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1. 发明申请

WO2011146902A9 BI-SPECIFIC FUSION PROTEINS 审中-公开
公开(公告)号：WO2011146902A9
公开(公告)日：2011-11-24
申请号：PCT/US2011/037459
申请日：2011-05-20
申请人： MERRIMACK PHARMACEUTICALS, INC. , NIELSEN, Ulrik , WICKHAM, Thomas , SCHOEBERL, Birgit , HARMS, Brian , LINGGI, Bryan , ONSUM, Matthew , DELABARRE, Byron , LIPPOW, Shaun, M.
发明人： NIELSEN, Ulrik , WICKHAM, Thomas , SCHOEBERL, Birgit , HARMS, Brian , LINGGI, Bryan , ONSUM, Matthew , DELABARRE, Byron , LIPPOW, Shaun, M.
IPC分类号： C12N15/62
摘要： Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

2. 发明申请

WO2010019952A2 METHODS, SYSTEMS AND PRODUCTS FOR PREDICTING RESPONSE OF TUMOR CELLS TO A THERAPEUTIC AGENT AND TREATING A PATIENT ACCORDING TO THE PREDICTED RESPONSE 审中-公开
标题翻译：肿瘤细胞对治疗药物的预测反应的方法，系统和产品，并根据预测的反应治疗患者
公开(公告)号：WO2010019952A2
公开(公告)日：2010-02-18
申请号：PCT/US2009/054051
申请日：2009-08-17
申请人： MERRIMACK PHARMACEUTICALS, INC. , SCHOEBERL, Birgit , HARMS, Brian , GIBBONS, Francis, David , FITZGERALD, Jonathan, Basil , ONSUM, Matthew, David , NIELSEN, Ulrik , KUBASEK, William
发明人： SCHOEBERL, Birgit , HARMS, Brian , GIBBONS, Francis, David , FITZGERALD, Jonathan, Basil , ONSUM, Matthew, David , NIELSEN, Ulrik , KUBASEK, William
IPC分类号： C12Q1/68 , C07K16/32
CPC分类号： G01N33/6893 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/31 , C12Q1/6809
摘要： The invention provides methods for treating patients which methods comprise methods for predicting responses of cells, such as tumor cells, to treatment with therapeutic agents. These methods involve measuring, in a sample of the cells, levels of one or more components of a cellular network and then computing a Network Activation State (NAS) or a Network Inhibition State (NIS) for the cells using a computational model of the cellular network. The response of the cells to treatment is then predicted based on the NAS or NIS value that has been computed. The invention also comprises predictive methods for cellular responsiveness in which computation of a NAS or NIS value for the cells (e.g., tumor cells) is combined with use of a statistical classification algorithm. Biomarkers for predicting responsiveness to treatment with a therapeutic agent that targets a component within the ErbB signaling pathway are also provided.
摘要翻译：本发明提供了治疗患者的方法，所述方法包括用于预测细胞如肿瘤细胞的应答的方法用于治疗剂的治疗。这些方法包括在细胞样本中测量蜂窝网络的一个或多个组分的水平，然后使用细胞的计算模型计算细胞的网络激活状态（NAS）或网络抑制状态（NIS）网络。然后基于已经计算的NAS或NIS值来预测细胞对治疗的反应。本发明还包括用于细胞反应性的预测方法，其中使用统计分类算法将细胞（例如，肿瘤细胞）的NAS或NIS值的计算结合在一起。还提供了用于预测用靶向ErbB信号通路中的组分的治疗剂对治疗的反应性的生物标志物。

