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1. 发明申请

WO2011033509A1 DEVICES, SYSTEMS AND METHODS FOR QUANTIFYING BOLUS DOSES ACCORDING TO USER PARAMETERS 审中-公开
标题翻译：根据用户参数量化固定剂量的装置，系统和方法
公开(公告)号：WO2011033509A1
公开(公告)日：2011-03-24
申请号：PCT/IL2010/000757
申请日：2010-09-16
申请人： MEDINGO LTD. , YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo, M.
发明人： YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo, M.
IPC分类号： A61K9/22
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/4839 , G06F19/00 , G06F19/3468 , G16H20/17
摘要： Devices, systems and methods for determining a recommended bolus dose of therapeutic fluid to be delivered to the body are disclosed. Such a recommended bolus dose may be provided by establishing an initial bolus dose for a user based on one or more first parameters relating to the user and adjusting (e.g., increasing or decreasing) this initial bolus dose amount based on one or more second user parameters by multiplying the initial bolus dose by one or more multiplier values that correlate to at least one of the second parameters and/or by adding or subtracting an absolute value of at least one of the second parameters from the initial bolus dose amount.
摘要翻译：公开了用于确定要输送到身体的治疗流体的推荐推注剂量的装置，系统和方法。可以通过基于与用户相关的一个或多个第一参数建立用户的初始推注剂量来提供这种推荐的推注剂量，并且基于一个或多个第二用户参数来调整（例如，增加或减少）该初始推注剂量通过将初始推注剂量乘以与第二参数中的至少一个相关联的一个或多个乘数值和/或通过从初始推注剂量来添加或减去至少一个第二参数的绝对值。

2. 发明申请

WO2010150257A2 A METHOD AND DEVICE FOR IMPROVING GLYCEMIC CONTROL BASED ON RESIDUAL INSULIN 审中-公开
标题翻译：一种用于改善基于残留胰岛素的糖化控制的方法和装置
公开(公告)号：WO2010150257A2
公开(公告)日：2010-12-29
申请号：PCT/IL2010/000501
申请日：2010-06-23
申请人： MEDINGO LTD. , YODFAT, Ofer , GESCHEIT, Iddo M. , SHAPIRA, Gali
发明人： YODFAT, Ofer , GESCHEIT, Iddo M. , SHAPIRA, Gali
IPC分类号： A61B5/1468 , A61K38/28
CPC分类号： A61M5/168 , A61B5/14532 , A61B5/4839 , A61K38/28 , A61M5/1723
摘要： Disclosed are systems, devices, and methods, including a system that includes a processor-based device implementing at least a residual insulin (RI) determination unit configured to determine a residual insulin in the patient's body at a particular time instance based on bolus doses previously delivered to the body of the patient, each bolus dose being associated with at least one dose value and a time representative of the time that dose value was delivered to the patient's body, and based on dose dependent RI time records that each includes at least a dose value and an associated duration value representative of dose-dependent duration of therapeutic effectiveness of the associated at least the dose value. The system also includes a pump to controllably dispense the insulin from a reservoir to the body of the patient based on the residual insulin determined by the RI determination unit.
摘要翻译：公开了系统，设备和方法，包括系统，其包括实施至少残留胰岛素（RI）确定单元的基于处理器的设备，其被配置为基于先前的推注剂量在特定时间段确定患者体内的残留胰岛素递送到患者体内，每次推注剂量与至少一个剂量值和代表剂量值被递送给患者身体的时间的时间相关联，并且基于剂量依赖性RI时间记录，每个包含至少一个剂量值和相关联的持续时间值，其代表相关联的至少剂量值的治疗有效性的剂量依赖性持续时间。该系统还包括泵，用于基于由RI确定单元确定的残留胰岛素将胰岛素从储存器可控地分配给患者的身体。

