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1. 发明申请

WO2007024941A3 POLYVALENT VACCINE 审中-公开
标题翻译：多价疫苗
公开(公告)号：WO2007024941A3
公开(公告)日：2010-01-28
申请号：PCT/US2006032907
申请日：2006-08-23
申请人： UNIV CALIFORNIA , BETH ISRAEL DEACONNESS MEDICAL , UNIV DUKE , UNIV ALABAMA RES FOUND , KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
发明人： KORBER BETTE T , PERKINS SIMON , BHATTACHARYA TANMOY , FISCHER WILLIAM M , THEILER JAMES , LETVIN NORMAN , HAYNES BARTON F , HAHN BEATRICE H , YUSIM KARINA , KUIKEN CARLA
IPC分类号： A61K39/21 , A61K38/00 , A61K39/00 , A61K39/12
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译：本发明通常涉及免疫原性组合物（例如疫苗），并且特别涉及多价免疫原性组合物，例如多价HIV疫苗，以及使用其的方法。本发明进一步涉及使用遗传算法来产生适用于例如疫苗接种策略的多价抗原组的方法。

2. 发明申请

WO2007024941A2 POLYVALENT VACCINE 审中-公开
标题翻译：多价疫苗
公开(公告)号：WO2007024941A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032907
申请日：2006-08-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BETH ISRAEL DEACONNESS MEDICAL CENTER , DUKE UNIVERSITY , THE UNIVERSITY OF ALABAMA AT BIRMINGHAM RESEARCH FOUNDATION , KORBER, Bette, T. , PERKINS, Simon , BHATTACHARYA, Tanmoy , FISCHER, William, M. , THEILER, James , LETVIN, Norman , HAYNES, Barton, F. , HAHN, Beatrice, H. , YUSIM, Karina , KUIKEN, Carla
发明人： KORBER, Bette, T. , PERKINS, Simon , BHATTACHARYA, Tanmoy , FISCHER, William, M. , THEILER, James , LETVIN, Norman , HAYNES, Barton, F. , HAHN, Beatrice, H. , YUSIM, Karina , KUIKEN, Carla
IPC分类号： A61K48/00
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , C12N2740/16034
摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.
摘要翻译：本发明一般涉及免疫原性组合物（例如疫苗），特别涉及多价免疫原性组合物，例如多价HIV疫苗，以及使用它们的方法。本发明还涉及使用遗传算法来产生适合于例如疫苗接种策略中使用的多价抗原组的方法。

3. 发明申请

WO2012012411A3 AUTOMATED SYSTEMS FOR REMOVING TISSUE SAMPLES FROM SEEDS, AND RELATED METHODS 审中-公开
标题翻译：用于从种子中去除组织样品的自动化系统及相关方法
公开(公告)号：WO2012012411A3
公开(公告)日：2012-05-24
申请号：PCT/US2011044514
申请日：2011-07-19
申请人： MONSANTO TECHNOLOGY LLC , DEPPERMANN KEVIN L , PETERSEN MICHAEL W , ONDES ALLEN N , FINLEY DAVID W , FISCHER WILLIAM M , JENSEN JOHN M , BUTRUILLE DAVID , DOTSON STANTON , EATHINGTON SAM , FORBES HEATHER M , SCHNICKER BRUCE , TAMULONIS JOHN
发明人： DEPPERMANN KEVIN L , PETERSEN MICHAEL W , ONDES ALLEN N , FINLEY DAVID W , FISCHER WILLIAM M , JENSEN JOHN M , BUTRUILLE DAVID , DOTSON STANTON , EATHINGTON SAM , FORBES HEATHER M , SCHNICKER BRUCE , TAMULONIS JOHN
IPC分类号： A01C1/00 , G01N1/00 , G01N1/08
CPC分类号： G01N35/00584 , A01C1/00 , A01C1/025 , G01N1/04 , G01N1/20 , G01N1/286 , G01N33/0098 , G01N33/5097 , G01N2001/002
摘要： A seed sampling system is provided having an automated seed loading assembly including a seed bin and being operable to singulate seeds from a plurality of seeds within the seed bin. The system also includes an automated seed sampling assembly operable to remove tissue samples from the singulated seeds, and an automated seed transport assembly operable to transfer the singulated seeds from the seed loading assembly to the seed sampling assembly. The seed transport assembly includes multiple retention members. Each of the retention members is movable relative to the seed loading assembly and to the seed sampling assembly. The seed transport assembly is operable to position one of the multiple retention members adjacent to the seed loading assembly for engaging one of the singulated seeds, while positioning another of the retention members adjacent to the seed sampling assembly for presenting another of the singulated seeds to the seed sampling assembly.
摘要翻译：提供种子采样系统，其具有包括种子仓的自动种子加载组件，并且可操作以从种子仓内的多个种子中分离种子。该系统还包括可操作以从单个种子中去除组织样本的自动种子采样组件，以及可操作以将单种化种子从种子装载组件转移到种子取样组件的自动种子运输组件。种子运输组件包括多个保持构件。每个保持构件可相对于种子装载组件和种子取样组件移动。种子运输组件可操作以将多个保持构件中的一个定位成与种子装载组件相邻以接合单个种子之一，同时将另一个保持构件定位成与种子取样组件相邻，以将另一个单个种子呈现到种子采样总成。

