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1. 发明申请

WO2012009568A3 ANTIBODY LIBRARIES 审中-公开
公开(公告)号：WO2012009568A3
公开(公告)日：2012-01-19
申请号：PCT/US2011/044063
申请日：2011-07-14
申请人： ADIMAB, LLC , VASQUEZ, Maximiliano , SIVASUBRAMANIAN, Arvind , FELDHAUS, Michael
发明人： VASQUEZ, Maximiliano , SIVASUBRAMANIAN, Arvind , FELDHAUS, Michael
IPC分类号： C40B30/04
摘要： Provided is a method that overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.

2. 发明申请

WO2012009568A2 ANTIBODY LIBRARIES 审中-公开
标题翻译：抗体图书馆
公开(公告)号：WO2012009568A2
公开(公告)日：2012-01-19
申请号：PCT/US2011044063
申请日：2011-07-14
申请人： ADIMAB LLC , VASQUEZ MAXIMILIANO , SIVASUBRAMANIAN ARVIND , FELDHAUS MICHAEL
发明人： VASQUEZ MAXIMILIANO , SIVASUBRAMANIAN ARVIND , FELDHAUS MICHAEL
IPC分类号： C40B30/04
CPC分类号： C12N15/1089 , C07K16/00 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08 , C40B50/02 , G01N33/543
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.
摘要翻译：本发明通过专门设计具有定向序列和长度多样性的文库来克服已知的用于产生抗体编码多核苷酸文库的方法中的不足之处。

3. 发明申请

WO2011140254A1 ANTIBODIES AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND USES THEREOF 审中-公开
标题翻译：抗生殖因子受体（EGFR）抗体及其用途
公开(公告)号：WO2011140254A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035238
申请日：2011-05-04
申请人： ADIMAB, LLC , BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric
发明人： BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K39/39558 , A61K2039/507 , C07K16/40 , C07K2317/21 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Anti- EGFR antibodies, therapeutic compositions comprising combinations of anti-EGFR antibodies, as well as methods for using such antibodies and compositions to treat EGFR-related disorders (e.g., cancers), are disclosed.
摘要翻译：公开了抗EGFR抗体，包含抗EGFR抗体组合的治疗组合物，以及使用这些抗体和组合物治疗EGFR相关病症（例如癌症）的方法。

4. 发明申请

WO2010105256A1 RATIONALLY DESIGNED, SYNTHETIC ANTIBODY LIBRARIES AND USES THEREFOR 审中-公开
标题翻译：方案设计，合成抗体库及其用途
公开(公告)号：WO2010105256A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/027312
申请日：2010-03-15
申请人： ADIMAB, INC. , VASQUEZ, Maximilliano , FELDHAUS, Michael , GERNGROSS, Tillman, U. , WITTRUP, K., Dane
发明人： VASQUEZ, Maximilliano , FELDHAUS, Michael , GERNGROSS, Tillman, U. , WITTRUP, K., Dane
IPC分类号： C07K16/00
CPC分类号： C12N15/1093 , C07K16/00 , C07K16/005 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/08
摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system, with or without DH segments derived from other species, and are based on rational design informed by examination of publicly available databases of antibody sequences.
摘要翻译：本发明通过专门设计具有定向序列和长度多样性的文库来克服已知的用于产生抗体编码多核苷酸文库的方法中的不足之处。图书馆的设计旨在反映人类免疫系统自然产生的免疫缺陷文库，具有或不具有衍生自其他物种的DH片段，并且基于通过检查可公开获得的抗体序列数据库而获得的合理设计。

