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1. 发明申请

WO2008016992A1 PULSE INVERSION SEQUENCES FOR NONLINEAR IMAGING 审中-公开
标题翻译：用于非线性成像的脉冲反相序列
公开(公告)号：WO2008016992A1
公开(公告)日：2008-02-07
申请号：PCT/US2007/074996
申请日：2007-08-01
申请人： SCIMED LIFE SYSTEMS, INC. , FRIJLINK, Martijn, E. , GOERTZ, David, E. , VAN DER STEEN, Antonius, F., W.
发明人： FRIJLINK, Martijn, E. , GOERTZ, David, E. , VAN DER STEEN, Antonius, F., W.
IPC分类号： A61B8/12 , G01S15/89
CPC分类号： G01S7/52038 , A61B8/4461 , A61B8/4488 , A61B8/481 , A61B8/483 , G01S7/52039 , G01S15/8956 , G01S15/8959 , G01S15/8963 , G01S15/8993
摘要： Provided herein are Pulse-Inversion (PI) sequences that provide for fundamental frequency suppression in nonlinear imaging applications. In an embodiment, a weighting scheme is applied to the received echo pulses resulting from transmit pulses of alternating polarity to reduce the effect of transducer motion. In an embodiment, a three-pulse weighting scheme is applied to a PI sequence. In other embodiments, different combinations of the three-pulse weighting scheme are applied to a PI sequence.
摘要翻译：本文提供了脉冲反转（PI）序列，其提供非线性成像应用中的基频抑制。在一个实施例中，将加权方案应用于由交替极性的发射脉冲产生的接收的回波脉冲，以减少换能器运动的影响。在一个实施例中，将三脉冲加权方案应用于PI序列。在其他实施例中，将三脉冲加权方案的不同组合应用于PI序列。

2. 发明申请

WO2005070472A2 HIGH FREQUENCY ULTRASOUND IMAGING USING CONTRAST AGENTS 审中-公开
标题翻译：使用对比剂进行高频超声成像
公开(公告)号：WO2005070472A2
公开(公告)日：2005-08-04
申请号：PCT/IB2005/001017
申请日：2005-01-20
申请人： SUNNYBROOK AND WOMEN'S COLLEGE HEALTH SCIENCES CENTRE, , GOERTZ, David, E. , FOSTER, Stuart, F.
发明人： GOERTZ, David, E. , FOSTER, Stuart, F.
IPC分类号： A61K49/22
CPC分类号： G01S7/52038 , A61K49/223 , G01S7/52039 , G01S7/52088 , G01S15/8956
摘要： Provided herein are compositions comprising a microbubble contrast agent, wherein at least 20% by volume of the microbubbles in the contrast agent has a size of less than 1 micron, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. Provided herein are compositions comprising a microbubble contrast agent, wherein at least 10% by volume of the microbubbles in the contrast agent has a size of less than 500 nanometers, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. Provided herein are compositions comprising a microbubble contrast agent, wherein at least 5% by volume of the microbubbles in the contrast agent has a size of less than 200 nanometers, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. The disclosed contrast agents can be targeted contrast agents. Further provided are methods of using the compositions disclosed herein. Specifically provided are methods for producing an ultrasound image comprising: administering contrast agent to a laboratory animal; generating ultrasound at a frequency of at least 20 MHz; transmitting ultrasound at a frequency of at least 20 MHz into the subject; receiving non-linear ultrasound from the contrast agent in the subject; processing the received ultrasound to provide an image.
摘要翻译：本文提供了包含微泡造影剂的组合物，其中造影剂中至少20体积％的微泡具有小于1微米的尺寸，其中造影剂当以超过上述频率的超声波接触时产生非线性散射 20 MHz。本文提供了包含微泡造影剂的组合物，其中造影剂中至少10体积％的微泡具有小于500纳米的尺寸，其中造影剂当以超过上述频率的超声波接触时产生非线性散射 20 MHz。本文提供了包含微泡造影剂的组合物，其中造影剂中的至少5体积％的微泡具有小于200纳米的尺寸，其中造影剂当以超过上述频率的超声波接触时产生非线性散射 20 MHz。所公开的造影剂可以是靶向造影剂。还提供了使用本文公开的组合物的方法。具体提供的是用于生产超声图像的方法，包括：向实验室动物施用造影剂; 以至少20MHz的频率生成超声波; 以至少20MHz的频率向所述对象发送超声波; 从受试者的造影剂接收非线性超声波; 处理所接收的超声波以提供图像。

3. 发明申请

WO2005070472A3 HIGH FREQUENCY ULTRASOUND IMAGING USING CONTRAST AGENTS 审中-公开
标题翻译：使用对比剂进行高频超声成像
公开(公告)号：WO2005070472A3
公开(公告)日：2006-07-27
申请号：PCT/IB2005001017
申请日：2005-01-20
申请人： TRE SUNNYBROOK AND WOMEN S COL , GOERTZ DAVID E , FOSTER STUART F
发明人： GOERTZ DAVID E , FOSTER STUART F
IPC分类号： A61K49/22 , G01S7/52
CPC分类号： G01S7/52038 , A61K49/223 , G01S7/52039 , G01S7/52088 , G01S15/8956
摘要： Provided herein are compositions comprising a microbubble contrast agent, wherein at least 20% by volume of the microbubbles in the contrast agent has a size of less than 1 micron, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. Provided herein are compositions comprising a microbubble contrast agent, wherein at least 10% by volume of the microbubbles in the contrast agent has a size of less than 500 nanometers, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. Provided herein are compositions comprising a microbubble contrast agent, wherein at least 5% by volume of the microbubbles in the contrast agent has a size of less than 200 nanometers, wherein the contrast agent produces non-linear scattering when contacted by ultrasound at a frequency above 20 MHz. The disclosed contrast agents can be targeted contrast agents. Further provided are methods of using the compositions disclosed herein. Specifically provided are methods for producing an ultrasound image comprising: administering contrast agent to a laboratory animal; generating ultrasound at a frequency of at least 20 MHz; transmitting ultrasound at a frequency of at least 20 MHz into the subject; receiving non-linear ultrasound from the contrast agent in the subject; processing the received ultrasound to provide an image.
摘要翻译：本文提供了包含微泡造影剂的组合物，其中造影剂中至少20体积％的微泡具有小于1微米的尺寸，其中造影剂当以超声波的频率接触时产生非线性散射 20 MHz。本文提供了包含微泡造影剂的组合物，其中造影剂中至少10体积％的微泡具有小于500纳米的尺寸，其中造影剂当以超声波以超声波接触时产生非线性散射 20 MHz。本文提供了包含微泡造影剂的组合物，其中造影剂中至少5体积％的微泡具有小于200纳米的尺寸，其中造影剂在以超声波的频率接触超声波时产生非线性散射 20 MHz。所公开的造影剂可以是靶向造影剂。还提供了使用本文公开的组合物的方法。具体提供的是用于生产超声图像的方法，包括：向实验室动物施用造影剂; 以至少20MHz的频率生成超声波; 以至少20MHz的频率向所述对象发送超声波; 从受试者的造影剂接收非线性超声波; 处理所接收的超声波以提供图像。

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