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1. 发明申请

WO2006027111A1 MODIFIED COAGULATION FACTOR VIII WITH ENHANCED STABILITY 审中-公开
标题翻译：改进的凝血因子VIII具有增强的稳定性
公开(公告)号：WO2006027111A1
公开(公告)日：2006-03-16
申请号：PCT/EP2005/009170
申请日：2005-08-25
申请人： ZLB BEHRING GMBH , HAUSER, Hans-Peter , WEIMER, Thomas , ROLLI, Véronique , ENJOLRAS, Nathalie , PLANTIER, Jean-Luc , NEGRIER, Claude
发明人： HAUSER, Hans-Peter , WEIMER, Thomas , ROLLI, Véronique , ENJOLRAS, Nathalie , PLANTIER, Jean-Luc , NEGRIER, Claude
IPC分类号： C07K14/755
CPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to modified nucleic acid sequences coding for coagulation factors, in particular for human factor VIII and their derivatives with improved stability, to recombinant expression vectors containing such nucleic acid sequences, to host cells transformed with such recombinant expression vectors, to recombinant polypeptides and derivatives which have biological activities of the unmodified wild type protein but have improved stability and to processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises modified DNA sequences.
摘要翻译：本发明涉及编码凝血因子的修饰的核酸序列，特别是对于具有改善的稳定性的人因子VIII及其衍生物，含有此类核酸序列的重组表达载体，将宿主细胞用这种重组表达载体转化的重组多肽以及具有未修饰的野生型蛋白质的生物活性但具有改善的稳定性的衍生物以及制备这些重组蛋白及其衍生物的方法。本发明还涵盖用于人基因治疗的转移载体，其包含修饰的DNA序列。

2. 发明申请

WO2005040213A1 MODIFIED cDNA FOR HIGH EXPRESSION LEVELS OF FACTOR VIII AND ITS DERIVATIVES 审中-公开
标题翻译：因子VIII及其衍生物的高表达水平的修饰cDNA
公开(公告)号：WO2005040213A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011445
申请日：2004-10-13
申请人： ZLB BEHRING GMBH , HAUSER, Hans-Peter , PLANTIER, Jean-Luc , DUCASSE, Cecille , NEGRIER, Claude
发明人： HAUSER, Hans-Peter , PLANTIER, Jean-Luc , DUCASSE, Cecille , NEGRIER, Claude
IPC分类号： C07K14/755
CPC分类号： C07K14/755 , A61K48/00
摘要： The present invention relates to modified DNA sequences coding for biologically active recombinant human factor VIII and its derivatives, recombinant expression vectors containing such DNA sequences, host cells transformed with such recombinant expression vectors, and processes for the manufacture of the recombinant human factor VIll and its derivatives. The invention also covers a transfer vector for use in human gene therapy which comprises such modified DNA sequences. The present invention relates to modified DNA sequences coding for biologically active recombinant human factor VIII and its derivatives, recombinant expression vectors containing such DNA sequences, host cells transformed with such recombinant expression vectors, and processes for the manufacture of the recombinant human factor VIII and its derivatives. The invention also covers a transfer vector for use in human gene therapy which comprises such modified DNA sequences.
摘要翻译：本发明涉及编码生物活性重组人因子VIII及其衍生物的修饰DNA序列，含有此类DNA序列的重组表达载体，用此类重组表达载体转化的宿主细胞，以及重组人因子VIII及其制备方法衍生物。本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA序列。本发明涉及编码生物活性重组人因子VIII及其衍生物的修饰DNA序列，含有这些DNA序列的重组表达载体，用这种重组表达载体转化的宿主细胞，以及重组人因子VIII及其制备方法衍生物。本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA序列。

3. 发明申请

WO1993004831A1 VERTICAL PRESS AND PROCESS FOR OPERATING THE SAME 审中-公开
标题翻译：垂直压力及其操作方法
公开(公告)号：WO1993004831A1
公开(公告)日：1993-03-18
申请号：PCT/CH1992000182
申请日：1992-09-07
申请人： LAEIS-BUCHER GMBH , HAUSER, Hans, Ulrich , LINDEMANS, Jörg , MICK, Martin
发明人： LAEIS-BUCHER GMBH
IPC分类号： B28B17/00
CPC分类号： B28B17/009 , B30B15/028
摘要： In order to simplify the transport of parts to be exchanged (5', 6, 6', 7, 7') of a vertical press (1), devices (10, 10', 11) for lifting and transporting these parts are incorporated into the press. Appropriately, the lifting and transporting devices (10, 10') are mounted on a movable, uppermost mould-carrying element (4) of the press (1), so that the drive and control arrangements for said mould-carrying element (4) used for pressing can also be used for verticaly moving the lifting and transporting devices (10, 10'). By means of a programmed control, the required displacements up to mould-specific intermediate positions, as well as coupling and decoupling processes to be carried out at these positions, can be programmed and automatically carried out for a series of moulds.
摘要翻译：为了简化垂直压力机（1）的待更换部件（5'，6'，7'，7'）的运输，结合了用于提升和运输这些零件的装置（10,10'，11）进入新闻界。适当地，提升和运输装置（10,10'）安装在压力机（1）的可移动的最上面的模具承载元件（4）上，使得所述模具承载元件（4）的驱动和控制装置用于压制也可用于垂直移动提升和运输装置（10,10'）。通过编程控制，可以对一系列模具进行编程并自动执行到模具特定中间位置所需的位移以及在这些位置执行的耦合和去耦工艺。

