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1. 发明申请

WO2010121265A8 A METHOD FOR NONLINEAR IMAGING OF ULTRASOUND CONTRAST AGENTS AT HIGH FREQUENCIES 审中-公开
标题翻译：超高频超声波对比剂非线性成像的方法
公开(公告)号：WO2010121265A8
公开(公告)日：2011-06-03
申请号：PCT/US2010031637
申请日：2010-04-19
申请人： VISUALSONICS INC , NEEDLES ANDREW , MEHI JAMES I , HIRSON DESMOND
发明人： NEEDLES ANDREW , MEHI JAMES I , HIRSON DESMOND
IPC分类号： A61B8/00
CPC分类号： G01S7/52038 , A61B8/06 , A61B8/13 , A61B8/14 , A61B8/481 , A61B8/543 , G01S7/52039 , G01S15/108 , G01S15/8956 , G01S15/8959
摘要： This invention employs multiple ultrasound pulse firings of either alternating phase and/or amplitude to detect nonlinear fundamental and subharmonic signals from microbubble contrast agents within living tissue, at high frequencies (- 15 MHz), e.g., with a linear array transducer. It can be shown that the contrast-to-tissue ratio (CTR) decreases with increasing ultrasound frequency because of nonlinear ultrasound propagation in tissue. However, using the subharmonic signal in addition to the nonlinear fundamental harmonic component, rather than the conventional second harmonic used at lower frequencies, provides appreciable signal strength to overcome the limitations of nonlinear tissue propagation. Additionally, the method provides for the ability to switch, at some desired frequency above 20 MHz, into a purely alternating phase inversion acquisition, in combination with bandpass filtering of the subharmonic frequency band, minimizing the losses in CTR as the frequency increases.
摘要翻译：本发明采用交替相位和/或振幅的多个超声波脉冲发射来检测来自微生物组织内的微泡造影剂的非线性基频和次谐波信号，例如在线性阵列换能器的高频（-15MHz）下。可以看出，由于组织中的非线性超声传播，对比组织比（CTR）随着超声频率的增加而降低。然而，除了非线性基本谐波分量之外，使用次谐波信号，而不是在较低频率下使用的常规二次谐波，提供了明显的信号强度来克服非线性组织传播的限制。另外，该方法提供了能够在20MHz以上的某个所需频率下，将它们转换为纯交替的相位反相采集，结合频带分频带的带通滤波，使频率增加时的CTR损耗最小化。

2. 发明申请

WO2010033867A1 METHODS FOR ACQUISITION AND DISPLAY IN ULTRASOUND IMAGING 审中-公开
标题翻译：超声成像采集和显示方法
公开(公告)号：WO2010033867A1
公开(公告)日：2010-03-25
申请号：PCT/US2009/057579
申请日：2009-09-18
申请人： VISUALSONICS INC. , MEHI, James, I. , WHITE, Christopher, A. , NEEDLES, Andrew , WEN, Jerrold , LIU, Kai, Wen , HIRSON, Desmond
发明人： MEHI, James, I. , WHITE, Christopher, A. , NEEDLES, Andrew , WEN, Jerrold , LIU, Kai, Wen , HIRSON, Desmond
IPC分类号： A61B8/00
CPC分类号： A61B8/543 , A61B8/13 , A61B8/14 , B06B1/0622 , H01L41/29 , Y10T29/42 , Y10T29/49005 , Y10T29/49156 , Y10T29/49169
摘要： In general, the invention provides methods for use in the acquisition and display of ultrasound images. In particular, the invention provides methods for displaying ultrasound images using a persistence algorithm, gating ultrasound acquisition based on subject respiration, triggering ultrasound acquisition based on subject ECG, and destroying bubble contrast agents during imaging. The methods may be employed with any suitable ultrasound system.
摘要翻译：通常，本发明提供了用于获取和显示超声图像的方法。特别地，本发明提供了使用持久性算法显示超声图像的方法，基于对象呼吸选通超声波获取，基于对象ECG触发超声波获取，以及在成像期间破坏气泡造影剂。所述方法可以与任何合适的超声系统一起使用。

