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1. 发明申请

WO2007067282A3 ARRAYED ULTRASONIC TRANSDUCER 审中-公开
标题翻译：阵列超声波传感器
公开(公告)号：WO2007067282A3
公开(公告)日：2007-08-16
申请号：PCT/US2006042889
申请日：2006-11-02
申请人： VISUALSONICS CORP , SUNNYBROOK AND WOMEN S COLLGE , LUKACS MARC , FOSTER STUART F , YIN JIANHUA , PANG GUOFENG , GARCIA RICHARD
发明人： LUKACS MARC , FOSTER STUART F , YIN JIANHUA , PANG GUOFENG , GARCIA RICHARD
IPC分类号： B06B1/06
CPC分类号： B06B1/064
摘要： An ultrasonic transducer comprises a stack having a first face 102, an opposed second face 104 and a longitudinal axis Ls extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises an upper unpoled piezoelectric layer 126, an underlying lower poled piezoelectric layer 106, and a dielectric layer 108. The dielectric layer 108 is connected to the piezoelectric layer 106 and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots 118 are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack through the upper piezoelectric layer 126 and into the lower piezoelectric layer 106 and a first predetermined length in a direction substantially parallel to the axis.
摘要翻译：超声波换能器包括具有第一面102，相对的第二面104和在它们之间延伸的纵向轴线Ls的叠层。叠层包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括上未被压电的压电层126，底部下极化压电层106和介电层108。电介质层108连接到压电层106并且限定在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。在其中限定了多个第一切口槽118，每个第一切口槽在其中通过上压电层126延伸堆叠中的预定深度并进入下压电层106，并且在基本上平行于轴线的方向上延伸第一预定长度。

2. 发明申请

WO2004034694A3 HIGH FREQUENCY HIGH FRAME-RATE ULTRASOUND IMAGING SYSTEM 审中-公开
标题翻译：高频高速超声成像系统
公开(公告)号：WO2004034694A3
公开(公告)日：2004-07-15
申请号：PCT/US0332320
申请日：2003-10-10
申请人： VISUALSONICS INC , MEHI JAMES I , MCCONAGHY ROBERT , CHAGGARES NICHOLAS CHRISTOPHER , FOSTER STUART
发明人： MEHI JAMES I , MCCONAGHY ROBERT , CHAGGARES NICHOLAS CHRISTOPHER , FOSTER STUART
IPC分类号： G01S7/52 , G01S7/521 , G01S15/89 , A61B8/00
CPC分类号： A61B8/4461 , A61B8/0841 , A61B8/0866 , A61B8/14 , A61B8/4245 , A61B8/4254 , A61B8/4281 , A61B8/4483 , A61B8/461 , A61B8/467 , A61B8/5207 , A61B8/54 , G01S7/52034 , G01S7/52079 , G01S7/52085 , G01S15/894 , G01S15/8956
摘要： A system for producing an ultrasound image comprises a scan head (106) having a transducer (124) capable of generating ultrasound energy at a frequency of at least 20 megahertz (MHz), and a processor (134) for receiving ultrasound energy and for generating an ultrasound image (116) at a frame rate of at least 15 frames per second (fps).
摘要翻译：一种用于产生超声波图像的系统包括具有能够以至少20兆赫兹（MHz）的频率产生超声能量的换能器（124）的扫描头（106）和用于接收超声能量并用于产生以每秒至少15帧（fps）的帧速率的超声图像（116）。

