专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010080563A3 METHOD FOR TREATING MACULAR DEGENERATION 审中-公开
标题翻译：处理微粒变形的方法
公开(公告)号：WO2010080563A3
公开(公告)日：2010-08-26
申请号：PCT/US2009068625
申请日：2009-12-18
申请人： SANOFI AVENTIS , HAHN CHANG S
发明人： HAHN CHANG S
IPC分类号： A61K31/4985 , A61K31/506 , A61P27/02
CPC分类号： A61K31/505
摘要： Provided herein are novel and useful methods for preventing, treating, or ameliorating a macular degeneration such as dry macular degeneration, wet macular degeneration and age related macular degeneration in a patient.
摘要翻译：本文提供了用于预防，治疗或改善黄斑变性的新颖且有用的方法，例如患者的黄斑变性，湿性黄斑变性和年龄相关性黄斑变性。

2. 发明申请

WO2010080563A2 METHOD FOR TREATING MACULAR DEGENERATION 审中-公开
标题翻译：治疗黄斑变性的方法
公开(公告)号：WO2010080563A2
公开(公告)日：2010-07-15
申请号：PCT/US2009/068625
申请日：2009-12-18
申请人： SANOFI-AVENTIS , HAHN, Chang S.
发明人： HAHN, Chang S.
IPC分类号： A61K31/4985 , A61K31/506 , A61P27/02
CPC分类号： A61K31/505 , Y02A50/395
摘要： Provided herein are novel and useful methods for preventing, treating, or ameliorating a macular degeneration such as dry macular degeneration, wet macular degeneration and age related macular degeneration in a patient.
摘要翻译：本文提供了用于预防，治疗或改善患者黄斑变性（例如干性黄斑变性，湿性黄斑变性和年龄相关性黄斑变性）的新型且有用的方法。

3. 发明申请

WO2009103072A3 ERBB4 INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： ERBB4抑制剂及其在治疗神经病学疾病中的应用
公开(公告)号：WO2009103072A3
公开(公告)日：2010-04-22
申请号：PCT/US2009034311
申请日：2009-02-17
申请人： UNIV PENNSYLVANIA , HAHN CHANG-GYU
发明人： HAHN CHANG-GYU
IPC分类号： A61K31/517 , A61K31/505
CPC分类号： A61K45/06 , A61K31/551 , A61K33/14 , A61K2300/00
摘要： This invention relates to treatment of neuro-psychiatricdisorders. Specifically, the invention relates to the use of small molecule agent specific against erbB4, erbB3 or their combination, or fragments thereof in inhibiting the attachment of erbB4, erbB3 or their combination to NRGl.
摘要翻译：本发明涉及神经精神病学疾病的治疗。具体地，本发明涉及对erbB4，erbB3或其组合或其片段特异性的小分子试剂在抑制erbB4，erbB3或其组合与NRG1的连接中的用途。

4. 发明申请

WO2003083050A2 HUMAN DEUBIQUITINATING PROTEASE GENE ON CHROMOSOME 7 AND ITS MURINE ORTHOLOG 审中-公开
标题翻译：人类免疫染色体基因7及其微量元素
公开(公告)号：WO2003083050A2
公开(公告)日：2003-10-09
申请号：PCT/US2003/008590
申请日：2003-03-21
申请人： AVENTIS PHARMACEUTICALS INC. , HAHN, Chang , LIU, Hong
发明人： HAHN, Chang , LIU, Hong
IPC分类号： C12N
CPC分类号： C12N9/6472 , A61K38/00 , C07K2319/00 , C12N15/87 , C12Q1/37 , G01N2500/04
摘要： Human and murine analogs of DUBs, hematopoietic-specific, cytokine-inducible deubiquitinating proteases, clustered on chromosome 7 and their respective regulatory regions are identified. The nucleotide or proteins encoded thereby may be used in assays to identify inhibitors of hDUB7 or mDUB7. The invention also includes transducing peptides comprising an NLS or transducing sequence of hDUB7 or mDUB7 linked to a cargo molecule, and methods of delivering a biologically active protein, therapeutically effective compound, antisense nucleotide, or test compound to a cell wherein a transducing peptide is added exogenously to a cell.
摘要翻译：鉴定了聚集在染色体7上的DUBs，造血特异性，细胞因子诱导性去泛素化蛋白酶的人类和鼠类似物及其各自的调节区。由此编码的核苷酸或蛋白质可用于鉴定hDUB7或mDUB7的抑制剂的测定中。本发明还包括转移肽，其包含与货物分子连接的nLS或转导序列hDUB7或mDUB7，以及将生物活性蛋白质，治疗有效化合物，反义核苷酸或测试化合物递送至其中加入转导肽的细胞的方法外生到细胞。

