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1. 发明申请

WO2012097223A3 OLIGOSACCHARIDE CONJUGATES FOR TARGETING BACTERIA AND USES RELATED THERETO 审中-公开
标题翻译：用于靶向细菌的低聚糖结合物及其相关用途
公开(公告)号：WO2012097223A3
公开(公告)日：2013-01-10
申请号：PCT/US2012021202
申请日：2012-01-13
申请人： UNIV EMORY , GEORGIA TECH RES FOUNDATION , GEORGIA STATE RES FOUNDATION , MURTHY NIREN , GILBERT ERIC SETH , NING XINGHAI , LEE SEUNGJUN , GOODMAN MARK , TZENG YIH-LING , DICKSON ROBERT M
发明人： MURTHY NIREN , GILBERT ERIC SETH , NING XINGHAI , LEE SEUNGJUN , GOODMAN MARK , TZENG YIH-LING , DICKSON ROBERT M
IPC分类号： A61K47/48 , A61K31/135 , A61K47/36 , A61P31/00
CPC分类号： A61K47/61 , A61K31/496 , A61K45/06 , A61K47/4823 , A61K49/0021 , A61K49/0032 , A61K49/0054 , A61K51/06 , A61K51/065 , C08B31/00 , C08L3/04
摘要： This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria comprising mixing bacteria with a non-naturally occurring conjugate under conditions such that the conjugate is transported across the bacterial cell wall. Typically, the conjugate comprises an oligosaccharide and a molecule of interest. In certain embodiments, the molecule of interest may be a tracer or an antibiotic.
摘要翻译：本公开涉及用于靶向细菌和相关用途的缀合物。在某些实施方案中，本公开涉及将感兴趣的分子转移到细菌中的方法，包括在使缀合物跨过细菌细胞壁传输的条件下将细菌与非天然存在的缀合物混合。通常，缀合物包含寡糖和感兴趣的分子。在某些实施方案中，感兴趣的分子可以是示踪剂或抗生素。

2. 发明申请

WO2011130673A3 AN ULTRASONICALLY CONTROLLABLE GREASE DISPENSING TOOL 审中-公开
标题翻译：超声波可控润滑脂分配工具
公开(公告)号：WO2011130673A3
公开(公告)日：2011-12-08
申请号：PCT/US2011032742
申请日：2011-04-15
申请人： UE SYSTEMS INC , GOODMAN MARK A , BISHOP WILLIAM , MOHR GARY
发明人： GOODMAN MARK A , BISHOP WILLIAM , MOHR GARY
IPC分类号： F16N29/02
CPC分类号： G01M7/00 , G01H3/125 , G01M3/24 , G01M13/045
摘要： Lubrication dispensing apparatus for lubricating a device with moving parts includes lubricant reservoir, lubricant dispenser, ultrasonic detection module detecting amplitude of ultrasonic energy emitted by said device when its parts are moving and produces an signal related thereto, control module analyzes the amplitude of the signal from the ultrasonic detection module causes the dispenser to automatically dispense lubricant onto the moving parts in response to a lubricate signal until the signal indicates the ultrasonic energy produced by the device has decreased to a particular level. Programmed processor and storage memory stores base value of the detected amplitude of ultrasonic energy when the device is operating properly. Processor causes dispenser to start flow of lubricant to the device, compares the signal from the ultrasonic detection module when the parts are moving, and causes dispenser to cease flow of lubricant when the signal substantially decreases.
摘要翻译：用于润滑具有运动部件的装置的润滑分配装置包括润滑剂储存器，润滑剂分配器，超声波检测模块，当其部件移动时检测由所述装置发射的超声能量的振幅并产生与其相关的信号，控制模块分析来自超声波检测模块使得分配器响应于润滑信号自动地将润滑剂分配到运动部件上，直到信号指示由装置产生的超声能量已经降低到特定水平。程序处理器和存储存储器存储当设备正常工作时检测到的超声波能量振幅的基值。处理器使分配器启动润滑剂流向设备，比较当零件移动时来自超声波检测模块的信号，并且当信号显着降低时使得分配器停止润滑剂流动。

