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1. 发明申请

WO2005054294A2 INHIBITORS OF GLYCOPROTEIN VI BASED ON MONOCLONAL ANTIBODY HGP 5C4 审中-公开
标题翻译：基于单克隆抗体HGP 5C4的糖蛋白Ⅵ的抑制剂
公开(公告)号：WO2005054294A2
公开(公告)日：2005-06-16
申请号：PCT/EP2004013779
申请日：2004-12-03
申请人： PROCORDE GMBH , GSF FORSCHUNGSZENTRUM UMWELT , GAWAZ MEINRAD , KREMMER ELISABETH , MUENCH GOETZ
发明人： GAWAZ MEINRAD , KREMMER ELISABETH , MUENCH GOETZ
IPC分类号： C07K16/28 , C07K16/00
CPC分类号： C07K16/2803 , A61K2039/505
摘要： The present invention relates to a specific inhibitor of human platelet glycoprotein VI. The inhibitor may be an optionally humanized antibody or function-conservative fragments or variants thereof, a specific fusion protein or conjugate. Moreover, the present invention relates to pharmaceutical compositions containing the specific inhibitor of the invention. The present invention also relates to hybridomas expressing the antibody of the present invention. Furthermore, the present invention relates to the use of the specific inhibitor of glycoprotein VI for the preparation of a medicament for the prevention of acute and chronic vascular diseases associated with arterial and/or intravenous thrombosis, such as acute coronary syndrome, acute carotid artery syndrome, acute myocardial infarction, acute cerebral stroke and chronic coronary or peripheral vessel disease. Finally, the present invention relates to a process for preparing the antibody of the invention and to a process for preparing a specific fragment of the antibody of the present invention.
摘要翻译：本发明涉及人血小板糖蛋白VI的特异性抑制剂。抑制剂可以是任选人源化抗体或其功能保守性片段或变体，特异性融合蛋白或缀合物。而且，本发明涉及含有本发明特异性抑制剂的药物组合物。本发明还涉及表达本发明抗体的杂交瘤。此外，本发明涉及糖蛋白VI的特异性抑制剂在制备用于预防与动脉和/或静脉内血栓形成相关的急性和慢性血管疾病如急性冠状动脉综合征，急性颈动脉综合征，急性心肌梗塞，急性脑卒中和慢性冠状动脉或外周血管疾病。最后，本发明涉及制备本发明抗体的方法和制备本发明抗体特异性片段的方法。

2. 发明申请

WO02072626A3 NOVEL FORM OF THE PHGPX PROTEIN AS A DIAGNOSTIC MARKER FOR MALE INFERTILITY 审中-公开
标题翻译： AS在男性不育症的诊断标志物蛋白phGPx新业态
公开(公告)号：WO02072626A3
公开(公告)日：2003-07-17
申请号：PCT/EP0201648
申请日：2002-02-15
申请人： HAHN MEITNER INST BERLIN GMBH , GSF FORSCHUNGSZENTRUM UMWELT , BEHNE DIETRICH , BORNKAMM GEORG , BRIELMEIER MARKUS , PFEIFER HENNING , KYRIAKOPOULOS ANTONIOS , CONRAD MARCUS , SCHMIDT JOERG
发明人： BEHNE DIETRICH , BORNKAMM GEORG , BRIELMEIER MARKUS , PFEIFER HENNING , KYRIAKOPOULOS ANTONIOS , CONRAD MARCUS , SCHMIDT JOERG
IPC分类号： A01K67/027 , A61K38/44 , A61P5/24 , A61P15/08 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/08 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/48 , G01N33/50 , C12N15/11 , C12N15/85
CPC分类号： C12Q1/6883
摘要： The invention relates to a novel form of the PHGPx protein, the sperm nuclei glutathione peroxidase (snGPx), to sections thereof, which play a part in the spermatogenesis of mammals and to nucleic acids that code for the same. The invention also relates to vectors containing said nucleic acids and to host cells that are transformed by the vectors. The invention further relates to antibodies that are specific to the aforementioned proteins and peptides and to the use of said proteins and peptides in the diagnosis or treatment of male infertility.
摘要翻译：本发明涉及PHGPx蛋白的新形式，所述精子细胞核谷胱甘肽过氧化物酶（snGPx）以及它们的部分，其在精子发生在哺乳动物中发挥作用，以及核酸编码这些。本发明还涉及由这些载体转化的含有这些核酸的载体和宿主细胞。本发明还包括特定于上述蛋白质/肽的抗体，以及在诊断或治疗男性不育症的使用蛋白/肽的。