5. 发明申请

WO03072724A2 HUMAN ANALOGS OF MURINE DEUBIQUITINATING PROTEASE GENES 审中-公开
标题翻译： MURINE DEUIQUITINATING PROTEASE基因的人类模拟
公开(公告)号：WO03072724A2
公开(公告)日：2003-09-04
申请号：PCT/US0305338
申请日：2003-02-20
申请人： AVENTIS PHARMA INC , HAHN CHANG , LIU HONG
发明人： HAHN CHANG , LIU HONG
IPC分类号： A61K38/00 , C12N9/16 , C12N9/64 , C12N
CPC分类号： C12N9/6472
摘要： The present invention is directed to human analogs of murine hematopoetic-specific, cytokine-inducible deubiquinating proteases ("DUBs") clustered on chromosomes 4 and 8 and their respective regulatory regions. The nucleotides or proteins encoded thereby my be used in assays to identify inhibitors of human DUBs.
摘要翻译：本发明涉及在染色体4和8上聚集的鼠造血特异性，细胞因子诱导性脱蛋白酶（“DUB”）及其各自调节区的人类类似物。由此编码的核苷酸或蛋白质可用于测定人类DUBs的抑制剂。

6. 发明申请

WO03007971A9 IMPROVED HETEROPOLYMER COMPLEXES AND METHODS FOR THEIR USE 审中-公开
标题翻译：改进的HETEROPOLYMER复合物及其使用方法
公开(公告)号：WO03007971A9
公开(公告)日：2003-04-10
申请号：PCT/US0223141
申请日：2002-07-17
申请人： UNIV VIRGINIA , TAYLOR RONALD P , CRAIG MARIA L , HAHN CHANG S
发明人： TAYLOR RONALD P , CRAIG MARIA L , HAHN CHANG S
IPC分类号： A61K39/395 , A61K47/48 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P35/00 , C07K1/113 , C07K16/08 , C07K16/10 , C07K16/12 , C07K16/28 , C07K16/30 , C07K19/00 , C12P21/08 , C12Q1/70 , G01N33/569 , G01N33/86 , A61K35/18 , A61K39/40 , A61K39/42
CPC分类号： C07K16/2896 , A61K47/6851 , A61K2039/505 , C07K16/08 , C07K16/1081 , C07K16/12 , C07K16/1214 , C07K16/1232 , C07K2317/31 , C07K2317/52 , C07K2317/55 , G01N33/569 , G01N33/86 , G01N2333/4716
摘要： The present invention relates to an improved heteropolymer complex. The improved heteropolymer complex comprises a first monoclonal antibody specific for a C3b- like receptor (known as complement receptor (CRl) or CD35 in primates and Factor H in other mammals, e.g., dog, mouse, rat, pig, rabbit) site chemically crosslinked (covalently linked) to a second monoclonal antibody, in which the isotype of at least the second monoclonal antibody is the isotype having the highest affinity for the Fc receptor, e.g., in humans, IgGl or IgG3. The present invention also relates to methods for immune clearance of an antigen in a mammal via the C3b-like receptor comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing viral infection or microbial infection in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing septic shock in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating cancer in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention further relates to pharmaceutical compositions for the treatment or prevention of viral infection, microbial infection, septic shock, and cancer comprising an improved heteropolymer complex of the invention.
摘要翻译：本发明涉及一种改进的异源聚合物复合物。改进的杂合聚合物复合物包含对C3b样受体（灵长类动物中称为补体受体（CR1）或CD35）和其他哺乳动物例如狗，小鼠，大鼠，猪，兔）中的因子H特异的第一单克隆抗体，化学交联（共价连接）第二单克隆抗体，其中至少第二单克隆抗体的同种型是对Fc受体具有最高亲和力的同种型，例如在人IgG1或IgG3中。本发明还涉及通过C3b样受体免疫清除哺乳动物中抗原的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物的病毒感染或微生物感染的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物感染性休克的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗哺乳动物癌症的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防病毒感染，微生物感染，败血性休克和包含本发明的改进的杂合聚合物复合物的癌症的药物组合物。

7. 发明申请

WO2010087605A2 HEAT RESISTANT ALUMINUM ALLOY, AND METHOD FOR MANUFACTURING SAME 审中-公开
标题翻译：耐热铝合金及其制造方法
公开(公告)号：WO2010087605A2
公开(公告)日：2010-08-05
申请号：PCT/KR2010000454
申请日：2010-01-25
申请人： KOREA AUTOMOTIVE TECH INST , SUNG SI YOUNG , HAN BEOM SUCK , KIM YOUNG JIG , CHOI BONG JAE , RYU YUNG MUN , KIM DONG OK , NOH SANG HO , HAHN CHANG SU
发明人： SUNG SI YOUNG , HAN BEOM SUCK , KIM YOUNG JIG , CHOI BONG JAE , RYU YUNG MUN , KIM DONG OK , NOH SANG HO , HAHN CHANG SU
IPC分类号： C22C21/00 , C22C21/12
CPC分类号： C22C21/12 , C21D6/00 , C21D2201/03 , C21D2211/004 , C22C1/03 , C22C21/00 , C22F1/04 , C22F1/057
摘要： The present invention relates to a heat resistant aluminum alloy in which two types of alloy elements are bonded to aluminum while forming a homogeneous solid solution strengthening phase. The heat resistant aluminum alloy according to the present invention has innovative heat resistant properties in that the alloy elements cooperate to form a homogeneous solid solution, and the homogeneous solid solution strengthening phase, which is formed to have no solvus line with respect to the aluminum serving as a matrix metal, is not coarsened or phase-decomposed by the reaction to the aluminum even at the high temperature of 300°C.
摘要翻译：本发明涉及一种耐热铝合金，其中两种合金元素与铝结合，同时形成均匀的固溶强化相。根据本发明的耐热铝合金具有创新的耐热性能，因为合金元素协作以形成均匀的固溶体，并且形成为相对于铝不形成固溶线的均匀固溶强化相作为基体金属，即使在300℃的高温下也不会因与铝的反应而发生粗化或相分解。

