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    • 2. 发明申请
    • PHARMACEUTICAL COMPONENT-MIXING DELIVERY ASSEMBLY
    • 药物成分混合输送装置
    • WO1994028964A1
    • 1994-12-22
    • PCT/US1993005586
    • 1993-06-11
    • HABLEY MEDICAL TECHNOLOGY CORPORATIONHABER, Terry, M.SMEDLEY, William, H.FOSTER, Clark, B.
    • HABLEY MEDICAL TECHNOLOGY CORPORATION
    • A61M37/00
    • A61J1/2093A61J1/201A61J1/2013A61J1/2027A61J1/2051A61M5/2448A61M5/31538A61M5/31555A61M5/31595
    • A pharmaceutical component-mixing syringe assembly (2) is particularly suited for packaging, reconstituting and dispensing a series of equal doses of a multiple component pharmaceutical, such as human growth hormone reconstituted from a diluent component (128) and a lyophilized component (34). The pharmaceutical components are contained within first and second cartridges (10, 36) of the type having a movable piston (12, 40). The second cartridge is forced into the interior of the first cartridge causing a spike assembly (132) between the two to fluidly couple the two cartridges and drive the piston of the first cartridge into the second cartridge causing the contents of the first cartridge to be driven into the second cartridge, thereby mixing. A reciprocating ratchet plunger (104) is used to drive the second piston. The distance the ratchet plunger moves, and thus the dose, is determined by the position of a user-inaccessible dosing key stop (116) along the length of the ratchet plunger.
    • 药物组分混合注射器组件(2)特别适用于包装,重构和分配一系列相等剂量的多组分药物,例如由稀释剂组分(128)和冻干组分(34)重构的人生长激素, 。 药物组分包含在具有可移动活塞(12,40)的类型的第一和第二药筒(10,36)内。 第二盒被迫进入第一盒的内部,使得两者之间的尖钉组件(132)流体地联接两个盒并将第一盒的活塞驱动到第二盒中,从而驱动第一盒的内容物被驱动 进入第二筒,由此混合。 往复棘轮柱塞(104)用于驱动第二活塞。 棘轮柱塞移动的距离以及因此的剂量由用户不可接近的剂量关键点(116)沿着棘轮柱塞的长度的位置确定。
    • 4. 发明申请
    • MIXING CONTAINER WITH COMBINATION STOPPER AND PUMP
    • 混合容器与组合式止动器和泵
    • WO1994006365A1
    • 1994-03-31
    • PCT/US1993009024
    • 1993-09-22
    • HABLEY MEDICAL TECHNOLOGY CORPORATIONHABER, Terry, M.FOSTER, Clark, B.SMEDLEY, William, H.
    • HABLEY MEDICAL TECHNOLOGY CORPORATION
    • A61B19/00
    • A61M5/2448A61M5/31596A61M2005/31598
    • A pharmaceutical mixing container for storing a liquid having at least two factions which tend to separate during storage. A housing (10) has an inner volume (12) and is closed at one end by a septum (15) arrangement and at another end by a combination sealing and pumping member (20). The combination sealing and pumping member has an integrally formed outer diaphragm element (25) forming a diaphragm chamber with the inner structure of this element, and a plurality of fluid channels (26) extending through the sealing and pumping element from the diaphragm chamber to the surface facing the inner volume of the container. A driving member assembly (30, 40) is coupled to the diaphragm element to enable this element to be extended and relaxed by manipulating the driving element assembly inwardly and outwardly of the container. Operation of the diaphragm element provides a reversible gentle fluid flow enabling the liquid and other constituents of the pharmaceutical to be drawn into the diaphragm chamber and expelled back into the inner volume of the container, thereby thoroughly admixing the constituents.
