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1. 发明申请

WO2007067282A2 ARRAYED ULTRASONIC TRANSDUCER 审中-公开
标题翻译：阵列超声波传感器
公开(公告)号：WO2007067282A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/042889
申请日：2006-11-02
申请人： VISUALSONICS CORP. , SUNNYBROOK AND WOMEN'S COLLGE HEAL SCIENCES CENTRE , LUKACS, Marc , FOSTER, Stuart, F. , YIN, Jianhua , PANG, Guofeng , GARCIA, Richard
发明人： LUKACS, Marc , FOSTER, Stuart, F. , YIN, Jianhua , PANG, Guofeng , GARCIA, Richard
IPC分类号： B06B1/06
CPC分类号： B06B1/064
摘要： An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises an upper unpoled piezoelectric layer, an underlying lower poled piezoelectric layer, and a dielectric layer. The dielectric layer is connected to the piezoelectric layer and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack through the upper piezoelectric layer and into the lower piezoelectric layer and a first predetermined length in a direction substantially parallel to the axis.
摘要翻译：超声波换能器包括具有第一面，相对的第二面和在它们之间延伸的纵轴的叠层。堆叠包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括上部未压电压电层，下部极化压电层和介电层。电介质层连接到压电层并且限定了在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。多个第一切口槽限定在其中，每个第一切口槽在其中通过上压电层延伸堆叠中的预定深度并进入下压电层，并且在基本上平行于轴线的方向上延伸第一预定长度。

2. 发明申请

WO2011029094A3 SYSTEMS, METHODS, AND COMPUTER READABLE MEDIA FOR HIGH- FREQUENCY CONTRAST IMAGING AND IMAGE-GUIDED THERAPEUTICS 审中-公开
标题翻译：用于高频对比成像和图像导向治疗的系统，方法和计算机可读介质
公开(公告)号：WO2011029094A3
公开(公告)日：2011-06-03
申请号：PCT/US2010047988
申请日：2010-09-07
申请人： UNIV NORTH CAROLINA , DAYTON PAUL A , GESSNER RYAN , LEE HYUNGGYUN MIKE , LUKACS MARC , FOSTER FRANCIS STUART
发明人： DAYTON PAUL A , GESSNER RYAN , LEE HYUNGGYUN MIKE , LUKACS MARC , FOSTER FRANCIS STUART
IPC分类号： A61B8/14 , A61B8/08 , G06T5/00
CPC分类号： A61B8/481 , A61M37/0092
摘要： Systems, methods, and computer readable media for high-frequency contrast imaging and image-guided therapeutics are disclosed. According to one aspect, a method for high frequency contrast imaging and image-guided therapeutics includes: providing ultrasound of a first frequency bandwidth, directed toward the volume to be imaged, the volume containing a carrier having non-linear acoustical properties, wherein the ultrasound of the first frequency bandwidth causes the carrier to generate ultrasound of a second frequency bandwidth that is different from the first frequency bandwidth; receiving, from the volume to be imaged, ultrasound of the second frequency bandwidth; and using the received ultrasound of the second frequency bandwidth to generate an image of the volume to be imaged, wherein the components of the second frequency bandwidth that are detected are of a frequency greater than 20 MHz. According to another aspect, ultrasound at a first frequency bandwidth enables imaging of a target, and ultrasound at a second frequency bandwidth mediates drug or gene delivery to a portion of the target, as guided by the image provided by the first frequency.
摘要翻译：公开了用于高频对比成像和图像引导治疗剂的系统，方法和计算机可读介质。根据一个方面，一种用于高频对比成像和图像引导治疗的方法包括：提供针对待成像体积的第一频率带宽的超声波，该体积包含具有非线性声学特性的载体，其中超声波所述第一频率带宽使得所述载波产生与所述第一频带宽度不同的第二频带的超声波; 从要成像的体积中接收第二频带的超声波; 以及使用所接收的所述第二频率带宽的超声波来生成要成像的体积的图像，其中所检测的所述第二频率带宽的分量具有大于20MHz的频率。根据另一方面，在第一频率带宽上的超声使得能够对目标进行成像，并且在由第一频率提供的图像的指导下，以第二频率带宽的超声介导药物或基因递送到目标的一部分。

