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1. 发明申请

WO9932418A8 IMPROVED METHOD FOR MAKING A METAL MATRIX COMPOSITE BODY BY AN INFILTRATION PROCESS 审中-公开
标题翻译：渗透法制备金属基复合材料体的改进方法
公开(公告)号：WO9932418A8
公开(公告)日：1999-10-14
申请号：PCT/US9826948
申请日：1998-12-18
申请人： LANXIDE TECHNOLOGY CO LTD , SCHIROKY GERHARD HANS , FISCHER WILLIAM , AGHAJANIAN MICHAEL K , WIENER ROBERT
发明人： SCHIROKY GERHARD HANS , FISCHER WILLIAM , AGHAJANIAN MICHAEL K , WIENER ROBERT
IPC分类号： C04B41/51 , C04B41/88 , C22C1/10
CPC分类号： C04B41/009 , C04B41/5155 , C04B41/88 , C22C1/1036 , C22C2001/1063 , C04B41/4523 , C04B35/10 , C04B38/00
摘要： Improvements in processing metal matrix composite materials by infiltration are disclosed. Specifically, a permeable mass comprising a preform or bedding material is provided to an infiltration setup in addition to that being the objective of the infiltration. The additional preform or bed is itself infiltrated at least at some point during processing to produce an additional, e.g., "sacrificial" MMC body. This sacrificial MMC reduces the amount that the carcass of matrix metal may shrink during cooling which in turn reduces the stress on and warping induced in the objective preform. The second or additional bed or preform is termed a "sacrificial" bed or sacrificial preform. The sacrificial bed or preform may be disposed between the object preform and the body of matrix metal, or opposite the body of matrix metal from the object preform, or both. The sacrificial MMC may be reused in subsequent infiltration setups to produce additional infiltrations of objective preforms. Further, a separation facilitator may be disposed between the objective preform and the sacrificial bedding/preform/MMC to assist in the recovery of the desired MMC body following infiltration and solidification of matrix metal.
摘要翻译：公开了通过渗透处理金属基质复合材料的改进。具体而言，除了作为渗透的目的之外，还向浸润装置提供包含预制品或衬垫材料的可渗透物质。至少在处理过程中的某一时刻，附加的预制件或床自身渗透，以产生另外的，例如“牺牲”MMC体。这种牺牲MMC降低了冷却过程中基体金属的骨架可能收缩的量，这又减少了目标预制件上的应力和翘曲。第二个或另外的床或预制件被称为“牺牲”床或牺牲预制件。牺牲床或预制件可以设置在目标预制件和基体金属体之间，或者与目标预制件的基体金属体相对，或两者。牺牲MMC可以在随后的渗透装置中重复使用，以产生目标预成型件的额外渗透。此外，分离促进剂可以设置在目标预成型件和牺牲衬垫/预成型件/ MMC之间，以在基体金属渗透和固化之后帮助恢复期望的MMC主体。

2. 发明申请

WO2010019262A2 POLYVALENT VACCINE 审中-公开
标题翻译：多价疫苗
公开(公告)号：WO2010019262A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/004664
申请日：2009-08-14
申请人： LOS ALAMOS NATIONAL SECURITY, LLC , BETH ISRAEL DEACONNESS MEDICAL CENTER , DUKE UNIVERSITY , THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION , KORBER, Bette, T. , FISCHER, William , LETVIN, Norman , LIAO, Hua-xin , HAYNES, Barton, F. , HAHN, Beatrice, H.
发明人： KORBER, Bette, T. , FISCHER, William , LETVIN, Norman , LIAO, Hua-xin , HAYNES, Barton, F. , HAHN, Beatrice, H.
IPC分类号： C07K14/155 , C12N15/49 , A61K39/21
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24143 , C12N2740/16022 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译：本发明一般涉及免疫原性组合物（例如疫苗），特别涉及多价免疫原性组合物，例如多价HIV疫苗，以及使用它们的方法。本发明还涉及使用遗传算法来产生适合于例如疫苗接种策略中使用的多价抗原组的方法。