5. 发明申请

WO1998026098A1 METHODS FOR MEASURING RELATIVE AMOUNTS OF NUCLEIC ACIDS IN A COMPLEX MIXTURE AND RETRIEVAL OF SPECIFIC SEQUENCES THEREFROM 审中-公开
标题翻译：用于测量复合混合物中核酸相对量的方法和其特异性序列的检索
公开(公告)号：WO1998026098A1
公开(公告)日：1998-06-18
申请号：PCT/US1997023173
申请日：1997-12-12
申请人： VENTANA GENETICS, INC. , KAMB, Alexander , FELDHAUS, Michael, John
发明人： VENTANA GENETICS, INC.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6809 , C12N15/1065 , C12N15/1075 , C12Q2545/114 , C12Q2563/149 , C12Q2565/514 , C12Q2565/515
摘要： The present invention relates to a method for the comparative assessment of the level of specific nucleic acid sequences in samples derived from different sources. More specifically, the invention relates to a method using oligonucleotides covalently linked to a solid support, such as beads, to isolate specific labeled nucleic acid sequences from complex mixtures. The methods disclosed allow quantitative comparisons of the amount of nucleic acid of defined sequence in a plurality of different samples of nucleic acid, e.g., from different cells or tissues or from genetic libraries. Nucleic acids from the samples are labeled in such a fashion that the signals can be distinguished and compared following hybridization to the oligonucleotides on the beads. According to the invention, the solid supports with the hybridized nucleic acid may be retrieved, and the target nucleic acid eluted and analyzed. Furthermore, the invention provides a method for tagging individual clones from a cDNA library such that they can be identified uniquely and retrieved by hybridization to specific beads.
摘要翻译：本发明涉及用于比较来自不同来源的样品中特异性核酸序列水平的比较评估方法。更具体地，本发明涉及使用与固体支持物（例如珠）共价连接的寡核苷酸以从复杂混合物中分离特异性标记的核酸序列的方法。所公开的方法允许定义的序列的核酸量在多个不同的核酸样品中，例如来自不同的细胞或组织或来自遗传图谱库的定量比较。来自样品的核酸以这样的方式进行标记，即在与珠上的寡核苷酸杂交后可以区分和比较信号。根据本发明，可以检索具有杂交核酸的固体支持物，并洗脱和分析靶核酸。此外，本发明提供了一种用于从cDNA文库标记单个克隆的方法，使得它们可以被独特地鉴定并通过与特定珠子的杂交获得。

6. 发明申请

WO2009036379A3 RATIONALLY DESIGNED, SYNTHETIC ANTIBODY LIBRARIES AND USES THEREFOR 审中-公开
标题翻译：方案设计，合成抗体库及其用途
公开(公告)号：WO2009036379A3
公开(公告)日：2009-08-13
申请号：PCT/US2008076300
申请日：2008-09-12
申请人： ADIMAB INC , VASQUEZ MAXIMILIANO , FELDHAUS MICHAEL , GERNGROSS TILLMAN U , WITTRUP K DANE
发明人： VASQUEZ MAXIMILIANO , FELDHAUS MICHAEL , GERNGROSS TILLMAN U , WITTRUP K DANE
IPC分类号： C07K16/00 , C12N15/13
CPC分类号： C07K16/18 , C07K16/005 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C40B40/10
摘要： Procedure to overcome the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity. The libraries are designed to reflect the preimmune repertoire naturally created by the human immune system and are based on rational design informed by examination of publicly available databases of human antibody sequences.
摘要翻译：通过专门设计具有定向序列和长度多样性的文库来克服用于产生抗体编码多核苷酸文库的已知方法中固有的不足之处。这些图书馆旨在反映由人类免疫系统自然产生的免疫缺陷文库，并且基于通过检查公开可得到的人抗体序列数据库的合理设计。

7. 发明申请

WO2013006547A3 ANTIBODIES AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND USES THEREOF 审中-公开
公开(公告)号：WO2013006547A3
公开(公告)日：2013-01-10
申请号：PCT/US2012/045235
申请日：2012-07-02
申请人： MERRIMACK PHARMACEUTICALS, INC. , ADIMAB, LLC , BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric , KEARNS, Jeffrey, David , LUGOVSKOY, Alexey, A. , NIELSEN, Ulrik
发明人： BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric , KEARNS, Jeffrey, David , LUGOVSKOY, Alexey, A. , NIELSEN, Ulrik
IPC分类号： A61K39/395 , C07K14/71 , C07K16/28
摘要： Anti- EGFR antibodies, therapeutic compositions comprising combinations of anti-EGFR antibodies, as well as methods for using such antibodies and compositions to treat EGFR-related disorders (e.g., cancers), are disclosed.