3. 发明申请

WO2010096426A2 COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT 审中-公开
标题翻译：化合物，组合物，合成方法和治疗方法
公开(公告)号：WO2010096426A2
公开(公告)日：2010-08-26
申请号：PCT/US2010/024393
申请日：2010-03-12
申请人： EMORY UNIVERSITY , STEHOUWER, Jeff , GOODMAN, Mark , KILTS, Clint , NEMEROFF, Charles
发明人： STEHOUWER, Jeff , GOODMAN, Mark , KILTS, Clint , NEMEROFF, Charles
IPC分类号： C07D487/04 , C07D403/04 , C07D487/14 , A61K49/06
CPC分类号： C07F7/2208 , A61K51/0459 , A61K51/0468 , A61K51/0472 , C07D471/04 , C07D471/14 , C07D471/16 , C07D487/04
摘要： Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods of imaging, method of forming a compound as described herein, and the like. In particular, embodiments of the disclosure include a series of triamino-pyridine derivatives and labeled triamino-pyridine derivatives, methods of synthesizing these compounds, intermediate compounds, methods of treatment using these compounds, methods of imaging, diagnosing, localizing, monitoring, and/or assessing a condition (e.g., corticotropin releasing factor type-1 (CRF1)) and/or related biological events, using triamino-pyridine derivatives, and the like. In addition, the present disclosure includes compositions (e.g., labeled triamino-pyridine derivatives that are ligands for the CRF1 receptor) used in and methods relating to non-invasive imaging (e.g., positron emission tomography (PET) imaging or SPECT imaging).
摘要翻译：简要描述，本公开的实施方案包括本文所述的化合物，本文所述的标记化合物，包含本文所述化合物的药物组合物，成像方法，形成本文所述的化合物的方法等。特别地，本公开的实施方案包括一系列三氨基 - 吡啶衍生物和标记的三氨基 - 吡啶衍生物，合成这些化合物的方法，中间体化合物，使用这些化合物的治疗方法，成像，诊断，定位，监测和/ 或使用三氨基 - 吡啶衍生物评估病症（例如促肾上腺皮质激素释放因子1型（CRF1））和/或相关的生物学事件等。此外，本公开内容包括组合物（例如，用作CRF1受体的配体的标记的三氨基 - 吡啶衍生物）和与非侵入性成像（例如，正电子发射断层摄影（PET）成像或SPECT成像）有关的方法和方法。

4. 发明申请

WO2007001940A3 IMAGING AGENTS 审中-公开
标题翻译：成像代理
公开(公告)号：WO2007001940A3
公开(公告)日：2007-06-07
申请号：PCT/US2006023699
申请日：2006-06-19
申请人： UNIV EMORY , GOODMAN MARK M
发明人： GOODMAN MARK M
IPC分类号： A61K51/00 , C07C61/04 , C07D345/00 , C07F13/00
CPC分类号： C07C229/48 , A61K51/0402 , A61K51/0406 , C07B59/001 , C07C2601/04 , C07D291/04 , C07D345/00 , C07F13/005
摘要： The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged retention in tumors and can be labeled with halogen isotopes such as fluorine-18, iodine-123, iodine-124, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77, bromine-82, astatine-210, astatine-211, and other astatine isotopes. These compounds can also be labeled with technetium and rhenium isotopes using known chelation complexes. The compounds disclosed herein bind tumor tissues in vivo with high specificity and selectivity when administered to a subject. Preferred compounds show a target to non-target ratio of at least 2:1, are stable in vivo and substantially localized to target within 1 hour after administration. Preferred compounds include 2-[ 18 F]FACBC and 2-[ 18 F]FMACBC. The labeled amino acid compounds of the invention are useful as imaging agents in detecting and/or monitoring tumors in a subject by PET or SPECT.
摘要翻译：本发明提供了可用于检测和评估脑和体肿瘤的新型氨基酸化合物。这些化合物具有在肿瘤中快速摄取和延长保留的有利特性，并且可以用卤素同位素如氟-18，碘-123，碘-124，碘-125，碘-131，溴-75，溴-76 ，溴-77，溴-82，ast ine -21，ast ine -211和其他ast同位素。这些化合物也可以使用已知的螯合络合物用锝和铼同位素标记。当给予受试者时，本文所公开的化合物以高特异性和选择性在体内结合肿瘤组织。优选的化合物显示至少2:1的目标与非目标比例，在给药后1小时内在体内是稳定的并且基本上定位于靶标上。优选的化合物包括2 - [SUP 18 F] FACBC和2 - [SUP 18 F] FMACBC。本发明的标记氨基酸化合物可用作通过PET或SPECT检测和/或监测受试者的肿瘤的成像剂。