3. 发明申请

WO2007056104A2 HIGH FREQUENCY ARRAY ULTRASOUND SYSTEM 审中-公开
标题翻译：高频阵列超声系统
公开(公告)号：WO2007056104A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/042891
申请日：2006-11-02
申请人： VISUALSONICS CORP. , MEHI, James , DAIGLE, Ronald, E. , BRASFIELD, Laurence, C. , STARKOSKI, Brian , WEN, Jerrold , LIU, Kai, Wen , PFLUGRATH, Lauren, S. , FOSTER, Stuart, F. , HIRSON, Desmond
发明人： MEHI, James , DAIGLE, Ronald, E. , BRASFIELD, Laurence, C. , STARKOSKI, Brian , WEN, Jerrold , LIU, Kai, Wen , PFLUGRATH, Lauren, S. , FOSTER, Stuart, F. , HIRSON, Desmond
IPC分类号： G01S7/52 , G01S15/89
CPC分类号： G01S7/52095 , A61B8/56 , A61B8/565 , G01S7/52017 , G01S7/5202 , G01S7/52034 , G01S7/52088 , G01S7/524 , G01S7/526 , G01S15/8915 , G01S15/8927 , G01S15/8956 , G01S15/8959 , G01S15/8997 , G10K11/341 , G10K11/346
摘要： A system for acquiring an ultrasound signal comprises a signal processing unit adapted for acquiring a received ultrasound signal from an ultrasound transducer having a plurality of elements. The system is adapted to receive ultrasound signals having a frequency of at least 20 megahertz (MHz) with a transducer having a field of view of at least 5.0 millimeters (mm) at a frame rate of at least 20 frames per second (fps). The signal processing can further produce an ultrasound image from the acquired ultrasound signal. The transducer can be a linear array transducer, a phased array transducer, a two-dimensional (2-D) array transducer, or a curved array transducer.
摘要翻译：一种用于获取超声信号的系统包括适于从具有多个元件的超声波换能器获取接收到的超声信号的信号处理单元。该系统适于以至少为20帧/秒（fps）的帧速率的具有至少5.0毫米（mm）视野的换能器接收频率至少为20兆赫兹（MHz）的超声信号。信号处理可以从所获取的超声信号进一步产生超声图像。换能器可以是线性阵列换能器，相控阵转换器，二维（2-D）阵列换能器或弯曲阵列换能器。

4. 发明申请

WO2005070472A2 HIGH FREQUENCY ULTRASOUND IMAGING USING CONTRAST AGENTS 审中-公开
标题翻译：使用对比剂进行高频超声成像
公开(公告)号：WO2005070472A2
公开(公告)日：2005-08-04
申请号：PCT/IB2005/001017
申请日：2005-01-20
申请人： SUNNYBROOK AND WOMEN'S COLLEGE HEALTH SCIENCES CENTRE, , GOERTZ, David, E. , FOSTER, Stuart, F.
发明人： GOERTZ, David, E. , FOSTER, Stuart, F.
IPC分类号： A61K49/22
CPC分类号： G01S7/52038 , A61K49/223 , G01S7/52039 , G01S7/52088 , G01S15/8956
摘要： Provided herein are compositions comprising a microbubble contrast agent, wherein at least 20% by volume of the microbubbles in the contrast agent has a size of less than 1 micron, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. Provided herein are compositions comprising a microbubble contrast agent, wherein at least 10% by volume of the microbubbles in the contrast agent has a size of less than 500 nanometers, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. Provided herein are compositions comprising a microbubble contrast agent, wherein at least 5% by volume of the microbubbles in the contrast agent has a size of less than 200 nanometers, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. The disclosed contrast agents can be targeted contrast agents. Further provided are methods of using the compositions disclosed herein. Specifically provided are methods for producing an ultrasound image comprising: administering contrast agent to a laboratory animal; generating ultrasound at a frequency of at least 20 MHz; transmitting ultrasound at a frequency of at least 20 MHz into the subject; receiving non-linear ultrasound from the contrast agent in the subject; processing the received ultrasound to provide an image.
摘要翻译：本文提供了包含微泡造影剂的组合物，其中造影剂中至少20体积％的微泡具有小于1微米的尺寸，其中造影剂当以超过上述频率的超声波接触时产生非线性散射 20 MHz。本文提供了包含微泡造影剂的组合物，其中造影剂中至少10体积％的微泡具有小于500纳米的尺寸，其中造影剂当以超过上述频率的超声波接触时产生非线性散射 20 MHz。本文提供了包含微泡造影剂的组合物，其中造影剂中的至少5体积％的微泡具有小于200纳米的尺寸，其中造影剂当以超过上述频率的超声波接触时产生非线性散射 20 MHz。所公开的造影剂可以是靶向造影剂。还提供了使用本文公开的组合物的方法。具体提供的是用于生产超声图像的方法，包括：向实验室动物施用造影剂; 以至少20MHz的频率生成超声波; 以至少20MHz的频率向所述对象发送超声波; 从受试者的造影剂接收非线性超声波; 处理所接收的超声波以提供图像。