3. 发明申请

WO2007024941A3 POLYVALENT VACCINE 审中-公开
标题翻译：多价疫苗
公开(公告)号：WO2007024941A3
公开(公告)日：2010-01-28
申请号：PCT/US2006032907
申请日：2006-08-23
申请人： UNIV CALIFORNIA , BETH ISRAEL DEACONNESS MEDICAL , UNIV DUKE , UNIV ALABAMA RES FOUND , KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
发明人： KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
IPC分类号： A61K39/21 , A61K38/00 , A61K39/00 , A61K39/12
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译：本发明通常涉及免疫原性组合物（例如疫苗），并且特别涉及多价免疫原性组合物，例如多价HIV疫苗，以及使用其的方法。本发明进一步涉及使用遗传算法来产生适用于例如疫苗接种策略的多价抗原组的方法。

4. 发明申请

WO2007024941A2 POLYVALENT VACCINE 审中-公开
标题翻译：多价疫苗
公开(公告)号：WO2007024941A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032907
申请日：2006-08-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BETH ISRAEL DEACONNESS MEDICAL CENTER , DUKE UNIVERSITY , THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION , KORBER, Bette, T. , PERKINS, Simon , BHATTACHARYA, Tanmoy , FISCHER, William, M. , THEILER, James , LETVIN, Norman , HAYNES, Barton, F. , HAHN, Beatrice, H. , YUSIM, Karina , KUIKEN, Carla
发明人： KORBER, Bette, T. , PERKINS, Simon , BHATTACHARYA, Tanmoy , FISCHER, William, M. , THEILER, James , LETVIN, Norman , HAYNES, Barton, F. , HAHN, Beatrice, H. , YUSIM, Karina , KUIKEN, Carla
IPC分类号： A61K48/00
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译：本发明一般涉及免疫原性组合物（例如疫苗），特别涉及多价免疫原性组合物，例如多价HIV疫苗，以及使用它们的方法。本发明还涉及使用遗传算法来产生适合于例如疫苗接种策略中使用的多价抗原组的方法。

5. 发明申请

WO2010059732A1 ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY 审中-公开
标题翻译：具有改善的细胞免疫原性的抗真菌药
公开(公告)号：WO2010059732A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064999
申请日：2009-11-18
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER , LOS ALAMOS NATIONAL LABORATORY , BAROUCH, Dan, H. , KORBER, Bette, T. , FISCHER, William, M.
发明人： BAROUCH, Dan, H. , KORBER, Bette, T. , FISCHER, William, M.
IPC分类号： C07K17/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent ( e.g. , 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
摘要翻译：本发明提供用于治疗或预防病毒感染的组合物，方法和试剂盒。本文所述的多价（例如2价）疫苗引入计算优化的病毒多肽，其可以增加接种受试者的细胞免疫应答的多样性或广度和深度。

6. 发明申请

WO2012012411A3 AUTOMATED SYSTEMS FOR REMOVING TISSUE SAMPLES FROM SEEDS, AND RELATED METHODS 审中-公开
标题翻译：用于从种子中去除组织样品的自动化系统及相关方法
公开(公告)号：WO2012012411A3
公开(公告)日：2012-05-24
申请号：PCT/US2011044514
申请日：2011-07-19
申请人： MONSANTO TECHNOLOGY LLC , DEPPERMANN KEVIN L , PETERSEN MICHAEL W , ONDES ALLEN N , FINLEY DAVID W , FISCHER WILLIAM M , JENSEN JOHN M , BUTRUILLE DAVID , DOTSON STANTON , EATHINGTON SAM , FORBES HEATHER M , SCHNICKER BRUCE , TAMULONIS JOHN
发明人： DEPPERMANN KEVIN L , PETERSEN MICHAEL W , ONDES ALLEN N , FINLEY DAVID W , FISCHER WILLIAM M , JENSEN JOHN M , BUTRUILLE DAVID , DOTSON STANTON , EATHINGTON SAM , FORBES HEATHER M , SCHNICKER BRUCE , TAMULONIS JOHN
IPC分类号： A01C1/00 , G01N1/00 , G01N1/08
CPC分类号： G01N35/00584 , A01C1/00 , A01C1/025 , G01N1/04 , G01N1/20 , G01N1/286 , G01N33/0098 , G01N33/5097 , G01N2001/002
摘要： A seed sampling system is provided having an automated seed loading assembly including a seed bin and being operable to singulate seeds from a plurality of seeds within the seed bin. The system also includes an automated seed sampling assembly operable to remove tissue samples from the singulated seeds, and an automated seed transport assembly operable to transfer the singulated seeds from the seed loading assembly to the seed sampling assembly. The seed transport assembly includes multiple retention members. Each of the retention members is movable relative to the seed loading assembly and to the seed sampling assembly. The seed transport assembly is operable to position one of the multiple retention members adjacent to the seed loading assembly for engaging one of the singulated seeds, while positioning another of the retention members adjacent to the seed sampling assembly for presenting another of the singulated seeds to the seed sampling assembly.
摘要翻译：提供种子采样系统，其具有包括种子仓的自动种子加载组件，并且可操作以从种子仓内的多个种子中分离种子。该系统还包括可操作以从单个种子中去除组织样本的自动种子采样组件，以及可操作以将单种化种子从种子装载组件转移到种子取样组件的自动种子运输组件。种子运输组件包括多个保持构件。每个保持构件可相对于种子装载组件和种子取样组件移动。种子运输组件可操作以将多个保持构件中的一个定位成与种子装载组件相邻以接合单个种子之一，同时将另一个保持构件定位成与种子取样组件相邻，以将另一个单个种子呈现到种子采样总成。