5. 发明申请

WO2007001958A3 STEREOSELECTIVE SYNTHESIS OF AMINO ACID ANALOGS FOR TUMOR IMAGING 审中-公开
公开(公告)号：WO2007001958A3
公开(公告)日：2007-01-04
申请号：PCT/US2006/023740
申请日：2006-06-19
申请人： EMORY UNIVERSITY , GOODMAN, Mark M. , YU, Weiping
发明人： GOODMAN, Mark M. , YU, Weiping
IPC分类号： A61K51/02 , C07B59/00 , C07C229/30 , C07F13/00
摘要： The radiolabeled non-natural amino acid 1-amino-3- cyclobutane-1-carboxylic acid (ACBC) and its analogs are candidate tumor imaging agents useful for positron emission tomography and single photon emission computed tomography due to their selective affinity for tumor cells. The present invention provides methods for stereo-selective synthesis of syn-ACBC analogs. The disclosed synthetic strategy is reliable and efficient and can be used to synthesize a gram quantity of various syn-isomers of the ACBC analogs, particularly, syn- [18F]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC) and syn- [123I]-1-amino-3-iodocyclobutane-1-carboxylic (IACBC) acid analogs.

6. 发明申请

WO2007001940A2 IMAGING AGENTS 审中-公开
标题翻译：成像剂
公开(公告)号：WO2007001940A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/023699
申请日：2006-06-19
申请人： EMORY UNIVERSITY , GOODMAN, Mark, M.
发明人： GOODMAN, Mark, M.
IPC分类号： A61K51/00 , C07F13/00 , C07D345/00 , C07C61/04
CPC分类号： C07C229/48 , A61K51/0402 , A61K51/0406 , C07B59/001 , C07C2601/04 , C07D291/04 , C07D345/00 , C07F13/005
摘要： The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged retention in tumors and can be labeled with halogen isotopes such as fluorine-18, iodine-123, iodine-124, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77, bromine-82, astatine-210, astatine-211, and other astatine isotopes. These compounds can also be labeled with technetium and rhenium isotopes using known chelation complexes. The compounds disclosed herein bind tumor tissues in vivo with high specificity and selectivity when administered to a subject. Preferred compounds show a target to non-target ratio of at least 2:1, are stable in vivo and substantially localized to target within 1 hour after administration. Preferred compounds include 2-[ 18 F]FACBC and 2-[ 18 F]FMACBC. The labeled amino acid compounds of the invention are useful as imaging agents in detecting and/or monitoring tumors in a subject by PET or SPECT.
摘要翻译：本发明提供了用于检测和评估脑和身体肿瘤的新型氨基酸化合物。这些化合物具有在肿瘤中快速摄取和延长滞留的有利特性，并且可以用卤素同位素如氟-18，碘-123，碘-124，碘-125，碘-131，溴-75，溴-76 ，溴-77，溴-82，ast -210，ast -211和其他ast同位素。这些化合物也可以使用已知的螯合络合物用锝和铼同位素标记。本文公开的化合物在施用于受试者时以高特异性和选择性在体内结合肿瘤组织。优选的化合物显示至少2：1的非靶标比率的靶标，在体内稳定并且在给药后1小时内基本上定位于靶标。优选的化合物包括2 - [18 F] FACBC和2 - [18 F] FMACBC。本发明的标记的氨基酸化合物可用作通过PET或SPECT检测和/或监测受试者中的肿瘤的显像剂。

