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1. 发明申请

WO2005116186A1 ADVANCED TISSUE ENGINEERING SYSTEM 审中-公开
标题翻译：高级组织工程系统
公开(公告)号：WO2005116186A1
公开(公告)日：2005-12-08
申请号：PCT/CA2005/000783
申请日：2005-05-26
申请人： MILLENIUM BIOLOGIX INC. , SMITH, Timothy, J.N. , PUGH, Sydney, M. , MISENER, Lowell , ORAM, Guy , HAGG, Rupert , TOMMASINI, Roberto , LARCHER, Yves
发明人： SMITH, Timothy, J.N. , PUGH, Sydney, M. , MISENER, Lowell , ORAM, Guy , HAGG, Rupert , TOMMASINI, Roberto , LARCHER, Yves
IPC分类号： C12M3/00
CPC分类号： C12M21/08 , C12M23/24 , C12M23/34 , C12M23/44 , C12M25/14 , C12M27/16 , C12M41/12 , C12M45/09 , C12M47/04
摘要： The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more bioreactor chamber assemblies and a fluid reservoir operationally engageable with the housing. The bioreactor chamber assemblies may be selected depending on the end product option desired and may include, for example, a cell therapy bioreactor chamber, a single implant bioreactor chamber and a multiple (mosaic) implant bioreactor chamber.
摘要翻译：本发明是一种自动化的高级组织工程系统，其包括壳体，其中一个或多个组织工程模块与控制组织工程模块功能的中央微处理器一起容纳。在一个实施例中，组织工程模块包括支撑一个或多个生物反应器室组件的壳体和可操作地与壳体接合的流体储存器。可以根据期望的最终产品选择来选择生物反应器室组件，并且可以包括例如细胞治疗生物反应器室，单个植入物生物反应器室和多个（镶嵌）植入物生物反应器室。

2. 发明申请

WO2003087292A2 AUTOMATED TISSUE ENGINEERING SYSTEM 审中-公开
标题翻译：自动化组织工程系统
公开(公告)号：WO2003087292A2
公开(公告)日：2003-10-23
申请号：PCT/CA2003/000519
申请日：2003-04-08
申请人： MILLENIUM BIOLOGIX INC. , SMITH, Timothy, J.N. , PUGH, Sydney, M. , PECARIC, Martin, R. , HAGG, Ruppert , TOMMASINI, Roberto , LARCHER, Yves , MISENER, D., Lowell
发明人： SMITH, Timothy, J.N. , PUGH, Sydney, M. , PECARIC, Martin, R. , HAGG, Ruppert , TOMMASINI, Roberto , LARCHER, Yves , MISENER, D., Lowell
IPC分类号： C12M
CPC分类号： C12M21/08 , C12M23/28 , C12M23/42 , C12M23/52 , C12M25/14 , C12M29/04 , C12M41/46 , C12M41/48 , C12M45/09 , C12M47/06 , C12M47/12 , C12N5/0068 , C12N5/0618 , C12N5/0654 , C12N5/0655 , C12N2509/00
摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.
摘要翻译：本发明提供用于组织工程产品的自动化培养，增殖，分化，生产和维护的系统，模块，生物反应器和方法。一方面是自动化组织工程系统，其包括壳体，由壳体支撑的至少一个生物反应器，生物反应器促进生理细胞功能和/或从细胞和/或组织来源产生一种或多种组织构建体。流体容纳系统由壳体支撑并且与生物反应器流体连通。一个或多个传感器与壳体，生物反应器或流体容纳系统中的一个或多个相关联，用于监测与生理细胞功能和/或组织构建体产生有关的参数; 和连接到一个或多个传感器的微处理器。本发明的系统，方法和产品可用于各种临床和实验室环境。

3. 发明申请

WO2011130865A3 AUTOMATED CELL CULTURE SYSTEM 审中-公开
标题翻译：自动细胞培养系统
公开(公告)号：WO2011130865A3
公开(公告)日：2012-03-15
申请号：PCT/CH2011000088
申请日：2011-04-20
申请人： LARCHER YVES , HAGG RUPERT
发明人： LARCHER YVES , HAGG RUPERT
IPC分类号： C12M3/00 , C12M1/00
CPC分类号： C12M21/00 , C12M23/44 , C12M23/48 , C12M23/50 , C12M33/10 , C12M41/14 , C12M41/36 , C12M41/48
摘要： The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.
摘要翻译：根据本发明的自动细胞培养装置包括至少一个具有至少一个生物反应器的闭孔培养模块。闭孔培养模块是封闭系统，这意味着在闭孔培养模块内可以保持封闭的无菌环境。根据本发明的自动细胞培养装置还包括至少一个用于泵送封闭细胞培养模块内的液体的泵和至少一个额外的工具模块，其被配置或配置为作用于或监视生物反应器的内容物，相对于所述至少一个闭孔培养模块是可移动的，或者其可相对于所述至少一个闭孔培养模块的一个或多个部件移动。

4. 发明申请

WO2011130865A2 AUTOMATED CELL CULTURE SYSTEM 审中-公开
标题翻译：自动细胞培养系统
公开(公告)号：WO2011130865A2
公开(公告)日：2011-10-27
申请号：PCT/CH2011/000088
申请日：2011-04-20
申请人： LARCHER, Yves , HAGG, Rupert
发明人： LARCHER, Yves , HAGG, Rupert
IPC分类号： C12M3/00
CPC分类号： C12M21/00 , C12M23/44 , C12M23/48 , C12M23/50 , C12M33/10 , C12M41/14 , C12M41/36 , C12M41/48
摘要： The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.
摘要翻译：根据本发明的自动细胞培养装置包括至少一个具有至少一个生物反应器的闭孔培养模块。闭孔培养模块是封闭系统，这意味着在闭孔培养模块内可以保持封闭的无菌环境。根据本发明的自动细胞培养装置还包括至少一个用于泵送闭孔细胞培养模块内的液体的泵和至少一个另外的工具模块，其被配置或配置为作用于或监视生物反应器的内容物，相对于所述至少一个闭孔培养模块是可移动的，或者其相对于所述至少一个闭孔培养模块的一个或多个部件是可移动的。

5. 发明申请

WO2003087292A3 AUTOMATED TISSUE ENGINEERING SYSTEM 审中-公开
公开(公告)号：WO2003087292A3
公开(公告)日：2003-10-23
申请号：PCT/CA2003/000519
申请日：2003-04-08
申请人： MILLENIUM BIOLOGIX INC. , SMITH, Timothy, J.N. , PUGH, Sydney, M. , PECARIC, Martin, R. , HAGG, Ruppert , TOMMASINI, Roberto , LARCHER, Yves , MISENER, D., Lowell
发明人： SMITH, Timothy, J.N. , PUGH, Sydney, M. , PECARIC, Martin, R. , HAGG, Ruppert , TOMMASINI, Roberto , LARCHER, Yves , MISENER, D., Lowell
IPC分类号： C12M3/04
摘要： The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources. A fluid containment system is supported by the housing and is in fluid communication with the bioreactor. One or more sensors are associated with one or more of the housing, bioreactor or fluid containment system for monitoring parameters related to the physiological cellular functions and/or generation of tissue constructs; and a microprocessor linked to one or more of the sensors. The systems, methods and products of the invention find use in various clinical and laboratory settings.

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