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1. 发明申请

WO2010123734A2 SYSTEM AND METHOD FOR CLOSURE OF AN INTERNAL OPENING IN TISSUE, SUCH AS A TRANS-APICAL ACCESS OPENING 审中-公开
标题翻译：用于关闭组织内部开放的系统和方法，例如转接开关
公开(公告)号：WO2010123734A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/031074
申请日：2010-04-14
申请人： MEDTRONIC INC. , AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
发明人： AHLBERG, Sarah , SIMMA, Sara , ROTHSTEIN, Paul T. , CLEMENTS, Martin , JELICH, Damian , LASKE, Timothy G. , CLAGUE, Cynthia , GREEN, Michael , IAIZZO, Paul
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/00243 , A61B2017/00663 , A61B2017/00867 , A61B2017/0441 , A61B2017/0443 , A61B2017/0464 , A61B2017/1142
摘要： A method for closing an opening at a target site including bodily tissue including embedding a plurality of self-closing clips into the target site in a spaced apart manner about a perimeter of the opening. Each of the clips has opposing clip ends and an intermediate segment. A flexible tether is coupled to the embedded clips to form a loop about the opening perimeter. A pulling force is applied onto at least one of the loop ends, thereby drawing the perimeter of the opening onto itself to completely close the opening. The loop ends are secured to maintain the target site in a closed state. In some embodiments, the target site is apical cardiac tissue, and the method is performed as part of a trans-apical access procedure.
摘要翻译：一种用于在包括身体组织在内的目标位置处关闭开口的方法，包括围绕开口的周边以间隔开的方式将多个自闭合夹子嵌入目标部位。每个夹子具有相对的夹子端部和中间部分。柔性系绳联接到嵌入的夹子上以围绕开口周边形成环。将拉力施加到至少一个环端，从而将开口的周边拉到其上以完全关闭开口。环路端部被固定以将目标部位保持在关闭状态。在一些实施方案中，靶位点是心尖心脏组织，并且该方法作为跨顶部进入程序的一部分进行。

2. 发明申请

WO2009120435A1 CARDIAC ABLATION AND ELECTRICAL INTERFACE SYSTEM AND INSTRUMENT 审中-公开
标题翻译：心脏吸收和电接口系统和仪器
公开(公告)号：WO2009120435A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/034859
申请日：2009-02-23
申请人： MEDTRONIC, INC. , FRANCISCHELLI, David E. , STEWART, Mark T. , CHEEK, Daniel S. , ROSS, Brian J. , HAMEED, Asif , ROTHSTEIN, Paul T. , BATCHELOR, Kester J. , COLON, William , KLEIN, Scott T. , CROWE, Douglas A.
发明人： FRANCISCHELLI, David E. , STEWART, Mark T. , CHEEK, Daniel S. , ROSS, Brian J. , HAMEED, Asif , ROTHSTEIN, Paul T. , BATCHELOR, Kester J. , COLON, William , KLEIN, Scott T. , CROWE, Douglas A.
IPC分类号： A61B18/14 , A61N1/37
CPC分类号： A61B18/1402 , A61B5/0422 , A61B18/1492 , A61B2017/00053 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61N1/06 , A61N1/36017
摘要： A system for ablating tissue and electrically interfacing with a heart including an electrosurgical instrument, an energy source, and a controller. The instrument includes a shaft maintaining first and second electrodes at a distal section. The electrodes are electrically isolated from one another. The controller controls delivery of energy from the energy source, and monitors electrical signals at the electrodes. The controller is programmed to operate in a monopolar mode and a bipolar mode. In the monopolar mode, the first and second electrodes are electrically uncoupled, and energy from the energy source is delivered to the first electrode in performing an ablation procedure. In the bipolar mode, first and second electrodes are electrically coupled and serve as opposite polarity poles to apply energy to a tissue target site, detect electrical signals at a tissue target site, or both.
摘要翻译：一种用于消融组织并与包括电外科器械，能量源和控制器的心脏电接口的系统。仪器包括轴，其在远端部分保持第一和第二电极。电极彼此电隔离。控制器控制能量从能源的传递，并监测电极处的电信号。控制器被编程为在单极模式和双极模式下工作。在单极模式中，第一和第二电极是电耦合的，并且来自能量源的能量在执行消融过程时被传送到第一电极。在双极模式中，第一和第二电极被电耦合并且用作相反的极性极以将能量施加到组织靶位点，检测组织靶位置处的电信号，或者两者。