8. 发明申请

WO2003083050A3 HUMAN DEUBIQUITINATING PROTEASE GENE ON CHROMOSOME 7 AND ITS MURINE ORTHOLOG 审中-公开
公开(公告)号：WO2003083050A3
公开(公告)日：2003-10-09
申请号：PCT/US2003/008590
申请日：2003-03-21
申请人： AVENTIS PHARMACEUTICALS INC. , HAHN, Chang , LIU, Hong
发明人： HAHN, Chang , LIU, Hong
IPC分类号： C12N9/64
摘要： Human and murine analogs of DUBs, hematopoietic-specific, cytokine-inducible deubiquitinating proteases, clustered on chromosome 7 and their respective regulatory regions are identified. The nucleotide or proteins encoded thereby may be used in assays to identify inhibitors of hDUB7 or mDUB7. The invention also includes transducing peptides comprising an NLS or transducing sequence of hDUB7 or mDUB7 linked to a cargo molecule, and methods of delivering a biologically active protein, therapeutically effective compound, antisense nucleotide, or test compound to a cell wherein a transducing peptide is added exogenously to a cell.

9. 发明申请

WO2003072724A3 HUMAN ANALOGS OF MURINE DEUBIQUITINATING PROTEASE GENES 审中-公开
公开(公告)号：WO2003072724A3
公开(公告)日：2003-09-04
申请号：PCT/US2003/005338
申请日：2003-02-20
申请人： AVENTIS PHARMACEUTICALS INC. , HAHN, Chang , LIU, Hong
发明人： HAHN, Chang , LIU, Hong
IPC分类号： C12N9/64
摘要： The present invention is directed to human analogs of murine hematopoetic-specific, cytokine-inducible deubiquinating proteases ("DUBs") clustered on chromosomes 4 and 8 and their respective regulatory regions. The nucleotides or proteins encoded thereby my be used in assays to identify inhibitors of human DUBs.

10. 发明申请

WO2003007971A1 IMPROVED HETEROPOLYMER COMPLEXES AND METHODS FOR THEIR USE 审中-公开
标题翻译：改进的HETEROPOLYMER复合物及其使用方法
公开(公告)号：WO2003007971A1
公开(公告)日：2003-01-30
申请号：PCT/US2002/023141
申请日：2002-07-17
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , TAYLOR, Ronald, P. , CRAIG, Maria, L. , HAHN, Chang, S.
发明人： TAYLOR, Ronald, P. , CRAIG, Maria, L. , HAHN, Chang, S.
IPC分类号： A61K35/18
CPC分类号： C07K16/2896 , A61K47/6851 , A61K2039/505 , C07K16/08 , C07K16/1081 , C07K16/12 , C07K16/1214 , C07K16/1232 , C07K2317/31 , C07K2317/52 , C07K2317/55 , G01N33/569 , G01N33/86 , G01N2333/4716 , Y02A50/403 , Y02A50/53
摘要： The present invention relates to an improved heteropolymer complex. The improved heteropolymer complex comprises a first monoclonal antibody specific for a C3b- like receptor (known as complement receptor (CRl) or CD35 in primates and Factor H in other mammals, e.g. , dog, mouse, rat, pig, rabbit) site chemically crosslinked (covalently linked) to a second monoclonal antibody, in which the isotype of at least the second monoclonal antibody is the isotype having the highest affinity for the Fc receptor, e.g. , in humans, IgGl or IgG3. The present invention also relates to methods for immune clearance of an antigen in a mammal via the C3b-like receptor comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing viral infection or microbial infection in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing septic shock in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating cancer in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention further relates to pharmaceutical compositions for the treatment or prevention of viral infection, microbial infection, septic shock, and cancer comprising an improved heteropolymer complex of the invention.
摘要翻译：本发明涉及一种改进的异源聚合物复合物。改进的杂合聚合物复合物包含对C3b样受体（称为补体受体（CR1））或灵长类动物中的CD35和其它哺乳动物（例如狗，小鼠，大鼠）中的因子H特异的第一单克隆抗体，猪，兔）与第二单克隆抗体化学交联（共价连接）的位点，其中至少第二单克隆抗体的同种型是对Fc受体具有最高亲和力的同种型，例如，人IgG1或IgG3。本发明还涉及通过C3b样受体免疫清除哺乳动物中抗原的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物的病毒感染或微生物感染的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物感染性休克的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗哺乳动物癌症的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防病毒感染，微生物感染，败血性休克和包含本发明的改进的杂合聚合物复合物的癌症的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式