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1. 发明申请

WO2010080563A3 METHOD FOR TREATING MACULAR DEGENERATION 审中-公开
标题翻译：处理微粒变形的方法
公开(公告)号：WO2010080563A3
公开(公告)日：2010-08-26
申请号：PCT/US2009068625
申请日：2009-12-18
申请人： SANOFI AVENTIS , HAHN CHANG S
发明人： HAHN CHANG S
IPC分类号： A61K31/4985 , A61K31/506 , A61P27/02
CPC分类号： A61K31/505
摘要： Provided herein are novel and useful methods for preventing, treating, or ameliorating a macular degeneration such as dry macular degeneration, wet macular degeneration and age related macular degeneration in a patient.
摘要翻译：本文提供了用于预防，治疗或改善黄斑变性的新颖且有用的方法，例如患者的黄斑变性，湿性黄斑变性和年龄相关性黄斑变性。

2. 发明申请

WO2010080563A2 METHOD FOR TREATING MACULAR DEGENERATION 审中-公开
标题翻译：治疗黄斑变性的方法
公开(公告)号：WO2010080563A2
公开(公告)日：2010-07-15
申请号：PCT/US2009/068625
申请日：2009-12-18
申请人： SANOFI-AVENTIS , HAHN, Chang S.
发明人： HAHN, Chang S.
IPC分类号： A61K31/4985 , A61K31/506 , A61P27/02
CPC分类号： A61K31/505 , Y02A50/395
摘要： Provided herein are novel and useful methods for preventing, treating, or ameliorating a macular degeneration such as dry macular degeneration, wet macular degeneration and age related macular degeneration in a patient.
摘要翻译：本文提供了用于预防，治疗或改善患者黄斑变性（例如干性黄斑变性，湿性黄斑变性和年龄相关性黄斑变性）的新型且有用的方法。

3. 发明申请

WO03007971A9 IMPROVED HETEROPOLYMER COMPLEXES AND METHODS FOR THEIR USE 审中-公开
标题翻译：改进的HETEROPOLYMER复合物及其使用方法
公开(公告)号：WO03007971A9
公开(公告)日：2003-04-10
申请号：PCT/US0223141
申请日：2002-07-17
申请人： UNIV VIRGINIA , TAYLOR RONALD P , CRAIG MARIA L , HAHN CHANG S
发明人： TAYLOR RONALD P , CRAIG MARIA L , HAHN CHANG S
IPC分类号： A61K39/395 , A61K47/48 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P35/00 , C07K1/113 , C07K16/08 , C07K16/10 , C07K16/12 , C07K16/28 , C07K16/30 , C07K19/00 , C12P21/08 , C12Q1/70 , G01N33/569 , G01N33/86 , A61K35/18 , A61K39/40 , A61K39/42
CPC分类号： C07K16/2896 , A61K47/6851 , A61K2039/505 , C07K16/08 , C07K16/1081 , C07K16/12 , C07K16/1214 , C07K16/1232 , C07K2317/31 , C07K2317/52 , C07K2317/55 , G01N33/569 , G01N33/86 , G01N2333/4716
摘要： The present invention relates to an improved heteropolymer complex. The improved heteropolymer complex comprises a first monoclonal antibody specific for a C3b- like receptor (known as complement receptor (CRl) or CD35 in primates and Factor H in other mammals, e.g., dog, mouse, rat, pig, rabbit) site chemically crosslinked (covalently linked) to a second monoclonal antibody, in which the isotype of at least the second monoclonal antibody is the isotype having the highest affinity for the Fc receptor, e.g., in humans, IgGl or IgG3. The present invention also relates to methods for immune clearance of an antigen in a mammal via the C3b-like receptor comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing viral infection or microbial infection in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing septic shock in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating cancer in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention further relates to pharmaceutical compositions for the treatment or prevention of viral infection, microbial infection, septic shock, and cancer comprising an improved heteropolymer complex of the invention.
摘要翻译：本发明涉及一种改进的异源聚合物复合物。改进的杂合聚合物复合物包含对C3b样受体（灵长类动物中称为补体受体（CR1）或CD35）和其他哺乳动物例如狗，小鼠，大鼠，猪，兔）中的因子H特异的第一单克隆抗体，化学交联（共价连接）第二单克隆抗体，其中至少第二单克隆抗体的同种型是对Fc受体具有最高亲和力的同种型，例如在人IgG1或IgG3中。本发明还涉及通过C3b样受体免疫清除哺乳动物中抗原的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物的病毒感染或微生物感染的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物感染性休克的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗哺乳动物癌症的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防病毒感染，微生物感染，败血性休克和包含本发明的改进的杂合聚合物复合物的癌症的药物组合物。