3. 发明申请

WO2006060431A1 DEVICES AND METHODS FOR INTERSTITIAL INJECTION OF BIOLOGIC AGENTS INTO TISSUE 审中-公开
标题翻译：用于将生物学代理进行组织间接注射的装置和方法
公开(公告)号：WO2006060431A1
公开(公告)日：2006-06-08
申请号：PCT/US2005/043200
申请日：2005-11-30
申请人： MEDTRONIC, INC. , BONNER, Matthew, D. , ROTHSTEIN, Paul, T. , HINIDUMA-LOKUGE, Prasanga, D. , KEOGH, James, R. , USHER, Raymond, W. , JAHNS, Scott, E. , CHEN, Victor, T.
发明人： BONNER, Matthew, D. , ROTHSTEIN, Paul, T. , HINIDUMA-LOKUGE, Prasanga, D. , KEOGH, James, R. , USHER, Raymond, W. , JAHNS, Scott, E. , CHEN, Victor, T.
IPC分类号： A61B17/34
CPC分类号： A61B17/3478 , A61B17/00234 , A61B17/205 , A61B2017/00243 , A61B2017/00247 , A61B2017/2926 , A61B2017/2936 , A61B2017/2943 , A61B2017/306 , A61B2018/00392 , A61B2090/034 , A61M25/0084
摘要： Apparatus and methods for injecting biological agents into tissue. Devices are provided having elongate shafts and distal injection heads for driving needles into tissue and injecting medical agents into the tissue through the needles. A longitudinal force directed along the shaft can be translated to a needle driving force. Some devices provide controllably variable needle penetration depth. Devices include mechanical needle drivers utilizing four link pantographs, rack and pinions, and drive yokes for driving a first needle bearing body toward a second tissue contacting body. Other devices include inflatable members for driving and retracting needles. Still other devices include magnets for biasing the needles in extended and/or retracted positions. The invention includes minimally invasive methods for epicardially injecting cardiocyte precursor cells into infarct myocardial tissue.
摘要翻译：将生物制剂注入组织的装置和方法。提供了具有细长轴和远端注射头的装置，用于将针驱动到组织中并通过针将药剂注射到组织中。沿着轴引导的纵向力可以转换成针驱动力。一些装置提供可控制的针穿透深度。设备包括利用四个连杆缩放仪，齿条和小齿轮的机械针驱动器和用于将第一滚针轴承体朝向第二组织接触体驱动的驱动轭。其他装置包括用于驱动和缩回针的可充气构件。还有其它装置包括用于在延伸和/或缩回位置偏置针的磁体。本发明包括用心外膜将心脏细胞前体细胞注入梗死心肌组织的微创方法。

4. 发明申请

WO2005120376A3 ABLATION DEVICE WITH JAWS 审中-公开
标题翻译：具有JAWS的装置
公开(公告)号：WO2005120376A3
公开(公告)日：2006-04-27
申请号：PCT/US2005019129
申请日：2005-06-01
申请人： MEDTRONIC INC , CHRISTIAN STEVEN C , DAIGLE TOM P , ROTHSTEIN PAUL T
发明人： CHRISTIAN STEVEN C , DAIGLE TOM P , ROTHSTEIN PAUL T
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B18/1492 , A61B2018/00363 , A61B2018/00375 , A61B2018/00577
摘要： System, device and method for ablating target tissue adjacent pulmonary veins of a patient through an incision. An ablation device can include a hinge including a cam assembly, a moving arm, a floating jaw, and a lower jaw. Fingers can engage the floating jaw to hold the floating jaw in a first position with respect to the moving arm. Some embodiments of the invention can provide an ablation device including a central support, an upper four-bar linkage coupled to the central support, an upper jaw coupled to the upper linkage, a lower four-bar linkage coupled to the central support, and a lower jaw coupled to the lower linkage. Some embodiments of the invention can provide an ablation device having an upper jaw including a first cannula connection and a lower jaw including a second cannula connection. The system can include a first catheter coupled to the first cannula connection and a second catheter coupled to the second cannula connection. The first and second catheters can be inserted through the incision and can move the upper and lower jaws adjacent the pulmonary veins.
摘要翻译：用于通过切口消融患者的肺静脉附近的靶组织的系统，装置和方法。消融装置可以包括铰链，其包括凸轮组件，移动臂，浮动夹爪和下颚。手指可以接合浮动的颚板将浮动颚部相对于移动臂保持在第一位置。本发明的一些实施例可以提供消融装置，其包括中央支撑件，联接到中心支撑件的上部四杆连接件，联接到上部连接件的上部钳口，联接到中心支撑件的下部四杆连杆，以及下颚连接到下连杆。本发明的一些实施例可以提供一种消融装置，其具有包括第一套管连接的上颚和包括第二插管连接的下颚。该系统可以包括耦合到第一插管连接的第一导管和耦合到第二插管连接的第二导管。第一和第二导管可以穿过切口插入并且能够移动邻近肺静脉的上下爪。