3. 发明申请

WO9502040A3 NEW STROMAL CELL LINES FROM HUMAN BONE MARROW AND THEIR USE 审中-公开
标题翻译：来自人体骨骼的新型细胞细胞系及其使用
公开(公告)号：WO9502040A3
公开(公告)日：2001-05-17
申请号：PCT/EP9402224
申请日：1994-07-07
申请人： GSF FORSCHUNGSZENTRUM UMWELT , THALMEIER KARIN , DOERMER PETER
发明人： THALMEIER KARIN , DOERMER PETER
IPC分类号： C12N5/10 , C07K14/535 , C07K14/54 , C12N5/077 , C12N15/09 , C12N15/85 , C12P21/00 , C12R1/91
CPC分类号： C12N5/0669 , C07K14/535 , C07K14/5412 , C12N15/85 , C12N2510/02
摘要： A human bone marrow stromal cell line, which is characterized in that the cells of the cell line, after irradiation which results in the growth being arrested, remain adherent, is suitable for use as a feeder layer for supporting the proliferation of blood cells.
摘要翻译：一种人骨髓基质细胞系，其特征在于细胞系的细胞在照射后导致生长被阻滞，保持粘附，适合用作用于支持血细胞增殖的饲养层。

4. 发明申请

WO9915692A3 DENGUE VIRUS ANTIGENS AND TREATMENT OF DENGUE FEVER 审中-公开
标题翻译：登革病毒抗原和登革热治疗
公开(公告)号：WO9915692A3
公开(公告)日：1999-06-24
申请号：PCT/EP9806009
申请日：1998-09-21
申请人： BAVARIAN NORDIC RES INST AS , GSF FORSCHUNGSZENTRUM UMWELT , UNIVERSITI MALAYSIA SARAWAK , VENTURE TECHNOLOGIES SDN BHD , DREXLER INGO , SUTTER GERD , CARDOSA MARY JANE , HOOI TIO PHAIK
发明人： DREXLER INGO , SUTTER GERD , CARDOSA MARY JANE , HOOI TIO PHAIK
IPC分类号： A61K39/00 , A61P31/12 , C07K14/18 , C07K16/10 , C12N15/40 , A61K39/12 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1081 , C12N2710/24143 , C12N2770/24122
摘要： The present invention relates to monoclonal antibodies and antigen binding fragments specific for and recognising antigenic epitopes capable of eliciting antibodies which protect against infection by dengue viruses as well as the said antigenic epitopes and their use for vaccine purposes. The present invention also relates to recombinant vaccinia viruses and for example such which are derived from the Modified Vaccinia Ankara (MVA) encoding for and capable of expressing dengue virus antigen, and the use of the same recombinant viruses encoding dengue virus antigens in vaccines. In addition the invention also relates to pharmaceutical compositions comprising the above monoclonal antibodies, pharmaceutical compositions comprising dengue virus antigens, and pharmaceutical compositions comprising dengue virus antigen expression vectors.
摘要翻译：本发明涉及对能够引发抗体的抗原表位特异性和识别的单克隆抗体和抗原结合片段，其能够防止登革热病毒以及所述抗原表位及其用于疫苗目的的感染。本发明还涉及重组痘苗病毒，例如衍生自编码和能够表达登革热病毒抗原并且能够表达登革热病毒抗原的修饰牛痘安卡拉（MVA），以及在疫苗中使用编码登革热病毒抗原的相同重组病毒。此外，本发明还涉及包含上述单克隆抗体的药物组合物，包含登革热病毒抗原的药物组合物和包含登革热病毒抗原表达载体的药物组合物。

5. 发明申请

WO2007019982A3 METHOD AND DEVICE FOR THE MASS SPECTROMETRIC DETECTION OF COMPOUNDS 审中-公开
标题翻译：用于质谱法检测化合物的方法和装置
公开(公告)号：WO2007019982A3
公开(公告)日：2007-11-29
申请号：PCT/EP2006007773
申请日：2006-08-05
申请人： GSF FORSCHUNGSZENTRUM UMWELT , MUEHLBERGER FABIAN , ZIMMERMANN RALF
发明人： MUEHLBERGER FABIAN , ZIMMERMANN RALF
IPC分类号： H01J49/10 , H01J49/16
CPC分类号： H01J49/107 , H01J49/162
摘要： The invention relates to a method for the mass spectrometric detection of compounds in a gas flow (2). According to said method: the volume units in the gas flow (2) are ionised, forming ions of the compounds, the ionisation being carried out by means of radiation (9, 10) crossing the gas flow, formed in the alternation of electron pulses or pulse sequences and photon pulses or pulse sequences; the ions are deviated by an electric field (13) towards a mass spectrometric method; and the ions are detected using a mass spectrometric method. The aim of the invention is to provide one such method with an extended measuring range and a significantly improved resolution. To this end, the photon pulses or pulse sequences are generated by an excimer lamp (11) and the alternation between the electron pulses or pulse sequences and the photon pulses or pulse sequences is carried out at an alternation frequency higher than 50 Hz.
摘要翻译：一种气体流（2）中的化合物的质谱表征方法，包括使气体流（2）中的体积单元离子化以形成化合物的离子，通过横过射束（9,10）的气流的电离交替交替电子脉冲或者形成脉冲串和光子脉冲或脉冲序列，通过电场（13）使离子偏转到质谱方法并且使用质谱方法检测离子。本发明的目的是提出一种具有扩展的测量范围和显着提高的分辨率的所述类型的方法。该目的通过由准分子灯（11）产生光子脉冲或脉冲序列来实现，并且该改变发生在电子脉冲或脉冲序列与具有高于50Hz的交变频率的光子脉冲或脉冲序列之间。

