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1. 发明申请

WO2003106033A1 REACTION CHAMBER 审中-公开
标题翻译：反应室
公开(公告)号：WO2003106033A1
公开(公告)日：2003-12-24
申请号：PCT/IB2003/002518
申请日：2003-06-10
申请人： MILLENIUM BIOLOGIX AG , ORAM, Guy , BRUNNER, Andreas , HAGG, Rupert , TOMMASINI, Roberto
发明人： ORAM, Guy , BRUNNER, Andreas , HAGG, Rupert , TOMMASINI, Roberto
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01J2219/00533 , B01J2219/00659 , B01J2219/00722 , B01L3/502715 , B01L7/52 , B01L2200/0689 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , C40B40/06 , G01N1/312 , G02B21/34
摘要： A reaction chamber assembly comprising a e.g. microscope slide or any other slide or carrier system and an assembly cover is described, wherein said assembly cover comprises at least one port and at least one channel having a first end at the port and a second end at a reaction compartment which reaction compartment together with the e.g. microscope slide forms a reaction chamber with predetermined volume.
摘要翻译：一种反应室组件，包括：描述了显微镜载玻片或任何其它滑动件或载体系统和组件盖，其中所述组件盖包括至少一个端口和至少一个通道，该通道在端口处具有第一端，第二端包括反应室，反应室与例如显微镜载玻片形成具有预定体积的反应室。

2. 发明申请

WO2005116186A1 ADVANCED TISSUE ENGINEERING SYSTEM 审中-公开
标题翻译：高级组织工程系统
公开(公告)号：WO2005116186A1
公开(公告)日：2005-12-08
申请号：PCT/CA2005/000783
申请日：2005-05-26
申请人： MILLENIUM BIOLOGIX INC. , SMITH, Timothy, J.N. , PUGH, Sydney, M. , MISENER, Lowell , ORAM, Guy , HAGG, Rupert , TOMMASINI, Roberto , LARCHER, Yves
发明人： SMITH, Timothy, J.N. , PUGH, Sydney, M. , MISENER, Lowell , ORAM, Guy , HAGG, Rupert , TOMMASINI, Roberto , LARCHER, Yves
IPC分类号： C12M3/00
CPC分类号： C12M21/08 , C12M23/24 , C12M23/34 , C12M23/44 , C12M25/14 , C12M27/16 , C12M41/12 , C12M45/09 , C12M47/04
摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.
摘要翻译：本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳。在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。

3. 发明申请

WO2003106706A2 IDENTIFICATION OF TISSUE/CELL SPECIFIC MARKER GENES AND USE THEREOF 审中-公开
标题翻译：组织/细胞特异性标记基因的鉴定及其用途
公开(公告)号：WO2003106706A2
公开(公告)日：2003-12-24
申请号：PCT/CH2003/000379
申请日：2003-06-12
申请人： MILLENIUM BIOLOGIX AG , BRUNNER, Andreas , HAGG, Rupert , TOMMASINI, Roberto
发明人： BRUNNER, Andreas , HAGG, Rupert , TOMMASINI, Roberto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158
摘要： A cartilage array comprises a plurality of different polynucleotide probe spots stably associated with a solid surface of a carrier, whereby each of said spots is made of a unique polynucleotide that corresponds to one specific cartilage marker gene. Said specific cartilage marker genes preferably are at least in part selected from a group of 467 genes that could be shown to be cartilage related.
摘要翻译：软骨阵列包括与载体的固体表面稳定相关的多个不同的多核苷酸探针点，其中每个所述斑点由对应于一个特定软骨标记基因的唯一多核苷酸制成。所述特定软骨标记基因优选至少部分选自可以显示为与软骨相关的467个基因的一组。

