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1. 发明申请

WO2005061719A1 2-MICRON FAMILY PLASMID AND USE THEREOF 审中-公开
标题翻译： 2-MICRON FAMILY PLASMID及其用途
公开(公告)号：WO2005061719A1
公开(公告)日：2005-07-07
申请号：PCT/GB2004/005435
申请日：2004-12-23
申请人： DELTA BIOTECHNOLOGY LIMITED , SLEEP, Darrell , FINNIS, Christopher, John, Arthur
发明人： SLEEP, Darrell , FINNIS, Christopher, John, Arthur
IPC分类号： C12N15/81
CPC分类号： C12N15/81
摘要： The present invention provides a 2µm-family plasmid comprising a polynucleotide sequence insertion, deletion and/or substitution between the first base after the last functional codon of at least one of either a REP2 gene or an FLP gene and the last base before the FRT site in an inverted repeat adjacent to said gene.
摘要翻译：本发明提供了包含在REP2基因或FLP基因中的至少一个的最后功能密码子之后的第一碱基与FRT位点之前的最后碱基之间的多核苷酸序列插入，缺失和/或置换的2μm家族质粒在与所述基因相邻的反向重复中。

2. 发明申请

WO1997024445A1 RECOMBINANT FUSION PROTEINS TO GROWTH HORMONE AND SERUM ALBUMIN 审中-公开
标题翻译：重组融合蛋白生长激素和血清白蛋白
公开(公告)号：WO1997024445A1
公开(公告)日：1997-07-10
申请号：PCT/GB1996003164
申请日：1996-12-19
申请人： DELTA BIOTECHNOLOGY LIMITED , BALLANCE, David, James
发明人： DELTA BIOTECHNOLOGY LIMITED
IPC分类号： C12N15/62
CPC分类号： A61K38/27 , C07K14/61 , C07K14/765 , C07K2319/00
摘要： Fusion proteins of albumin and growth hormone, or fusions of variants of either, are secreted well in yeast and have increased serum and storage stability.
摘要翻译：白蛋白和生长激素的融合蛋白或其变体的融合物在酵母中分泌良好，并且具有增加的血清和储存稳定性。

3. 发明申请

WO1996037515A1 PROCESS OF HIGH PURITY ALBUMIN PRODUCTION 审中-公开
标题翻译：高纯度铝生产工艺
公开(公告)号：WO1996037515A1
公开(公告)日：1996-11-28
申请号：PCT/GB1996000449
申请日：1996-02-29
申请人： DELTA BIOTECHNOLOGY LIMITED , GOODEY, Andrew, Robert , SLEEP, Darrell , VAN URK, Hendrik , BEREZENKO, Stephen , WOODROW, John, Rodney , JOHNSON, Richard, Alan , WOOD, Patricia, Carol , BURTON, Stephen, James , QUIRK, Alan, Victor
发明人： DELTA BIOTECHNOLOGY LIMITED
IPC分类号： C07K14/765
CPC分类号： C07K14/70571 , C07K14/765 , C07K2319/10
摘要： A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an intact C-terminus. The process comprises passing albumin (preferably expressed and secreted by transformed yeast) through positive mode cation exchange and then positive mode anion exchange chromatography. Other steps may also be employed, for example ultrafiltration, gel permeation chromatography, affinity chromatography binding the albumin (for example using blue dyes) and affinity chromatography binding contaminants (for example using an aminophenylboronic acid resin). Elution of albumin, with a compound having affinity for albumin, from a material having no specific affinity for albumin is also disclosed, as is removal of ammonium ions with a counter-ion.
摘要翻译：提供了一种制备白蛋白的方法，其具有极低水平或基本上不含着色剂，金属离子，人蛋白质，宿主蛋白质，白蛋白片段，白蛋白和病毒的聚合物或聚集体，并且基本上未被糖化，游离硫醇相对较高，具有完整的C末端。该方法包括使白蛋白（优选由转化的酵母表达和分泌）通过阳离子阳离子交换然后进行阳性阴离子交换层析。还可以采用其他步骤，例如超滤，凝胶渗透色谱法，结合白蛋白的亲和层析（例如使用蓝色染料）和亲和层析结合污染物（例如使用氨基苯基硼酸树脂）。还公开了从对白蛋白没有特异性亲和力的物质洗脱白蛋白和具有对白蛋白的亲和性的化合物，以及用抗衡离子除去铵离子。