7. 发明申请

WO2010042817A1 USE OF HIV MOSAIC ENVELOPE PROTEINS TO OPTIMIZE T-CELL RESPONSES AGAINST HIV ENVELOPE 审中-公开
标题翻译：使用艾滋病毒弥漫性包膜蛋白来优化抗艾滋病毒感染的T细胞应答
公开(公告)号：WO2010042817A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060167
申请日：2009-10-09
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , Los Alamos National Security, LLC , NABEL, Gary J. , KONG, Wing-pui , WU, Lan , KORBER, Bette , FISCHER, William M.
发明人： NABEL, Gary J. , KONG, Wing-pui , WU, Lan , KORBER, Bette , FISCHER, William M.
IPC分类号： A61K39/21 , A61K39/295 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N2740/16134
摘要： The invention is directed to a nucleic acid sequence encoding a HIV-1 Env polypeptide comprising an insertion of at least one T-cell epitope that is not naturally present in the Env polypeptide, as well as a method of making the nucleic acid sequence. The invention also provides a method of inducing an immune response against HIV-1 in a mammal.
摘要翻译：本发明涉及编码HIV-1 Env多肽的核酸序列，其包含插入至少一种不天然存在于Env多肽中的T细胞表位，以及制备该核酸序列的方法。本发明还提供在哺乳动物中诱导针对HIV-1的免疫应答的方法。

8. 发明申请

WO2012012411A2 AUTOMATED SYSTEMS FOR REMOVING TISSUE SAMPLES FROM SEEDS, AND RELATED METHODS 审中-公开
标题翻译：用于从种子去除组织样本的自动化系统及相关方法
公开(公告)号：WO2012012411A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/044514
申请日：2011-07-19
申请人： MONSANTO TECHNOLOGY LLC , DEPPERMANN, Kevin, L. , PETERSEN, Michael, W. , ONDES, Allen, N. , FINLEY, David, W. , FISCHER, William, M. , JENSEN, John, M. , BUTRUILLE, David , DOTSON, Stanton , EATHING, Sam , FORBES, Heather, M. , SCHNICKER, Bruce , TAMULONIS, John
发明人： DEPPERMANN, Kevin, L. , PETERSEN, Michael, W. , ONDES, Allen, N. , FINLEY, David, W. , FISCHER, William, M. , JENSEN, John, M. , BUTRUILLE, David , DOTSON, Stanton , EATHING, Sam , FORBES, Heather, M. , SCHNICKER, Bruce , TAMULONIS, John
IPC分类号： A01C1/00 , G01N1/00 , G01N1/08
CPC分类号： G01N35/00584 , A01C1/00 , A01C1/025 , G01N1/04 , G01N1/20 , G01N1/286 , G01N33/0098 , G01N33/5097 , G01N2001/002
摘要： A seed sampling system is provided having an automated seed loading assembly including a seed bin and being operable to singulate seeds from a plurality of seeds within the seed bin. The system also includes an automated seed sampling assembly operable to remove tissue samples from the singulated seeds, and an automated seed transport assembly operable to transfer the singulated seeds from the seed loading assembly to the seed sampling assembly. The seed transport assembly includes multiple retention members. Each of the retention members is movable relative to the seed loading assembly and to the seed sampling assembly. The seed transport assembly is operable to position one of the multiple retention members adjacent to the seed loading assembly for engaging one of the singulated seeds, while positioning another of the retention members adjacent to the seed sampling assembly for presenting another of the singulated seeds to the seed sampling assembly.
摘要翻译：提供了一种种子采样系统，其具有包括种子箱的自动化种子装载组件，并且可操作以从种子箱内的多个种子中分拣种子。该系统还包括可操作以从分拣出的种子移除组织样本的自动化种子取样组件以及可操作以将分拣出的种子从种子装载组件转移到种子取样组件的自动化种子传送组件。种子传送组件包括多个保持构件。每个保持构件可相对于种子加载组件和种子采样组件移动。所述种子传送组件可操作以将所述多个保持部件中的一个邻近所述种子装载组件定位以用于接合所述单个化种子中的一个，同时将所述保持部件中的另一个定位成邻近于所述种子采样组件以用于将所述单个化种子中的另一个呈递给种子采样组件。