3. 发明申请

WO2006091209A3 BISPECIFIC BINDING AGENTS FOR MODULATING BIOLOGICAL ACTIVITY 审中-公开
标题翻译：用于调节生物活性的双重结合剂
公开(公告)号：WO2006091209A3
公开(公告)日：2006-10-26
申请号：PCT/US2005015638
申请日：2005-05-05
申请人： MERRIMACK PHARMACEUTICALS INC , NIELSEN ULRIK B , SCHOEBERL BIRGIT M
发明人： NIELSEN ULRIK B , SCHOEBERL BIRGIT M
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/52 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： Methods for improving the specific binding ability of bispecific binding compositions are described. The bispecific binding compositions are able to target cells by a high affinity targeting domain to a target cell surface marker and a low affinity binding domain that binds specifically to a second cell surface marker, wherein the binding of each domain to its respective cell surface marker increases or decreases, as desired, the biological activity of the respective cell surface markers. The invention further provides bispecific binding agents for use in the methods, as well as uses for the agents.
摘要翻译：描述了改善双特异性结合组合物的特异性结合能力的方法。双特异性结合组合物能够通过高亲和力靶向结构域将细胞靶向靶细胞表面标志物和特异性结合第二细胞表面标志物的低亲和力结合结构域，其中每个结构域与其相应细胞表面标志物的结合增加或者根据需要降低各细胞表面标志物的生物活性。本发明进一步提供了用于该方法的双特异性结合剂，以及该试剂的用途。

4. 发明申请

WO2017218533A1 METHODS AND COMPOSITIONS FOR PROMOTING IMMUNE CELL FUNCTION 审中-公开
标题翻译：促进免疫细胞功能的方法和组合物
公开(公告)号：WO2017218533A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037249
申请日：2017-06-13
申请人： TORQUE THERAPEUTICS, INC. , PUCCI, Ferdinando , ANDRESEN, Thomas, Lars , JONES, Douglas, Scott , NIELSEN, Ulrik , RAKESTRAW, James, Andrew
发明人： PUCCI, Ferdinando , ANDRESEN, Thomas, Lars , JONES, Douglas, Scott , NIELSEN, Ulrik , RAKESTRAW, James, Andrew
IPC分类号： A61K38/20 , A61K47/54 , A61K47/68 , A61K38/17
摘要： The present disclosure features, at least in part, methods for conserving cell function, immune cell function, e.g., after one or more cycles of freezing and/or thawing the nucleated cell. In embodiments, the methods comprise contacting an immune cell with a protein nanoparticle comprising an IL-15 complex.
摘要翻译：本公开至少部分地特征在于例如在一个或多个冷冻和/或融化有核细胞之后保存细胞功能，免疫细胞功能的方法。在实施方案中，所述方法包括使免疫细胞与包含IL-15复合物的蛋白质纳米颗粒接触。

5. 发明申请

WO2014202531A1 DETECTION OF INDICATIONS OF PSYCHOACTIVE COMPONENTS IN A LIQUID 审中-公开
标题翻译：检测液体中PSYCHOACTIVE COMPONENTS的适应症
公开(公告)号：WO2014202531A1
公开(公告)日：2014-12-24
申请号：PCT/EP2014/062569
申请日：2014-06-16
申请人： NIELSEN, Ulrik Merrild
发明人： NIELSEN, Ulrik Merrild
IPC分类号： G01N21/35 , G01N33/14 , G01J3/02
CPC分类号： G01N21/49 , G01J3/0256 , G01J3/10 , G01J3/108 , G01J2003/104 , G01N21/3577 , G01N21/51 , G01N2021/3196 , G01N2201/0221 , G01N2201/1293
摘要： A method of contactless detection of indications of psychoactive components in a liquid (6) is disclosed and an apparatus therefor, the method comprising the steps of emitting substantially monochromatic light at least at two different wavelengths (La, Lb) and detecting the reflection in a free surface (12) of said liquid (6) by means of a photo detector (5), analysing an output signal from the photo detector (5) to identify output parts caused by light emitted from the first (3a) and second emitter (3b), respectively, and determine whether the liquid (6) contains at least one psychoactive component.
摘要翻译：公开了一种对液体（6）中的精神活性成分的指示进行非接触式检测的方法及其装置，所述方法包括以下步骤：至少在两个不同波长（La，Lb）发射基本上单色的光，并检测在通过光电检测器（5）对所述液体（6）的自由表面（12）进行分析，分析来自光电检测器（5）的输出信号，以识别由第一（3a）和第二发射器 3b），并且确定液体（6）是否包含至少一种精神活性成分。