5. 发明申请

WO2007067282A8 ARRAYED ULTRASONIC TRANSDUCER 审中-公开
标题翻译：阵列超声波传感器
公开(公告)号：WO2007067282A8
公开(公告)日：2008-10-02
申请号：PCT/US2006042889
申请日：2006-11-02
申请人： VISUALSONICS INC , SUNNYBROOK & WOMENS COLLEGE , LUKACS MARC , FOSTER STUART F , YIN JIANHUA , PANG GUOFENG , GARCIA RICHARD
发明人： LUKACS MARC , FOSTER STUART F , YIN JIANHUA , PANG GUOFENG , GARCIA RICHARD
IPC分类号： B06B1/06
CPC分类号： B06B1/064
摘要： An ultrasonic transducer comprises a stack having a first face 102, an opposed second face 104 and a longitudinal axis Ls extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises an upper unpoled piezoelectric layer 126, an underlying lower poled piezoelectric layer 106, and a dielectric layer 108. The dielectric layer 108 is connected to the piezoelectric layer 106 and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots 118 are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack through the upper piezoelectric layer 126 and into the lower piezoelectric layer 106 and a first predetermined length in a direction substantially parallel to the axis.
摘要翻译：超声波换能器包括具有第一面102，相对的第二面104和在它们之间延伸的纵向轴线Ls的叠层。叠层包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括上未被压电的压电层126，底部下极化压电层106和介电层108。电介质层108连接到压电层106并且限定在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。在其中限定了多个第一切口槽118，每个第一切口槽在其中通过上压电层126延伸堆叠中的预定深度并进入下压电层106，并且在基本上平行于轴线的方向上延伸第一预定长度。

6. 发明申请

WO2007056104A3 HIGH FREQUENCY ARRAY ULTRASOUND SYSTEM 审中-公开
标题翻译：高频阵列超声系统
公开(公告)号：WO2007056104A3
公开(公告)日：2007-08-30
申请号：PCT/US2006042891
申请日：2006-11-02
申请人： VISUALSONICS CORP , MEHI JAMES , DAIGLE RONALD E , BRASFIELD LAURENCE C , STARKOSKI BRIAN , WEN JERROLD , LIU KAI WEN , PFLUGRATH LAUREN S , FOSTER STUART F , HIRSON DESMOND
发明人： MEHI JAMES , DAIGLE RONALD E , BRASFIELD LAURENCE C , STARKOSKI BRIAN , WEN JERROLD , LIU KAI WEN , PFLUGRATH LAUREN S , FOSTER STUART F , HIRSON DESMOND
IPC分类号： G01S7/52 , G01S15/89
CPC分类号： G01S7/52095 , A61B8/56 , A61B8/565 , G01S7/52017 , G01S7/5202 , G01S7/52034 , G01S7/52088 , G01S7/524 , G01S7/526 , G01S15/8915 , G01S15/8927 , G01S15/8956 , G01S15/8959 , G01S15/8997 , G10K11/341 , G10K11/346
摘要： A system for acquiring an ultrasound signal comprises a signal processing unit adapted for acquiring a received ultrasound signal from an ultrasound transducer having a plurality of elements. The system is adapted to receive ultrasound signals having a frequency of at least 20 megahertz (MHz) with a transducer having a field of view of at least 5.0 millimeters (mm) at a frame rate of at least 20 frames per second (fps). The signal processing can further produce an ultrasound image from the acquired ultrasound signal. The transducer can be a linear array transducer, a phased array transducer, a two-dimensional (2-D) array transducer, or a curved array transducer.
摘要翻译：用于获取超声信号的系统包括适于从具有多个元件的超声换能器获取接收到的超声信号的信号处理单元。该系统适合于以至少20帧/秒（fps）的帧速率用具有至少5.0毫米（mm）的视场的换能器接收频率为至少20兆赫兹（MHz）的超声信号。信号处理可以进一步从采集的超声信号产生超声图像。换能器可以是线性阵列换能器，相控阵换能器，二维（2-D）阵列换能器或曲线阵列换能器。