3. 发明申请

WO2010092572A1 INSULIN DELIVERY SAFETY 审中-公开
标题翻译：胰岛素递送安全
公开(公告)号：WO2010092572A1
公开(公告)日：2010-08-19
申请号：PCT/IL2010/000118
申请日：2010-02-11
申请人： MEDINGO LTD. , YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo, M.
发明人： YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo, M.
IPC分类号： A61M5/172
CPC分类号： A61M5/172 , A61M5/14248 , A61M2005/14208 , A61M2005/14268 , A61M2005/14296 , A61M2205/3523 , A61M2205/502 , G06F19/00 , G06F19/3468 , G16H50/50
摘要： Embodiments of the present disclosure are directed to systems, devices/apparatuses and methods for assessing a residual insulin value for a user/patient. Such embodiments may be implemented by selecting a first value corresponding to a duration of insulin action; selecting a second value corresponding to a lock out time duration, selecting a first time period beginning at a time point T0 minus the first value and ending at the time point T0 minus the second value, selecting one or more boluses delivered during the first time period; for each of the one or more boluses selecting a corresponding residual insulin value estimated at the time point T0, computing the cumulative residual insulin value by summation of the corresponding residual insulin values.
摘要翻译：本公开的实施例涉及用于评估用户/患者的残留胰岛素值的系统，设备/装置和方法。这样的实施例可以通过选择对应于胰岛素作用的持续时间的第一值来实现; 选择对应于锁定持续时间的第二值，选择从时间点T0开始的第一时间段减去第一值，并在时间点T0减去第二个值结束，选择在第一时间段期间传送的一个或多个聚合 ; 对于选择在时间点T0估计的相应的残留胰岛素值的一个或多个大剂量中的每一个，通过相应的残留胰岛素值的相加来计算累积残留胰岛素值。

4. 发明申请

WO2011030343A1 DEVICES, SYSTEMS AND METHODS FOR ADJUSTING FLUID DELIVERY PARAMETERS 审中-公开
标题翻译：用于调节流体输送参数的装置，系统和方法
公开(公告)号：WO2011030343A1
公开(公告)日：2011-03-17
申请号：PCT/IL2010/000744
申请日：2010-09-07
申请人： MEDINGO LTD. , YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo M.
发明人： YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo M.
IPC分类号： A61K9/00
CPC分类号： A61M5/16877 , A61M5/14244 , A61M5/16804 , A61M5/16831 , A61M5/172 , A61M2205/3569 , G06F19/3468
摘要： Devices, systems and methods for adjusting fluid delivery based on past or historical fluid delivery data and/or personal parameters of a user are disclosed. Devices, and corresponding systems and methods, may comprise a dispensing unit configured to deliver a fluid from a reservoir into the body of a user and a processor having instructions operating thereon to retrieve data relating to one or more time windows from a memory, assess a correction delivery for the one or more time windows based on the data, determine a new CIR value for the one or more time windows if the correction delivery regularly follows a meal bolus and/or determine a new basal delivery profile for the one or more time windows if the correction delivery regularly precedes a meal bolus.
摘要翻译：公开了用于基于过去或历史的流体输送数据和/或用户的个人参数来调节流体输送的装置，系统和方法。设备和相应的系统和方法可以包括分配单元，其被配置为将流体从储存器输送到用户的身体中;以及处理器，其具有在其上操作的指令以从存储器检索与一个或多个时间窗口相关的数据，基于数据对一个或多个时间窗口进行校正传送，如果校正传送定期地跟随膳食推注和/或确定一个或多个时间的新的基础传送配置文件，则确定一个或多个时间窗口的新的CIR值如果校正交付经常在餐前推注，则窗口。

5. 发明申请

WO2009016636A3 PORTABLE INFUSION DEVICE PROVIDED WITH MEANS FOR MONITORING AND CONTROLLING FLUID DELIVERY 审中-公开
标题翻译：便携式输液装置，用于监测和控制流体输送
公开(公告)号：WO2009016636A3
公开(公告)日：2009-03-19
申请号：PCT/IL2008001057
申请日：2008-07-31
申请人： MEDINGO LTD , YODFAT OFER , GESCHEIT IDDO M
发明人： YODFAT OFER , GESCHEIT IDDO M
IPC分类号： A61M5/142
CPC分类号： A61M5/14248 , A61M5/1413 , A61M5/14232 , A61M5/1456 , A61M5/14566 , A61M2005/14252 , A61M2005/14268 , A61M2209/01 , A61M2230/201
摘要： A device (1000) for delivering a therapeutic fluid (e.g. insulin) into a body of a patient are provided. In one aspect, the device can be implemented with a help of a patch unit (10) securable to a cradle unit (20) or to the body of the patient. The patch unit can employ a driving mechanism (120), a power source (210), a processor (110), a user interface (14) and a display(12). The processor can be adapted for controlling the driving mechanism by using one or more inputs. The inputs can corresponding to a basal rate and/or a bolus profile. The display can be adapted for displaying the inputs. The user interface can be adapted for adjusting the inputs.
摘要翻译：提供了用于将治疗流体（例如胰岛素）输送到患者体内的装置（1000）。在一个方面，该装置可以借助于可固定到支架单元（20）或贴在患者身上的贴片单元（10）来实现。贴片单元可以使用驱动机构（120），电源（210），处理器（110），用户接口（14）和显示器（12）。处理器可以适于通过使用一个或多个输入来控制驱动机构。输入可以对应于基本速率和/或推注轮廓。显示器可以适于显示输入。用户界面可以适应于调整输入。

