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1. 发明申请

WO9933866A3 ANTIVIRALLY ACTIVE OLIGOPEPTIDE ISOLATED FROM ROYAL JELLY 审中-公开
标题翻译：蜂王浆隔离抗病毒有效寡肽
公开(公告)号：WO9933866A3
公开(公告)日：1999-09-10
申请号：PCT/EP9807811
申请日：1998-12-02
申请人： GSF FORSCHUNGSZENTRUM UMWELT
发明人： BENGSCH EBERHARD , KETTRUP ANTONIUS , POLSTER JUERGEN
IPC分类号： A61K38/00 , C07K14/415 , C07K14/435 , A61K38/17
CPC分类号： C07K14/415 , A61K38/00 , C07K14/43572
摘要： The invention relates to a family of oligopeptides with a completely new structure which occurs in selectively obtained royal jellies of certain vegetable origin and has been correlated with marked antiviral properties. The pilot structure is a molecule with 52 amino acids. Numerous analogous, nearly identical molecules are present in a satellite-like manner. The substances have a broad spectrum of antiviral activity, including against retroviruses, and have no toxic effect on humans even at high doses. A further surprising characteristic is their extreme resistance to all controlled proteases and other enzymes. The molecules are highly convoluted and resistant to attack. Despite their convolution they are geometrically very flexible and can form several conformers. The native state is easily soluble in water. Chemical synthesis results in a water insoluble form which can, however, be easily transformed into a soluble bioactive conformer which is similar to the native form. These new oligopeptides are therefore the first to combine in an optimal manner all the properties required of a potentially antiviral substance category.
摘要翻译：本发明涉及一类寡肽与发生在选择性地收集果冻royales特定植物来源一个完全新的结构，并具有较强的抗病毒效果相关。导频结构是具有52个氨基酸的分子。卫星状这是众多模拟几乎相同的分子。该物质具有活性的宽谱抗病毒，包括反转录病毒甚至人类无毒高剂量。令人惊讶的也是他们极强的抗所有受控蛋白酶等酶。分子是高度缠结和无懈可击。尽管纠缠他们是几何高度灵活，可形成多种构象。在天然状态下是有易溶于水的形式。从化学合成的结果中不溶于水的形式，但其可转化为可溶的，密切相关的天然形式的生物活性构象异构体。新寡肽结合从而在第一时间，最佳的，所有必须由潜在的抗病毒药物类被请求的属性。

2. 发明申请

WO9615798A2 USE OF BIOASSIMILABLE BORON COMPOUNDS FOR THE CONTROL OF SUBVIRAL PATHOGENIC AGENTS 审中-公开
标题翻译： BIO-同化硼化合物的利用互联网打击亚病毒病原体
公开(公告)号：WO9615798A2
公开(公告)日：1996-05-30
申请号：PCT/EP9504494
申请日：1995-11-15
申请人： GSF FORSCHUNGSZENTRUM UMWELT , BENGSCH EBERHARD , KETTRUP ANTONIUS , POLSTER JUERGEN
发明人： BENGSCH EBERHARD , KETTRUP ANTONIUS , POLSTER JUERGEN
IPC分类号： A01N25/00 , A01N59/14 , A61K31/69 , A61K31/695 , A61K33/00 , A61K33/22 , A61K33/34 , A61K36/00 , A61P25/00 , A61P31/12 , C12N7/02 , A61K35/78
CPC分类号： A61K33/22 , A61K31/69
摘要： The use of bioassimilable boron compounds is disclosed. The object of the invention is a new use of bioassimilable boron compounds. Boron compounds are used to prepare a medicament for fighting subviral particles that cause subacute, degenerative, non-inflammatory diseases of the central nervous systems in animals and humans or for protecting plants against the action of subviral pathogenic agents. The boron compounds can also be used in combination with bioassimilable silicon or copper compounds.
摘要翻译：本发明涉及利用生物同化的硼化合物。本发明的目的是提供一种新的使用的生物可吸收的硼化合物。该目的是通过使用有机硼化合物的在制备药物中的打击亚病毒颗粒，导致动物和人的区域亚急性中枢神经系统变性，非炎性疾病或针对的亚病毒病原体在植物中的作用的保护来实现。硼化合物也可与生物可利用的硅或铜的化合物组合使用。

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