    • 一种药物混合容器,用于储存在储存期间倾向于分离的至少两个派系的液体。 壳体(10)具有内部容积(12),并且在一端由隔膜(15)布置封闭,另一端由组合密封和泵送构件(20)封闭。 组合密封和泵送构件具有形成具有该元件的内部结构的隔膜室的整体形成的外隔膜元件(25),以及多个流体通道(26),其通过密封和泵送元件从隔膜室延伸到 面向容器的内部容积的表面。 驱动构件组件(30,40)联接到隔膜元件,以通过将驱动元件组件向内和向外操纵容器来使其能够被延伸和松弛。 隔膜元件的操作提供了可逆的平缓流体流动,使得药物的液体和其它成分能够被吸入隔膜室并排出回到容器的内部体积中,从而完全混合了组分。
    • 5. 发明申请
    • ENDOSCOPIC SURGICAL INSTRUMENT WITH ROTARY END-EFFECT ELEMENT
    • 具有旋转末端效应元件的内窥镜手术器械
    • WO1993016644A1
    • 1993-09-02
    • PCT/US1993001464
    • 1993-02-18
    • HABLEY MEDICAL TECHNOLOGY CORPORATIONHABER, Terry, M.SMEDLEY, William, H.FOSTER, Clark, B.
    • HABLEY MEDICAL TECHNOLOGY CORPORATION
    • A61B17/00
    • A61B17/29A61B17/0469A61B17/2909A61B2017/2923A61B2017/2929A61B2017/2934A61B2017/2936
    • An endoscopic surgical instrument (2; 602) includes an elongate body (4; 604, 630) with an end-effect element, such as jaws (26, 28; 425, 426; 608, 610), movably mounted to the distal end of the body. A jaw driver assembly (14; 606) includes a user-manipulatable thumb and finger loops (16, 18; 616, 618) pivotally mounted to the base (6, 622) of the body and a jaw driver assembly (42, 40, 32; 244, 246, 232, 258, 280; 624, 660) coupling the thumb and finger loops to the jaws. The jaws are secured to a removable tip assembly (10; 607) which is rotated about the axis (22; 614) of the instrument by the linear actuation of a rotary actuator trigger (78; 626) coupled to the tip assembly by a rotatable tube (8; 630) through a spiral groove (90; 632) formed in the tube. The instrument can be configured to telescope (401-437), to supply suture material (93) through the interior of the body to the tip assembly, and to allow the user to selectively prevent the telescoping of the instrument or the rotation of the tip assembly.
    • 内窥镜外科器械(2; 602)包括具有终端效应元件的细长主体(4; 604,630),诸如可移动地安装到远端的夹爪(26,28; 425,426; 608,610) 的身体。 钳口驱动器组件(14; 606)包括可枢转地安装到主体的基部(6,622)的用户可操纵的拇指和手指环(16,18; 616,618),以及钳口驱动器组件(42,44,66) 32; 244,246,232,258,280; 624,660),其将拇指和手指环耦合到钳口。 夹爪被固定到可移除的尖端组件(10; 607)上,该组件通过旋转执行器触发器(78; 626)的线性致动而围绕仪器的轴线(22; 614)旋转,旋转致动器触发器(78; 626) 管(8; 630)通过形成在管中的螺旋槽(90; 632)。 仪器可以被配置为望远镜(401-437),以将缝合材料(93)穿过身体的内部提供到尖端组件,并且允许使用者选择性地防止仪器的伸缩或尖端的旋转 部件。
    • 7. 发明申请
    • TIMING AND VELOCITY CONTROLLED POWDERED PHARMACEUTICAL INHALER
    • 时间和速度控制粉末药物吸入器
    • WO1993003784A1
    • 1993-03-04
    • PCT/US1992006926
    • 1992-08-18
    • HABLEY MEDICAL TECHNOLOGY CORPORATIONHABER, Terry, M.SMEDLEY, William, H.FOSTER, Clark, B.