6. 发明申请

WO2013006547A3 ANTIBODIES AGAINST EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND USES THEREOF 审中-公开
公开(公告)号：WO2013006547A3
公开(公告)日：2013-01-10
申请号：PCT/US2012/045235
申请日：2012-07-02
申请人： MERRIMACK PHARMACEUTICALS, INC. , ADIMAB, LLC , BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric , KEARNS, Jeffrey, David , LUGOVSKOY, Alexey, A. , NIELSEN, Ulrik
发明人： BUKHALID, Raghida , FELDHAUS, Michael , KING, Anne , KOHLI, Neeraj , KRAULAND, Eric , KEARNS, Jeffrey, David , LUGOVSKOY, Alexey, A. , NIELSEN, Ulrik
IPC分类号： A61K39/395 , C07K14/71 , C07K16/28
摘要： Anti- EGFR antibodies, therapeutic compositions comprising combinations of anti-EGFR antibodies, as well as methods for using such antibodies and compositions to treat EGFR-related disorders (e.g., cancers), are disclosed.

7. 发明申请

WO2011022727A2 ANTIBODIES AGAINST THE ECTODOMAIN OF ERBB3 AND USES THEREOF 审中-公开
标题翻译：抗体对ERBB3的ECTODOMAIN及其用途
公开(公告)号：WO2011022727A2
公开(公告)日：2011-02-24
申请号：PCT/US2010/046364
申请日：2010-08-23
申请人： MERRIMACK PHARMACEUTICALS, INC. , SCHOEBERL, Birgit , NIELSEN, Ulrik , FELDHAUS, Michael
发明人： SCHOEBERL, Birgit , NIELSEN, Ulrik , FELDHAUS, Michael
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/92
摘要： The present invention provides a novel class of antibodies and antigen binding fragments thereof that bind the extracellular domain of ErbB3 receptor and inhibit various ErbB3 functions. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor. Such antibodies and antigen binding fragments thereof have the useful characteristic of inhibiting the proliferation of cancer cells expressing ErbB3.
摘要翻译：本发明提供了结合ErbB3受体的细胞外结构域并抑制各种ErbB3功能的新一类抗体及其抗原结合片段。例如，本文所述的抗体和抗原结合片段能够结合称为ErbB3的受体并抑制受体的EGF样配体介导的磷酸化。这些抗体及其抗原结合片段具有抑制表达ErbB3的癌细胞增殖的有用特征。

8. 发明申请

WO2008100624A3 ANTIBODIES AGAINST ERBB3 AND USES THEREOF 审中-公开
标题翻译：反对ERBB3的抗体及其用途
公开(公告)号：WO2008100624A3
公开(公告)日：2009-01-15
申请号：PCT/US2008002119
申请日：2008-02-15
申请人： MERRIMACK PHARMACEUTICALS INC , SCHOEBERL BIRGIT , NIELSEN ULRIK , FELDHAUS MICHAEL
发明人： SCHOEBERL BIRGIT , NIELSEN ULRIK , FELDHAUS MICHAEL
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/32 , A61K9/0019 , A61K31/337 , A61K31/517 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： The present invention provides a novel class of monoclonal antibodies which bind ErbB3 receptor and inhibits various ErbB3 functions. For example, the antibodies described herein are capable of binding to ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor.
摘要翻译：本发明提供了一种新型的结合ErbB3受体并抑制各种ErbB3功能的单克隆抗体。例如，本文所述的抗体能够结合ErbB3并抑制EGF样配体介导的受体的磷酸化。

9. 发明申请

WO2005117973A3 BISPECIFIC BINDING AGENTS FOR MODULATING BIOLOGICAL ACTIVITY 审中-公开
标题翻译：用于调节生物活性的双重结合剂
公开(公告)号：WO2005117973A3
公开(公告)日：2006-03-30
申请号：PCT/US2005015639
申请日：2005-05-05
申请人： MERRIMACK PHARMACEUTICALS INC , NIELSEN ULRIK B , SCHOEBERL BIRGIT M
发明人： NIELSEN ULRIK B , SCHOEBERL BIRGIT M
IPC分类号： A61K39/395 , C07K16/30 , A61K38/00 , A61K49/16 , C07K16/00
CPC分类号： A61K39/39558 , C07K16/30 , C07K2317/32 , C07K2317/92
摘要： Methods for improving the biological and pharmaceutical properties of bispecific binding agents are described herein where the bispecific binding agent are able to target cells by a high affinity binding domain to a first cell surface marker that does not induce a significant biological effect and a low affinity binding domain that binds specifically to a second cell surface marker, causing a significant and desired biological effect. Compositions of such bispecific binding agents, uses for them, and kits containing them are also provided.
摘要翻译：本文描述了用于改善双特异性结合剂的生物学和药学性质的方法，其中双特异性结合剂能够通过高亲和力结合结构域将细胞靶向第一细胞表面标志物，其不诱导显着的生物学作用和低亲和力结合结构域，其特异性结合第二细胞表面标记，引起显着和期望的生物学效应。还提供了这种双特异性结合剂的组合物，它们的用途和含有它们的试剂盒。