9. 发明申请

WO2012006572A1 METHOD AND SYSTEM FOR SELECTION OF FOODSTUFFS 审中-公开
标题翻译：食品选择的方法和系统
公开(公告)号：WO2012006572A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/043429
申请日：2011-07-08
申请人： FISHER PRINTING, INC. , FISCHER, William
发明人： FISCHER, William
IPC分类号： G06Q30/00
CPC分类号： G06Q50/12 , G06Q30/0601 , G06Q30/0603 , G06Q30/0621 , G06Q30/0641 , G06Q30/0643
摘要： A method and system for online selection of ingredients and/or use with the selection of a prepared foodstuff supplied by a food vendor is provided. The present invention utilizes an online grid system which lists the toppings and/or ingredients which can be included in any particular food item. The grid has a plurality of columns which includes icons with particular food items and allows the consumer to visually indicate the inclusion of specific food ingredients in their food choices. Additionally, the columns allow the individual consumer to determine the amounts of each ingredient to be included in the preparation of a food item and may also include information relating to directing the food vendor where to locate the particular ingredient, such as including only one ingredient on only a part of a foodstuff, for example, a pizza.
摘要翻译：提供了用于在线选择成分和/或用于选择由食品供应商提供的制备的食品的方法和系统。本发明利用在线网格系统，其列出可以包括在任何特定食品中的浇头和/或成分。网格具有多个列，其包括具有特定食品的图标，并允许消费者在其食物选择中可视地指示特定食物成分的包含。此外，列允许个体消费者确定要包括在食品制备中的每种成分的量，并且还可以包括关于指导食品供应商在哪里定位特定成分的信息，例如仅包括一种成分只是食物的一部分，例如比萨饼。

10. 发明申请

WO2012006567A1 DYNAMIC WEBSITE BUILDING SYSTEM 审中-公开
标题翻译：动态网站建设系统
公开(公告)号：WO2012006567A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/043421
申请日：2011-07-08
申请人： FISHER PRINTING, INC. , FISCHER, William
发明人： FISCHER, William
IPC分类号： G06F17/00
CPC分类号： G06F17/2247 , G06F3/0481 , G06F3/0484 , G06F17/248 , G06F17/30864 , G06F17/3089
摘要： A dynamically integrated website that allows for collection of web page templates and themes to be used in the development of an individual or business website is provided. The system allows for use of a plurality of different colors, images, and text within the website development and checks for availability of any particular domain name through a customizable search mechanism. The system also maintains a database having a plurality of image libraries with the ability for the individual user to choose stored images, texts and the like, and the ability to download and/or upload customized text, images, and other data to the system for integration into the website. Moreover, the system may add title tag and metatag information to help search engine keyword searches during development of the website. Additionally, the system may have a online support portion whereby support tickets may be utilized to help individual system users. The system may also utilize an online live chat help mechanism allowing for individualized help in the creation of the customized website.
摘要翻译：提供了一个动态集成的网站，允许收集用于个人或商业网站开发中使用的网页模板和主题。该系统允许在网站开发中使用多种不同的颜色，图像和文本，并通过可定制的搜索机制检查任何特定域名的可用性。该系统还维护具有多个图像库的数据库，其具有个体用户选择存储的图像，文本等的能力，以及将定制的文本，图像和其他数据下载和/或上传到系统的能力，融入网站。此外，该系统可以添加标题标签和元标签信息，以帮助在开发网站期间搜索引擎关键词搜索。此外，系统可以具有在线支持部分，由此可以利用支持票据来帮助个体系统用户。该系统还可以利用在线在线聊天帮助机制，允许个性化的帮助来创建定制的网站。

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