4. 发明申请

WO2008049025A2 VEHICLE CONTROL SYSTEMS AND METHODS 审中-公开
标题翻译：车辆控制系统和方法
公开(公告)号：WO2008049025A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/081683
申请日：2007-10-17
申请人： MTD PRODUCTS, INC. , RUEBUSCH, Rick , OBRZUT, Tim , HAUSER, Hans
发明人： RUEBUSCH, Rick , OBRZUT, Tim , HAUSER, Hans
IPC分类号： B60K17/30
CPC分类号： B62D3/12 , B62D3/02 , B62D7/10 , B62D11/006 , B62D11/24 , Y10T74/18096
摘要： Systems and methods for controlling the speed and direction of vehicles such as tractors.
摘要翻译：用于控制诸如拖拉机的车辆的速度和方向的系统和方法。

5. 发明申请

WO2007014030A3 STEERING SYSTEMS, STEERING AND SPEED COORDINATION SYSTEMS, AND ASSOCIATED VEHICLES 审中-公开
标题翻译：转向系统，转向和速度协调系统及相关车辆
公开(公告)号：WO2007014030A3
公开(公告)日：2007-10-04
申请号：PCT/US2006028357
申请日：2006-07-21
申请人： INFINITRAK LLC , SCHAEDLER AXEL , HAUSER HANS , RUEBUSCH RICK , CORNWELL IAN DAVID , GREENWOOD CHRIS
发明人： SCHAEDLER AXEL , HAUSER HANS , RUEBUSCH RICK , CORNWELL IAN DAVID , GREENWOOD CHRIS
IPC分类号： B60K17/00
CPC分类号： B62D7/09 , B60W10/10 , B60W10/20 , B60W30/045 , B62D3/02 , B62D7/08 , B62D9/00 , B62D11/006 , B62D11/24
摘要： In a broad respect, vehicles that are capable of making a low- to zero-radius turn using the independent rotation of drive wheels and by turning the non-driving steerable structure or structures (such as wheels) with a steering input device (in some embodiments, the driving wheels also may be capable of being turned). This may be accomplished using a steering system, a speed control system and an integration device (together, a control system) that are configured to work together to provide correct steering in forward and reverse, and, in some embodiments, to reduce the speed of the outboard drive wheel of the vehicle when it enters an extreme turn under constant speed input. Different systems configured for use in such vehicles are included.
摘要翻译：在广泛的方面，能够使用驱动轮的独立旋转并且通过用转向输入装置转动非驱动的可转向结构（例如车轮）来实现低至零半径的转弯的车辆（在某些方面实施例中，驱动轮也可以被转动）。这可以使用转向系统，速度控制系统和集成装置（在一起，控制系统）来完成，该装置被配置为一起工作以提供正向和反向的正确转向，并且在一些实施例中可以降低速度当在恒定速度输入下进入极限转弯时，车辆的外侧驱动轮。包括配置用于这种车辆的不同系统。

6. 发明申请

WO2007014030A2 STEERING SYSTEMS, STEERING AND SPEED COORDINATION SYSTEMS, AND ASSOCIATED VEHICLES 审中-公开
标题翻译：转向系统，转向和速度协调系统以及相关车辆
公开(公告)号：WO2007014030A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/028357
申请日：2006-07-21
申请人： INFINITRAK LLC , SCHAEDLER, Axel , HAUSER, Hans , RUEBUSCH, Rick , CORNWELL, Ian, David , GREENWOOD, Chris
发明人： SCHAEDLER, Axel , HAUSER, Hans , RUEBUSCH, Rick , CORNWELL, Ian, David , GREENWOOD, Chris
IPC分类号： B60K28/16
CPC分类号： B62D7/09 , B60W10/10 , B60W10/20 , B60W30/045 , B62D3/02 , B62D7/08 , B62D9/00 , B62D11/006 , B62D11/24
摘要： In a broad respect, vehicles that are capable of making a low- to zero-radius turn using the independent rotation of drive wheels and by turning the non-driving steerable structure or structures (such as wheels) with a steering input device (in some embodiments, the driving wheels also may be capable of being turned). This may be accomplished using a steering system, a speed control system and an integration device (together, a control system) that are configured to work together to provide correct steering in forward and reverse, and, in some embodiments, to reduce the speed of the outboard drive wheel of the vehicle when it enters an extreme turn under constant speed input. Different systems configured for use in such vehicles are included.
摘要翻译：在广泛的方面，使用驱动轮的独立旋转并且通过转动非驱动的可转向结构或结构（例如轮）能够使得半径小到零的车辆转向，利用转向输入装置（在一些实施例中，驱动轮也可以能够转动）。这可以使用转向系统，速度控制系统和集成设备（一起，控制系统）来实现，其被配置为一起工作以提供正向和反向的正确转向，并且在一些实施例中，以降低在恒速输入下进入极限转弯时车辆的外侧驱动轮。包括配置用于这种车辆的不同系统。