8. 发明申请

WO2011022727A2 ANTIBODIES AGAINST THE ECTODOMAIN OF ERBB3 AND USES THEREOF 审中-公开
标题翻译：抗体对ERBB3的ECTODOMAIN及其用途
公开(公告)号：WO2011022727A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/046364
申请日：2010-08-23
申请人： MERRIMACK PHARMACEUTICALS, INC. , SCHOEBERL, Birgit , NIELSEN, Ulrik , FELDHAUS, Michael
发明人： SCHOEBERL, Birgit , NIELSEN, Ulrik , FELDHAUS, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention provides a novel class of antibodies and antigen binding fragments thereof that bind the extracellular domain of ErbB3 receptor and inhibit various ErbB3 functions. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor. Such antibodies and antigen binding fragments thereof have the useful characteristic of inhibiting the proliferation of cancer cells expressing ErbB3.
摘要翻译：本发明提供了结合ErbB3受体的细胞外结构域并抑制各种ErbB3功能的新一类抗体及其抗原结合片段。例如，本文所述的抗体和抗原结合片段能够结合称为ErbB3的受体并抑制受体的EGF样配体介导的磷酸化。这些抗体及其抗原结合片段具有抑制表达ErbB3的癌细胞增殖的有用特征。

9. 发明申请

WO2010059315A1 HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF 审中-公开
标题翻译：人血清白蛋白连接体及其结合位点
公开(公告)号：WO2010059315A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/060721
申请日：2009-10-14
申请人： MERRIMACK PHARMACEUTICALS, INC. , MCDONAGH, Charlotte , FELDHAUS, Michael , HUHALOV, Alexandra
发明人： MCDONAGH, Charlotte , FELDHAUS, Michael , HUHALOV, Alexandra
IPC分类号： C07K14/76 , A61K38/38
CPC分类号： C07K16/32 , A61K38/00 , A61K2039/505 , C07K14/765 , C07K16/2863 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/94 , C07K2319/31 , C07K2319/74
摘要： Disclosed is a human serum albumin (HSA) linker and HSA linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the HSA linker is covalently bonded to amino and carboxy terminal binding moieties that are first and second single-chain Fv molecules (scFvs). Exemplified conjugates are useful, e.g., in reducing tumor cell proliferation, e.g., for therapeutic therapeutic applications. Also disclosed are methods and kits for the diagnostic and therapeutic application of an HSA linker conjugate.
摘要翻译：披露了与其结合的结合，诊断和治疗剂的人血清白蛋白（HSA）接头和HSA接头。还公开了缀合物，其中HSA接头共价键合到作为第一和第二单链Fv分子（scFv）的氨基和羧基末端结合部分。示例性缀合物可用于例如减少肿瘤细胞增殖，例如用于治疗性治疗应用。还公开了用于诊断和治疗应用HSA接头缀合物的方法和试剂盒。

10. 发明申请

WO2009126920A3 HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF 审中-公开
标题翻译：人血清白蛋白连接体及其结合位点
公开(公告)号：WO2009126920A3
公开(公告)日：2010-03-18
申请号：PCT/US2009040259
申请日：2009-04-10
申请人： MERRIMACK PHARMACEUTICALS INC , MCDONAGH CHARLOTTE , FELDHAUS MICHAEL , HUHALOV ALEXANDRA
发明人： MCDONAGH CHARLOTTE , FELDHAUS MICHAEL , HUHALOV ALEXANDRA
IPC分类号： C12P21/04
CPC分类号： C07K16/32 , A61K2039/505 , A61K2039/545 , C07K14/765 , C07K2317/31 , C07K2317/622 , C07K2319/31
摘要： The present invention relates to a human serum albumin (HSA) linker and binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed are methods and kits for the diagnostic and therapeutic application of an HSA linker conjugate.
摘要翻译：本发明涉及人血清白蛋白（HSA）接头和与其缀合的结合，诊断和治疗剂。还公开了用于诊断和治疗应用HSA接头缀合物的方法和试剂盒。

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