7. 发明申请

WO0129688A9 METHOD AND APPARATUS FOR ONLINE HEALTH MONITORING 审中-公开
标题翻译：在线健康监测方法与装置
公开(公告)号：WO0129688A9
公开(公告)日：2002-08-01
申请号：PCT/US0028899
申请日：2000-10-16
申请人： UE SYSTEMS INC , O'HANLON TERRENCE J , BANDES ALAN S , GOODMAN MARK A , OSTERER MICHAEL F
发明人： O'HANLON TERRENCE J , BANDES ALAN S , GOODMAN MARK A , OSTERER MICHAEL F
IPC分类号： A61B5/00 , A61B5/022 , G06F19/00 , G06Q50/24 , G06F15/42
CPC分类号： G06Q50/24 , G06F19/3418 , G06F19/3456 , G16H10/20 , G16H10/60 , G16H40/63 , G16H50/30
摘要： Methods for providing online health monitoring (16) and accumulating data from patients worldwide and accompanying apparatus for using the same, are disclosed. Such monitoring is particularly useful for both diagnosing and prescribing preventive medical treatment, and is particularly suited for the field of cardiovascular health care. Preferred methods and devices include using a sensitive acoustic device such as an electret, to analyze a patient's cardiovascular functions from a location such as a public computer kiosk, a doctor's office or a patient's home computer. The data may be downloaded from an acoustic device to a central database located, for example on the Internet. The data may be retrieved by the patient, or upon instructions from the patient, may be transferred to or accessed by doctors for purposes of diagnosis, monitoring and treatment. Data may include patient demographics. This data is accessible by researchers who will have medical statistics on a wide variety of patients from various age groups and medical histories.
摘要翻译：公开了用于提供在线健康监测（16）和累积来自世界各地患者的数据的方法以及使用其的伴随装置。这种监测对诊断和处方预防性治疗特别有用，特别适用于心血管保健领域。优选的方法和装置包括使用诸如驻极体的敏感的声学装置从诸如公共计算机信息亭，医生办公室或患者的家庭计算机的位置分析患者的心血管功能。数据可以从声学装置下载到例如位于因特网上的中央数据库。为了诊断，监测和治疗的目的，可以由患者检索数据，或者根据患者的指示将其转移到医生或由医生访问。数据可能包括患者人口统计。研究人员可以访问这些数据，这些研究人员将对来自不同年龄组和病史的各种患者进行医学统计。

8. 发明申请

WO2011094389A3 CXCR4 ANTAGONISTS FOR IMAGING OF CANCER AND INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于癌症和炎性疾病成像的CXCR4拮抗剂
公开(公告)号：WO2011094389A3
公开(公告)日：2011-08-04
申请号：PCT/US2011/022696
申请日：2011-01-27
申请人： EMORY UNIVERSITY , SHIM, Hyunsuk , LIOTTA, Dennis, C. , ZHU, Aizhi , GOODMAN, Mark
发明人： SHIM, Hyunsuk , LIOTTA, Dennis, C. , ZHU, Aizhi , GOODMAN, Mark
IPC分类号： A61K31/506 , A61K31/505 , A61K31/495 , A61P35/00 , A61P29/00
摘要： The invention provides radiolabeled CXCR4 antagonists, compositions and methods of use for imaging of chemokine CXCR4 receptors and biological conditions associated with the expression of CXCR4 receptors, including cancer, metastasis, and inflammatory disorders.
摘要翻译：本发明提供了放射性标记的CXCR4拮抗剂，用于成像趋化因子CXCR4受体的组合物和方法以及与CXCR4受体表达相关的生物学病症，包括癌症，转移和炎性病症。

