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1. 发明申请

WO1993024116A1 PHARMACEUTICAL COMPOSITIONS COMPRISING 5-HT1 RECEPTOR AGONISTS AND ABSORPTION ENHANCERS 审中-公开
标题翻译：包含5-HT1受体激动剂和吸收增强剂的药物组合物
公开(公告)号：WO1993024116A1
公开(公告)日：1993-12-09
申请号：PCT/EP1993001301
申请日：1993-05-24
申请人： GLAXO CANADA INC. , DOHERTY, Christopher , GAMBHIR, Renu
发明人： GLAXO CANADA INC.
IPC分类号： A61K31/00
CPC分类号： A61K9/0095 , A61K31/40 , A61K31/445 , A61K47/10 , A61K47/12
摘要： The invention relates to a liquid pharmaceutical composition for oral administration which comprises a compound which acts as a 5HT1-like receptor agonist or a physiologically acceptable salt or solvate thereof, as active ingredient, and an absorption enhancing carrier. Methods for the manufacture of such compositions and for their use in the treatment of cephalic pain are also described.
摘要翻译：本发明涉及一种用于口服给药的液体药物组合物，其包含作为5HT1样受体激动剂或其生理学上可接受的盐或溶剂合物作为活性成分的化合物和吸收增强载体。还描述了制备这种组合物并用于治疗头痛的方法。

2. 发明申请

WO1993020203A2 STABILITY-ENHANCED VARIANTS OF PARATHYROID HORMONE 审中-公开
标题翻译：稳定性增强的PARATHYROID HORMONE变量
公开(公告)号：WO1993020203A2
公开(公告)日：1993-10-14
申请号：PCT/CA1993000136
申请日：1993-03-31
申请人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC. , KRONIS, K., Anne , BOZZATO, Richard, P.
发明人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC.
IPC分类号： C12N15/16
CPC分类号： C07K14/635 , A61K38/00
摘要： Herein described are variants of parathyroid hormone that retain significant PTH activity and are substantially resistant to trypsin and trypsin-like enzymes. The variants are useful pharmaceutically, to treat bone disorders such as osteoporosis and in other therapeutic applications. Specific embodiments of the invention include [His ]PTH, [His G1n ]PTH and [His His Leu ]PTH.
摘要翻译：本文描述了甲状旁腺激素的变体，其保留显着的PTH活性并且基本上对胰蛋白酶和胰蛋白酶样酶具有抗性。这些变体在药学上是有用的，用于治疗骨骼疾病如骨质疏松症和其它治疗应用。本发明的具体实施方案包括[His 25] PTH，[His 26> G1n 27] PTH和[His 25 B 18 Leu 27] PTH。

3. 发明申请

WO1992011286A1 OXIDATION RESISTANT VARIANTS OF PARATHYROID HORMONE 审中-公开
标题翻译：抗氧化剂抗氧化剂
公开(公告)号：WO1992011286A1
公开(公告)日：1992-07-09
申请号：PCT/CA1991000451
申请日：1991-12-18
申请人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC.
发明人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC. , BOZATTO, Richard, P. , KRONIS, K., Anne
IPC分类号： C07K07/10
CPC分类号： C07K14/635
摘要： Described herein are methionine-substituted variants of parathyroid hormone which, relative to their natural counterparts, exhibit reduced sensitivity to oxidation and substantial PTH activity. Their production using recombinant DNA-based techniques is also described, as is their therapeutic use, e.g. in the treatment of osteoporosis.
摘要翻译：本文描述了甲状旁腺激素的甲硫氨酸取代的变体，其相对于其天然对应物显示降低的氧化敏感性和实质性PTH活性。还描述了使用基于重组DNA的技术的生产，以及它们的治疗用途，例如，在治疗骨质疏松症。