4. 发明申请

WO2010042817A1 USE OF HIV MOSAIC ENVELOPE PROTEINS TO OPTIMIZE T-CELL RESPONSES AGAINST HIV ENVELOPE 审中-公开
标题翻译：使用艾滋病毒弥漫性包膜蛋白来优化抗艾滋病毒感染的T细胞应答
公开(公告)号：WO2010042817A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060167
申请日：2009-10-09
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , Los Alamos National Security, LLC , NABEL, Gary J. , KONG, Wing-pui , WU, Lan , KORBER, Bette , FISCHER, William M.
发明人： NABEL, Gary J. , KONG, Wing-pui , WU, Lan , KORBER, Bette , FISCHER, William M.
IPC分类号： A61K39/21 , A61K39/295 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C12N2740/16134
摘要： The invention is directed to a nucleic acid sequence encoding a HIV-1 Env polypeptide comprising an insertion of at least one T-cell epitope that is not naturally present in the Env polypeptide, as well as a method of making the nucleic acid sequence. The invention also provides a method of inducing an immune response against HIV-1 in a mammal.
摘要翻译：本发明涉及编码HIV-1 Env多肽的核酸序列，其包含插入至少一种不天然存在于Env多肽中的T细胞表位，以及制备该核酸序列的方法。本发明还提供在哺乳动物中诱导针对HIV-1的免疫应答的方法。

5. 发明申请

WO2010059732A1 ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY 审中-公开
标题翻译：具有改善的细胞免疫原性的抗真菌药
公开(公告)号：WO2010059732A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/064999
申请日：2009-11-18
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER , LOS ALAMOS NATIONAL LABORATORY , BAROUCH, Dan, H. , KORBER, Bette, T. , FISCHER, William, M.
发明人： BAROUCH, Dan, H. , KORBER, Bette, T. , FISCHER, William, M.
IPC分类号： C07K17/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/235 , A61K39/275 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10343 , C12N2710/24043 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , Y02A50/467
摘要： The invention provides compositions, methods, and kits for the treatment or prevention of viral infections. The polyvalent ( e.g. , 2-valent) vaccines described herein incorporate computationally-optimized viral polypeptides that can increase the diversity or breadth and depth of cellular immune response in vaccinated subjects.
摘要翻译：本发明提供用于治疗或预防病毒感染的组合物，方法和试剂盒。本文所述的多价（例如2价）疫苗引入计算优化的病毒多肽，其可以增加接种受试者的细胞免疫应答的多样性或广度和深度。