    • HABLEY MEDICAL TECHNOLOGY CORPORATION
    • A61M15/00
    • A61M15/0091A61M15/0028A61M15/0093A61M15/0096A61M2202/064A61M2205/073A61M2205/8225
    • A powdered pharmaceutical inhaler (2) includes, broadly, an air pressurization chamber (6), housing a piston and cylinder arrangement for providing a charge of pressurized air to the air pressurization chamber, and an inhalation chamber (4), including a mouthpiece region (16) and a pharmaceutical region (92) containing the pharmaceutical (156). The inhaler is actuated by inhaling on the mouthpiece region which automatically opens a fluid pathway between the air pressurization chamber and the supply of powdered pharmaceutical. When this occurs the air rushes from the air pressurization chamber through the powdered pharmaceutical, thus entraining the powdered pharmaceutical in an airstream, the entrained pharmaceutical being inhaled into the lungs of the user. The inhaler is thus activated by the inhalation by the user and is provided a pneumatic boost from the pressurized air in the air pressurization chamber. The invention is designed to be used with replaceable pharmaceutical-containing cartridges (12).
    • 粉末药物吸入器(2)广泛地包括空气加压室(6),其容纳用于向空气加压室提供加压空气的活塞和气缸装置,以及吸入室(4),其包括接口区域 (16)和含有药物(156)的药物区域(92)。 吸入器通过吸入口部区域而被致动,自动打开空气加压室和动力药物供应之间的流体通路。 当这种情况发生时,空气通过动力药物从空气加压室冲出,从而将粉状药物夹带在气流中,夹带的药物被吸入使用者的肺部。 因此吸入器被使用者的吸入激活,并且从空气加压室中的加压空气提供气动升压。 本发明被设计成与可替换的含药药筒(12)一起使用。 药筒安装到吸入室的吸口区域,并含有粉末状药物。 因此,在每次使用之后,盒被处理,使得可以处理可能被粉末状药物,唾液等堵塞或以其它方式污染的所有表面。
    • 8. 发明申请
    • METERED SYRINGE FILLING DEVICE FOR PHARMACEUTICAL CONTAINERS
    • 用于药物容器的计量灌装装置
    • WO1993002921A1
    • 1993-02-18
    • PCT/US1992006464
    • 1992-08-06
    • HABLEY MEDICAL TECHNOLOGY CORPORATIONHABER, Terry, M.FOSTER, Clark, B.
    • HABLEY MEDICAL TECHNOLOGY CORPORATION
    • B65B01/04
    • A61M5/1782A61J1/062A61J1/201A61J1/2051A61J1/2096A61M5/31551B65B3/003
    • A syringe filling and metering device (2) for pharmaceutical containers (4) including a variable volume region housing the liquid pharmaceutical (78) and a needle access portion, such as a septum (74) which is pierced by the needle cannula (72) of the syringe (6), such as by mounting the syringe in a syringe carrier (8). An elongate piston stop (58) is held in place by a piston driver (42) to which the syringe carrier is threadably connected. The syringe carrier (8) is screwed into the piston driver (42) to drive the barrel of the cartridge (4) over the piston (60), thus forcing the contents of the cartridge through the needle cannula and into the syringe. The invention can also be practiced with needle cannula piercing the piston so that the movement of the piston into the barrel of the container forces the liquid pharmaceutical through the needle cannula and into the syringe.
    • 一种用于药物容器(4)的注射器填充和计量装置(2),其包括容纳液体药物(78)的可变容积区域和由针插管(72)刺穿的诸如隔膜(74)的针入口部分, (6),例如通过将注射器安装在注射器托架(8)中。 细长的活塞止动件(58)通过活塞驱动器(42)保持就位,注射器支架螺纹连接到活塞驱动器。 将注射器托架(8)拧入活塞驱动器(42)中以驱动药筒(4)的筒体在活塞(60)上方,从而迫使药筒的内容物通过针插管进入注射器。 本发明还可以用针套管刺穿活塞来实施,使得活塞进入容器的筒体的运动迫使液体药物通过针插管进入注射器。