4. 发明申请

WO1994008627A1 PREPARATION OF FURTHER DIAGNOSTIC AGENTS 审中-公开
标题翻译：进一步诊断试剂的制备
公开(公告)号：WO1994008627A1
公开(公告)日：1994-04-28
申请号：PCT/GB1993002091
申请日：1993-10-08
申请人： DELTA BIOTECHNOLOGY LIMITED , SUTTON, Andrew, Derek , JOHNSON, Richard, Alan
发明人： DELTA BIOTECHNOLOGY LIMITED
IPC分类号： A61K49/00
CPC分类号： A61K9/5052 , A61K9/1658 , A61K9/5031 , A61K47/42 , A61K49/22 , A61K49/223
摘要： Microspheres are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microspheres and (ii) reducing the water-solubility of at least the outside of the intermediate microspheres. Suitable wall-forming materials include proteins such as albumin and gelatin. The microsphere have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced. In particular, the microspheres may be 15-20 mu m, targeted to selected areas of the body or of prolonged life in the circulation.
摘要翻译：微球通过包括以下步骤的方法制备：（i）喷雾干燥成壁材料的溶液或分散体以获得中间体微球，和（ii）降低至少中间微球外部的水溶性。合适的成壁材料包括蛋白质如白蛋白和明胶。微球具有40-500nm厚的壁，并且可用于超声成像。中等尺寸，尺寸分布和成壁材料的不溶解和交联程度的控制允许制备新的微球制剂。特别地，微球可以是15-20μm，靶向身体的选定区域或在循环中延长使用寿命。

5. 发明申请

WO1992018164A1 PREPARATION OF DIAGNOSTIC AGENTS 审中-公开
标题翻译：诊断试剂的制备
公开(公告)号：WO1992018164A1
公开(公告)日：1992-10-29
申请号：PCT/GB1992000643
申请日：1992-04-10
申请人： DELTA BIOTECHNOLOGY LIMITED , SUTTON, Andrew, Derek , JOHNSON, Richard, Alan , SENIOR, Peter, James , HEATH, David
发明人： DELTA BIOTECHNOLOGY LIMITED
IPC分类号： A61K49/00
CPC分类号： A61K49/00 , A61K9/1688 , A61K9/1694 , A61K9/5089 , A61K49/223 , A61K49/225 , B01J13/04 , B01J13/043 , B01J13/14 , Y10S516/928
摘要： Microcapsules are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microcapsules and (ii) reducing the water-solubility of at least the outside of the intermediate microcapsules. Suitable wall-forming materials include proteins such as albumin and gelatin. The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilisation and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.

6. 发明申请

WO2005054286A2 INTERLEUKIN-11 FUSION PROTEINS 审中-公开
标题翻译： INTERLEUKIN-11融合蛋白
公开(公告)号：WO2005054286A2
公开(公告)日：2005-06-16
申请号：PCT/GB2004/005091
申请日：2004-12-03
申请人： DELTA BIOTECHNOLOGY LIMITED , KRÖZ, M. , DICKNEITE, G. , HAUSER, Hans-Peter , WEIMER, T. , SLEEP, Darrell
发明人： KRÖZ, M. , DICKNEITE, G. , HAUSER, Hans-Peter , WEIMER, T. , SLEEP, Darrell
IPC分类号： C07K14/54
CPC分类号： A61K38/38 , A61K38/2073 , C07K14/5431 , C07K14/76 , C07K14/765 , C07K2319/31 , Y02A50/473
摘要： The invention relates to proteins comprising Interleukin 11 (IL-11) (including, but not limited to, fragments and variants thereof), which exhibit thrombopoietic or antiinflammatory properties, fused to albumin (including, but not limited to fragments or variants of albumin). These fusion proteins are herein collectively referred to as "albumin fusion proteins of the invention". These fusion proteins exhibit extended shelf-life and/ or pharmacokinetic properties and/or extended or therapeutic activity. The invention encompasses therapeutic albumin fusion proteins, compositions, pharmaceutical compositions, formulations and kits. The invention also encompasses nucleic acid molecules encoding the albumin fusion proteins of the invention, as well as vectors containing these nucleic acids, host cells transformed with these nucleic acids and vectors, and methods of making the albumin fusion proteins of the invention using these nucleic acids, vectors, and/or host cells. The invention also relates to compositions and methods for treatment or prophylaxis of thrombocytopenia or inflammatory diseases.
摘要翻译：本发明涉及与白蛋白（包括但不限于白蛋白的片段或变体）融合的表现出血小板生成或抗炎特性的白介素11（IL-11）（包括但不限于其片段和变体）的蛋白质，。这些融合蛋白在本文中统称为“本发明的白蛋白融合蛋白”。这些融合蛋白具有延长的保质期和/或药代动力学性质和/或延长或治疗活性。本发明包括治疗性白蛋白融合蛋白，组合物，药物组合物，制剂和试剂盒。本发明还包括编码本发明的白蛋白融合蛋白的核酸分子以及含有这些核酸的载体，用这些核酸和载体转化的宿主细胞，以及使用这些核酸制备本发明的白蛋白融合蛋白的方法，载体和/或宿主细胞。本发明还涉及用于治疗或预防血小板减少症或炎性疾病的组合物和方法。