6. 发明申请

WO2012012411A2 AUTOMATED SYSTEMS FOR REMOVING TISSUE SAMPLES FROM SEEDS, AND RELATED METHODS 审中-公开
标题翻译：用于从种子去除组织样本的自动化系统及相关方法
公开(公告)号：WO2012012411A2
公开(公告)日：2012-01-26
申请号：PCT/US2011/044514
申请日：2011-07-19
申请人： MONSANTO TECHNOLOGY LLC , DEPPERMANN, Kevin, L. , PETERSEN, Michael, W. , ONDES, Allen, N. , FINLEY, David, W. , FISCHER, William, M. , JENSEN, John, M. , BUTRUILLE, David , DOTSON, Stanton , EATHING, Sam , FORBES, Heather, M. , SCHNICKER, Bruce , TAMULONIS, John
发明人： DEPPERMANN, Kevin, L. , PETERSEN, Michael, W. , ONDES, Allen, N. , FINLEY, David, W. , FISCHER, William, M. , JENSEN, John, M. , BUTRUILLE, David , DOTSON, Stanton , EATHING, Sam , FORBES, Heather, M. , SCHNICKER, Bruce , TAMULONIS, John
IPC分类号： A01C1/00 , G01N1/00 , G01N1/08
CPC分类号： G01N35/00584 , A01C1/00 , A01C1/025 , G01N1/04 , G01N1/20 , G01N1/286 , G01N33/0098 , G01N33/5097 , G01N2001/002
摘要： A seed sampling system is provided having an automated seed loading assembly including a seed bin and being operable to singulate seeds from a plurality of seeds within the seed bin. The system also includes an automated seed sampling assembly operable to remove tissue samples from the singulated seeds, and an automated seed transport assembly operable to transfer the singulated seeds from the seed loading assembly to the seed sampling assembly. The seed transport assembly includes multiple retention members. Each of the retention members is movable relative to the seed loading assembly and to the seed sampling assembly. The seed transport assembly is operable to position one of the multiple retention members adjacent to the seed loading assembly for engaging one of the singulated seeds, while positioning another of the retention members adjacent to the seed sampling assembly for presenting another of the singulated seeds to the seed sampling assembly.
摘要翻译：提供了一种种子采样系统，其具有包括种子箱的自动化种子装载组件，并且可操作以从种子箱内的多个种子中分拣种子。该系统还包括可操作以从分拣出的种子移除组织样本的自动化种子取样组件以及可操作以将分拣出的种子从种子装载组件转移到种子取样组件的自动化种子传送组件。种子传送组件包括多个保持构件。每个保持构件可相对于种子加载组件和种子采样组件移动。所述种子传送组件可操作以将所述多个保持部件中的一个邻近所述种子装载组件定位以用于接合所述单个化种子中的一个，同时将所述保持部件中的另一个定位成邻近于所述种子采样组件以用于将所述单个化种子中的另一个呈递给种子采样组件。

7. 发明申请

WO2007064734A1 METHOD, SYSTEM AND AIRCARFT FOR COMMUNICATING WITH AIR TRAFFIC CONTROL USING A PLURALITY OF DATA LINK STANDARDS 审中-公开
标题翻译：使用数据链接标准多样化进行空中交通管制的方法，系统和飞机
公开(公告)号：WO2007064734A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/045742
申请日：2006-11-29
申请人： THE BOEING COMPANY , SANDELL, Gordon, R. , LEE, Stephen, Y. , FISCHER, William, M. , CORNELL, Bradley, D.
发明人： SANDELL, Gordon, R. , LEE, Stephen, Y. , FISCHER, William, M. , CORNELL, Bradley, D.
IPC分类号： G08G5/00
CPC分类号： G08G5/0013
摘要： Systems and methods for communication using a plurality of data link standards through a common operator interface are disclosed. In one embodiment, the system includes components configured to select and establish communication with an air traffic control center using one of a plurality of data link standards. The system further includes components configured to format at least one downlink page to only allow appropriate data inputs based on one or more functionalities of the data link standard, and encode one or more entered data inputs based on the selected data link standard and transmit the inputs to the air traffic control center. In a particular embodiment, the system further includes a components configured to receive and display each of the decoded uplink data transmission in a text message on a corresponding uplink display page according to one or more message text conventions of the selected data link standard.
摘要翻译：公开了通过公共操作员接口使用多个数据链路标准的通信的系统和方法。在一个实施例中，系统包括被配置为使用多个数据链路标准之一来选择和建立与空中交通管制中心的通信的组件。该系统还包括被配置为格式化至少一个下行链路页面的组件，以仅基于数据链路标准的一个或多个功能来允许适当的数据输入，并且基于所选择的数据链路标准对一个或多个输入的数据输入进行编码，并且传送输入到空中交通管制中心。在特定实施例中，系统还包括被配置为根据所选择的数据链路标准的一个或多个消息文本约定在对应的上行链路显示页面上的文本消息中接收和显示每个解码的上行链路数据传输的组件。

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