3. 发明申请

WO2007056104A9 HIGH FREQUENCY ARRAY ULTRASOUND SYSTEM 审中-公开
公开(公告)号：WO2007056104A9
公开(公告)日：2007-07-12
申请号：PCT/US2006042891
申请日：2006-11-02
申请人： VISUALSONICS CORP , MEHI JAMES , DAIGLE RONALD E , BRASFIELD LAURENCE C , STARKOSKI BRIAN , WEN JERROLD , LIU KAI WEN , PFLUGRATH LAUREN S , FOSTER STUART F , HIRSON DESMOND
发明人： MEHI JAMES , DAIGLE RONALD E , BRASFIELD LAURENCE C , STARKOSKI BRIAN , WEN JERROLD , LIU KAI WEN , PFLUGRATH LAUREN S , FOSTER STUART F , HIRSON DESMOND
IPC分类号： G01S7/52 , G01S15/89
CPC分类号： G01S7/52095 , A61B8/56 , A61B8/565 , G01S7/52017 , G01S7/5202 , G01S7/52034 , G01S7/52088 , G01S7/524 , G01S7/526 , G01S15/8915 , G01S15/8927 , G01S15/8956 , G01S15/8959 , G01S15/8997 , G10K11/341 , G10K11/346
摘要： A system for acquiring an ultrasound signal comprises a signal processing unit adapted for acquiring a received ultrasound signal from an ultrasound transducer having a plurality of elements. The system is adapted to receive ultrasound signals having a frequency of at least 20 megahertz (MHz) with a transducer having a field of view of at least 5.0 millimeters (mm) at a frame rate of at least 20 frames per second (fps). The signal processing can further produce an ultrasound image from the acquired ultrasound signal. The transducer can be a linear array transducer, a phased array transducer, a two-dimensional (2-D) array transducer, or a curved array transducer.

4. 发明申请

WO2007022505A2 SYSTEMS AND METHODS FOR CAPTURE AND DISPLAY OF BLOOD PRESSURE AND ULTRASOUND DATA 审中-公开
标题翻译：用于捕获和显示血压和超声数据的系统和方法
公开(公告)号：WO2007022505A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/032586
申请日：2006-08-18
申请人： VISUALSONICS CORP. , HENDRIKS, Randall, Albert , HIRSON, Desmond , RABUKA, Christopher, Scott
发明人： HENDRIKS, Randall, Albert , HIRSON, Desmond , RABUKA, Christopher, Scott
IPC分类号： A61B8/00 , A61B5/02
CPC分类号： A61B8/5284 , A61B5/0205 , A61B5/021 , A61B5/0215 , A61B8/08 , A61B8/0883 , A61B8/14 , A61B8/4416 , A61B8/4444 , A61B8/463 , A61B8/486 , G06F19/00
摘要： An ultrasonic imaging system comprises a processing system and an ultrasound imaging probe that is configured to transmit ultrasound energy into a selected portion of a subject and to receive echoes therefrom and to transmit data signals representative thereof to the processing system. The system further comprises a blood pressure sensor that is configured to measure the blood pressure of the subject and to transmit data signals representative thereof to the processing system. The processing system can processes the received ultrasound data signals to generate an ultrasound image and the received blood pressure data signals to generate a blood pressure trace. The processing system can also display the ultrasound image and blood pressure trace in a display image in which portions of the ultrasound image are displayed in temporal synchrony with portions of the blood pressure trace.
摘要翻译：超声波成像系统包括处理系统和超声成像探头，其被配置为将超声能量发送到被摄体的选定部分并从其接收回波并将其代表的数据信号发送到处理系统。该系统还包括血压传感器，其被配置为测量受试者的血压并将代表其的数据信号发送到处理系统。处理系统可以处理所接收的超声数据信号以产生超声图像和所接收的血压数据信号以产生血压曲线。处理系统还可以在显示图像中显示超声图像和血压曲线，其中超声图像的部分与血压迹线的部分同时显示。