7. 发明申请

WO2005070472A3 HIGH FREQUENCY ULTRASOUND IMAGING USING CONTRAST AGENTS 审中-公开
标题翻译：使用对比剂进行高频超声成像
公开(公告)号：WO2005070472A3
公开(公告)日：2006-07-27
申请号：PCT/IB2005001017
申请日：2005-01-20
申请人： TRE SUNNYBROOK AND WOMEN S COL , GOERTZ DAVID E , FOSTER STUART F
发明人： GOERTZ DAVID E , FOSTER STUART F
IPC分类号： A61K49/22 , G01S7/52
CPC分类号： G01S7/52038 , A61K49/223 , G01S7/52039 , G01S7/52088 , G01S15/8956
摘要： Provided herein are compositions comprising a microbubble contrast agent, wherein at least 20% by volume of the microbubbles in the contrast agent has a size of less than 1 micron, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. Provided herein are compositions comprising a microbubble contrast agent, wherein at least 10% by volume of the microbubbles in the contrast agent has a size of less than 500 nanometers, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. Provided herein are compositions comprising a microbubble contrast agent, wherein at least 5% by volume of the microbubbles in the contrast agent has a size of less than 200 nanometers, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. The disclosed contrast agents can be targeted contrast agents. Further provided are methods of using the compositions disclosed herein. Specifically provided are methods for producing an ultrasound image comprising: administering contrast agent to a laboratory animal; generating ultrasound at a frequency of at least 20 MHz; transmitting ultrasound at a frequency of at least 20 MHz into the subject; receiving non-linear ultrasound from the contrast agent in the subject; processing the received ultrasound to provide an image.
摘要翻译：本文提供了包含微泡造影剂的组合物，其中造影剂中至少20体积％的微泡具有小于1微米的尺寸，其中造影剂当以超声波的频率接触时产生非线性散射 20 MHz。本文提供了包含微泡造影剂的组合物，其中造影剂中至少10体积％的微泡具有小于500纳米的尺寸，其中造影剂当以超声波以超声波接触时产生非线性散射 20 MHz。本文提供了包含微泡造影剂的组合物，其中造影剂中至少5体积％的微泡具有小于200纳米的尺寸，其中造影剂在以超声波的频率接触超声波时产生非线性散射 20 MHz。所公开的造影剂可以是靶向造影剂。还提供了使用本文公开的组合物的方法。具体提供的是用于生产超声图像的方法，包括：向实验室动物施用造影剂; 以至少20MHz的频率生成超声波; 以至少20MHz的频率向所述对象发送超声波; 从受试者的造影剂接收非线性超声波; 处理所接收的超声波以提供图像。

8. 发明申请

WO2004034694A9 HIGH FREQUENCY HIGH FRAME-RATE ULTRASOUND IMAGING SYSTEM 审中-公开
标题翻译：高频高帧率超声成像系统
公开(公告)号：WO2004034694A9
公开(公告)日：2004-06-03
申请号：PCT/US0332320
申请日：2003-10-10
申请人： VISUALSONICS INC , MEHI JAMES I , MCCONAGHY ROBERT , CHAGGARES NICHOLAS CHRISTOPHER , FOSTER STUART
发明人： MEHI JAMES I , MCCONAGHY ROBERT , CHAGGARES NICHOLAS CHRISTOPHER , FOSTER STUART
IPC分类号： G01S7/52 , G01S7/521 , G01S15/89 , H04N
CPC分类号： A61B8/4461 , A61B8/0841 , A61B8/0866 , A61B8/14 , A61B8/4245 , A61B8/4254 , A61B8/4281 , A61B8/4483 , A61B8/461 , A61B8/467 , A61B8/5207 , A61B8/54 , G01S7/52034 , G01S7/52079 , G01S7/52085 , G01S15/894 , G01S15/8956
摘要： A system for producing an ultrasound image comprises a scan head having a transducer capable of generating ultrasound energy at a frequency of at least 20 megahertz (MHz), and a processor for receiving ultrasound energy and for generating an ultrasound image at a frame rate of at least 15 frames per second (fps).
摘要翻译：一种用于产生超声图像的系统，包括具有能够以至少20兆赫（MHz）的频率产生超声能量的换能器的扫描头，以及用于接收超声能量并用于以帧速率为每秒至少15帧（fps）。