6. 发明申请

WO2010150257A3 A METHOD AND DEVICE FOR IMPROVING GLYCEMIC CONTROL BASED ON RESIDUAL INSULIN 审中-公开
标题翻译：一种用于改善基于残留胰岛素的糖化控制的方法和装置
公开(公告)号：WO2010150257A3
公开(公告)日：2011-05-19
申请号：PCT/IL2010000501
申请日：2010-06-23
申请人： MEDINGO LTD , YODFAT OFER , GESCHEIT IDDO M , SHAPIRA GALI
发明人： YODFAT OFER , GESCHEIT IDDO M , SHAPIRA GALI
IPC分类号： A61B5/1468
CPC分类号： A61M5/168 , A61B5/14532 , A61B5/4839 , A61K38/28 , A61M5/1723
摘要： Disclosed are systems, devices, and methods, including a system that includes a processor-based device implementing at least a residual insulin (RI) determination unit configured to determine a residual insulin in the patient's body at a particular time instance based on bolus doses previously delivered to the body of the patient, each bolus dose being associated with at least one dose value and a time representative of the time that dose value was delivered to the patient's body, and based on dose dependent RI time records that each includes at least a dose value and an associated duration value representative of dose-dependent duration of therapeutic effectiveness of the associated at least the dose value. The system also includes a pump to controllably dispense the insulin from a reservoir to the body of the patient based on the residual insulin determined by the RI determination unit.
摘要翻译：公开了系统，设备和方法，包括系统，其包括实施至少残留胰岛素（RI）确定单元的基于处理器的设备，其被配置为基于先前的推注剂量在特定时间段确定患者体内的残留胰岛素递送到患者体内，每次推注剂量与至少一个剂量值和代表剂量值被递送给患者身体的时间的时间相关联，并且基于剂量依赖性RI时间记录，每个包含至少一个剂量值和相关联的持续时间值，其代表相关联的至少剂量值的治疗有效性的剂量依赖性持续时间。该系统还包括泵，用于基于由RI确定单元确定的残留胰岛素将胰岛素从储存器可控地分配给患者的身体。

7. 发明申请

WO2009133558A3 A METHOD FOR SELECTING BOLUS DOSES AND BOLUS DELIVERY PATTERNS IN A DRUG DELIVERY DEVICE 审中-公开
标题翻译：用于选择药物递送装置中的胶体剂量和胶体递送模式的方法
公开(公告)号：WO2009133558A3
公开(公告)日：2010-06-10
申请号：PCT/IL2009000454
申请日：2009-04-28
申请人： MEDINGO LTD , YODFAT OFER , GESCHEIT IDDO M , SHAPIRA GALI
发明人： YODFAT OFER , GESCHEIT IDDO M , SHAPIRA GALI
IPC分类号： A61M5/142 , G06F19/00
CPC分类号： A61M5/14248 , A61M5/1723 , A61M2005/14296 , A61M2205/3569 , A61M2205/3576 , A61M2205/3592 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/3468
摘要： Embodiments of the present disclosure include methods, systems and devices for selecting a bolus configuration and may include one or more of providing a user interface for selection of one or more user interface elements, where each element corresponds to a bolus configuration of a drug, each element is spatially positioned within a multi-dimensional space corresponding to at least three dimensions and the element's position corresponding to each dimension.
摘要翻译：本公开的实施例包括用于选择推注配置的方法，系统和设备，并且可以包括提供用于选择一个或多个用户界面元素的用户界面中的一个或多个，其中每个元素对应于药物的推注配置，每个元素在空间上位于对应于至少三维的多维空间中，并且元素的位置对应于每个维度。