3. 发明申请

WO2010031192A1 METHODS FOR MANUFACTURING ULTRASOUND TRANSDUCERS AND OTHER COMPONENTS 审中-公开
标题翻译：制造超声换能器和其他部件的方法
公开(公告)号：WO2010031192A1
公开(公告)日：2010-03-25
申请号：PCT/CA2009/001363
申请日：2009-09-18
申请人： VISUALSONICS INC. , LUKACS, Marc , CHAGGARES, Chris , HIRSON, Desmond , PANG, Guofang
发明人： LUKACS, Marc , CHAGGARES, Chris , HIRSON, Desmond , PANG, Guofang
IPC分类号： H01L21/64 , H04R17/00 , H04R31/00
CPC分类号： A61B8/543 , A61B8/13 , A61B8/14 , B06B1/0622 , H01L41/29 , Y10T29/42 , Y10T29/49005 , Y10T29/49156 , Y10T29/49169
摘要： The invention features methods for the manufacture of electrical components such as ultrasound transducers. In particular, the inventions provides methods of patterning electrodes, e.g., in the connection of an ultrasound transducer to an electrical circuit; methods of depositing metal on surfaces; and methods of making integrated matching layer for an ultrasound transducer. The invention also features ultrasound transducers produced by the methods described herein.
摘要翻译：本发明的特征在于用于制造诸如超声换能器的电部件的方法。特别地，本发明提供了图案化电极的方法，例如在将超声换能器连接到电路上的方法; 在表面沉积金属的方法; 以及制造用于超声换能器的集成匹配层的方法。本发明的特征还在于通过本文所述的方法生产的超声波换能器。

4. 发明申请

WO2007067282A3 ARRAYED ULTRASONIC TRANSDUCER 审中-公开
标题翻译：阵列超声波传感器
公开(公告)号：WO2007067282A3
公开(公告)日：2007-08-16
申请号：PCT/US2006042889
申请日：2006-11-02
申请人： VISUALSONICS CORP , SUNNYBROOK AND WOMEN S COLLGE , LUKACS MARC , FOSTER STUART F , YIN JIANHUA , PANG GUOFENG , GARCIA RICHARD
发明人： LUKACS MARC , FOSTER STUART F , YIN JIANHUA , PANG GUOFENG , GARCIA RICHARD
IPC分类号： B06B1/06
CPC分类号： B06B1/064
摘要： An ultrasonic transducer comprises a stack having a first face 102, an opposed second face 104 and a longitudinal axis Ls extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises an upper unpoled piezoelectric layer 126, an underlying lower poled piezoelectric layer 106, and a dielectric layer 108. The dielectric layer 108 is connected to the piezoelectric layer 106 and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots 118 are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack through the upper piezoelectric layer 126 and into the lower piezoelectric layer 106 and a first predetermined length in a direction substantially parallel to the axis.
摘要翻译：超声波换能器包括具有第一面102，相对的第二面104和在它们之间延伸的纵向轴线Ls的叠层。叠层包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括上未被压电的压电层126，底部下极化压电层106和介电层108。电介质层108连接到压电层106并且限定在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。在其中限定了多个第一切口槽118，每个第一切口槽在其中通过上压电层126延伸堆叠中的预定深度并进入下压电层106，并且在基本上平行于轴线的方向上延伸第一预定长度。

5. 发明申请

WO2005104210A3 ARRAYED ULTRASONIC TRANSDUCER 审中-公开
标题翻译：阵列超声波传感器
公开(公告)号：WO2005104210A3
公开(公告)日：2006-12-14
申请号：PCT/US2005013473
申请日：2005-04-20
申请人： VISUALSONICS INC , SUNNYBROOK & WOMENS COLLEGE , LUKACS MARC , FOSTER STUART F
发明人： LUKACS MARC , FOSTER STUART F
IPC分类号： H01L41/04 , B06B1/06 , H01L21/44 , H01L21/48 , H01L41/083
CPC分类号： B06B1/0622
摘要： An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises a piezoelectric layer and a dielectric layer. The dielectric layer is connected to the piezoelectric layer and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack and a first predetermined length in a direction substantially parallel to the axis. The first predetermined length of each first kerf slot is at least as long as the second predetermined length of the opening defined by the dielectric layer and is shorter than the longitudinal distance between the first face and the opposed second face of the stack in a lengthwise direction substantially parallel to the axis.
摘要翻译：超声波换能器包括具有第一面，相对的第二面和在它们之间延伸的纵轴的叠层。所述堆叠包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括压电层和电介质层。电介质层连接到压电层并且限定了在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。在其中限定了多个第一切口槽，每个第一切口槽在堆叠中延伸预定深度，并且在基本上平行于轴线的方向上延伸第一预定长度。每个第一切口槽的第一预定长度至少等于由电介质层限定的开口的第二预定长度，并且短于堆叠的第一面和相对的第二面之间在纵向上的纵向距离基本上平行于轴线。