4. 发明申请

WO2011130865A3 AUTOMATED CELL CULTURE SYSTEM 审中-公开
标题翻译：自动细胞培养系统
公开(公告)号：WO2011130865A3
公开(公告)日：2012-03-15
申请号：PCT/CH2011000088
申请日：2011-04-20
申请人： LARCHER YVES , HAGG RUPERT
发明人： LARCHER YVES , HAGG RUPERT
IPC分类号： C12M3/00 , C12M1/00
CPC分类号： C12M21/00 , C12M23/44 , C12M23/48 , C12M23/50 , C12M33/10 , C12M41/14 , C12M41/36 , C12M41/48
摘要： The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.
摘要翻译：根据本发明的自动细胞培养装置包括至少一个具有至少一个生物反应器的闭孔培养模块。闭孔培养模块是封闭系统，这意味着在闭孔培养模块内可以保持封闭的无菌环境。根据本发明的自动细胞培养装置还包括至少一个用于泵送封闭细胞培养模块内的液体的泵和至少一个额外的工具模块，其被配置或配置为作用于或监视生物反应器的内容物，相对于所述至少一个闭孔培养模块是可移动的，或者其可相对于所述至少一个闭孔培养模块的一个或多个部件移动。

5. 发明申请

WO2003106706A3 IDENTIFICATION OF SPECIFIC MARKER GENES AND USE THEREOF 审中-公开
公开(公告)号：WO2003106706A3
公开(公告)日：2003-12-24
申请号：PCT/CH2003/000379
申请日：2003-06-12
申请人： MILLENIUM BIOLOGIX AG , BRUNNER, Andreas , HAGG, Rupert , TOMMASINI, Roberto
发明人： BRUNNER, Andreas , HAGG, Rupert , TOMMASINI, Roberto
IPC分类号： C12Q1/68
摘要： A cartilage array comprises a plurality of different polynucleotide probe spots stably associated with a solid surface of a carrier, whereby each of said spots is made of a unique polynucleotide that corresponds to one specific cartilage marker gene. Said specific cartilage marker genes preferably are at least in part selected from a group of 467 genes that could be shown to be cartilage related.

6. 发明申请

WO2011130865A2 AUTOMATED CELL CULTURE SYSTEM 审中-公开
标题翻译：自动细胞培养系统
公开(公告)号：WO2011130865A2
公开(公告)日：2011-10-27
申请号：PCT/CH2011/000088
申请日：2011-04-20
申请人： LARCHER, Yves , HAGG, Rupert
发明人： LARCHER, Yves , HAGG, Rupert
IPC分类号： C12M3/00
CPC分类号： C12M21/00 , C12M23/44 , C12M23/48 , C12M23/50 , C12M33/10 , C12M41/14 , C12M41/36 , C12M41/48
摘要： The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.
摘要翻译：根据本发明的自动细胞培养装置包括至少一个具有至少一个生物反应器的闭孔培养模块。闭孔培养模块是封闭系统，这意味着在闭孔培养模块内可以保持封闭的无菌环境。根据本发明的自动细胞培养装置还包括至少一个用于泵送闭孔细胞培养模块内的液体的泵和至少一个另外的工具模块，其被配置或配置为作用于或监视生物反应器的内容物，相对于所述至少一个闭孔培养模块是可移动的，或者其相对于所述至少一个闭孔培养模块的一个或多个部件是可移动的。

7. 发明申请

WO2003106705A1 IN VITRO SCREENING OF CELLULAR EVENTS USING 3D CELL CULTURE SYSTEMS 审中-公开
标题翻译：使用3D细胞培养系统进行细胞活性筛选
公开(公告)号：WO2003106705A1
公开(公告)日：2003-12-24
申请号：PCT/CH2003/000377
申请日：2003-06-12
申请人： MILLENIUM BIOLOGIX AG , FULDE, Fabienne, Andrea , HAGG, Rupert , TOMMASINI, Roberto
发明人： FULDE, Fabienne, Andrea , HAGG, Rupert , TOMMASINI, Roberto
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0393 , C12N15/8509 , C12N2503/02 , C12N2517/02 , G01N33/502 , G01N33/5061 , G01N33/5073
摘要： The present invention relates to in vitro cell culture conditions wherein transfected cells containing promoter-reporter constructs are cultivated in a 3D tissue-like environment. The referred 3D culture conditions may eventually implement appropriate biomaterial or scaffolds.
摘要翻译：本发明涉及体外细胞培养条件，其中含有启动子 - 报道构建体的转染细胞在3D组织样环境中培养。所提及的3D培养条件可能最终实现适当的生物材料或支架。

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