8. 发明申请

WO2009016638A1 DEVICE FOR FACILITATING INFUSION OF THERAPEUTIC FLUIDS AND SENSING OF BODILY ANALYTES 审中-公开
标题翻译：促进治疗性流感和感染分析的手段
公开(公告)号：WO2009016638A1
公开(公告)日：2009-02-05
申请号：PCT/IL2008/001059
申请日：2008-07-31
申请人： MEDINGO LTD. , YODFAT, Ofer , GESCHEIT, Illai , GESCHEIT, Iddo M.
发明人： YODFAT, Ofer , GESCHEIT, Illai , GESCHEIT, Iddo M.
IPC分类号： A61M5/142 , A61M5/172 , A61M5/158 , A61B5/00
CPC分类号： A61M5/14248 , A61B5/14532 , A61B5/6849 , A61M5/158 , A61M5/1723 , A61M5/1782 , A61M5/3287 , A61M2005/1581 , A61M2005/1585 , G06F19/00
摘要： Disclosed is an assembly for use with a portable therapeutic device. The assembly includes a mounting housing securable to skin of a patient, and a cannula subcutaneously insertable through a passageway provided within the housing. The cannula is configured to be inserted subsequent to securing of the housing to the skin of the patient.
摘要翻译：公开了一种用于便携式治疗装置的组件。该组件包括可固定于患者皮肤的安装壳体，以及通过设置在壳体内的通道皮下可插入的套管。套管被构造成在将壳体固定到患者皮肤之后插入。

9. 发明申请

WO2009001348A1 A METHOD SYSTEM AND DEVICE FOR ASSESSING INSULIN SENSITIVITY 审中-公开
标题翻译：用于评估胰岛素敏感性的方法系统和装置
公开(公告)号：WO2009001348A1
公开(公告)日：2008-12-31
申请号：PCT/IL2008/000862
申请日：2008-06-25
申请人： MEDINGO LTD. , YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo, M.
发明人： YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo, M.
IPC分类号： G06F19/00 , G01N33/66
CPC分类号： A61M5/1723 , A61M5/1413 , A61M5/14244 , A61M5/14248 , A61M2005/14296 , A61M2230/20 , G01N33/66 , G01N2800/042 , G06F19/00 , G06F19/3456 , G16H20/17 , G16H50/50
摘要： A method and a system for determining insulin sensitivity (IS) is described. In one aspect the method and the system can be.implemented by receiving a first parameter corresponding to an insulin dose in a subcutaneous tissue;. applying a first kinetic. model to obtain a plasma insulin concentration based on the first parameter; receiving a second parameter corresponding to a plasma glucose concentration; determining the insulin sensitivity (IS) based on the plasma insulin concentration and the second parameter. In the preferred methods, the level of plasma insulin in a diabetic patient is predicted by means of the Kobayashi's model on the basis of the rate of continuous s.c. insulin infusion,.and IS is calculated by means of the QUICKI or the HOMA model on the basis of this prediction and the glucose data.
摘要翻译：描述了用于确定胰岛素敏感性（IS）的方法和系统。在一个方面，该方法和系统可以通过接收对应于皮下组织中的胰岛素剂量的第一参数来实现。应用第一动力学。模型，以获得基于第一参数的血浆胰岛素浓度; 接收对应于血浆葡萄糖浓度的第二参数; 基于血浆胰岛素浓度和第二参数确定胰岛素敏感性（IS）。在优选的方法中，糖尿病患者的血浆胰岛素水平是通过Kobayashi模型根据连续血糖的速率预测的。基于该预测和葡萄糖数据，通过QUICKI或HOMA模型计算胰岛素输注，IS。

10. 发明申请

WO2011089600A1 A METHOD AND DEVICE FOR IMPROVING GLYCEMIC CONTROL 审中-公开
标题翻译：一种改善糖化控制的方法和装置
公开(公告)号：WO2011089600A1
公开(公告)日：2011-07-28
申请号：PCT/IL2011/000061
申请日：2011-01-20
申请人： MEDINGO LTD. , YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo M.
发明人： YODFAT, Ofer , SHAPIRA, Gali , GESCHEIT, Iddo M.
IPC分类号： A61M31/00
CPC分类号： A61M5/172 , A61B5/14532 , A61B5/4839 , A61M5/1413 , A61M5/14248 , A61M5/1723 , A61M2005/14268 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Systems, devices and methods are presented in the subject disclosure for recommending an insulin dose adapted for use with an insulin delivery device. In some embodiments, the method may include receiving blood glucose (BG) data, determining one or more insulin sensitivity (IS) values associated with the BG data, and determining an insulin dose based on the determined one or more IS values. A system for carrying out such a method is also presented.
摘要翻译：本发明公开了系统，装置和方法，以推荐适用于胰岛素递送装置的胰岛素剂量。在一些实施例中，该方法可以包括接收血糖（BG）数据，确定与BG数据相关联的一个或多个胰岛素敏感性（IS）值，以及基于所确定的一个或多个IS值来确定胰岛素剂量。还提出了一种执行这种方法的系统。

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