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1. 发明申请

WO2010094452A3 COMPOSITION COMPRISING N2 - (1-OXOHEXADECYL) - LYSYL - VALYL - LYSINE FOR TREATING ROSACEA AND ITS SYMPTOMS 审中-公开
标题翻译：包含N 2 - （1-氧代十八烷基）-LYSYL - VALYL - 用于治疗ROSACEA及其症状的赖氨酸的组合物
公开(公告)号：WO2010094452A3
公开(公告)日：2010-10-14
申请号：PCT/EP2010000943
申请日：2010-02-16
申请人： DSM IP ASSETS BV , GEMPLER MATHIAS , GRAEUB REMO , HOCHEGGER LEO , IMFELD DOMINIK , MOSER HEIDI
发明人： GEMPLER MATHIAS , GRAEUB REMO , HOCHEGGER LEO , IMFELD DOMINIK , MOSER HEIDI
IPC分类号： A61K38/06 , A61K31/201 , A61P17/00
CPC分类号： A61K8/362 , A61K8/64 , A61K8/922 , A61K9/0014 , A61K9/107 , A61K31/201 , A61K38/06 , A61K47/12 , A61K47/183 , A61K47/44 , A61Q19/005 , A61Q19/007 , A61K2300/00
摘要： The present invention relates to a composition comprising N2-(1-oxohexadecyl)-lysyl-valyl- lysine or a salt thereof, spent grain wax and/ or conjugated linoleic acid. The compositions are particularly useful for the treatment or co-treatment of rosacea and its symptoms. Furthermore the invention relates to a stable W/O emulsion pre-mix comprising the composition according to the invention.
摘要翻译：本发明涉及包含N2-（1-氧代十六烷基） - 赖氨酰 - 缬氨酰赖氨酸或其盐，废谷物蜡和/或共轭亚油酸的组合物。组合物特别可用于治疗或共同治疗酒渣鼻及其症状。此外，本发明涉及包含本发明组合物的稳定的W / O乳液预混物。

2. 发明申请

WO2012116992A2 ORAL USE 审中-公开
标题翻译：口服使用
公开(公告)号：WO2012116992A2
公开(公告)日：2012-09-07
申请号：PCT/EP2012053374
申请日：2012-02-28
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , GRAEUB REMO
发明人： GORALCZYK REGINA , GRAEUB REMO
IPC分类号： A61K8/60 , A61K8/63 , A61K8/97 , A61Q17/04 , A61Q19/04
CPC分类号： A61Q19/04 , A61K8/36 , A61K8/602 , A61K2800/92 , A61Q17/04 , A61Q19/08
摘要： The invention relates to the use of an oral composition comprising Steviol or Isosteviol as skin tanning agent. It further relates to methods of enhancing the natural skin tan by oral administration of an effective amount of Steviol or Isosteviol.
摘要翻译：本发明涉及包含甜菊醇或异头二醇的口腔组合物作为皮肤鞣剂的用途。本发明进一步涉及通过口服施用有效量的甜菊醇或异硫酚来增强天然皮肤褐变的方法。

3. 发明申请

WO2012010624A2 TOPICAL USE OF STEVIOL OR DERIVATIVES IN HAIR CARE 审中-公开
标题翻译：在头发护理中使用史蒂芬或衍生物
公开(公告)号：WO2012010624A2
公开(公告)日：2012-01-26
申请号：PCT/EP2011/062425
申请日：2011-07-20
申请人： DSM IP ASSETS B.V. , GORALCZYK, Regina , GRAEUB, Remo , MAYNE-MECHAN, Annis Olivia , PIUSSI, Jenny , RIEGER, Henry , MOHAJERI, Hasan
发明人： GORALCZYK, Regina , GRAEUB, Remo , MAYNE-MECHAN, Annis Olivia , PIUSSI, Jenny , RIEGER, Henry , MOHAJERI, Hasan
IPC分类号： A61K8/365 , A61K8/60 , A61Q5/00 , A61Q7/00
CPC分类号： A61K8/365 , A61Q5/00 , A61Q5/002 , A61Q5/006 , A61Q5/06 , A61Q5/065 , A61Q5/10 , A61Q5/12 , A61Q7/00 , A61Q17/00
摘要： The present invention relates to the use of steviol and/or isosteviol, or a salt, ester, a diester, or an ether thereof as depicted in formula (I), wherein R1 is hydrogen (H) or a saturated, straight or branched C 1 -C 8 alkyl group non substituted or substituted with up to 3 hydroxyl-, alkoxy- amino-, alkylamino- or dialkylamino- groups, R2 is independently a saturated, straight or branched C 1 -C 8 alkyl group, -O-C 1 -C 8 alkyl group, -OH group, a -O-C(O)-C 1 -C 8 alkyl, or, -COO(C 1 -C 8 alkyl) group, R3 is independently CH 2 , O, or CH-(C 1 -C 7 alkyl), wherein the enhancement of the appearance of hair is selected from the group consisting of: restoring hair color and delaying the onset of greyness in hair, lessening hair loss, restoring hair growth after the onset of baldness has occurred, increasing the thickness of hair, counteracting age-associated hair thinning, preventing premature hair loss, or delaying the onset or severity of age-associated hair loss and thinning, maintaining of the natural hair color, increasing hair shininess, glossiness or volume.
摘要翻译：本发明涉及式（I）所示的甜菊醇和/或异雄甾烯或其盐，酯，二酯或其醚的用途，其中R 1是氢（H）或饱和的直链或支链C1 未被取代或被至多3个羟基，烷氧基 - 氨基 - 烷基氨基或二烷基氨基取代的-C8烷基，R2独立地为饱和的，直链或支链的C1-C8烷基，-O-C1-C8烷基，-OH基团，-OC（O）-C 1 -C 8烷基或-COO（C 1 -C 8烷基）基团，R 3独立地是CH 2，O或CH-（C 1 -C 7烷基），其中增强毛发的外观选自：恢复头发颜色并延缓头发中的灰白色发作，减轻脱发，恢复发秃后恢复毛发生长，增加头发的厚度，抵抗年龄相关的头发变薄，防止过早脱发，或延缓年龄相关脱发和变薄的发病或严重程度，保持自然头发颜色，增加头发光泽，光泽度或体积。