7. 发明申请

WO2003060071A2 ALBUMIN FUSION PROTEINS 审中-公开
标题翻译： ALBUMIN融合蛋白
公开(公告)号：WO2003060071A2
公开(公告)日：2003-07-24
申请号：PCT/US2002/040891
申请日：2002-12-23
申请人： HUMAN GENOME SCIENCES, INC. , DELTA BIOTECHNOLOGY LIMITED , PRINCIPIA PHARMACEUTICAL CORPORATION , BALLANCE, David, James , TURNER, Andrew, John , ROSEN, Craig, A. , HASELTINE, William, A.
发明人： BALLANCE, David, James , TURNER, Andrew, John , ROSEN, Craig, A. , HASELTINE, William, A.
IPC分类号： C12N
CPC分类号： C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白治疗，预防或改善疾病，病症或病症的方法。

8. 发明申请

WO1995023857A1 YEAST STRAINS AND MODIFIED ALBUMINS 审中-公开
标题翻译： YEAST菌株和改良的ALBUMINS
公开(公告)号：WO1995023857A1
公开(公告)日：1995-09-08
申请号：PCT/GB1995000434
申请日：1995-03-01
申请人： DELTA BIOTECHNOLOGY LIMITED , KERRY-WILLIAMS, Sean, Martin , GILBERT, Sarah, Catherine
发明人： DELTA BIOTECHNOLOGY LIMITED
IPC分类号： C12N15/12
CPC分类号： C07K14/765 , C12N9/60 , C12N15/81
摘要： Albumin, for example human albumin, is expressed and secreted in yeast which has been mutated to lack the yeast aspartyl protease 3 (Yap3p) or its equivalent, thereby reducing the production of a 45kD albumin fragment. A further reduction is achieved by additionally deleting the Kex2p function. Alternatively, a modified albumin is prepared which is not susceptible to Yap3p cleavage, for example human albumin which is R410A, K413Q and K414Q.
摘要翻译：白蛋白，例如人白蛋白，在已被突变以缺乏酵母天冬氨酰蛋白酶3（Yap3p）或其等同物的酵母中表达和分泌，从而减少45kD白蛋白片段的产生。通过另外删除Kex2p功能来进一步减少。或者，制备对Yap3p切割不敏感的修饰的白蛋白，例如R410A，K413Q和K414Q的人白蛋白。

9. 发明申请

WO1992010206A1 USE OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE 2 IN THE TREATMENT OF CANCER 审中-公开
标题翻译：在治疗癌症中使用类胰岛素激活剂2型抑制剂2
公开(公告)号：WO1992010206A1
公开(公告)日：1992-06-25
申请号：PCT/GB1991002177
申请日：1991-12-09
申请人： DELTA BIOTECHNOLOGY LIMITED , SHINKFIELD, Mark, Noel, Forsyth
发明人： DELTA BIOTECHNOLOGY LIMITED
IPC分类号： A61K37/64
CPC分类号： A61K38/57
摘要： PAI-2 (placental-type plasminogen activator inhibitor; plasminogen activator inhibitor type 2; minactivin) may be used at low doses to combat cancers, especially peritoneal cancers. It may be administered via an implanted depot or delivery device for controlled release.
摘要翻译：可以以低剂量使用PAI-2（胎盘型纤溶酶原激活物抑制剂; 2型纤溶酶原激活物抑制剂;灭活素）来对抗癌症，特别是腹膜癌。它可以通过植入的贮库或递送装置进行控制以便控制释放。

10. 发明申请

WO1992004367A1 SEPARATION OF PROTEINS AND DYES 审中-公开
标题翻译：蛋白质和染色体的分离
公开(公告)号：WO1992004367A1
公开(公告)日：1992-03-19
申请号：PCT/GB1991001556
申请日：1991-09-12
申请人： DELTA BIOTECHNOLOGY LIMITED , JOHNSON, Richard, Alan , QUIRK, Alan, Victor , WOODROW, John, Rodney
发明人： DELTA BIOTECHNOLOGY LIMITED
IPC分类号： C07K03/20
CPC分类号： C07K1/18 , C07K14/765
摘要： Problem: when proteins are purified using a protein-binding dye immobilised on a chromatographic matrix, the dye or a portion/derivative may leak into the eluant. Solution: an ion-exchange resin (e.g. Dowex-1) and a disrupting material (e.g. salt and a fatty acid such as sodium octanoate) are used to separate the dye from the protein.

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