7. 发明申请

WO2005054286A3 INTERLEUKIN-11 FUSION PROTEINS 审中-公开
标题翻译： INTERLEUKIN-11融合蛋白
公开(公告)号：WO2005054286A3
公开(公告)日：2006-11-30
申请号：PCT/GB2004005091
申请日：2004-12-03
申请人： DELTA BIOTECHNOLOGY LTD , KROEZ M , DICKNEITE G , HAUSER HANS-PETER , WEIMER T , SLEEP DARRELL
发明人： KROEZ M , DICKNEITE G , HAUSER HANS-PETER , WEIMER T , SLEEP DARRELL
IPC分类号： C07K14/54 , A61K38/00 , A61K38/20 , A61K38/38 , C07K14/76 , C07K14/765
CPC分类号： A61K38/38 , A61K38/2073 , C07K14/5431 , C07K14/76 , C07K14/765 , C07K2319/31
摘要： The invention relates to proteins comprising Interleukin 11 (IL-11) (including, but not limited to, fragments and variants thereof), which exhibit thrombopoietic or antiinflammatory properties, fused to albumin (including, but not limited to fragments or variants of albumin). These fusion proteins are herein collectively referred to as "albumin fusion proteins of the invention". These fusion proteins exhibit extended shelf-life and/ or pharmacokinetic properties and/or extended or therapeutic activity. The invention encompasses therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits. The invention also encompasses nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins of the invention using these nucleic acids, vectors, and/or host cells. The invention also relates to compositions and methods for treatment or prophylaxis of thrombocytopenia or inflammatory diseases.
摘要翻译：本发明涉及与白蛋白（包括但不限于白蛋白的片段或变体）融合的表现出血小板生成或抗炎特性的白介素11（IL-11）（包括但不限于其片段和变体）的蛋白质，。这些融合蛋白在本文中统称为“本发明的白蛋白融合蛋白”。这些融合蛋白具有延长的保质期和/或药代动力学性质和/或延长或治疗活性。本发明包括治疗性白蛋白融合蛋白，组合物，药物组合物，制剂和试剂盒。本发明还包括编码本发明的白蛋白融合蛋白的核酸分子以及含有这些核酸的载体，用这些核酸和载体转化的宿主细胞，以及使用这些核酸制备本发明的白蛋白融合蛋白的方法，载体和/或宿主细胞。本发明还涉及用于治疗或预防血小板减少症或炎性疾病的组合物和方法。

8. 发明申请

WO2006108590A1 MODIFIED COAGULATION FACTOR VIII WITH ENHANCED STABILITY AND ITS DERIVATES 审中-公开
标题翻译：改进的凝血因子VIII具有增强的稳定性及其衍生物
公开(公告)号：WO2006108590A1
公开(公告)日：2006-10-19
申请号：PCT/EP2006/003249
申请日：2006-04-10
申请人： ZLB BEHRING GMBH , HAUSER, Hans-Peter , WEIMER, Thomas , PLANTIER, Jean-Luc , RODRIGUEZ, Marie-Hélène , NÉGRIER, Claude
发明人： HAUSER, Hans-Peter , WEIMER, Thomas , PLANTIER, Jean-Luc , RODRIGUEZ, Marie-Hélène , NÉGRIER, Claude
IPC分类号： C07K14/755 , C12N15/63
CPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to modified nucleic acid sequences coding for coagulation factors, in particular human Factor VIII and their derivatives with improved stability, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises modified DNA sequences.
摘要翻译：本发明涉及编码凝血因子的修饰的核酸序列，特别是具有改善的稳定性的人因子VIII及其衍生物，含有此类核酸序列的重组表达载体，用这种重组表达载体转化的宿主细胞，重组多肽和衍生物具有未经修饰的野生型蛋白质的生物活性，但具有改进的稳定性和制备这些重组蛋白质及其衍生物的方法。本发明还涵盖用于人基因治疗的转移载体，其包含修饰的DNA序列。