6. 发明申请

WO2005104210A2 ARRAYED ULTRASONIC TRANSDUCER 审中-公开
标题翻译：阵列超声波传感器
公开(公告)号：WO2005104210A2
公开(公告)日：2005-11-03
申请号：PCT/US2005/013473
申请日：2005-04-20
申请人： VISUALSONICS INC. , SUNNYBROOK AND WOMEN'S COLLEGE HEALTH SCIENCES CENTRE , LUKACS, Marc , FOSTER, Stuart, F.
发明人： LUKACS, Marc , FOSTER, Stuart, F.
IPC分类号： H01L21/44
CPC分类号： B06B1/0622
摘要： An ultrasonic transducer comprises a stack having a first face, an opposed second face and a longitudinal axis extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises a piezoelectric layer and a dielectric layer. The dielectric layer is connected to the piezoelectric layer and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack and a first predetermined length in a direction substantially parallel to the axis. The first predetermined length of each first kerf slot is at least as long as the second predetermined length of the opening defined by the dielectric layer and is shorter than the longitudinal distance between the first face and the opposed second face of the stack in a lengthwise direction substantially parallel to the axis.
摘要翻译：超声波换能器包括具有第一面，相对的第二面和在它们之间延伸的纵轴的叠层。所述堆叠包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括压电层和电介质层。电介质层连接到压电层并且限定了在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。在其中限定了多个第一切口槽，每个第一切口槽在堆叠中延伸预定深度，并且在基本上平行于轴线的方向上延伸第一预定长度。每个第一切口槽的第一预定长度至少等于由电介质层限定的开口的第二预定长度，并且短于堆叠的第一面和相对的第二面之间在纵向上的纵向距离基本上平行于轴线。

7. 发明申请

WO2011029094A2 SYSTEMS, METHODS, AND COMPUTER READABLE MEDIA FOR HIGH- FREQUENCY CONTRAST IMAGING AND IMAGE-GUIDED THERAPEUTICS 审中-公开
标题翻译：用于高频造影成像和图像引导治疗的系统，方法和计算机可读介质
公开(公告)号：WO2011029094A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047988
申请日：2010-09-07
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , DAYTON, Paul, A. , GESSNER, Ryan , LEE, Hyunggyun (mike) , LUKACS, Marc , FOSTER, Francis, Stuart
发明人： DAYTON, Paul, A. , GESSNER, Ryan , LEE, Hyunggyun (mike) , LUKACS, Marc , FOSTER, Francis, Stuart
IPC分类号： A61B8/14 , A61B8/08 , G06T5/00
CPC分类号： A61B8/481 , A61M37/0092
摘要： Systems, methods, and computer readable media for high-frequency contrast imaging and image-guided therapeutics are disclosed. According to one aspect, a method for high frequency contrast imaging and image-guided therapeutics includes: providing ultrasound of a first frequency bandwidth, directed toward the volume to be imaged, the volume containing a carrier having non-linear acoustical properties, wherein the ultrasound of the first frequency bandwidth causes the carrier to generate ultrasound of a second frequency bandwidth that is different from the first frequency bandwidth; receiving, from the volume to be imaged, ultrasound of the second frequency bandwidth; and using the received ultrasound of the second frequency bandwidth to generate an image of the volume to be imaged, wherein the components of the second frequency bandwidth that are detected are of a frequency greater than 20 MHz. According to another aspect, ultrasound at a first frequency bandwidth enables imaging of a target, and ultrasound at a second frequency bandwidth mediates drug or gene delivery to a portion of the target, as guided by the image provided by the first frequency.
摘要翻译：公开了用于高频对比成像和图像引导治疗的系统，方法和计算机可读介质。根据一个方面，一种用于高频对比成像和图像引导治疗的方法包括：提供指向待成像体积的第一频率带宽的超声，所述体积包含具有非线性声学特性的载体，其中所述超声所述第一频率带宽使所述载波生成与所述第一频率带宽不同的第二频率带宽的超声波; 从待成像的体接收第二频率带宽的超声波; 以及使用所接收的第二频率带宽的超声波来生成要成像的体积的图像，其中被检测到的第二频率带宽的分量具有大于20MHz的频率。根据另一方面，第一频率带宽处的超声波使得靶标成像，并且第二频率带宽处的超声波介导药物或基因递送至靶标的一部分，如由第一频率提供的图像所指导。

