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    • 1. 发明申请
    • SYSTEMS FOR EXTRACTING BODILY FLUID AND MONITORING AN ANALYTE THEREIN
    • 提取体液和监测分析物的系统
    • WO2004107977A1
    • 2004-12-16
    • PCT/US2004/018144
    • 2004-06-07
    • LIFESCAN, INC.RACCHINI, JoelSTOUT, PhilHILGERS, Michael, EdwardRADEMACHER, ThomasMECHELKE, JoelHANSON, Cass, A.
    • RACCHINI, JoelSTOUT, PhilHILGERS, Michael, EdwardRADEMACHER, ThomasMECHELKE, JoelHANSON, Cass, A.
    • A61B5/15
    • A61B5/14532A61B5/0002A61B5/022A61B5/1455A61B5/1486A61B5/150022A61B5/150068A61B5/150175A61B5/150221A61B5/150358A61B5/150412A61B5/15087A61B5/15117A61B5/15159A61B5/157A61B5/6824A61B2560/0431A61B2562/0295
    • A system for extracting a bodily fluid sample (e.g., an interstitial fluid [ISF] sample) and monitoring an analyte therein includes a disposable cartridge and a local controller module. The disposable cartridge includes a sampling module adapted to extract a bodily fluid sample and an analysis module adapted to measure an analyte (e.g., glucose) in the bodily fluid sample. The local controller module is in electronic communication with the disposable cartridge and is adapted to receive and store measurement data from the analysis module. An ISF extraction device includes a penetration member configured for penetrating and residing in a target site of a user's skin layer and, subsequently, extracting an ISF sample therefrom. The device also includes a pressure ring(s) adapted for applying pressure to the user's skin layer in the vicinity of the target site. The device is configured such that the pressure ring(s) is capable of applying pressure in an oscillating manner whereby an ISF glucose lag of the ISF sample extracted by the penetration member is mitigated. A method for extracting ISF includes providing an ISF fluid extraction device with a penetration member and a pressure ring(s). Next, a user's skin layer is contacted by the pressure ring(s) and penetrated by the penetration member. An ISF sample is then extracted from the user's skin layer while pressure is being applied in an oscillating manner by the pressure ring(s). The oscillating pressure mitigates an ISF glucose lag of the extracted ISF sample.
    • 用于提取体液样品(例如,间质液体[ISF]样品)和监测其中的分析物的系统包括一次性盒和本地控制器模块。 一次性盒包括适于提取体液样品的采样模块和适于测量体液样品中分析物(例如葡萄糖)的分析模块。 本地控制器模块与一次性盒子电子通信,并且适于从分析模块接收和存储测量数据。 ISF提取装置包括穿透构件,其被配置为穿透和驻留在使用者皮肤层的目标部位中,并且随后从其提取ISF样品。 该装置还包括适于向目标部位附近的使用者皮肤层施加压力的压力环。 该装置被构造成使得压力环能够以振荡方式施加压力,由此减轻由穿透构件提取的ISF样品的ISF葡萄糖滞后。 提供ISF的方法包括提供具有穿透构件和压力环的ISF流体提取装置。 接下来,用户的皮肤层被压力环接触并被穿透构件穿透。 然后从用户的皮肤层提取ISF样品,同时通过压力环以振荡方式施加压力。 振荡压力降低了提取的ISF样品的ISF葡萄糖滞后。