5. 发明申请

WO2010127199A2 SYSTEM FOR PHOTOACOUSTIC IMAGING AND RELATED METHODS 审中-公开
标题翻译：光电成像系统及相关方法
公开(公告)号：WO2010127199A2
公开(公告)日：2010-11-04
申请号：PCT/US2010/033086
申请日：2010-04-30
申请人： VISUALSONICS INC. , HIRSON, Desmond , MEHI, James, I. , NEEDLES, Andrew
发明人： HIRSON, Desmond , MEHI, James, I. , NEEDLES, Andrew
IPC分类号： G06T7/20
CPC分类号： G01S15/8993 , A61B5/0073 , A61B5/0095 , A61B8/4218 , A61B8/483 , A61B2562/0204 , G01N21/1702 , G01N21/4795 , G01S15/899
摘要： Photoacoustic imaging systems and methods that allow for the creation of three-dimensional (3D) images of a subject are described herein. The systems include one or more optical fibers attached to an ultrasound transducer. Ultrasonic waves are generated by laser light emitted from the optical fiber(s) and detected by the ultrasound transducer. 3D images are acquired by ultrasound signals from a series of adjacent scan planes or frames that are then stacked together to create 3D volume data.
摘要翻译：本文描述了允许创建受试者的三维（3D）图像的光声成像系统和方法。该系统包括附接到超声换能器的一个或多个光纤。超声波是通过从光纤发射并由超声波换能器检测的激光产生的。通过来自一系列相邻的扫描平面或帧的超声信号获取3D图像，然后将它们堆叠在一起以产生3D体积数据。

6. 发明申请

WO2010121265A1 A METHOD FOR NONLINEAR IMAGING OF ULTRASOUND CONTRAST AGENTS AT HIGH FREQUENCIES 审中-公开
标题翻译：超高频超声波对比剂非线性成像的方法
公开(公告)号：WO2010121265A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/031637
申请日：2010-04-19
申请人： VISUALSONICS INC. , NEEDLES, Andrew , MEHI, James, I. , HIRSON, Desmond
发明人： NEEDLES, Andrew , MEHI, James, I. , HIRSON, Desmond
IPC分类号： A61B8/00
CPC分类号： G01S7/52038 , A61B8/06 , A61B8/13 , A61B8/14 , A61B8/481 , A61B8/543 , G01S7/52039 , G01S15/108 , G01S15/8956 , G01S15/8959
摘要： This invention employs multiple ultrasound pulse firings of either alternating phase and/or amplitude to detect nonlinear fundamental and subharmonic signals from microbubble contrast agents within living tissue, at high frequencies (- 15 MHz), e.g., with a linear array transducer. It can be shown that the contrast-to-tissue ratio (CTR) decreases with increasing ultrasound frequency because of nonlinear ultrasound propagation in tissue. However, using the subharmonic signal in addition to the nonlinear fundamental harmonic component, rather than the conventional second harmonic used at lower frequencies, provides appreciable signal strength to overcome the limitations of nonlinear tissue propagation. Additionally, the method provides for the ability to switch, at some desired frequency above 20 MHz, into a purely alternating phase inversion acquisition, in combination with bandpass filtering of the subharmonic frequency band, minimizing the losses in CTR as the frequency increases.
摘要翻译：本发明采用交替相位和/或振幅的多个超声波脉冲发射来检测来自微生物组织内的微泡造影剂的非线性基频和次谐波信号，例如在线性阵列换能器的高频（-15MHz）下。可以看出，由于组织中的非线性超声传播，对比组织比（CTR）随着超声频率的增加而降低。然而，除了非线性基本谐波分量之外，使用次谐波信号，而不是在较低频率下使用的常规二次谐波，提供了明显的信号强度来克服非线性组织传播的限制。另外，该方法提供了能够在20MHz以上的某个所需频率下，将它们转换为纯交替的相位反相采集，结合频带分频带的带通滤波，使频率增加时CTR的损耗最小化。