10. 发明申请

WO2013156075A1 METALLIC ELEMENT USEFUL AS SPACER OR INTERCONNECT FOR A HIGH TEMPERATURE FUEL CELL 审中-公开
标题翻译：金属元件作为高温燃料电池的间隔或互连
公开(公告)号：WO2013156075A1
公开(公告)日：2013-10-24
申请号：PCT/EP2012/057244
申请日：2012-04-20
申请人： TOPSØE FUEL CELL A/S , USTERUD, Harald , NIELSEN, Ulrik, Jens , OLSEN, Christian
发明人： USTERUD, Harald , NIELSEN, Ulrik, Jens , OLSEN, Christian
IPC分类号： H01M8/02 , H01M8/12 , H01M8/14
CPC分类号： H01M8/0206 , H01M8/0258 , H01M8/0273 , H01M8/2425 , H01M8/2457 , H01M8/2483 , H01M2008/1293 , H01M2008/147 , Y02E60/526
摘要： The invention concerns ametallic element for a high tem- perature fuel cell stack, wherein each individual fuel cell comprises an anode, a cathode, an electrolyte and an elec- trochemically active area. The metallic element (1) com- prises a metallic sheet (2) having first and second planar surfaces (3,4) on opposite sides of the metallic sheet (2) and a first, second, third and fourth periphery (5,6,7,8), the first and third peripheries (5,7) and the second and fourth peripheries (6,8) forming opposing peripheries. The metallic sheet (1) is provided with inlet and outlet gas openings (99,100) extending completely through the metallic sheet from the first planar surface (3) to the second pla- nar surface (4) and positioned at first and third peripher- ies (5,7) only of the metallic sheet (2), at least one inlet gas opening (99) and at least one outlet gas (100) opening being partially open and extending into one or more micro channels (13) located on the first planar surface (3). Each micro channel (13) extends continuously or dis- continuously from the at least one inlet gas opening (99) or at least one outlet gas opening (100) adjacent to the electrochemically active area of the fuel cell. This metal- lic element ensures an improved flow distribution of gases taking part in electrochemical reactions within the fuel cell, and it is well suited for use as an interconnect in a solid oxide fuel cell (SOFC) or a solid oxide electrolysis cell (SOEC).
摘要翻译：本发明涉及用于高温燃料电池堆的非金属元素，其中每个单独的燃料电池包括阳极，阴极，电解质和电化学活性区域。金属元件（1）包括在金属片（2）的相对侧上具有第一和第二平面（3,4）的金属片（2）和第一，第二，第三和第四外围（5,6 ，7,8），第一和第三外围（5,7）以及形成相对的外围的第二和第四周边（6,8）。金属片（1）设置有从第一平面（3）到第二平面（4）完全延伸穿过金属片的入口和出口气体开口（99,100），并定位在第一和第三外围（5,7），仅有金属片（2），至少一个入口气体开口（99）和至少一个出口气体（100）开口部分地开口并延伸到位于所述金属片材上的一个或多个微通道（13）中第一平面（3）。每个微通道（13）从邻近燃料电池的电化学活性区域的至少一个入口气体开口（99）或至少一个出口气体开口（100）连续地或不连续地延伸。该金属元素确保了燃料电池中参与电化学反应的气体的改善的流量分布，并且非常适合用作固体氧化物燃料电池（SOFC）或固体氧化物电解池（SOEC）中的互连，。

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