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1. 发明申请

WO2005054294A2 INHIBITORS OF GLYCOPROTEIN VI BASED ON MONOCLONAL ANTIBODY HGP 5C4 审中-公开
标题翻译：基于单克隆抗体HGP 5C4的糖蛋白Ⅵ的抑制剂
公开(公告)号：WO2005054294A2
公开(公告)日：2005-06-16
申请号：PCT/EP2004013779
申请日：2004-12-03
申请人： PROCORDE GMBH , GSF FORSCHUNGSZENTRUM UMWELT , GAWAZ MEINRAD , KREMMER ELISABETH , MUENCH GOETZ
发明人： GAWAZ MEINRAD , KREMMER ELISABETH , MUENCH GOETZ
IPC分类号： C07K16/28 , C07K16/00
CPC分类号： C07K16/2803 , A61K2039/505
摘要： The present invention relates to a specific inhibitor of human platelet glycoprotein VI. The inhibitor may be an optionally humanized antibody or function-conservative fragments or variants thereof, a specific fusion protein or conjugate. Moreover, the present invention relates to pharmaceutical compositions containing the specific inhibitor of the invention. The present invention also relates to hybridomas expressing the antibody of the present invention. Furthermore, the present invention relates to the use of the specific inhibitor of glycoprotein VI for the preparation of a medicament for the prevention of acute and chronic vascular diseases associated with arterial and/or intravenous thrombosis, such as acute coronary syndrome, acute carotid artery syndrome, acute myocardial infarction, acute cerebral stroke and chronic coronary or peripheral vessel disease. Finally, the present invention relates to a process for preparing the antibody of the invention and to a process for preparing a specific fragment of the antibody of the present invention.
摘要翻译：本发明涉及人血小板糖蛋白VI的特异性抑制剂。抑制剂可以是任选人源化抗体或其功能保守性片段或变体，特异性融合蛋白或缀合物。而且，本发明涉及含有本发明特异性抑制剂的药物组合物。本发明还涉及表达本发明抗体的杂交瘤。此外，本发明涉及糖蛋白VI的特异性抑制剂在制备用于预防与动脉和/或静脉内血栓形成相关的急性和慢性血管疾病如急性冠状动脉综合征，急性颈动脉综合征，急性心肌梗塞，急性脑卒中和慢性冠状动脉或外周血管疾病。最后，本发明涉及制备本发明抗体的方法和制备本发明抗体特异性片段的方法。

2. 发明申请

WO2006045392A3 KASPP (LRRKE) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译： KASPP（LRRKE）基因，其生产和用于检测和治疗神经损伤性疾病
公开(公告)号：WO2006045392A3
公开(公告)日：2006-08-10
申请号：PCT/EP2005010428
申请日：2005-09-27
申请人： BH GSF FORSCHUNGSZENTRUM FUER , UNIV EBERHARD KARLS , MAYO CLINIC , MEITINGER THOMAS , STROM TIM MATTHIAS , BISKUP SASKIA , UEFFING MARIUS , KREMMER ELISABETH , GLOECKNER CHRISTIAN J , GASSER THOMAS , LEITNER PETRA , ASMUS FRIEDRICH , PATENGE NADJA , ZIMPRICH ALEXANDER , FARRER MATTHEW J , KACHERGUS JENNIFER M , LINCOLN SARA J , HULIHAN MARY M , WSZOLEK ZIBIGNIEW , UITTI RYAN
发明人： MEITINGER THOMAS , STROM TIM MATTHIAS , BISKUP SASKIA , UEFFING MARIUS , KREMMER ELISABETH , GLOECKNER CHRISTIAN J , GASSER THOMAS , LEITNER PETRA , ASMUS FRIEDRICH , PATENGE NADJA , ZIMPRICH ALEXANDER , FARRER MATTHEW J , KACHERGUS JENNIFER M , LINCOLN SARA J , HULIHAN MARY M , WSZOLEK ZIBIGNIEW , UITTI RYAN
IPC分类号： C12N9/12
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
摘要翻译：本发明涉及一种新发现的基因名为KASPP的激酶，与帕金森综合征相关，具有多形性病理学，或者称为LRRK2，用于亮氨酸重复激酶2，其生产，生物化学表征和用于检测和治疗神经变性疾病如帕金森病疾病（PD）包括但不限于散发性PD，阿尔茨海默病（AD），肌萎缩性侧索硬化（ALS）和其他突触核蛋白病和/或tau蛋白病，以及与PD分离的KASPP / LRRK2基因中的几种多态性和突变。

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