5. 发明申请

WO2009132009A1 SUCTION FORCE ABLATION DEVICE 审中-公开
标题翻译：吸收力消除装置
公开(公告)号：WO2009132009A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/041261
申请日：2009-04-21
申请人： MEDTRONIC, INC. , AHLBERG, Sarah, E. , DAIGLE, Tom, P. , FRANCISCHELLI, David, E. , PODBELSKI, Adam, A. , HAEG, Daniel, C. , ROTHSTEIN, Paul, T. , RAMBERG, Steve, V. , BATCHELOR, Kester, J. , CONWAY, Thomas, J.
发明人： AHLBERG, Sarah, E. , DAIGLE, Tom, P. , FRANCISCHELLI, David, E. , PODBELSKI, Adam, A. , HAEG, Daniel, C. , ROTHSTEIN, Paul, T. , RAMBERG, Steve, V. , BATCHELOR, Kester, J. , CONWAY, Thomas, J.
IPC分类号： A61B8/14
CPC分类号： A61B18/1492 , A61B2018/00065 , A61B2018/00113 , A61B2018/00291 , A61B2018/00351 , A61B2018/00642 , A61B2018/00702 , A61B2018/00726 , A61B2018/00863 , A61B2018/1472 , A61B2090/064 , A61B2218/002 , A61B2218/007
摘要： An ablation device for ablating tissue having an outer wall and an inner wall, approximately parallel and concentric with said outer wall, defining an inner fluid chamber and an outer low pressure chamber. Each of the outer wall and the inner wall have an edge defining an open face of the fluid chamber and the low pressure chamber. An ablative element is contained within the fluid chamber. A source of low pressure is coupled to the low pressure chamber. When the edge of the outer wall and the edge of the inner wall contact a surface, the ablation device is at least partially secured to the surface by low pressure created in the low pressure chamber by the source of low pressure. The fluid chamber is at least partially fluidly isolated from the low pressure chamber when the ablation device is at least partially secured to the surface.
摘要翻译：一种用于烧蚀组织的消融装置，其具有与所述外壁大致平行并同心的外壁和内壁，限定内部流体室和外部低压室。外壁和内壁中的每一个具有限定流体室和低压室的敞开面的边缘。消融元件包含在流体室内。低压源连接到低压室。当外壁的边缘和内壁的边缘接触表面时，消融装置通过由低压源产生的低压室中的低压至少部分地固定到表面。当消融装置至少部分地固定到表面时，流体室至少部分地与低压室流体隔离。