6. 发明申请

WO2004024756A3 ORTHOPOXVIRUS ANTIGENS AND USE THEREOF 审中-公开
标题翻译： ORTHOPOXVIRUS抗原及其用途
公开(公告)号：WO2004024756A3
公开(公告)日：2005-01-27
申请号：PCT/EP0310226
申请日：2003-09-12
申请人： GSF FORSCHUNGSZENTRUM UMWELT , DREXLER INGO , ERFLE VOLKER , STAIB CAROLINE , SUTTER GERD
发明人： DREXLER INGO , ERFLE VOLKER , STAIB CAROLINE , SUTTER GERD
IPC分类号： A61K38/00 , A61K39/00 , C07K14/065 , C07K14/07 , C07K14/11 , C12N1/21 , C12N15/39 , G01N33/50 , A61K31/711 , A61K31/713 , A61K38/04 , A61K39/285 , C07K7/06 , C12N5/10 , C12N15/63
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2710/24022 , C12N2710/24122 , G01N33/505 , G01N2333/065
摘要： The present invention is directed to a method of detecting a T cell response induced by smallpox vaccines or Orthopoxvirus vector vaccines in a mammal and to immunogenic Orthopoxvirus antigens and the nucleic acids encoding same. The present invention further relates to pharmaceutical compositions and their use in the protective immunization against a smallpox infection.
摘要翻译：本发明涉及一种检测哺乳动物中天花疫苗或正痘病毒载体疫苗诱导的T细胞应答和免疫原性正痘病毒抗原及其编码核酸的方法。本发明还涉及药物组合物及其在针对天花感染的保护性免疫中的用途。

7. 发明申请

WO2004029852A2 METHOD, COMPUTER PROGRAM PRODUCT AND SYSTEM FOR MICROARRAY CROSS-HYBRIDISATION DETECTION 审中-公开
标题翻译：方法，计算机程序产品和微阵列交叉检测系统
公开(公告)号：WO2004029852A2
公开(公告)日：2004-04-08
申请号：PCT/EP0309733
申请日：2003-09-02
申请人： GSF FORSCHUNGSZENTRUM UMWELT , BECKERS JOHANNES , HRABE DE ANGELIS MARTIN , MACHKA CHRISTINE , SELTMANN MATTHIAS , HORSCH MARION , LIEBSCHER VOLKMAR
发明人： BECKERS JOHANNES , HRABE DE ANGELIS MARTIN , MACHKA CHRISTINE , SELTMANN MATTHIAS , HORSCH MARION , LIEBSCHER VOLKMAR
IPC分类号： C12Q1/68 , G06F19/20 , G06F19/00
CPC分类号： G06F19/20
摘要： The present invention concerns a method for determining hybridisation on a microarray and a respective system. The method comprises the steps of conducting in situ fractionation of hybridised target in at least one probe of the microarray by means of at least one wash with a defined stringency. Furthermore, labelling intensity data at or after the in situ fractionation is collected with a defined stringency. The above two steps are repeated, wherein in a subsequence cycle the defined stringency is increased. Moreover, instead of data corresponding to at least the stringency and the respective labelling intensity data obtained by each cycle for said cycles according to the connecting labelling intensity data is generated. Finally, a set of data for determining hybridisation in at least one probe is analysed.
摘要翻译：本发明涉及用于确定微阵列和相应系统上的杂交的方法。该方法包括以下步骤：通过至少一次具有限定的严格性的洗涤，在微阵列的至少一个探针中进行原位分离杂交的靶。此外，以定义的严格性收集原位分离或其后的标记强度数据。重复上述两个步骤，其中在次序循环中增加了所定义的严格性。此外，代替产生与至少严格性相对应的数据，并且生成根据连接标签强度数据的针对所述周期的每个周期获得的各个标记强度数据。最后，分析用于确定至少一个探针中的杂交的一组数据。