4. 发明申请

WO2012010624A3 TOPICAL USE OF STEVIOL OR DERIVATIVES IN HAIR CARE 审中-公开
标题翻译：在头发护理中使用史蒂芬或衍生物
公开(公告)号：WO2012010624A3
公开(公告)日：2012-09-27
申请号：PCT/EP2011062425
申请日：2011-07-20
申请人： DSM IP ASSETS BV , GORALCZYK REGINA , GRAEUB REMO , MAYNE-MECHAN ANNIS OLIVIA , PIUSSI JENNY , RIEGER HENRY , MOHAJERI HASAN
发明人： GORALCZYK REGINA , GRAEUB REMO , MAYNE-MECHAN ANNIS OLIVIA , PIUSSI JENNY , RIEGER HENRY , MOHAJERI HASAN
IPC分类号： A61K8/365 , A61K8/60 , A61Q5/00 , A61Q7/00
CPC分类号： A61K8/365 , A61Q5/00 , A61Q5/002 , A61Q5/006 , A61Q5/06 , A61Q5/065 , A61Q5/10 , A61Q5/12 , A61Q7/00 , A61Q17/00
摘要： The present invention relates to the use of steviol and/or isosteviol, or a salt, ester, a diester, or an ether thereof as depicted in formula (I), formula (I): R1 wherein R1 is hydrogen (H) or a saturated, straight or branched C1-C8 alkyl group non substituted or substituted with up to 3 hydroxyl-, alkoxy-, amino-, alkylamino- or dialkylamino- groups, R2 is independently a saturated, straight or branched C1-C8 alkyl group, -O-C1-C8 alkyl group, -OH group, a -O-C(O)-C1-C8 alkyl, or, -COO(C1-C8 alkyl) group, R3 is independently CH2, O, or CH-(C1-C7 alkyl), wherein the enhancement of the appearance of hair is selected from the group consisting of: restoring hair color and delaying the onset of greyness in hair, lessening hair loss, restoring hair growth after the onset of baldness has occurred, increasing the thickness of hair, counteracting age-associated hair thinning, preventing premature hair loss, or delaying the onset or severity of age-associated hair loss and thinning, maintaining of the natural hair colour, increasing hair shininess, glossiness or volume. In particular, the compound is applied topically.
摘要翻译：本发明涉及式（I），式（I）所示的甜菊醇和/或异硬脂醇或其盐，酯，二酯或其醚的用途：其中R1是氢（H）或未被取代或被至多3个羟基，烷氧基，氨基，烷基氨基或二烷基氨基取代的饱和，直链或支链C 1 -C 8烷基，R 2独立地为饱和的，直链或支链的C 1 -C 8烷基， O-C 1 -C 8烷基，-OH基团，-OC（O）-C 1 -C 8烷基或-COO（C 1 -C 8烷基）基团，R 3独立地是CH 2，O或CH-（C 1 -C 7 烷基），其中提高毛发的外观选自：恢复头发颜色并延迟头发中的灰色发作，减少脱发，恢复发秃后恢复毛发生长，增加毛发的厚度头发，抵抗年龄相关的头发变薄，防止过早的脱发，或延迟年龄相关脱发和变薄的发作或严重程度，维持 g的天然头发颜色，增加头发光泽，光泽度或体积。特别地，化合物局部施用。

5. 发明申请

WO2010094452A2 NOVEL COMPOSITION 审中-公开
标题翻译：新组合
公开(公告)号：WO2010094452A2
公开(公告)日：2010-08-26
申请号：PCT/EP2010/000943
申请日：2010-02-16
申请人： DSM IP ASSETS B.V. , GEMPLER, Mathias , GRAEUB, Remo , HOCHEGGER, Leo , IMFELD, Dominik , MOSER, Heidi
发明人： GEMPLER, Mathias , GRAEUB, Remo , HOCHEGGER, Leo , IMFELD, Dominik , MOSER, Heidi
IPC分类号： A61K38/06 , A61K31/201 , A61P17/00
CPC分类号： A61K8/362 , A61K8/64 , A61K8/922 , A61K9/0014 , A61K9/107 , A61K31/201 , A61K38/06 , A61K47/12 , A61K47/183 , A61K47/44 , A61Q19/005 , A61Q19/007 , A61K2300/00
摘要： The present invention relates to a composition comprising N2-(1-oxohexadecyl)-lysyl-valyl- lysine or a salt thereof, spent grain wax and/ or conjugated linoleic acid. The compositions are particularly useful for the treatment or co-treatment of rosacea and its symptoms. Furthermore the invention relates to a stable W/O emulsion pre-mix comprising the composition according to the invention.
摘要翻译：本发明涉及包含N 2 - （1-氧代十六烷基） - 赖氨酰 - 缬氨酰赖氨酸或其盐，废谷物蜡和/或共轭亚油酸的组合物。组合物特别可用于治疗或共同治疗酒渣鼻及其症状。此外，本发明涉及包含本发明组合物的稳定的W / O乳液预混物。

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