6. 发明申请

WO2005120374A1 COMPOUND BIPOLAR ABLATION DEVICE AND METHOD 审中-公开
标题翻译：复合双极性吸收装置及方法
公开(公告)号：WO2005120374A1
公开(公告)日：2005-12-22
申请号：PCT/US2005/019022
申请日：2005-06-01
申请人： MEDTRONIC, INC. , ROTHSTEIN, Paul, T. , BRISCOE, Roderick, E. , FRANCISCHELLI, David, E. , KIM, David, Jin, Sung , LUTTERMAN, Alison
发明人： ROTHSTEIN, Paul, T. , BRISCOE, Roderick, E. , FRANCISCHELLI, David, E. , KIM, David, Jin, Sung , LUTTERMAN, Alison
IPC分类号： A61B18/14
CPC分类号： A61B18/1442 , A61B2018/00363 , A61B2018/00375 , A61B2018/00577
摘要： Method and apparatus for ablating target tissue adjacent pulmonary veins of a patient. The ablation device (30) can include a lower jaw assembly (32) including a proximal jaw (42) having a proximal electrode (50) and a distal jaw (62) having a distal electrode (70), and an upper jaw assembly (90) including an upper jaw (94) having an upper electrode (98). A proximal actuator (54) can be movable between a first position in which the proximal jaw is open and a second position in which the proximal jaw is clamped with respect to the upper jaw. A distal actuator (76) can be movable between a third position in which the distal jaw is open and a fourth position in which the distal jaw is clamped with respect to the upper jaw.
摘要翻译：用于消融患者的肺静脉附近的靶组织的方法和装置。消融装置（30）可以包括下钳口组件（32），其包括具有近端电极（50）的近端钳口（42）和具有远端电极（70）的远端钳口（62）和上钳口组件 90），包括具有上电极（98）的上钳口（94）。近侧致动器（54）可以在其中近侧颚打开的第一位置和相对于上颚夹紧近端颌的第二位置之间移动。远侧致动器（76）可以在其中远侧钳口打开的第三位置和相对于上钳口夹紧远端钳口的第四位置之间移动。

7. 发明申请

WO2004100800A2 SURGICAL SUTURE HOLDING DEVICE 审中-公开
标题翻译：外科手术器械
公开(公告)号：WO2004100800A2
公开(公告)日：2004-11-25
申请号：PCT/US2004/009843
申请日：2004-03-31
申请人： MEDTRONIC, INC. , ROTHSTEIN, Paul, T. , PIGNATO, Paul, A. , DAIGLE, Thomas, P. , GOODMAN, Jack
发明人： ROTHSTEIN, Paul, T. , PIGNATO, Paul, A. , DAIGLE, Thomas, P. , GOODMAN, Jack
IPC分类号： A61B17/04
CPC分类号： A61B17/06061 , A61B17/0483 , A61B90/50 , A61B2017/0237
摘要： A device for holding a surgical suture including a base, a guide body, a cam body, a bearing member, and a spring member. The base has a top side, a front edge, and a back edge. The guide body projects from the top side of the base and defines a guide face having an entrance side and an exit side. The entrance side is adjacent the front edge and the exit side is adjacent the back edge. The cam body is pivotally mounted to the top side and forms a toothed surface positioned to selectively secure a surgical suture against the guide face. The spring member is positioned between the cam body and the bearing member, biasing the toothed surface toward the guide face.
摘要翻译：一种用于保持包括基部，引导体，凸轮体，支承构件和弹簧构件的手术缝合线的装置。底座具有顶侧，前边缘和后边缘。引导体从基部的顶侧突出并且限定具有入口侧和出口侧的引导面。入口侧邻近前缘，出口侧邻近后缘。凸轮主体枢转地安装到顶侧并形成齿形表面，其被定位成选择性地将外科缝合线固定抵靠引导面。弹簧构件定位在凸轮本体和轴承构件之间，将齿形表面朝向引导面偏置。

8. 发明申请

WO2011136935A1 METHODS AND DEVICES FOR CARDIAC VALVE REPAIR OR REPLACEMENT 审中-公开
标题翻译：心脏瓣膜修复或替代的方法和装置
公开(公告)号：WO2011136935A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/032422
申请日：2011-04-14
申请人： MEDTRONIC INC. , ROTHSTEIN, Paul T. , QUILL, Jason
发明人： ROTHSTEIN, Paul T. , QUILL, Jason
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B90/39 , A61B2017/00243 , A61B2017/00783 , A61B2017/0409 , A61B2017/0443 , A61B2017/0464 , A61B2017/0472 , A61F2/2427
摘要： A delivery system for percutaneously guiding a repair or replacement device into a desired position relative to a valve within a patient. The delivery system includes a longitudinal support tube having a distal end, a deformable centering loop extending from the distal end of the support tube, at least one stop positioned on the centering loop and spaced from the distal end of the support tube, at least one clip delivery system slideably attached to the centering loop, and a sheath that is longitudinally slideable relative to the support tube, the centering loop, and the at least one clip delivery tube.
摘要翻译：一种用于将修复或更换装置经皮引导到相对于患者内的阀的期望位置的输送系统。输送系统包括纵向支撑管，其具有远端，从支撑管的远端延伸的可变形定心环，至少一个止动件，其位于定心环上并与支撑管的远端间隔开，至少一个夹子传送系统，其可滑动地附接到定心环，以及相对于支撑管，定心环和至少一个夹子输送管可纵向滑动的护套。