7. 发明申请

WO2007103144A3 ULTRASONIC MATCHING LAYER AND TRANSDUCER 审中-公开
标题翻译：超声波匹配层和传感器
公开(公告)号：WO2007103144A3
公开(公告)日：2008-04-24
申请号：PCT/US2007005301
申请日：2007-03-01
申请人： VISUALSONICS INC , CHAGGARES N CHRIS , MEHI JAMES , HIRSON DESMOND
发明人： CHAGGARES N CHRIS , MEHI JAMES , HIRSON DESMOND
IPC分类号： A61B8/14
CPC分类号： G10K11/02 , A61B8/4281 , A61B8/4444 , B06B1/067
摘要： In one aspect, matching layers for an ultrasonic transducer stack having a matching layer comprising a matrix material loaded with a plurality of micron-sized and nano-sized particles. In another aspect, the matrix material is loaded with a plurality of heavy and light particles. In another aspect, an ultrasound transducer stack comprises a piezoelectric layer and at least one matching layer. In one aspect, the matching layer comprises a composite material comprising a matrix material loaded with a plurality of micron-sized and nano-sized particles. In a further aspect, the composite material can also comprise a matrix material loaded with a plurality of heavy and light particles. In a further aspect, a matching layer can also comprise cyanoacrylate.
摘要翻译：在一个方面，用于具有匹配层的超声换能器叠层的匹配层，所述匹配层包括加载有多个微米尺寸和纳米尺寸颗粒的基体材料。另一方面，基体材料装载有多个重质和轻质颗粒。另一方面，超声换能器叠层包括压电层和至少一个匹配层。在一个方面，匹配层包括复合材料，该复合材料包含加载有多个微米尺寸和纳米尺寸颗粒的基体材料。另一方面，复合材料还可以包含装载有多个重和轻颗粒的基质材料。另一方面，匹配层也可以包含氰基丙烯酸酯。

8. 发明申请

WO2010031192A8 METHODS FOR MANUFACTURING ULTRASOUND TRANSDUCERS AND OTHER COMPONENTS 审中-公开
标题翻译：制造超声波传感器及其他部件的方法
公开(公告)号：WO2010031192A8
公开(公告)日：2010-06-17
申请号：PCT/CA2009001363
申请日：2009-09-18
申请人： VISUALSONICS INC , LUKACS MARC , CHAGGARES CHRIS , HIRSON DESMOND , PANG GUOFANG
发明人： LUKACS MARC , CHAGGARES CHRIS , HIRSON DESMOND , PANG GUOFANG
IPC分类号： H01L21/64 , H04R17/00 , H04R31/00
CPC分类号： A61B8/543 , A61B8/13 , A61B8/14 , B06B1/0622 , H01L41/29 , Y10T29/42 , Y10T29/49005 , Y10T29/49156 , Y10T29/49169
摘要： The invention features methods for the manufacture of electrical components such as ultrasound transducers. In particular, the inventions provides methods of patterning electrodes, e.g., in the connection of an ultrasound transducer to an electrical circuit; methods of depositing metal on surfaces; and methods of making integrated matching layer for an ultrasound transducer. The invention also features ultrasound transducers produced by the methods described herein.
摘要翻译：本发明的特征在于制造诸如超声换能器的电气部件的方法。特别地，本发明提供了图案化电极的方法，例如在超声换能器与电路的连接中; 在表面上沉积金属的方法; 以及制造用于超声换能器的集成匹配层的方法。本发明还具有通过本文所述的方法产生的超声换能器。

