：本发明提供了使植物抵抗寄生杂草，抗性转基因植物，载体和综合寄生杂草管理方法的方法。

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