8. 发明申请

WO0188530A3 METHOD FOR SELECTING ENZYME INHIBITORS 审中-公开
标题翻译：法抑制剂在酶SELECTING
公开(公告)号：WO0188530A3
公开(公告)日：2002-11-14
申请号：PCT/EP0105661
申请日：2001-05-17
申请人： GSF FORSCHUNGSZENTRUM UMWELT , WARMUTH MARKUS , MATHES RUTH , HALLEK MICHAEL
发明人： WARMUTH MARKUS , MATHES RUTH , HALLEK MICHAEL
IPC分类号： C12Q1/48 , G01N33/68 , C12N9/12
CPC分类号： C12Q1/485
摘要： The present invention relates to a method for selecting enzyme inhibitors and for using inhibitors selected as treatment and/or prevention agents. The invention also relates to a mutant form that can be used within said method as well as a method used to check an inhibitor specificity in a model system.
摘要翻译：本发明涉及选择抑制剂的酶的方法，以及使用所选择的抑制剂作为治疗和/或预防剂，在突变体的过程中可使用的和用于在其在一个模型系统特异性的抑制剂的测试方法。

9. 发明申请

WO0168833A3 RECOMBINANT HHV8 DNA 审中-公开
标题翻译：重组HHV-8 DNA
公开(公告)号：WO0168833A3
公开(公告)日：2002-04-11
申请号：PCT/EP0103031
申请日：2001-03-16
申请人： GSF FORSCHUNGSZENTRUM UMWELT , DELECLUSE HENRI JACQUES , KOST MANUELA , HAMMERSCHMIDT WOLFGANG
发明人： DELECLUSE HENRI-JACQUES , KOST MANUELA , HAMMERSCHMIDT WOLFGANG
IPC分类号： C12N15/09 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N7/00 , C12N7/01 , C12N15/869 , C12P19/34 , C12Q1/68 , C12Q1/70 , C12R1/645 , C12N15/38 , C12N15/70 , C12N15/81
CPC分类号： C12N15/86 , C12N2710/16443 , C12Q1/705
摘要： The invention relates to recombinant HHV8 DNA and to a method for the production thereof.
摘要翻译：本发明涉及重组HHV-8 DNA以及它们的制备方法。

10. 发明申请

WO9933866A3 ANTIVIRALLY ACTIVE OLIGOPEPTIDE ISOLATED FROM ROYAL JELLY 审中-公开
标题翻译：蜂王浆隔离抗病毒有效寡肽
公开(公告)号：WO9933866A3
公开(公告)日：1999-09-10
申请号：PCT/EP9807811
申请日：1998-12-02
申请人： GSF FORSCHUNGSZENTRUM UMWELT
发明人： BENGSCH EBERHARD , KETTRUP ANTONIUS , POLSTER JUERGEN
IPC分类号： A61K38/00 , C07K14/415 , C07K14/435 , A61K38/17
CPC分类号： C07K14/415 , A61K38/00 , C07K14/43572
摘要： The invention relates to a family of oligopeptides with a completely new structure which occurs in selectively obtained royal jellies of certain vegetable origin and has been correlated with marked antiviral properties. The pilot structure is a molecule with 52 amino acids. Numerous analogous, nearly identical molecules are present in a satellite-like manner. The substances have a broad spectrum of antiviral activity, including against retroviruses, and have no toxic effect on humans even at high doses. A further surprising characteristic is their extreme resistance to all controlled proteases and other enzymes. The molecules are highly convoluted and resistant to attack. Despite their convolution they are geometrically very flexible and can form several conformers. The native state is easily soluble in water. Chemical synthesis results in a water insoluble form which can, however, be easily transformed into a soluble bioactive conformer which is similar to the native form. These new oligopeptides are therefore the first to combine in an optimal manner all the properties required of a potentially antiviral substance category.
摘要翻译：本发明涉及一类寡肽与发生在选择性地收集果冻royales特定植物来源一个完全新的结构，并具有较强的抗病毒效果相关。导频结构是具有52个氨基酸的分子。卫星状这是众多模拟几乎相同的分子。该物质具有活性的宽谱抗病毒，包括反转录病毒甚至人类无毒高剂量。令人惊讶的也是他们极强的抗所有受控蛋白酶等酶。分子是高度缠结和无懈可击。尽管纠缠他们是几何高度灵活，可形成多种构象。在天然状态下是有易溶于水的形式。从化学合成的结果中不溶于水的形式，但其可转化为可溶的，密切相关的天然形式的生物活性构象异构体。新寡肽结合从而在第一时间，最佳的，所有必须由潜在的抗病毒药物类被请求的属性。

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