9. 发明申请

WO2011008985A3 CONJUGATES COMPRISING DNA-BINDING AGENT FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：包含用于定向递送治疗药物的DNA结合剂的结合
公开(公告)号：WO2011008985A3
公开(公告)日：2011-04-14
申请号：PCT/US2010042175
申请日：2010-07-15
申请人： GEORGIA TECH RES INST , UNIV EMORY , MURTHY NIREN , DAVIS MICHAEL E , KIM DONGIN , DASARI MADHURI , LEE SUNGMUN , LEE SEUNGJUN , SY JAY , GOODMAN MARK
发明人： MURTHY NIREN , DAVIS MICHAEL E , KIM DONGIN , DASARI MADHURI , LEE SUNGMUN , LEE SEUNGJUN , SY JAY , GOODMAN MARK
IPC分类号： A61K47/48
CPC分类号： A61K47/545
摘要： Among other things, this disclosure provides for compounds having a targeting moiety linked to a therapeutic moiety and/or a diagnostic moiety; the synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and, methods for treating or diagnosing disorders. Some of the compounds include a linker which can be cleaved under physiological conditions, including linkers comprising an amide or disulfide bond. Examples of targeting moieties are derivatives of DNA binding agents, which may comprise derivatives of Hoechst 33258. Examples of therapeutic moieties are compounds useful for treating a cancer, which may comprise derivatives of nucleotides and nucleosides such as gemcitabine. This abstract is intended to be used as a scanning tool for the purposes of searching in the particular art and is not intended to limiting of the present disclosure.
摘要翻译：除此之外，本公开提供了具有连接到治疗部分和/或诊断部分的靶向部分的化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及治疗或诊断疾病的方法。一些化合物包括可以在生理条件下切割的接头，包括包含酰胺或二硫键的接头。靶向部分的实例是DNA结合剂的衍生物，其可以包含Hoechst 33258的衍生物。治疗性部分的实例是可用于治疗癌症的化合物，其可以包含核苷酸和核苷的衍生物，例如吉西他滨。该摘要旨在用作扫描工具，用于在特定技术中进行搜索，并不意图限制本公开。

10. 发明申请

WO2004045088A3 SYSTEM AND METHOD FOR HETERODYNING AN ULTRASONIC SIGNAL 审中-公开
公开(公告)号：WO2004045088A3
公开(公告)日：2004-05-27
申请号：PCT/US2003/036169
申请日：2003-11-12
申请人： U-E SYSTEMS, INC. , BISHOP, William , GOODMAN, Mark, A.
发明人： BISHOP, William , GOODMAN, Mark, A.
IPC分类号： H01B1/06
摘要： A method and apparatus for detecting leaks and mechanical faults by way of an ultrasonic device. An output from a variable gain amplifier (18) is supplied to a pair of heterodyning circuits (20, 32), i.e., a dual heterodyning circuit. At each respective heterodyning circuit, the output signal from the variable gain amplifier (18) is multiplied by a local oscillator (21, 34) that is internal to each circuit (20, 32). The dual heterodyning circuit is used to provide an enhanced input transducer signal for spectral analysis. This permits the capture of low level frequency components for extraction during spectral analysis. The dual heterodyning circuit (20, 32) of the present invention to provide the enhanced spectrum to thereby permit an easy determination of whether the resonance is mechanical or electrical becomes clear. In addition, fault frequencies are also more easily discernable. In other words, the enhanced signal output provides a lower signal to noise ratio such that the ease with which frequency components are analyzed is increased.

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