9. 发明申请

WO2003066824A3 ALBUMIN-FUSED KUNITZ DOMAIN PEPTIDES 审中-公开
公开(公告)号：WO2003066824A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003616
申请日：2003-02-07
申请人： AVENTIS BEHRING GMBH , AVENTIS BEHRING L.L.C. , DELTA BIOTECHNOLOGY LIMITED , DYAX CORPORATION , HAUSER, Hans-Peter , WEIMER, Thomas , ROMBERG, Val , KEE, Scott, M. , SLEEP, Darrell , LADNER, Robert, Charles , LEY, Arthur, C.
发明人： HAUSER, Hans-Peter , WEIMER, Thomas , ROMBERG, Val , KEE, Scott, M. , SLEEP, Darrell , LADNER, Robert, Charles , LEY, Arthur, C.
IPC分类号： C07K14/765 , C07K14/81 , C07K19/00 , C12N15/14 , C12N15/15 , C12N15/62 , C12N15/81
摘要： The invention relates to albumin fusion proteins comprising an albumin fusion partner and a protease inhibitor fusion partner which may be a Kunitz domain protease inhibitor capable of inhibiting a serine protease, including neutrophil elastase, kallikrein, and plasm The fusion proteins exhibit extended shelf life and/or extended therapeutic activity in solution. The invention encompasses therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits comprising the albumin fusion proteins, a well as nucleic acid molecules encoding the albumin fusion proteins, vectors comprising these nucleic acids, host cells transformed w these nucleic acids and vectors, and methods of making the encoded proteins using the nucleic acids, vectors and/or host cells. The invention also relates to compositions and methods for inhibiting neutrophil elastase, kallikrein, and plasmin, and to compositions an methods for treating cystic fibrosis and cancer.

10. 发明申请

WO2003066824A2 ALBUMIN-FUSED KUNITZ DOMAIN PEPTIDES 审中-公开
标题翻译：阿姆斯特朗融合的昆虫域蛋白
公开(公告)号：WO2003066824A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003616
申请日：2003-02-07
申请人： AVENTIS BEHRING GMBH , AVENTIS BEHRING L.L.C. , DELTA BIOTECHNOLOGY LIMITED , DYAX CORPORATION , HAUSER, Hans-Peter , WEIMER, Thomas , ROMBERG, Val , KEE, Scott, M. , SLEEP, Darrell , LADNER, Robert, Charles , LEY, Arthur, C.
发明人： HAUSER, Hans-Peter , WEIMER, Thomas , ROMBERG, Val , KEE, Scott, M. , SLEEP, Darrell , LADNER, Robert, Charles , LEY, Arthur, C.
IPC分类号： C12N
CPC分类号： A61K47/48315 , A01K2217/05 , A61K9/0019 , A61K31/7088 , A61K38/00 , A61K38/39 , A61K39/00 , A61K39/0005 , A61K47/643 , A61K48/00 , A61K2039/53 , C07K14/005 , C07K14/47 , C07K14/765 , C07K14/78 , C07K14/8114 , C07K2319/00 , C07K2319/31 , C12N15/62 , C12N2740/16122 , C12Y301/26003
摘要： The invention relates to proteins comprising serine protease inhibiting peptides, such as Kunitz domain peptides (including, but not limited to, fragments and variants thereof) fused to albumin, or fragments or variants thereof. These fusion proteins are herein collectively referred to as "albumin fusion proteins of the invention."These fusion proteins exhibit extended shelf-life and/or extended or therapeutic activity in solution. The invention encompasses, therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits. The invention also encompasses nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins of the invention using these nucleic acids, vectors, and/or host cells. The invention also relates to compositions and methods for inhibiting neutrophil elastase, kallikrein, and plasmin. The invention further relates to compositions and methods for treating cystic fibrosis and cancer.
摘要翻译：本发明涉及包含丝氨酸蛋白酶抑制肽的蛋白质，例如Kunitz结构域肽，包括但不限于与白蛋白融合的片段和变体，或其片段或变体。这些融合蛋白在本文中统称为“本发明的白蛋白融合蛋白”。这些融合蛋白在溶液中表现出延长的保质期和/或延长或治疗活性。本发明包括治疗性白蛋白融合蛋白，组合物，药物组合物，制剂和试剂盒。本发明还包括编码本发明的白蛋白融合蛋白的核酸分子以及含有这些核酸的载体，用这些核酸和载体转化的宿主细胞，以及使用这些核酸制备本发明的白蛋白融合蛋白的方法，载体和/或宿主细胞。本发明还涉及抑制嗜中性粒细胞弹性蛋白酶，激肽释放酶和纤溶酶的组合物和方法。本发明还涉及治疗囊性纤维化和癌症的组合物和方法。

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