8. 发明申请

WO2010031192A8 METHODS FOR MANUFACTURING ULTRASOUND TRANSDUCERS AND OTHER COMPONENTS 审中-公开
标题翻译：制造超声波传感器及其他部件的方法
公开(公告)号：WO2010031192A8
公开(公告)日：2010-06-17
申请号：PCT/CA2009001363
申请日：2009-09-18
申请人： VISUALSONICS INC , LUKACS MARC , CHAGGARES CHRIS , HIRSON DESMOND , PANG GUOFANG
发明人： LUKACS MARC , CHAGGARES CHRIS , HIRSON DESMOND , PANG GUOFANG
IPC分类号： H01L21/64 , H04R17/00 , H04R31/00
CPC分类号： A61B8/543 , A61B8/13 , A61B8/14 , B06B1/0622 , H01L41/29 , Y10T29/42 , Y10T29/49005 , Y10T29/49156 , Y10T29/49169
摘要： The invention features methods for the manufacture of electrical components such as ultrasound transducers. In particular, the inventions provides methods of patterning electrodes, e.g., in the connection of an ultrasound transducer to an electrical circuit; methods of depositing metal on surfaces; and methods of making integrated matching layer for an ultrasound transducer. The invention also features ultrasound transducers produced by the methods described herein.
摘要翻译：本发明的特征在于制造诸如超声换能器的电气部件的方法。特别地，本发明提供了图案化电极的方法，例如在超声换能器与电路的连接中; 在表面上沉积金属的方法; 以及制造用于超声换能器的集成匹配层的方法。本发明还具有通过本文所述的方法产生的超声换能器。

9. 发明申请

WO2007067282A8 ARRAYED ULTRASONIC TRANSDUCER 审中-公开
标题翻译：阵列超声波传感器
公开(公告)号：WO2007067282A8
公开(公告)日：2008-10-02
申请号：PCT/US2006042889
申请日：2006-11-02
申请人： VISUALSONICS INC , SUNNYBROOK & WOMENS COLLEGE , LUKACS MARC , FOSTER STUART F , YIN JIANHUA , PANG GUOFENG , GARCIA RICHARD
发明人： LUKACS MARC , FOSTER STUART F , YIN JIANHUA , PANG GUOFENG , GARCIA RICHARD
IPC分类号： B06B1/06
CPC分类号： B06B1/064
摘要： An ultrasonic transducer comprises a stack having a first face 102, an opposed second face 104 and a longitudinal axis Ls extending therebetween. The stack comprises a plurality of layers, each layer having a top surface and an opposed bottom surface, wherein the plurality of layers of the stack comprises an upper unpoled piezoelectric layer 126, an underlying lower poled piezoelectric layer 106, and a dielectric layer 108. The dielectric layer 108 is connected to the piezoelectric layer 106 and defines an opening extending a second predetermined length in a direction substantially parallel to the axis of the stack. A plurality of first kerf slots 118 are defined therein the stack, each first kerf slot extending a predetermined depth therein the stack through the upper piezoelectric layer 126 and into the lower piezoelectric layer 106 and a first predetermined length in a direction substantially parallel to the axis.
摘要翻译：超声波换能器包括具有第一面102，相对的第二面104和在它们之间延伸的纵向轴线Ls的叠层。叠层包括多个层，每个层具有顶表面和相对的底表面，其中堆叠的多个层包括上未被压电的压电层126，底部下极化压电层106和介电层108。电介质层108连接到压电层106并且限定在基本上平行于堆叠的轴线的方向上延伸第二预定长度的开口。在其中限定了多个第一切口槽118，每个第一切口槽在其中通过上压电层126延伸堆叠中的预定深度并进入下压电层106，并且在基本上平行于轴线的方向上延伸第一预定长度。

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