9. 发明申请

WO2010132254A1 SUB-XIPHOID ABLATION CLAMP AND METHOD OF SUB-XIPHOID ABLATION 审中-公开
标题翻译：子切除术和子切除术的方法
公开(公告)号：WO2010132254A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/033719
申请日：2010-05-05
申请人： MEDTRONIC INC. , STEWART, Mark, T. , DIAGLE, Tom, P. , FRANCISCHELLI, David, E. , LIDDICOAT, John, R. , ROTHSTEIN, Paul, T.
发明人： STEWART, Mark, T. , DIAGLE, Tom, P. , FRANCISCHELLI, David, E. , LIDDICOAT, John, R. , ROTHSTEIN, Paul, T.
IPC分类号： A61B18/14
CPC分类号： A61B18/1445 , A61B1/00087 , A61B1/05 , A61B1/06 , A61B34/20 , A61B2017/00057 , A61B2017/2945 , A61B2018/00107 , A61B2018/00142 , A61B2018/0022 , A61B2018/00375 , A61B2018/00982 , A61B2018/1432 , A61N1/362
摘要： Device for sub-xiphoid ablation of patient tissue. A sub-xiphoid access clamp has a handle, an elongate neck coupled to the handle and first and second opposing jaws. The first and second opposing jaws have first and second opposing relief segments being generally co-planar and concave with respect to one another to form a void therebetween, and first and second opposing elongate ablation elements positioned along the first and second opposing jaws and distal of the first and second opposing relief segments relative to the handle. The first and second opposing jaws are articulate between a closed position and an open position to admit, at least in part, a second portion of tissue of the patient within the void created by the first and second opposing relief segments while the first portion of tissue is positioned between the first and second ablation elements in the closed position.
摘要翻译：用于患者组织的亚剑突消融的装置。副剑杆通道夹具具有手柄，连接到手柄的细长颈部以及第一和第二相对的夹爪。第一和第二相对的钳口具有第一和第二相对的浮雕段，它们大致共面并相对于彼此凹入以在它们之间形成空隙，并且第一和第二相对的细长消融元件沿着第一和第二相对的夹爪定位，第一和第二相对的释放段相对于把手。第一和第二相对的夹爪在关闭位置和打开位置之间铰接，以至少部分地允许患者在由第一和第二相对的浮雕段产生的空隙内的组织的第二部分，同时组织的第一部分位于第一和第二消融元件之间处于关闭位置。

10. 发明申请

WO2010123672A1 AUTO-CLOSURE APICAL ACCESS POSITIONER DEVICE AND METHOD 审中-公开
标题翻译：自动关闭自动接近定位装置及方法
公开(公告)号：WO2010123672A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/029675
申请日：2010-04-01
申请人： MEDTRONIC INC. , ROTHSTEIN, Paul, T. , HILL, Alexander, J. , HOBDAY, Michael, J. , GREEN, Michael, M. , IAIZZO, Paul, A.
发明人： ROTHSTEIN, Paul, T. , HILL, Alexander, J. , HOBDAY, Michael, J. , GREEN, Michael, M. , IAIZZO, Paul, A.
IPC分类号： A61B17/34
CPC分类号： A61B17/3423 , A61B17/064 , A61B17/068 , A61B90/30 , A61B2017/00022 , A61B2017/00243 , A61B2017/00575 , A61B2017/306 , A61B2017/3425 , A61B2017/3488
摘要： A positioning device for providing access to a ventricle of a heart. In one embodiment, the device includes a cup positionable over an apex of the heart and at least a first access valve in the cup for accessing an entry point to the ventricle of the heart.
摘要翻译：一种用于提供对心脏心室的通路的定位装置。在一个实施例中，该装置包括可定位在心脏的顶点上方的杯子，以及杯中的至少第一进入阀，用于接近心脏心室的入口点。

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