4. 发明申请

WO1995017207A1 PARATHYROID HORMONE FORMULATION 审中-公开
标题翻译： PARATHYROID HORMONE配方
公开(公告)号：WO1995017207A1
公开(公告)日：1995-06-29
申请号：PCT/CA1994000693
申请日：1994-12-16
申请人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC.
发明人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC. , HOLTHUIS, Josephus, Johannes, Maria , MEKKING, Albert , VOETMAN, Alwinus, Antonius
IPC分类号： A61K38/29
CPC分类号： A61K38/29 , A61K9/0019 , A61K9/19 , A61K47/12 , A61K47/26 , Y10S514/97
摘要： Described herein are preparations containing parathyroid hormone that has been stabilized with an excipient and buffering agent. Preferred preparations incorporate human PTH(1-84), mannitol as excipient and citrate as buffering agent, and are incorporated in vials as a freeze-dried powder for reconstitution to treat osteoporosis.
摘要翻译：本文描述了含有已经用赋形剂和缓冲剂稳定的甲状旁腺激素的制剂。优选的制剂包括人PTH（1-84），甘露醇作为赋形剂和柠檬酸盐作为缓冲剂，并且作为冷冻干燥粉末并入小瓶中用于重建以治疗骨质疏松症。

5. 发明申请

WO1992011845A1 METHOD FOR PRODUCTION OF SOLID PHARMACEUTICAL PREPARATION 审中-公开
标题翻译：生产固体药物制剂的方法
公开(公告)号：WO1992011845A1
公开(公告)日：1992-07-23
申请号：PCT/CA1992000004
申请日：1992-01-03
申请人： GLAXO CANADA INC. , MOLLOY, Thomas, Patrick , LEE, David , CHOPRA, Sham, Kumar
发明人： GLAXO CANADA INC.
IPC分类号： A61K09/28
CPC分类号： A61K9/0004 , A61K9/2846 , A61K9/2866
摘要： The invention provides a method for the production of a solid pharmaceutical preparation characterised by mixing together finely divided particles or granules of a medicament, or granules containing a medicament and excipients, and appropriate amounts of a finely divided amorphous or substantially amorphous coating polymer and plasticizer which dissolves the polymer, compressing the mixture into tablets, and heating the tablets to a temperature at which fusion of the polymer particles occurs; and a method for the production of a solid pharmaceutical preparation characterised in that a solid core is coated with a film coat by mixing or granulating finely divided particles of a membrane-forming amorphous or substantially amorphous polymer with a plasticizer which dissolves the polymer, encasing said solid core with the polymer mix, and heating the polymer-encased material to a temperature at which the amorphous or substantially amorphous polymer forms a continuous film.
摘要翻译：本发明提供了一种制备固体药物制剂的方法，其特征在于将药物的细碎颗粒或颗粒混合在一起，或含有药物和赋形剂的颗粒以及适量的细碎无定形或基本无定形的涂层聚合物和增塑剂溶解聚合物，将混合物压制成片剂，并将片剂加热到聚合物颗粒熔融发生的温度; 以及制备固体药物制剂的方法，其特征在于，通过将成膜非晶态或基本无定形聚合物的细碎颗粒与可溶解聚合物的增塑剂混合或造粒，将固体芯涂覆在薄膜涂层上，将包含所述固体芯与聚合物混合物，并将聚合物封装的材料加热至无定形或基本无定形聚合物形成连续膜的温度。

6. 发明申请

WO1992017501A1 ISOLATED OSTEOGENIC FACTOR 审中-公开
标题翻译：分离的生物因子
公开(公告)号：WO1992017501A1
公开(公告)日：1992-10-15
申请号：PCT/CA1992000130
申请日：1992-03-25
申请人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC.
发明人： ALLELIX BIOPHARMACEUTICALS INC. , GLAXO CANADA INC. , LAGARDE, Alain, E. , ABDULWAJID, Abdulwahid , BUESCHKENS, Donna , BYRNE, Deanna
IPC分类号： C07K15/06
CPC分类号： C07K14/51 , A61K38/00 , Y10S530/84
摘要： Described is a purified osteogenic factor that when delivered to bone in association with a physiologically acceptable delivery vehicle is capable of inducing new bone growth at the bone surface. The osteogenic factor is water soluble, and is characterized physically by a molecular weight of about 2.5 kD when measured by gel filtration under dissociating conditions and an isoelectric point in the pH range from about 4.6 to 7.2. Use of the purified factor in treating bone defects is described. Also described is a method for obtaining the purified factor from mammalian bone.

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