4. 发明申请

WO2003007971A1 IMPROVED HETEROPOLYMER COMPLEXES AND METHODS FOR THEIR USE 审中-公开
标题翻译：改进的HETEROPOLYMER复合物及其使用方法
公开(公告)号：WO2003007971A1
公开(公告)日：2003-01-30
申请号：PCT/US2002/023141
申请日：2002-07-17
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , TAYLOR, Ronald, P. , CRAIG, Maria, L. , HAHN, Chang, S.
发明人： TAYLOR, Ronald, P. , CRAIG, Maria, L. , HAHN, Chang, S.
IPC分类号： A61K35/18
CPC分类号： C07K16/2896 , A61K47/6851 , A61K2039/505 , C07K16/08 , C07K16/1081 , C07K16/12 , C07K16/1214 , C07K16/1232 , C07K2317/31 , C07K2317/52 , C07K2317/55 , G01N33/569 , G01N33/86 , G01N2333/4716 , Y02A50/403 , Y02A50/53
摘要： The present invention relates to an improved heteropolymer complex. The improved heteropolymer complex comprises a first monoclonal antibody specific for a C3b- like receptor (known as complement receptor (CRl) or CD35 in primates and Factor H in other mammals, e.g. , dog, mouse, rat, pig, rabbit) site chemically crosslinked (covalently linked) to a second monoclonal antibody, in which the isotype of at least the second monoclonal antibody is the isotype having the highest affinity for the Fc receptor, e.g. , in humans, IgGl or IgG3. The present invention also relates to methods for immune clearance of an antigen in a mammal via the C3b-like receptor comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing viral infection or microbial infection in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating or preventing septic shock in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention also relates to methods for treating cancer in a mammal comprising administering to said mammal an improved heteropolymer complex of the invention. The present invention further relates to pharmaceutical compositions for the treatment or prevention of viral infection, microbial infection, septic shock, and cancer comprising an improved heteropolymer complex of the invention.
摘要翻译：本发明涉及一种改进的异源聚合物复合物。改进的杂合聚合物复合物包含对C3b样受体（称为补体受体（CR1））或灵长类动物中的CD35和其它哺乳动物（例如狗，小鼠，大鼠）中的因子H特异的第一单克隆抗体，猪，兔）与第二单克隆抗体化学交联（共价连接）的位点，其中至少第二单克隆抗体的同种型是对Fc受体具有最高亲和力的同种型，例如，人IgG1或IgG3。本发明还涉及通过C3b样受体免疫清除哺乳动物中抗原的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物的病毒感染或微生物感染的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防哺乳动物感染性休克的方法，其包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗哺乳动物癌症的方法，包括向所述哺乳动物施用改进的本发明的杂合聚合物复合物。本发明还涉及用于治疗或预防病毒感染，微生物感染，败血性休克和包含本发明的改进的杂合聚合物复合物的癌症的药物组合物。

5. 发明申请

WO2005054485A2 ADENOVIRUS-TRANSFECTED PRIMARY CELLS AND METHODS OF PATHWAY MAPPING 审中-公开
标题翻译：腺病毒转染的原代细胞和途径定位方法
公开(公告)号：WO2005054485A2
公开(公告)日：2005-06-16
申请号：PCT/US2004/040054
申请日：2004-12-01
申请人： AVENTIS PHARMACEUTICALS INC. , HAHN, Chang, S. , LI, Li
发明人： HAHN, Chang, S. , LI, Li
IPC分类号： C12N15/861
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2830/002
摘要： A primary cell culture is transfected with a vector comprising a reporter gene operatively linked to a cis-element. Expression of a candidate regulatory protein is induced in the cell culture and its effects on the cis-element are assayed.
摘要翻译：原代细胞培养物用含有可操作地连接于顺式元件的报道基因的载体转染。在细胞培养中诱导候选调控蛋白的表达，并测定其对顺式元件的影响。

6. 发明申请

WO2005054485A3 ADENOVIRUS-TRANSFECTED PRIMARY CELLS AND METHODS OF PATHWAY MAPPING 审中-公开
标题翻译： ADENOVIRUS转移的主要细胞和路径图的方法
公开(公告)号：WO2005054485A3
公开(公告)日：2005-12-15
申请号：PCT/US2004040054
申请日：2004-12-01
申请人： AVENTIS PHARMA INC , HAHN CHANG S , LI LI
发明人： HAHN CHANG S , LI LI
IPC分类号： A61K48/00 , C07K14/47 , C12N15/861
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2830/002
摘要： A primary cell culture is transfected with a vector comprising a reporter gene operatively linked to a cis-element. Expression of a candidate regulatory protein is induced in the cell culture and its effects on the cis-element are assayed.
摘要翻译：用包含可操作地连接到顺式元件的报告基因的载体转染原代细胞培养物。在细胞培养物中诱导候选调节蛋白的表达，并测定其对顺式元件的影响。

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