9. 发明申请

WO2009066184A2 HIGH FREQUENCY PIEZOCOMPOSITE AND METHODS FOR MANUFACTURING SAME 审中-公开
标题翻译：高频拼接剂及其制造方法
公开(公告)号：WO2009066184A2
公开(公告)日：2009-05-28
申请号：PCT/IB2008/003874
申请日：2008-10-29
申请人： VISUALSONICS, INC. , BROWN, Jeremy , FOSTER, Stuart, F. , YIN, Jianhua
发明人： BROWN, Jeremy , FOSTER, Stuart, F. , YIN, Jianhua
IPC分类号： B01J19/10
CPC分类号： H01L41/1876 , A61B1/06 , A61B8/12 , B06B1/02 , B06B1/0292 , B06B1/06 , B06B1/0607 , B06B1/0622 , B06B1/064 , G01S15/8925 , G01S15/8956 , H01L41/08 , H01L41/25 , H01L41/27 , H01L41/29 , H01L41/33 , H01L41/338 , Y10T29/42 , Y10T29/49005
摘要： A transducer with triangular cross-sectional shaped pillars is described for suppressing lateral modes within a composite, and a method for producing the same. According to one aspect of the present application, a plurality of triangular cross- sectional shaped pillars extends outwardly from a substrate and form an array of pillars. The resulting array of pillars is configured to suppress the lateral modes of the transducer at higher operating frequencies, such as, at or above 15MHz, at or above 20 MHz, or at or above 30MHz.
摘要翻译：描述了一种具有三角截面形状的支柱的传感器，用于抑制复合材料内的横向模式及其制造方法。根据本申请的一个方面，多个三角形横截面形状的支柱从衬底向外延伸并形成柱状阵列。所形成的支柱阵列被配置为在更高的工作频率（例如，15MHz或更高于20MHz，或高于20MHz，或在30MHz以上）抑制换能器的横向模式。

10. 发明申请

WO2007056104A9 HIGH FREQUENCY ARRAY ULTRASOUND SYSTEM 审中-公开
公开(公告)号：WO2007056104A9
公开(公告)日：2007-07-12
申请号：PCT/US2006042891
申请日：2006-11-02
申请人： VISUALSONICS CORP , MEHI JAMES , DAIGLE RONALD E , BRASFIELD LAURENCE C , STARKOSKI BRIAN , WEN JERROLD , LIU KAI WEN , PFLUGRATH LAUREN S , FOSTER STUART F , HIRSON DESMOND
发明人： MEHI JAMES , DAIGLE RONALD E , BRASFIELD LAURENCE C , STARKOSKI BRIAN , WEN JERROLD , LIU KAI WEN , PFLUGRATH LAUREN S , FOSTER STUART F , HIRSON DESMOND
IPC分类号： G01S7/52 , G01S15/89
CPC分类号： G01S7/52095 , A61B8/56 , A61B8/565 , G01S7/52017 , G01S7/5202 , G01S7/52034 , G01S7/52088 , G01S7/524 , G01S7/526 , G01S15/8915 , G01S15/8927 , G01S15/8956 , G01S15/8959 , G01S15/8997 , G10K11/341 , G10K11/346
摘要： A system for acquiring an ultrasound signal comprises a signal processing unit adapted for acquiring a received ultrasound signal from an ultrasound transducer having a plurality of elements. The system is adapted to receive ultrasound signals having a frequency of at least 20 megahertz (MHz) with a transducer having a field of view of at least 5.0 millimeters (mm) at a frame rate of at least 20 frames per second (fps). The signal processing can further produce an ultrasound image from the acquired ultrasound signal. The transducer can be a linear array transducer, a phased array transducer, a two-dimensional (2-D) array transducer, or a curved array transducer.

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