9. 发明申请

WO2007103143A2 ULTRASONIC MATCHING LAYER AND TRANSDUCER 审中-公开
标题翻译：超声波匹配层和传感器
公开(公告)号：WO2007103143A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005300
申请日：2007-03-01
申请人： VISUALSONICS INC. , CHAGGARES, N., Chris , MEHI, James , HIRSON, Desmond
发明人： CHAGGARES, N., Chris , MEHI, James , HIRSON, Desmond
IPC分类号： H01L41/00
CPC分类号： B06B3/00 , A61B8/4209 , B06B1/06 , B06B1/067 , B32B7/12 , G10K9/122 , G10K11/02 , G10K11/30 , H01L41/083 , Y10T156/10 , Y10T428/31855
摘要： In one aspect, matching layers for an ultrasonic transducer stack having a matching layer comprising a matrix material loaded with a plurality of micron-sized and nano-sized particles. In another aspect, the matrix material is loaded with a plurality of heavy and light particles. In another aspect, an ultrasound transducer stack comprises a piezoelectric layer and at least one matching layer. In one aspect, the matching layer comprises a composite material comprising a matrix material loaded with a plurality of micron-sized and nano-sized particles. In a further aspect, the composite material can also comprise a matrix material loaded with a plurality of heavy and light particles. In a further aspect, a matching layer can also comprise cyanoacrylate.
摘要翻译：在一个方面，用于具有匹配层的超声波换能器叠层的匹配层包括装载有多个微米尺寸和纳米尺寸颗粒的基质材料。在另一方面，基质材料装载有多个重和轻的颗粒。在另一方面，超声换能器叠层包括压电层和至少一个匹配层。在一个方面，匹配层包括复合材料，其包含负载有多个微米级和纳米尺寸颗粒的基质材料。在另一方面，复合材料还可以包含装载有多个重和轻颗粒的基质材料。在另一方面，匹配层还可以包含氰基丙烯酸酯。

10. 发明申请

WO2007056104A3 HIGH FREQUENCY ARRAY ULTRASOUND SYSTEM 审中-公开
标题翻译：高频阵列超声系统
公开(公告)号：WO2007056104A3
公开(公告)日：2007-08-30
申请号：PCT/US2006042891
申请日：2006-11-02
申请人： VISUALSONICS CORP , MEHI JAMES , DAIGLE RONALD E , BRASFIELD LAURENCE C , STARKOSKI BRIAN , WEN JERROLD , LIU KAI WEN , PFLUGRATH LAUREN S , FOSTER STUART F , HIRSON DESMOND
发明人： MEHI JAMES , DAIGLE RONALD E , BRASFIELD LAURENCE C , STARKOSKI BRIAN , WEN JERROLD , LIU KAI WEN , PFLUGRATH LAUREN S , FOSTER STUART F , HIRSON DESMOND
IPC分类号： G01S7/52 , G01S15/89
CPC分类号： G01S7/52095 , A61B8/56 , A61B8/565 , G01S7/52017 , G01S7/5202 , G01S7/52034 , G01S7/52088 , G01S7/524 , G01S7/526 , G01S15/8915 , G01S15/8927 , G01S15/8956 , G01S15/8959 , G01S15/8997 , G10K11/341 , G10K11/346
摘要： A system for acquiring an ultrasound signal comprises a signal processing unit adapted for acquiring a received ultrasound signal from an ultrasound transducer having a plurality of elements. The system is adapted to receive ultrasound signals having a frequency of at least 20 megahertz (MHz) with a transducer having a field of view of at least 5.0 millimeters (mm) at a frame rate of at least 20 frames per second (fps). The signal processing can further produce an ultrasound image from the acquired ultrasound signal. The transducer can be a linear array transducer, a phased array transducer, a two-dimensional (2-D) array transducer, or a curved array transducer.
摘要翻译：用于获取超声信号的系统包括适于从具有多个元件的超声换能器获取接收到的超声信号的信号处理单元。该系统适合于以至少20帧/秒（fps）的帧速率用具有至少5.0毫米（mm）的视场的换能器接收频率为至少20兆赫兹（MHz）的超声信号。信号处理可以进一步从采集的超声信号产生超声图像。换能器可以是线性阵列换能器，相控阵换能器，二维（2-D）阵列换能器或曲线阵列换能器。

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